- |||||||||| fluoxetine / Generic mfg.
Journal: Sex-specific effects of psychoactive pollution on behavioral individuality and plasticity in fish. (Pubmed Central) - Nov 16, 2023
In sharp contrast, effects on behavioral plasticity were observed in females-but not in males-whereby exposure to even low levels of fluoxetine resulted in a substantial decrease (activity) and increase (freezing behavior) in the behavioral plasticity of females. Our evidence reveals that psychoactive pollution has sex-specific effects on the individual behavior of fish, suggesting that males and females might not be equally vulnerable to global pollutants.
- |||||||||| fluoxetine / Generic mfg.
Limitations of Bedside Behavioral Evaluations in Detecting Covert Consciousness: A Case Report () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_818;
Standardized bedside assessments are often inadequate to correctly identify patients with diagnoses that may result in covert consciousness. The failure to accurately detect covert consciousness can negatively impact the expected quality of life, discharge planning, and decisions regarding life-sustaining therapies in patients following severe brain injury.
- |||||||||| fluoxetine / Generic mfg.
Journal: De Novo Variants in KCNA3 Cause Developmental and Epileptic Encephalopathy. (Pubmed Central) - Nov 15, 2023
The failure to accurately detect covert consciousness can negatively impact the expected quality of life, discharge planning, and decisions regarding life-sustaining therapies in patients following severe brain injury. We describe a novel association of de novo missense variants in KCNA3 with a human DEE, and provide evidence that fluoxetine might represent a potential targeted treatment for individuals carrying variants with significant GoF effects.
- |||||||||| fluoxetine / Generic mfg.
Journal: Impact of environmentally relevant concentrations of fluoxetine on zebrafish larvae: From gene to behavior. (Pubmed Central) - Nov 15, 2023
In addition, altered levels of neurochemicals belonging to the serotonergic and dopaminergic systems (increased levels of tryptophan and norepinephrine) highlighted the sensitivity of early life stages of zebrafish to low concentrations of fluoxetine, inducing effects that may compromise larval survival. The obtained data support the necessity to test low concentrations of SSRIs in environmental risk assessment and the use of biomarkers at different levels of biological organization for a better understanding of modes of action.
- |||||||||| paroxetine / Generic mfg.
Enrollment change: Effects of Paroxetine on Cardiovascular Function in Septic Patients (clinicaltrials.gov) - Nov 14, 2023
P2, N=92, Recruiting,
The obtained data support the necessity to test low concentrations of SSRIs in environmental risk assessment and the use of biomarkers at different levels of biological organization for a better understanding of modes of action. N=20 --> 92
- |||||||||| peginterferon lambda-1a (BMS-914143) / Eiger, Stanford University
Trial completion date, Trial primary completion date: Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms (clinicaltrials.gov) - Nov 14, 2023
P3, N=6246, Recruiting,
Collectively, these findings indicate that neuronal VEGF-Flk-1 signaling contributes to the antidepressant-like actions of conventional antidepressants. Trial completion date: Nov 2023 --> Apr 2024 | Trial primary completion date: Oct 2023 --> Feb 2024
- |||||||||| fluoxetine / Generic mfg.
Journal: Persistence of norfluoxetine in marine mussels. (Pubmed Central) - Nov 13, 2023
The levels of NFLU in the mussels' tissues after the depuration period were comparable to the levels detected at the end of exposure. This indicates that NFLU is not efficiently removed by the mussels and points to a potential risk for consumers of such marine organisms.
- |||||||||| Journal: Mechanisms of SSRI Therapy and Discontinuation. (Pubmed Central) - Nov 13, 2023
This compelling view of SSRI action is underpinning attempts to understand fast-acting antidepressants, such as ketamine and psychedelic drugs, and aid the development of future therapies...Nevertheless, evidence of rebound increases in 5-HT neuron excitability immediately on cessation of SSRI treatment provide a starting point for future investigation. Indeed, this evidence allows formulation of a mechanistic explanation of SSRI discontinuation which draws on parallels with the withdrawal states of other psychotropic drugs.
- |||||||||| amitriptyline / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Journal, HEOR: Cost-minimization analysis of escitalopram, fluoxetine, and amitriptyline in the treatment of depression. (Pubmed Central) - Nov 10, 2023
Among the drugs compared, fluoxetine seems to offer greater value for money. The study emphasizes that selective serotonin reuptake inhibitors are the most commonly prescribed antidepressants not only because of their favorable pharmacological profile but also because of their affordability.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal, Adverse events: Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats. (Pubmed Central) - Nov 8, 2023
Our results suggest that both rTMS and fluoxetine could benefit the CUMS-induced abnormal behaviors including depressive-like behaviors, and the beneficial effects of rTMS as well as fluoxetine on depression might be partly related to their neuroprotective effect on attenuating astroglial activation and BDNF decrease. Our findings may provide new insights into the cardiac and hepatic adverse effects of FLX.
- |||||||||| Quviviq (daridorexant) / Idorsia, Mochida, Syneos Health, Sosei, Viibryd (vilazodone) / AbbVie
Enrollment open: Department of Defense PTSD Adaptive Platform Trial - Master Protocol (clinicaltrials.gov) - Nov 7, 2023
P2, N=600, Recruiting,
Our findings may provide new insights into the cardiac and hepatic adverse effects of FLX. Not yet recruiting --> Recruiting
- |||||||||| fluoxetine / Generic mfg.
Fluoxetine exerts anti-inflammatory effects on human epidermal keratinocytes, and suppresses their endothelin release () - Nov 6, 2023 - Abstract #ISDS2023ISDS_327;
Collectively, our findings demonstrate that fluoxetine exerts potent anti-inflammatory effects, and suppresses the release of the endogenous itch mediator endothelins in human keratinocytes, most likely via indirect inhibition of PI3K. Thus, clinical studies are encouraged to explore whether the currently reported beneficial effects translate in vivo following its topical administration in inflammatory and pruritic dermatoses.
- |||||||||| fluoxetine / Generic mfg.
Employing an improved iSeroSnFR biosensor to track serotonin release in cortical and subcortical circuitry during acute vs. chronic SSRI administration (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_13813;
Additionally, we examined the effects of acute (1 day) and chronic (28 days) oral administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on 5-HT release in these regions, alongside behavioral measures of aversive learning...Chronic SSRI treatment caused a mild increase of cue-triggered 5HT release compared to no drug control but less so than acutely treated mice. Our findings contribute to a more thorough understanding of therapeutic interventions that systemically target 5-HT circuitry, elucidating region-specific drug effects on neurochemical release.
- |||||||||| fluoxetine / Generic mfg.
Effects of serotonergic manipulation in the brainstem in overnourished rats. (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_13419;
Aim: Investigate the effects of serotonergic manipulation by Fluoxetine in the brainstem of adult rats submitted or not to overnutrition during lactation... Our data suggest that, at least in the brainstem, the serotonin modulation in overnourished/obese animals positively affects oxidative balance and mitochondrial dynamics.
- |||||||||| fluoxetine / Generic mfg.
Characterizing the effects of SSRI exposure on histone serotonylation in autistic and typical iPSC-derived neurons (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_12621;
NPCs and neurons from all subjects were exposed to an acute 48hr dose of fluoxetine (50 ng/ml) or vehicle...Ongoing research will further characterize the relationship between genetic background, SSRI exposure, histone serotonylation, and gene expression. The results of this project will be valuable for assessing histone serotonylation as a potential target for ASD prevention, diagnostics, and therapeutics.
- |||||||||| fluoxetine / Generic mfg.
Brain FNDC5/irisin expression in patients and mouse models of major depression (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_12098;
Finally, fluoxetine, but not other antidepressants, increased fndc5 gene expression in the mouse frontal cortex...Our finding of decreased prefrontal cortex fndc5 expression in MDD individuals differs from results in mice, highlighting the importance of carefully interpreting observations in mice. The reduction in fndc5 mRNA suggests that decreased central FNDC5/irisin could comprise a shared pathologic mechanism between MDD and AD.
- |||||||||| ketamine / Generic mfg., fluoxetine / Generic mfg.
Profiling Transcriptional Maladaptations in a Mouse Model of Treatment-Resistant Depression (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_10721;
Fluoxetine (FLX) and like antidepressants have been widely used to treat MDD, nonetheless, ~50% of patients do not achieve full remission...More recently, Ketamine (KET) has been shown to induce a rapid antidepressant response in ~50% of TRD patients, providing a novel therapeutic approach...The KET response rate in FLX-non-responders is similar to that seen in TRD patients, lending further validity to our model. Moreover, our findings suggest that prior unsuccessful antidepressant treatment induces a "priming effect" that increases the likelihood of successful response to KET.
- |||||||||| fluoxetine / Generic mfg.
Neurophysiological consequences of developmental serotonin transporter disruption (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9838;
To perturb serotonin, we used either a SERT knock-out line or we dosed wildtype pups with the SERT inhibitor fluoxetine...Our data suggest that early postnatal life is a critical juncture in emergent cognition when SERT activity acts to sculpt and constrain emergent circuits. Thus, altered serotonin signalling likely leads to an imbalance in early sensory representation that manifests in a life-long manner.
- |||||||||| atomoxetine / Generic mfg., fluoxetine / Generic mfg.
Amphetamine, punishment, and rewards:monoaminergic modulation of inhibitory impulse control (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9493;
In contrast, the 5-HT transporter blocker Fluoxetine (0,1, 0...0 mg/kg), thankfully, did not have any effects on behavioral control. These findings suggest increased monoamine transmission can markedly enhance the ability of cues signalling potential punishment to suppress impulsive reward-seeking under threat, which may be mediated by either NA or DA in a sex-dependent manner.
- |||||||||| bupropion / Generic mfg., fluoxetine / Generic mfg.
Interaction between serotoninergic and dopaminergic signaling in a developmental model of SSRI exposure (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9366;
In conclusion, we found that early-life fluoxetine exposure leads to deficits in serotonergic-dopaminergic signaling, deficits in dopaminergic response to rewarding stimulus, deficits in motivation and increased anxiety. There deficits could be ameliorated by enhancement of dopaminergic signaling in the adult.
- |||||||||| fluoxetine / Generic mfg.
Neurogenesis-dependent effects of electroconvulsive shock require mGluR2 (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7988;
Like other more common forms of antidepressant treatment such as fluoxetine, ECS has been shown to increase neurogenesis in the hippocampal dentate gyrus of rodent models...We find that mGluR2 knockdown prevents anti-depressant-like behavioral effects of ECS. Together, these findings reveal the importance of mGluR2 both in the suppression of mature granule neuron activity and in the therapeutic effect of ECS.
- |||||||||| dizocilpine (MK801) / Merck (MSD)
A multi-parameter zebrafish screen for identifying molecules with anxiolytic properties (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_6918;
We believe that the screen has utility as a first line screen prior to mouse experiments enabling fewer drugs and thus fewer animals to be tested. To conclude, we characterised behavioural profiles of anxiolytic/anti-depressant drugs in zebrafish larvae and utilised them to predict action of JNK pathway relevant drugs.
- |||||||||| fluoxetine / Generic mfg.
Weak base drugs and lysosome stress responses (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_6108;
Using SH-SY5Y neuroblastoma cells, U87MG astrocytoma cells, and pharmacologically relevant doses, we showed that atropine, azithromycin, fluoxetine, metoprolol, and tamoxifen (1) de-acidified endolysosomes, (2) decreased endolysosome Fe2+ levels (3) increased cytosolic and mitochondrial Fe2+ and ROS levels, (4) depolarized mitochondria membrane potential, and (5) induced cell death; effects all blocked by the endolysosome-iron chelator deferoxamine. These cell biology findings suggest that, in general, weak base pharmaceuticals can induce lysosome stress responses that might affect their safety profiles.
- |||||||||| fluoxetine / Generic mfg.
Chronic caffeine administration reduces fluoxetine-induced sexual dysfunction in female Long-Evans rats (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5287;
Therefore, we concluded that chronic caffeine administration combined with an acute dose of fluoxetine significantly increased sexual motivation compared to controls and protected against fluoxetine-induced sexual dysfunction. The results of this study provide valuable insight that could explain why some people experience fluoxetine-induced sexual dysfunction whereas others are unaffected by this side effect.
- |||||||||| diazepam / Generic mfg., fluoxetine / Generic mfg.
Proximal and distal threat elicit opposing brain-body states during freezing (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5248;
Therefore, despite identical overt behavior, mice freeze close to threat in an aroused, panic-like state, compatible with flight preparation, but shift to a tranquilized, anxiety-like state dominated by internally-driven activity when threat is distal. The identification of these novel freezing types differing by somatic, neurophysiological and pharmacological profiles should allow this widely-studied behavior to be re-evaluated according to level of threat.
- |||||||||| fluoxetine / Generic mfg.
Parietal-frontal pathway controls relapse of fear memory in a novel context (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5247;
In addition, we found that parvalbumin (PV)-expressing interneurons (PPC-ACCPV) control novel context-dependent fear renewal, which was blocked by the chronic administration of fluoxetine, a first-line pharmacotherapy for post-traumatic stress disorder. Our findings highlight the PPC-ACC pathway as a potential therapeutic target for fear-related disorders.
- |||||||||| fluoxetine / Generic mfg.
Efficacy of fluoxetine and R-S ketamine in attenuating conditioned fear in mice (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_4033;
Future experiments will include analyzing protein adaptation in brain regions that drive PTSD and GAD. This study will contribute to current research related to the topic of PTSD and determine the efficacy of R-ketamine and FLX as a treatment for this disorder.
- |||||||||| donepezil / Generic mfg., fluoxetine / Generic mfg.
Development of high content in vitro assays for the assessment of structural neuroplasticity (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_3339;
One of the psychedelic compounds that was inactive in the NOG assay, psilocin, was active in the synaptogenesis assay on the other hand, indicating that the two assays in combination could be valuable tools to identify and elucidate the function of molecules with novel mechanisms.In conclusion, we have validated a high content NOG assay with excellent reproducibility and the ability to differentiate compounds based on their efficacy and potency. Using the two assays in combination will be a powerful approach to identify compounds with differential effects and understand their mechanism of action on neuroplasticity.
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