fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / Generic mfg.
    Retrospective data, Review, Journal:  Inflammatory modulation of fluoxetine use in patients with depression: A systematic review and meta-analysis. (Pubmed Central) -  Sep 10, 2021   
    Heterogeneous changes in cytokine levels were also evaluated from the SMD forest plot of individual studies. After analysis, we observed that fluoxetine was able to decrease TNF-α levels (SMD ± 0.90, 95% CI = 0.16, 1.165, Z ± 2.40, p = 0.02), but not change IL-6 levels (SMD ± 0.37, 95% CI = 0.21, 0.95, Z ± 1.25, p = 0.21).Fluoxetine acts by modulating neuroimmunology, and not only by acting only on the independent restoration of neurotransmission and neuroinflammation pathways.
  • ||||||||||  venlafaxine / Generic mfg.
    Preclinical, Journal:  Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress. (Pubmed Central) -  Sep 9, 2021   
    It is possible that that apart from DNA methylation, a crucial role of expression level of genes may be played by other forms of epigenetic regulation, such as histone modification or microRNA interference. These findings provide strong evidence for thesis that analysis of the level of mRNA and protein expression as well as the status of promoter methylation can help in understanding the pathomechanisms of mental diseases, including depression, and the mechanisms of action of drugs effective in their therapy.
  • ||||||||||  paracetamol / Generic mfg., fluoxetine / Generic mfg.
    Drug-Induced Liver Injury (DILI) Secondary to Kratom Use (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_590;    
    Otherwise, she denies any other drug use including no Tylenol use...Kratom induced hepatotoxicity via a cholestatic injury or a mixed pattern as reported by the case reports. Our case suggested a mixed pattern as evident but both cholestasis and aminotransferases enzymes elevation.
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Antidepressant Prescriptions, Including Tricyclics, Continue to Increase in Canadian Children. (Pubmed Central) -  Sep 4, 2021   
    Analysis indicated that fluoxetine was the most frequently recommended drug...However, the observed increase in TCA use for a pediatric population is unexpected. The data source is descriptive and lacks detailed measures supporting comprehensive explanation of the findings, therefore, further research is required.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Perinatal fluoxetine treatment promotes long-term behavioral changes in adult mice. (Pubmed Central) -  Sep 4, 2021   
    We also observed a low cognitive performance in the object recognition task and poor motor skill learning in the rotarod test. These findings suggest that programming with FLX during the neonatal period alters a hippocampal serotonergic system, promoting anxiety and antidepressant behavior in adults, as well as a low mnemonic capacity.
  • ||||||||||  amphetamine / Generic mfg.
    Clinical, Review, Journal:  Stroke recovery enhancing therapies: lessons from recent clinical trials. (Pubmed Central) -  Sep 3, 2021   
    Numerous experimental studies suggest great opportunities for such treatments, but the results from recent large clinical trials using neuromodulators such as dopamine and fluoxetine are disappointing...For example, the design of clinical recovery trials varies widely and was characterized by the selection of different clinical endpoints, the inclusion a broad spectrum of stroke subtypes and clinical syndromes as well as different time windows for treatment initiation after infarct onset. This review will discuss these aspects based on the results of the recent stroke recovery trials with the goal to contribute to the currently biggest unmet need in stroke research - the development of a recovery enhancing therapy that improves the functional outcome of a chronic stroke patient.
  • ||||||||||  clonazepam / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Evaluation of the neuropharmacological effects of Gardenin A in mice. (Pubmed Central) -  Sep 3, 2021   
    GA showed anxiolytic-like actions with activity comparable to that of clonazepam in all experimental tests...Furthermore, GA showed significant antidepressant-like actions in both models with activity comparable to that of fluoxetine...These findings suggest that GA induces anxiolytic-like effects and has anticonvulsant actions by the possible involvement of the GABAergic system. The antidepressant-like actions of GA may be mediated by noradrenergic neurotransmission.
  • ||||||||||  clonazepam / Generic mfg., fluoxetine / Generic mfg.
    Clinical, Journal:  Tourette syndrome or PANDAS-a case report. (Pubmed Central) -  Sep 2, 2021   
    Treatment with clonazepam and fluoxetine, along with behavioral therapy, have improved the severity of her condition. This report presents a case of TS reemergence against the background of immunological reaction or PANDAS with a late adolescent onset.
  • ||||||||||  citalopram / Generic mfg., fluoxetine / Generic mfg.
    Clinical, Journal:  Can the Risk of Severe Depression-Related Outcomes be Reduced by Tailoring the Antidepressant Therapy to Patient Characteristics? (Pubmed Central) -  Sep 2, 2021   
    To find an optimal treatment strategy, we used dynamic weighted survival modelling considering patient features such as age, sex, body mass index, previous psychiatric diagnoses, and medications. Our findings suggest that using patient characteristics to tailor the antidepressant drug therapy is associated with an increase of 4 days in the median time to SDO (95% confidence interval: 2, 10 days).
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Do initial concentration and activated sludge seasonality affect pharmaceutical biotransformation rate constants? (Pubmed Central) -  Sep 2, 2021   
    Carbamazepine, diatrizoic acid, diclofenac, and fluoxetine were not converted...• Higher initial concentrations resulted in higher biotransformation rate constants for biodegradable pharmaceuticals. • Summer and winter inocula produced slightly different biotransformation rate constants although microbial community composition did not significantly change.
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Fluoxetine-induced liver injury and skin reaction: A case report. (Pubmed Central) -  Aug 31, 2021   
    • Summer and winter inocula produced slightly different biotransformation rate constants although microbial community composition did not significantly change. No abstract available
  • ||||||||||  sertraline / Generic mfg.
    Journal:  Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives. (Pubmed Central) -  Aug 29, 2021   
    Interestingly, the effect of antidepressants on serotonin homeostasis in rat placenta was sex dependent. As accurate fetal programming requires optimal serotonin levels in the fetoplacental unit throughout gestation, inhibition of SERT-/OCT3-mediated serotonin uptake may help explain the poor outcomes of antidepressant use in pregnancy.
  • ||||||||||  sertraline / Generic mfg.
    Review, Journal, Adverse events:  Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. (Pubmed Central) -  Aug 28, 2021   
    Ultimately, when prescribing SSRIs to any patient, a risk-benefit analysis must factor in the potential treatment effects, adverse effects, and dangers of the illness to be treated. The aim of this review is to educate clinicians on potential adverse effects of SSRIs.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Cannabinoid receptor agonist WIN55212-2 reduces unpredictable mild stress-induced depressive behavior of rats. (Pubmed Central) -  Aug 26, 2021   
    Male Sprague-Dawley (SD) rats aged 6-8 weeks were randomly divided into six groups: control group (control), depression group (CUMS), depression + fluoxetine group (Flu), depression + WIN55212-2 group (WIN), depression + NF-κB inhibitor group (PDTC), and depression + WIN + PDTC group (WIN + PDTC)...In addition, WIN could significantly inhibit the activation of the NF-κB signaling pathway. This study showed that cannabinoid receptor agonists can reduce the CUMS-induced depressive behaviors of rats by blocking the NF-κB signaling pathway to alleviate neuroinflammation and oxidative stress injury.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice. (Pubmed Central) -  Aug 22, 2021   
    UCMS procedure upregulated the expression of proBDNF and p75 in monocytes/macrophages of peripheral blood and intestinal lamina propria, which may be involved in the pathogenesis of depression-associated GI disorders. Fluoxetine reversed the GI dysfunction, infiltration of macrophages, and upregulation of proBDNF signaling in the depressive mice.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity. (Pubmed Central) -  Aug 21, 2021   
    Serotonin treatment could enhance the proliferation of PCa cell lines; moreover, fluoxetine could reverse this result...In mechanism, it can regulate the uptaking of serotonin and inhibit the growth of prostate cancer. These results suggested the potential function of GPM6B as a diagnostic marker of PCa and provided clues for the development of new treatment targets for PCa.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Neurochemical exposure disrupts sex-specific trade-offs between body length and behaviour in a freshwater crustacean. (Pubmed Central) -  Aug 21, 2021   
    Here, we use a laboratory experiment to assess baseline behavioural variation (spontaneous activity level and geotaxic behaviour) in the freshwater fairy shrimp Branchipodopsis wolfi and how this is affected by chronic exposure to an environmentally-relevant concentration of the anxiolytic pharmaceutical fluoxetine...This is of particular interest since it is an effective proof of principle that neurochemicals may impact ecologically-relevant trade-offs between conspicuous morphology and antipredator behaviour. In natural ecosystems, such disturbed antipredator behavioural responses could have far-reaching fitness consequences.
  • ||||||||||  olanzapine/fluoxetine / Generic mfg., olanzapine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism Caenorhabditis elegans. (Pubmed Central) -  Aug 20, 2021   
    This study aims to evaluate the body fat and food intake of C. elegans in response to treatment olanzapine and fluoxetine. Here we report that, with careful consideration to the dosage used, administration of fluoxetine and olanzapine increases body fat and food intake in C. elegans.
  • ||||||||||  sertraline / Generic mfg.
    Preclinical, Journal:  The teratogenic effects of sertraline in mice. (Pubmed Central) -  Aug 20, 2021   
    These data indicate that in utero exposure to sertraline at 25 and 60 mg/kg was embryotoxic, teratogenic, and fetotoxic in mice. The incidence of CP observed in groups 3 and 4 (2.99% and 2.5%, respectively) were higher than the maximum range value noted in historical controls and indicate sertraline is a teratogen in ICR mice.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage. (Pubmed Central) -  Aug 20, 2021   
    The incidence of CP observed in groups 3 and 4 (2.99% and 2.5%, respectively) were higher than the maximum range value noted in historical controls and indicate sertraline is a teratogen in ICR mice. Women with sustained antidepressant exposure, especially at higher doses, were at increased risk for preeclampsia and PPH, but underlying depression and anxiety may contribute to the increased risk.