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Journal: Genetic Background Underlying 5-HT Receptor Functioning Affects the Response to Fluoxetine. (Pubmed Central) - Mar 11, 2021 These data demonstrate that changes in genetic background may have a dramatic effect on sensitivity to classic antidepressants from the Selective Serotonin Reuptake Inhibitors family. Additionally, the results provide new evidence confirming our idea on the disrupted functioning of 5-HT autoreceptors in the brains of B6-M76C mice, suggesting these mice as a model of antidepressant resistance.
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Journal: Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment. (Pubmed Central) - Mar 10, 2021 Behavioral and neurogenic effects of chronic treatment with the SSRI, fluoxetine, are abolished by mossy cell-specific knockout of p11 or Smarca3 or by an inhibition of the p11/AnxA2/SMARCA3 heterohexamer, an SSRI-inducible protein complex...The present data establish that mossy cells play a crucial role in mediating the effects of chronic antidepressant medication. Our results indicate that compounds that target mossy cell activity would be attractive candidates for the development of new antidepressant medications.
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Preclinical, Journal: Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression. (Pubmed Central) - Mar 10, 2021 H2-cyanome, like fluoxetine, also modulated several intracellular signaling pathways previously involved in antidepressant response. Our findings provide proof-of-concept of antidepressant efficacy of an OCT blocker, and a mechanistic framework for the development of new classes of antidepressants and therapeutic alternatives for resistant depression and other psychiatric disturbances such as anxiety.
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Journal: Pitolisant (Wakix) for narcolepsy. (Pubmed Central) - Mar 10, 2021 Our findings provide proof-of-concept of antidepressant efficacy of an OCT blocker, and a mechanistic framework for the development of new classes of antidepressants and therapeutic alternatives for resistant depression and other psychiatric disturbances such as anxiety. No abstract available
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Journal: Brain Proteomic Analysis on the Effects of the Antidepressant Fluoxetine. (Pubmed Central) - Mar 9, 2021 As this signature pointed toward changes in synaptic structure, we also present a protocol for Western blot analysis targeting selected proteins identified by the combined 2D-DIGE-MALDI-TOF mass spectrometry procedure. Such validation experiments are critical for the translation of putative biomarkers into preclinical and clinical studies.
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Journal: Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment. (Pubmed Central) - Mar 9, 2021 Lsamp, another IgLON family protein, increased in mouse dentate gyrus after fluoxetine treatment. These findings suggest that Negr1-Fgfr2 pathway plays a role in the modulation of synaptic plasticity induced by antidepressant treatment to promote therapeutic efficacy by rearranging connectivity in corticolimbic circuits impaired in depression.
- |||||||||| sildenafil / Generic mfg., diazepam / Generic mfg., fluoxetine / Generic mfg.
Journal: Pharmacological insights on the antidepressant, anxiolytic and aphrodisiac potentials of Aglaonema hookerianum Schott. (Pubmed Central) - Mar 9, 2021 These findings suggest that Negr1-Fgfr2 pathway plays a role in the modulation of synaptic plasticity induced by antidepressant treatment to promote therapeutic efficacy by rearranging connectivity in corticolimbic circuits impaired in depression. Taken together, MEAH can be recommended as a potent source of neuroprotective and a libido-boosting drug candidate for the management of neurological and sexual disorders.
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Journal: Analysis of K Channels Opening Probability of Hippocampus Cells Treated with Kainic Acid. (Pubmed Central) - Mar 9, 2021 The treatment effects of 10 mM glucose and 30 μM fluoxetine on K channels NPo of β-cells were assessed via cell-attached patch-clamp recordings...No effect was shown in 10 mM KA treatment, suggesting that only lower than 10 mM KA produced significant changes in K channels. This implies further validation of KA concentration to be used in the future.
- |||||||||| ketamine / Generic mfg., fluoxetine / Generic mfg.
Journal: Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat. (Pubmed Central) - Mar 9, 2021 Moreover, in rats that were continuously treated with fluoxetine (10 mg/kg/day for 11 days), the sucrose solution consumption increased, the immobility time in the FST decreased, and locomotor activity increased compared to vehicle-treated rats. The present results demonstrate that a lesion of HDB cholinergic neurons results in depressive-like and anxiety-like behaviors and that antidepressants such as fluoxetine or ketamine, can reverse these depressive-like behaviors but not anxiety-like behaviors, and suggest that a lesion of HDB cholinergic neurons and followed hippocampus damage may be involved in the pathogenesis of depression.
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[VIRTUAL] Major Depressive Disorder, Bone, and Ketamine () - Mar 7, 2021 - Abstract #CINP2021CINP_182; Use of selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, is associated with an increased rate of bone loss at the hip in MDD patients...These data suggest that in addition to its antidepressant effects, (R)-ketamine also has a salutary effect on a major medical complication of depressive illness. It is likely that (R)-ketamine would be a potential therapeutic drug for MDD patients with osteoporosis.
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[VIRTUAL] SSRI Doses in Swedish Primary Care () - Mar 7, 2021 - Abstract #CINP2021CINP_173; For paroxetine and fluoxetine, however, the lowest optimal dose was also the one most commonly prescribed. Our results suggest that most patients treated in primary care might not experience the full benefit of SSRI treatment.
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[VIRTUAL] C57/BL6 Mice Demonstrate Increased Immobility Time in the FST with Chronic Fluoxetine Treatment () - Mar 7, 2021 - Abstract #CINP2021CINP_122; The results contrast with reduced immobility time in the FST reported after chronic treatment with fluoxetine in the BALB/c genetic strain of mice (Dulawa et al, 2004). In our C57/BL6 mice we also noted that the effect of chronic fluoxetine in prolonging immobility time persisted despite an acute injection of propofol, a GABA-A agonist with affinity at the NMDA receptor (Daniel et al, 2019).
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Journal: Transgenerational reproductive effects of two serotonin reuptake inhibitors after acute exposure in Daphnia magna embryos. (Pubmed Central) - Mar 4, 2021 Our results suggest that SSRI exposure has transgenerational consequences to the unexposed generation and potentially beyond, even at low concentration (10-100× lower than what can be found in natural ecosystems) and as a result of embryonic exposure. Because of the short reproductive period of D. magna and their integral role in aquatic food webs, these findings have population-level implications and deserve further investigation.
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Clinical, Review, Journal: Evaluation of current post-concussion protocols. (Pubmed Central) - Mar 2, 2021 Among pharmaceutical agents, fluoxetine has been a popular choice for the symptom management of PCS...However, over-arching claims that some treatments may benefit more than others can be made. This review evaluates both the pharmaceutical and non-pharmaceutical protocols that are most commonly utilized in post-concussive patients for their efficacy in treatment of post-concussive syndrome (PCS).
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[VIRTUAL] Therapeutic Management of Mood Disorders during Acute Schizophrenia () - Mar 1, 2021 - Abstract #SIRS2021SIRS_518; Short-acting benzodiazepines (lorazepam, midazolam) were allowed for administration during the 6-month of active monitoring, but not more than 4 consecutive weeks...Antidepressant may be added to atypical antipsychotics without significant impact over the treatment tolerability. Antidepressants may improve the quality of life by decreasing the severity of depression in patients with schizophrenia.
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[VIRTUAL] Therapeutic Management of Mood Disorders during Acute Schizophrenia () - Mar 1, 2021 - Abstract #SIRS2021SIRS_380; Short-acting benzodiazepines (lorazepam, midazolam) were allowed for administration during the 6-month of active monitoring, but not more than 4 consecutive weeks...Antidepressant may be added to atypical antipsychotics without significant impact over the treatment tolerability. Antidepressants may improve the quality of life by decreasing the severity of depression in patients with schizophrenia.
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Preclinical, Journal: Dextromethorphan improved cyclosporine-induced depression in mice model of despair. (Pubmed Central) - Feb 26, 2021 Dxt was a useful drug for preventing Cyc-induced depression that remained effective for 24 h in mice. Since interpretation from animal studies to humans must be done with caution further clinical studies on the effect of Dxt in patients suffering from psychological side effects of Cyc may be reasonable.
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Trial completion: Acupuncture for Ischemic Post-stroke Depression (clinicaltrials.gov) - Feb 24, 2021 P=N/A, N=208, Completed, Anxiolytic- and antidepressant-like effects of this species, reported for first time in this study could improve some aspects of mental health. Recruiting --> Completed
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Preclinical, Journal: Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice. (Pubmed Central) - Feb 23, 2021 Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups...The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.
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Journal: Fluoxetine chronic exposure affects growth, behavior and tissue structure of zebrafish. (Pubmed Central) - Feb 20, 2021 Mild to moderate damage of hepatic tissue and a decrease epithelium height and increase in villus height of intestine were observed in fish exposed to concentrations as low as 0.01 μg/L. Based on obtained results, chronic exposure of fish to FLX could affect swimming and feeding behavior and alter morphological structure of liver and intestine tissues at environmental levels.
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Et le prozac ! (Twitter) - Feb 19, 2021
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[VIRTUAL] THE EFFECT OF SELECTIVE SEROTONIN REUPTAKE INHIBITOR ON POST-TAVR MORTALITY (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_3042; In order to understand the potential impact of SSRIs, we queried the TriNetx database (Research Network) between January 1, 2015 and July 18, 2020 and identified 2,034 cases with defined SSRI usage including escitalopram, sertraline, citalopram, fluoxetine, and paroxetine). In a large multi-national database of patients that underwent a TAVR we found a suggestive relationship between those that were on a SSRI vs no SSRI through long term mortality.
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