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Retrospective data, Review, Journal: Inflammatory modulation of fluoxetine use in patients with depression: A systematic review and meta-analysis. (Pubmed Central) - Sep 10, 2021 Heterogeneous changes in cytokine levels were also evaluated from the SMD forest plot of individual studies. After analysis, we observed that fluoxetine was able to decrease TNF-α levels (SMD ± 0.90, 95% CI = 0.16, 1.165, Z ± 2.40, p = 0.02), but not change IL-6 levels (SMD ± 0.37, 95% CI = 0.21, 0.95, Z ± 1.25, p = 0.21).Fluoxetine acts by modulating neuroimmunology, and not only by acting only on the independent restoration of neurotransmission and neuroinflammation pathways.
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Preclinical, Journal: Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress. (Pubmed Central) - Sep 9, 2021 It is possible that that apart from DNA methylation, a crucial role of expression level of genes may be played by other forms of epigenetic regulation, such as histone modification or microRNA interference. These findings provide strong evidence for thesis that analysis of the level of mRNA and protein expression as well as the status of promoter methylation can help in understanding the pathomechanisms of mental diseases, including depression, and the mechanisms of action of drugs effective in their therapy.
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Drug-Induced Liver Injury (DILI) Secondary to Kratom Use (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_590; Otherwise, she denies any other drug use including no Tylenol use...Kratom induced hepatotoxicity via a cholestatic injury or a mixed pattern as reported by the case reports. Our case suggested a mixed pattern as evident but both cholestasis and aminotransferases enzymes elevation.
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Clinical, Journal: Antidepressant Prescriptions, Including Tricyclics, Continue to Increase in Canadian Children. (Pubmed Central) - Sep 4, 2021 Analysis indicated that fluoxetine was the most frequently recommended drug...However, the observed increase in TCA use for a pediatric population is unexpected. The data source is descriptive and lacks detailed measures supporting comprehensive explanation of the findings, therefore, further research is required.
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Preclinical, Journal: Perinatal fluoxetine treatment promotes long-term behavioral changes in adult mice. (Pubmed Central) - Sep 4, 2021 We also observed a low cognitive performance in the object recognition task and poor motor skill learning in the rotarod test. These findings suggest that programming with FLX during the neonatal period alters a hippocampal serotonergic system, promoting anxiety and antidepressant behavior in adults, as well as a low mnemonic capacity.
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Clinical, Review, Journal: Stroke recovery enhancing therapies: lessons from recent clinical trials. (Pubmed Central) - Sep 3, 2021 Numerous experimental studies suggest great opportunities for such treatments, but the results from recent large clinical trials using neuromodulators such as dopamine and fluoxetine are disappointing...For example, the design of clinical recovery trials varies widely and was characterized by the selection of different clinical endpoints, the inclusion a broad spectrum of stroke subtypes and clinical syndromes as well as different time windows for treatment initiation after infarct onset. This review will discuss these aspects based on the results of the recent stroke recovery trials with the goal to contribute to the currently biggest unmet need in stroke research - the development of a recovery enhancing therapy that improves the functional outcome of a chronic stroke patient.
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Preclinical, Journal: Evaluation of the neuropharmacological effects of Gardenin A in mice. (Pubmed Central) - Sep 3, 2021 GA showed anxiolytic-like actions with activity comparable to that of clonazepam in all experimental tests...Furthermore, GA showed significant antidepressant-like actions in both models with activity comparable to that of fluoxetine...These findings suggest that GA induces anxiolytic-like effects and has anticonvulsant actions by the possible involvement of the GABAergic system. The antidepressant-like actions of GA may be mediated by noradrenergic neurotransmission.
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Clinical, Journal: Tourette syndrome or PANDAS-a case report. (Pubmed Central) - Sep 2, 2021 Treatment with clonazepam and fluoxetine, along with behavioral therapy, have improved the severity of her condition. This report presents a case of TS reemergence against the background of immunological reaction or PANDAS with a late adolescent onset.
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Clinical, Journal: Fluoxetine-induced liver injury and skin reaction: A case report. (Pubmed Central) - Aug 31, 2021 • Summer and winter inocula produced slightly different biotransformation rate constants although microbial community composition did not significantly change. No abstract available
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Review, Journal, Adverse events: Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. (Pubmed Central) - Aug 28, 2021 Ultimately, when prescribing SSRIs to any patient, a risk-benefit analysis must factor in the potential treatment effects, adverse effects, and dangers of the illness to be treated. The aim of this review is to educate clinicians on potential adverse effects of SSRIs.
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Preclinical, Journal: Cannabinoid receptor agonist WIN55212-2 reduces unpredictable mild stress-induced depressive behavior of rats. (Pubmed Central) - Aug 26, 2021 Male Sprague-Dawley (SD) rats aged 6-8 weeks were randomly divided into six groups: control group (control), depression group (CUMS), depression + fluoxetine group (Flu), depression + WIN55212-2 group (WIN), depression + NF-κB inhibitor group (PDTC), and depression + WIN + PDTC group (WIN + PDTC)...In addition, WIN could significantly inhibit the activation of the NF-κB signaling pathway. This study showed that cannabinoid receptor agonists can reduce the CUMS-induced depressive behaviors of rats by blocking the NF-κB signaling pathway to alleviate neuroinflammation and oxidative stress injury.
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Preclinical, Journal: Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice. (Pubmed Central) - Aug 22, 2021 UCMS procedure upregulated the expression of proBDNF and p75 in monocytes/macrophages of peripheral blood and intestinal lamina propria, which may be involved in the pathogenesis of depression-associated GI disorders. Fluoxetine reversed the GI dysfunction, infiltration of macrophages, and upregulation of proBDNF signaling in the depressive mice.
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Journal: GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity. (Pubmed Central) - Aug 21, 2021 Serotonin treatment could enhance the proliferation of PCa cell lines; moreover, fluoxetine could reverse this result...In mechanism, it can regulate the uptaking of serotonin and inhibit the growth of prostate cancer. These results suggested the potential function of GPM6B as a diagnostic marker of PCa and provided clues for the development of new treatment targets for PCa.
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Journal: Neurochemical exposure disrupts sex-specific trade-offs between body length and behaviour in a freshwater crustacean. (Pubmed Central) - Aug 21, 2021 Here, we use a laboratory experiment to assess baseline behavioural variation (spontaneous activity level and geotaxic behaviour) in the freshwater fairy shrimp Branchipodopsis wolfi and how this is affected by chronic exposure to an environmentally-relevant concentration of the anxiolytic pharmaceutical fluoxetine...This is of particular interest since it is an effective proof of principle that neurochemicals may impact ecologically-relevant trade-offs between conspicuous morphology and antipredator behaviour. In natural ecosystems, such disturbed antipredator behavioural responses could have far-reaching fitness consequences.
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Preclinical, Journal: The teratogenic effects of sertraline in mice. (Pubmed Central) - Aug 20, 2021 These data indicate that in utero exposure to sertraline at 25 and 60 mg/kg was embryotoxic, teratogenic, and fetotoxic in mice. The incidence of CP observed in groups 3 and 4 (2.99% and 2.5%, respectively) were higher than the maximum range value noted in historical controls and indicate sertraline is a teratogen in ICR mice.
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Journal: Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage. (Pubmed Central) - Aug 20, 2021 The incidence of CP observed in groups 3 and 4 (2.99% and 2.5%, respectively) were higher than the maximum range value noted in historical controls and indicate sertraline is a teratogen in ICR mice. Women with sustained antidepressant exposure, especially at higher doses, were at increased risk for preeclampsia and PPH, but underlying depression and anxiety may contribute to the increased risk.
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