fluoxetine / Generic mfg. 
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  • ||||||||||  olanzapine / Generic mfg., fluoxetine / Generic mfg.
    [VIRTUAL] Elucidating Genetic Contributions to Accelerated Biological Degeneration Related to Antipsychotic Induced Weight Gain () -  Sep 30, 2020 - Abstract #ACNP2020ACNP_60;    
    As a starting point towards developing personalized approaches to AP-induced increases in adiposity, we propose a patient-to-gene pharmacogenomics pipeline to characterize the full genomic contribution to AIWG. The final step in the process will be to employ CRISPRi/a assays generating rapid feedback on the functional nature of candidate variants/regions to detect causal genetic variants for AIWG
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effects of Fluoxetine and/or DHEA (clinicaltrials.gov) -  Sep 28, 2020   
    P1,  N=60, Recruiting, 
    The final step in the process will be to employ CRISPRi/a assays generating rapid feedback on the functional nature of candidate variants/regions to detect causal genetic variants for AIWG Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2020 --> Dec 2022
  • ||||||||||  bupropion / Generic mfg., fluoxetine / Generic mfg., Edronax (reboxetine) / Pfizer
    Journal:  Antidepressants upregulate c-Fos expression in the lateral entorhinal cortex and hippocampal dorsal subiculum: study in rats. (Pubmed Central) -  Sep 26, 2020   
    All the drugs at the behaviorally relevant doses activated two brain areas, the lateral entorhinal cortex and dorsal subiculum of the hippocampus; none of the drugs affected the c-Fos expression in the medial orbital, prelimbic and infralimbic cortex, caudate putamen, nucleus accumbens core, bed nucleus of stria terminalis, hipothalamic paraventricular nucleus, medial amygdaloid nucleus, lateral habenula, substantia nigra pars compacta and pars reticulata, ventral tegmental area, hippocampal ventral subiculum, dorsal and ventral periaqueductal gray matters, and medial entorhinal cortex. These findings suggest that the stimulation of the lateral entorhinal cortex and hippocampal dorsal subiculum play a role in therapeutic effects of antidepressants.
  • ||||||||||  Journal:  LC-MS/MS METHOD FOR THE DETERMINATION OF ANTIDEPRESSANTS AND BENZODIAZEPINES IN MECONIUM. (Pubmed Central) -  Sep 25, 2020   
    The authentic meconium samples tested positive for alprazolam, α-hydroxyalprazolam, clonazepam, diazepam, nordiazepam, fluoxetine, norfluoxetine, clomipramine and norclomipramine. Therefore, the present LC-MS/MS method allows a high throughput determination of the most common benzodiazepines and antidepressants in meconium, which could be useful in clinical and forensic settings.
  • ||||||||||  Journal:  Developing and Validating a Fast and Accurate Method to Quantify 18 Antidepressants in Oral Fluid Samples Using SPE and LC-MS-MS. (Pubmed Central) -  Sep 25, 2020   
    We developed and validated a comprehensive liquid chromatography-tandem mass spectrometry method for 18 antidepressants (amitriptyline, bupropion, citalopram, clomipramine, cyclobenzaprine, desipramine, desvenlafaxine, doxepin, duloxetine, fluoxetine, imipramine, mirtazapine, nortriptyline, paroxetine, sertraline, trazodone, trimipramine, venlafaxine) in oral fluid collected by Quantisal® oral collection devices...The authentic patient sample showed a percentage difference compared to the previously calculated concentration of 86.3-111%. This method provides for the rapid detection of 18 antidepressants and metabolites in OF, which is readily applicable to a routine laboratory.
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Time-to-effect of fluoxetine in children with depression. (Pubmed Central) -  Sep 24, 2020   
    However, more research is needed to elucidate the optimal length of the initial treatment period. There is conflicting evidence regarding the risk of suicidality in this population, so close patient monitoring is required when using fluoxetine in children and adolescents.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle. (Pubmed Central) -  Sep 24, 2020   
    This single device will have significant potential for clinical measurements of anorectum function and signalling, that can direct therapeutic management of patients with bowel disorders. Taken together, these data are the first to illustrate the effects of fluoxetine on behavior and adult hippocampal neurogenesis across all four phases of the murine estrous cycle.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Multiple cellular targets involved in the antidepressant-like effect of glutathione. (Pubmed Central) -  Sep 24, 2020   
    These results suggest that the antidepressant-like effect induced by GSH is connected to the activation of α1 adrenergic and GABAA receptors, as well as the inhibition of GABAB and NMDA receptors and NO biosyntesis. We speculate that redox-mediated signaling on the extracelular portion of cell membrane receptors would be a common mechanism of action of GSH.
  • ||||||||||  Journal, Adverse events:  Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders. (Pubmed Central) -  Sep 19, 2020   
    This effect could be mediate by activation of 5-HT-receptors. Because of ahigh risk of interactions and related adverse effects, especially in older patients, each decision regarding combination of a particular antidepressant with a medication used in treatment of cardiovascular disorders should be preceded by a detailed analysis of safety and risk-benefit ratio, and also be associated with the search for the safest, alternative combinations of the above-mentioned medications.
  • ||||||||||  sertraline / Generic mfg., fluoxetine / Generic mfg.
    Clinical, Journal:  Incidence of Depression and First-Line Antidepressant Therapy in People with Obesity and Depression in Primary Care. (Pubmed Central) -  Sep 18, 2020   
    Because of ahigh risk of interactions and related adverse effects, especially in older patients, each decision regarding combination of a particular antidepressant with a medication used in treatment of cardiovascular disorders should be preceded by a detailed analysis of safety and risk-benefit ratio, and also be associated with the search for the safest, alternative combinations of the above-mentioned medications. We recommend guidance on antidepressant drug prescribing and specific services for people with obesity and depression that address both symptoms and behaviors.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  The dynamics of Poststroke depression among Ghanaians. (Pubmed Central) -  Sep 16, 2020   
    80% Ghanaian stroke survivors have early PSD declining to 20% at month 9. Stroke severity is the persistent factor associated with PSD at baseline and follow-up, and good be a target for screening and promptly treating PSD.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. (Pubmed Central) -  Sep 16, 2020   
    Combined treatment also elicited a transient early increase in activated microglia in the hippocampus, suggesting therapy-induced neuroinflammation that subsided by 15 weeks. Together, the results of this study suggest that interventions targeting the serotonin axis may help ameliorate certain neurological side effects associated with the clinical management of GBM to improve the overall quality of life for cancer patients.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date:  STEP: The Staged Treatment in Early Psychosis Study (clinicaltrials.gov) -  Sep 16, 2020   
    P3,  N=340, Active, not recruiting, 
    Together, the results of this study suggest that interventions targeting the serotonin axis may help ameliorate certain neurological side effects associated with the clinical management of GBM to improve the overall quality of life for cancer patients. Trial completion date: Dec 2021 --> May 2021
  • ||||||||||  methylphenidate tablet / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Attention-Deficit Hyperactivity Disorder, Disruptive Behaviors, and Drug Shortage. (Pubmed Central) -  Sep 10, 2020   
    Overall, the behaviors resulted in parents being unable to go to dinner as a couple or provide individual attention to their other children. The parents described the family as "on edge." How would you approach Kyle's management?
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Nod-like receptors are critical for gut-brain axis signalling in mice. (Pubmed Central) -  Sep 10, 2020   
    We also identified that intestinal epithelial cell-specific deletion of Nod1 (VilCre Nod1 ), but not Nod2, increased susceptibility to stress-induced anxiety-like behaviour and cognitive impairment following exposure to stress. Together these data suggest that intestinal epithelial NLR are novel modulators of gut-brain communication and may serve as potential novel therapeutic targets for the treatment of gut-brain disorders.
  • ||||||||||  [VIRTUAL] T‐cell pseudolymphoma secondary to ixazomib for multiple myeloma () -  Sep 9, 2020 - Abstract #BAD2020BAD_41;    
    This occurred shortly after his third cycle of treatment with ixazomib, thalidomide and dexamethasone for multiple myeloma...Among other triggers, lymphomatoid drug reactions are reported with phenytoin, chlorpromazine, atenolol, enalapril, verapamil, lorazepam, fluoxetine, cimetidine and lovastatin (Polysangam et al.). Ixazomib is an oral proteasome inhibitor used in the treatment of multiple myeloma...Use of ixazomib is increasing, as are rates of multiple myeloma. It is therefore useful for dermatologists to recognize this potential effect and be aware that conservative management with topical steroids, temporary cessation of treatment or dose reduction may be adequate to alleviate the rash and allow continuation of ixazomib treatment.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Review, Journal:  The effects of perinatal SSRI exposure on anxious behavior and neurobiology in rodent and human offspring. (Pubmed Central) -  Sep 8, 2020   
    Finally, some key factors to consider when examining the role of perinatal SSRIs on offspring anxiety will be discussed, such as the duration of SSRI exposure and the potential neuroprotective effects of SSRIs. Given the extensive prescribing of SSRIs, the potential health consequences of perinatal SSRI exposure, and the discrepancies in the literature, it will be necessary to critically examine the factors underlying offspring anxiety outcomes.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Maternal fluoxetine exposure alters cortical hemodynamic and calcium response of offspring to somatosensory stimuli. (Pubmed Central) -  Sep 8, 2020   
    In order to isolate the effect of perinatal SSRI exposure from genetic variables or a maternal psychiatric diagnosis, we used in vivo functional neuroimaging to examine adult cortical function both at rest and in response to a somatosensory input in a mouse model of perinatal SSRI exposure. Our mouse model displayed no global disruption of brain function at rest when compared to controls, while its cortical response to a somatosensory stimulus was reduced, as measured by both hemodynamics and excitatory calcium signaling.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda, sertraline / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Vortioxetine reduces marble burying but only transiently enhances social interaction preference in adult male BTBR TItpr3/J mice. (Pubmed Central) -  Sep 6, 2020   
    We hypothesized that vortioxetine through its actions at SERT and 5-HT could improve BTBR sociability and via 5-HT could reduce burying better than sertraline, a selective SERT blocker...Based on vortioxetine occupancy SERT and/or 5-HT are more likely to underlie these effects than 5-HT occupancy. Overall, vortioxetine has great potential for suppressing restrictive-repetitive behaviors, but appears less promising as a sociability enhancer.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Serum levels of chemokines in adolescents with major depression treated with fluoxetine. (Pubmed Central) -  Sep 4, 2020   
    Despite the consumption of fluoxetine, patients had significantly higher chemokine levels, even after considering the improvement in HDRS score. The high levels of eotaxin, IP-10, and IL-8 partially explain certain aspects that are affected in MDD such as cognition, memory, and learning.
  • ||||||||||  Trial completion, Enrollment change:  The Gut Microbiota in Obsessive-Compulsive Disorder (clinicaltrials.gov) -  Sep 2, 2020   
    P=N/A,  N=43, Completed, 
    The high levels of eotaxin, IP-10, and IL-8 partially explain certain aspects that are affected in MDD such as cognition, memory, and learning. Recruiting --> Completed | N=25 --> 43
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion, Trial primary completion date:  EFFECTS: Efficacy of Fluoxetine - a Trial in Stroke (clinicaltrials.gov) -  Sep 2, 2020   
    P3,  N=1500, Completed, 
    Recruiting --> Completed | N=25 --> 43 Recruiting --> Completed | Trial primary completion date: Dec 2019 --> Jun 2020
  • ||||||||||  fluoxetine / Generic mfg.
    Retrospective data, Journal, Adverse events:  Prenatal Antidepressant Use and Risk of Adverse Neonatal Outcomes. (Pubmed Central) -  Sep 1, 2020   
    These features of antidepressant-induced plasticity may be useful when designing treatment strategies involving long-term antidepressant treatment in humans. Although findings support continuation of the lowest effective dose to treat depression or anxiety, which benefits the mother, they also highlight an increased risk for newborn respiratory distress in all groups and preterm birth at moderate to high sustained doses.