- |||||||||| fluoxetine / Generic mfg.
Journal: A framework for inferring and analyzing pharmacotherapy treatment patterns. (Pubmed Central) - Mar 13, 2024
Furthermore, our outcomes are also indications for both disease and treatment. Despite these limitations, we demonstrate the usefulness of our framework in providing operational insight into clinical practice, and our results underscore the need for increased monitoring during critical points of treatment.
- |||||||||| fluoxetine / Generic mfg.
Multifaceted quantification of drug-polymer complexes on gold nanoparticles (Hybrid; Room 239 (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_2477;
A series of linear polyacrylamides functionalized with varying amounts of fluoxetine and 3-methyl(thiol)propylamine were synthesized via a thermally induced free radical polymerization...Synthesized polymers were linked to the surface of citrate-capped AuNPs via the thioether moiety of MTP, with successful attachment confirmed by UV-Vis spectroscopy, Dynamic Light Scattering, Zeta Potential, and ICP-OES measurements. This work demonstrates a variety of techniques that can be used to determine the loading of the polymer-drug-nanoparticle construct at a number of different end points.
- |||||||||| fluoxetine / Generic mfg.
Journal: Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis. (Pubmed Central) - Mar 11, 2024
Co-catalpol alleviated fluoxetine-induced hepatic injury while enhancing its antidepressant efficacy, and that ATF3/FSP1 signaling-mediated inhibition of ferroptosis was involved in its co-administration detoxification mechanism. This study was the first to reveal the hepatotoxicity characteristics, targets, and mechanisms of fluoxetine; provide a detoxification and efficiency regimen by co-catalpol; and elucidate the detoxification mechanism.
- |||||||||| Ocrevus (ocrelizumab) / Roche, Biogen, Rituxan (rituximab) / Roche
Enterovirus Radiculomyelitis in a Relapsing-remitting Multiple Sclerosis Patient (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_2476;
To our knowledge, this is the first Ocrelizumab-associated severe enterovirus radiculomyelitis case. In addition to IVIG and steroids, the patient was treated with fluoxetine, that inhibits enterovirus replication in vitro.
- |||||||||| fluoxetine / Generic mfg.
Trial completion date, Trial primary completion date: The Effects of Fluoxetine and/or DHEA (clinicaltrials.gov) - Mar 6, 2024
P1, N=60, Recruiting,
The H group showed significant improvement in postpartum depression in rats, and processed Polygonatum cyrtonema Hua can be used as a developing drug for the prevention or treatment of depression. Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Feb 2024 --> Feb 2025
- |||||||||| fluoxetine / Generic mfg.
To investigate the effect of fluoxetine combined with radiation therapy on hepatocellular carcinoma (Section 45) - Mar 5, 2024 - Abstract #AACR2024AACR_2505;
To conclude, the induction of apoptosis, DNA damage, and autophagy emerges as a crucial mechanism contributing to the heightened sensitivity of HCC cells to RT when combined with Fluoxetine. These results suggest that the combination of Fluoxetine with RT presents a promising novel approach for the treatment of HCC.
- |||||||||| fluoxetine / Generic mfg.
Journal: Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth. (Pubmed Central) - Mar 4, 2024
These results suggest that the combination of Fluoxetine with RT presents a promising novel approach for the treatment of HCC. These data do not support a recommendation for routine plasma concentration monitoring or CYP2D6 pharmacogenetic testing for pregnant people treated with FLX; however, monitoring for symptom relapse is recommended because of declining plasma drug concentrations.
- |||||||||| fluoxetine / Generic mfg.
Journal: Reversible Morphological Remodeling of Prefrontal and Hippocampal Serotonergic Fibers by Fluoxetine. (Pubmed Central) - Mar 4, 2024
Importantly, a 1-month washout period was sufficient to reverse morphological changes in both the medial prefrontal cortex and in the previously characterized hippocampus, as well as to normalize behavior, highlighting an intriguing relationship between axon density and an antidepressant-like effect. Overall, these results further demonstrate the bidirectional plasticity of defined serotonergic axons and provide additional insights into fluoxetine effects on the serotonergic system.
- |||||||||| fluoxetine / Generic mfg.
Journal: Decreased Brain Serotonin in rbfox1 Mutant Zebrafish and Partial Reversion of Behavioural Alterations by the SSRI Fluoxetine. (Pubmed Central) - Feb 24, 2024
Acute fluoxetine exposure did not reverse the alterations observed in the aggression and social novelty tests, suggesting the involvement of other neurological mechanisms in these behaviours. These findings underscore the importance of investigating the intricate working mechanisms of RBFOX1 in neurodevelopmental and psychiatric disorders to gain a better understanding of the associated disorders along with their pharmacological treatment.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Review, Journal: Post-Stroke Depression in Older Adults: An Overview. (Pubmed Central) - Feb 24, 2024
High-quality RCTs recruiting large samples of older adults are needed in order to better manage PSD in this population. In addition, adequate screening and diagnosis instruments, with reliable timing of evaluation, should be applied.
- |||||||||| imipramine / Generic mfg., fluoxetine / Generic mfg., haloperidol / Generic mfg.
Preclinical, Journal: The sinking platform test: a novel paradigm to measure persistence in animal models. (Pubmed Central) - Feb 24, 2024
Finally, comparing transcriptomic profiles of the prefrontal cortex of mice with high and low SPT performance revealed significant enrichment of immediate-early genes known to shape susceptibility for chronic stress. These findings highlight the potential of SPT as a promising method to uncover the biological mechanisms of persistence and evaluate novel interventions to enhance this response.
- |||||||||| fluoxetine / Generic mfg.
Journal: Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. (Pubmed Central) - Feb 21, 2024
The effect of fluoxetine on PFC synaptic alterations in vivo was abolished by 5-HT2A and 5-HT7 receptor antagonists. Our data describe a molecular basis of 5-HT-dependent excitatory synaptic plasticity at the level of single spines in the PFC during early postnatal development.
- |||||||||| fluoxetine / Generic mfg.
Journal: Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. (Pubmed Central) - Feb 20, 2024
This effect was localized in the ventral DRN subregion and prevented by the antidepressant fluoxetine...We conclude that 5-HT-glutamate co-releasing neurons are recruited by exposure to uncontrollable stress. Furthermore, natural variation in the balance of 5-HT and glutamate co-released at the 5-HT synapse may impact stress susceptibility.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. (Pubmed Central) - Feb 10, 2024
Similar reversal effects of fluoxetine and vortioxetine were observed, including SERT in the amygdala and NET in the mPFC, whereas different reversal effects were observed for NET in the hippocampus and vesicular monoamine transporters expression in the nucleus accumbens. Overall, these results demonstrate the validity of the LBN paradigm to induce depression-like behaviors in female mice, highlight the involvement of region-specific MATs in ES-induced depression-like behaviors, and provide insights for further investigation of neurobiological mechanisms, treatment, and prevention associated with depression in women.
- |||||||||| Journal: Pharmaceuticals, hazard and ecotoxicity in surface and wastewater in a tropical dairy production area in Latin America. (Pubmed Central) - Feb 6, 2024
Six pharmaceuticals were considered either of high (albendazole, lovastatin and caffeine) or intermediate estimated hazard (ciprofloxacin, acetaminophen and ketoprofen) based on the HQ approach, while 26% of the samples were considered of high estimated hazard according to the cumulative ?HQ approach...Seven out of these compounds showed high estimated risk (risperidone, diphenhydramine, trimethoprim, fluoxetine, ofloxacin, caffeine and ibuprofen), while three (gemfibrozil, ciprofloxacin and cephalexin) exhibited intermediate estimated risk...Despite being nontoxic for D. magna or V. fischeri, frequent inhibition (>20%) of GI in L. sativa was determined in 34% of surface water samples; such findings raise concern on the apparent inceptive environmental pollution and risk within the area. According to the pharmaceutical content patterns in both kinds of studied matrices, no clear evidence of significant contamination in surface water due to livestock activities could be retrieved, suggesting a main role of urban influence.
- |||||||||| fluoxetine / Generic mfg.
Journal: Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae. (Pubmed Central) - Feb 4, 2024
Future research is warranted to assess the efficacy and safety of these agents in children and adolescents. Our data suggest that diosgenin reverses SDS?+?EtOH interaction-induced behavioral changes via normalization of hypothalamic-pituitary-adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains.
- |||||||||| Savella (milnacipran) / AbbVie, Pierre Fabre
Journal: Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities (Pubmed Central) - Jan 31, 2024
Regarding the CYP3A subfamily, the effects of various compounds including endogenous steroid hormones on the 6?-hydroxylation of steroid hormones, such as testosterone, progesterone, and cortisol, were determined; it was found that testosterone, dehydroepiandrosterone, and/or ?-naphthoflavone activated 6?-hydroxylation of cortisol and/or progesterone, but the effects varied in the presence of different CYP3A subfamily members. Further studies are required to confirm the mechanisms and therapeutic relevance of these activation phenomena.
- |||||||||| fluoxetine / Generic mfg.
Journal: The role of serotonin in modulating social competence in a cooperatively breeding fish. (Pubmed Central) - Jan 30, 2024
While the serotonin enhancer Fluoxetine did not affect the frequency of submission towards territory owners, reducing serotonin by a low dosage of 4-Chloro-DL-phenylalanine (PCPA) increased submissive behaviour...5-HT activation increased threat displays by intruders, indicating that this receptor may not be involved in regulating social competence. We conclude that serotonin, but not its receptor 5-HT plays an important role in the regulation of social competence.
- |||||||||| Journal: Effects of Antidepressants on Sleep in Post-traumatic Stress Disorder: An Overview of Reviews. (Pubmed Central) - Jan 30, 2024
?here was a meta-analytical trend indicating improvement of nightmares with fluoxetine, less insomnia with amitriptyline and more with brofaromine, as well as more somnolence with paroxetine vs. placebo, respectively...Evidence is insufficient to draw safe conclusions. More and better-designed RCTs, with consistent reporting of sleep-related outcomes, are needed.
- |||||||||| Viibryd (vilazodone) / AbbVie
Journal: Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. (Pubmed Central) - Jan 30, 2024
Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and (S)-citalopram are competitive inhibitors of hSERTs and are commonly the first-line medications for major depressive disorder (MDD)...Interestingly, vilazodone emerged with polypharmacological (competitive and allosteric) inhibitions on hSERTs, amenable to improved efficacy...Similarly, the two ligands also docked to the allosteric pocket (PDB 5I73) with scores of -8.15 and -8.40?kcal/mol and MM-GBSA of -96.14 and -68.46?kcal/mol whereas (S)-citalopram has -6.90 and -69.39?kcal/mol respectively. The ligands also conferred conformational stability on the receptors during 100?ns MD simulations and displayed interesting ADMET profiles, representing promising hSERT modulators for MDD upon experimental validation.Communicated by Ramaswamy H. Sarma.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine mitigates depressive-like behaviors in mice via anti-inflammation and enhancing neuroplasticity. (Pubmed Central) - Jan 29, 2024
Based on these results, fluoxetine has been demonstrated effectively to ameliorate depressive mood and cognitive dysfunction, possibly through the enhancement of synaptic plasticity. Overall, our study contributes to a further understanding of the mechanisms underlying the therapeutic effects of fluoxetine and its potential role in improving depressive symptoms and cognitive impairments.
- |||||||||| methylphenidate tablet / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Chronic oral methylphenidate plus fluoxetine treatment in adolescent rats increases cocaine self-administration. (Pubmed Central) - Jan 26, 2024
Chronic oral treatment during adolescence with the combination of MP plus FLX resulted in increased cocaine use after 2 weeks of cocaine self-administration in rats. These novel findings suggest that the combined exposure to these two drugs chronically, during adolescence, may produce increased vulnerability towards cocaine abuse during young adulthood.
- |||||||||| Journal: The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman. (Pubmed Central) - Jan 24, 2024
During breastfeeding, the drug of choice for approximately 74.0% of the practitioners was paroxetine, but avoided by 15.0% of practitioners...On the other hand, high teratogenicity, neonatal side effects, limited data, and lack of evidence were among the most common reasons behind avoiding prescribing during pregnancy, while high levels of breast milk, neonatal side effects, limited evidence, and safety concerns were the most common reasons during the breastfeeding period. There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.
- |||||||||| fluoxetine / Generic mfg.
Journal: Fluoxetine removal by anodic oxidation using different anode materials and graphite cathode. (Pubmed Central) - Jan 18, 2024
The specific energy consumption (SEC) after 120 min of operation was 51.0 kWh/m for the Ti/Pt electrode, 39.6 kWh/m for the Ti/IrO electrode, and 48.6 kWh/m for the Ti/RuO electrode under optimised conditions. Overall, electrochemical anodic oxidation is an effective method for removing FLX from water and wastewater, with Ti/IrO and Ti/RuO electrodes providing superior performance compared to Ti/Pt electrodes.
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