- |||||||||| Clinical, Retrospective data, Journal: Pharmacological management of fibromyalgia: a Bayesian network meta-analysis. (Pubmed Central) - Apr 1, 2022
According to published evidence, pregabalin and duloxetine evidenced the greatest improvement of the FIQ and SF36 Physical and Mental subscales, along with the lowest rate of adverse events leading to study discontinuation. The results must be interpreted in the light of possible adverse events with the use of these drugs.
- |||||||||| fluoxetine / Generic mfg.
Journal: Specific sub-regions of the longitudinal axis of the hippocampus mediate behavioural responses to chronic psychosocial stress. (Pubmed Central) - Mar 30, 2022
We recently found that the iHi is involved in the behavioural effects of chronic treatment with the antidepressant fluoxetine in the forced swim test...Interestingly, iHi lesions increased stress-induced social avoidance in the social interaction test. In summary, we found that all hippocampal sub-regions are involved in the anxiogenic effects of chronic stress but that the iHi plays a predominant role in stress-induced social avoidance and the vHi has a predominant role in active coping behaviours and antidepressant-like behaviour following chronic stress.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Antidepressant-like effect of sodium orthovanadate in a mouse model of chronic unpredictable mild stress. (Pubmed Central) - Mar 30, 2022
Sodium orthovanadate (5 mg/kg, 10 mg/kg) and fluoxetine (FLX-10 mg/kg) was given to mice orally for 21days before 30 min of stress induction...Decreased serum corticosterone levels observed with SOV (5 & 10 mg/kg), FLX-10 mg/kg, FLX (10 mg/kg) + SOV (5 mg/kg); and SOV-10 mg/kg per-se treatment and elevated BDNF level with SOV (5 & 10 mg/kg), FLX-10 mg/kg were associated with attenuation of depressive-like behavior. The findings of this preliminary study indicate that SOV has the potential to restore antidepressant-like effects or prevent stress-induced anhedonia and so further molecular mechanisms are warranted for clinical translation.
- |||||||||| sertraline / Generic mfg., duloxetine / Generic mfg.
Journal: Are all antidepressants the same? The consumer has a point. (Pubmed Central) - Mar 30, 2022
This research points out that the subjective experience of patients under treatment should be taken into consideration when selecting an AD as differences between agents were evident. In contrast to the more frequent treatment decisions, users might prefer receiving a non-serotoninergic agent over a serotonergic one due to their lower propensity to produce emotional blunting.
- |||||||||| fluoxetine / Generic mfg.
Journal: Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis. (Pubmed Central) - Mar 29, 2022
MIS extract and fluoxetine were given daily for 30 min before exposing animals to stressors...Therefore, it is highly recommended to test the selected lead-like compound catechin in the laboratory with biological system analysis to confirm its activity as MAO-A and MAO-B inhibitors so it can be declared as one of the novel therapeutic options with anti-depressant activity. Our findings concluded that M. indica seeds could be a significant and alternative anti-depressant therapy.
- |||||||||| sertraline / Generic mfg.
Preclinical, Journal: Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines. (Pubmed Central) - Mar 27, 2022
5-fluorouracil (5-FU) and doxorubicin (DOX) are potent anti-tumour agents commonly used for colon and breast cancer therapy, respectively...It was found that bee venom combined with 5-FU and fluphenazine in HT-29 cells resulted in less cytotoxic effects compared to the co-treatment of fluoxetine, sertraline and thioridazine plus bee venom, which resulted in less than 15% of viable cells for the whole range of concentrations...These results support that the combination of honeybee venom with repurposed drugs and chemotherapeutic agents can help improve their anti-cancer activity, especially for lower concentrations, in both cell lines. Overall, the present study corroborates the enormous bioactive potential of honeybee venom for colon and breast cancer treatments, both alone and in combination with chemotherapy or repurposed drugs.
- |||||||||| Dayvigo (lemborexant) / Eisai
PK/PD data, Journal: Physiologically Based Pharmacokinetic Modeling to Predict Drug Interactions of Lemborexant with CYP3A Inhibitors. (Pubmed Central) - Mar 23, 2022
The model further predicted that DDI effects of weak CYP3A inhibitors (fluoxetine and ranitidine) are weak, and effects of moderate inhibitors (erythromycin and verapamil) are moderate. Based on the PBPK simulations and clinical efficacy and safety data, the maximum daily recommended lemborexant dose when administered with weak CYP3A inhibitors is 5 mg; coadministration of moderate and strong inhibitors should be avoided except in countries where 2.5 mg has been approved.
- |||||||||| indomethacin / Generic mfg., fluoxetine / Generic mfg.
Journal: Design, Synthesis, and Biological Activity of Chalcone Analogs Containing 4-Phenylquinolin and Benzohydrazide. (Pubmed Central) - Mar 23, 2022
Results of the acetic acid-induced abdominal writhing test showed that, at 30 mg/kg, excepted for compounds 3a, 3b and 3d, all the other 10 compounds can show certain analgesic activity (inhibition rate 67-99.9 %). The use of Auto dock Vina (simina) to simulate molecular target docking shows that the development of quinoline and benzohydrazide groups is of great significance to MAO inhibitors.
- |||||||||| atomoxetine / Generic mfg.
Journal: A role for cortical dopamine in the paradoxical calming effects of psychostimulants. (Pubmed Central) - Mar 23, 2022
In contrast, pharmacological NE depletion and DA elevation using nepicastat also inhibits hyperactivity in DAT-KO mice. Together, these data suggest elevation of PFC DA and not NE or 5-HT, as a convergent mechanism for the paradoxical effects of psychostimulants observed in ADHD therapy.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: ROS-Scavenging Selenofluoxetine Derivatives Inhibit In Vivo Serotonin Reuptake. (Pubmed Central) - Mar 23, 2022
Excitingly, we show that one of these agents (1-F) carries the ability to inhibit serotonin reuptake in vivo in mice. We therefore present a frontier dual strategy that paves the way for the future of antidepressant therapies.
- |||||||||| atorvastatin / Generic mfg., fluoxetine / Generic mfg.
Journal: Implications of PFAS definitions using fluorinated pharmaceuticals. (Pubmed Central) - Mar 23, 2022
The most inclusive definitions include several top prescribed pharmaceuticals, e.g., Prozac and Lipitor. This analysis provides a framework against which organizations can make decisions about how best to proceed when defining PFAS.
- |||||||||| fluoxetine / Generic mfg.
Unilateral nevoid acanthosis nigricans () - Mar 21, 2022 - Abstract #AAD2022AAD_2591;
He has a history of depression and is on fluoxetine, but this was started after the development of his rash...Commonly affected areas include the umbilicus, lateral neck, chest, and upper extremities. Development generally occurs during childhood, puberty, or young adulthood.
- |||||||||| fluoxetine / Generic mfg., dextromethorphan / Generic mfg.
Enrollment open, Trial initiation date: Study of Dextromethorphan in OCD and Related Disorders (clinicaltrials.gov) - Mar 21, 2022
P2, N=60, Recruiting,
Development generally occurs during childhood, puberty, or young adulthood. Not yet recruiting --> Recruiting | Initiation date: Sep 2021 --> Jan 2022
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Chronic Vicarious Social Defeat Stress Attenuates New-born Neuronal Cell Survival in Mouse Hippocampus. (Pubmed Central) - Mar 18, 2022
Furthermore, treatment with the chronic antidepressant fluoxetine reversed the social behavioral deficits and promoted new-born neurons survival. These results demonstrate that emotional stress in the vicarious social defeat stress paradigm influences neuronal cell survival in the hippocampus, which reinforces its validity as an animal model of depression.
- |||||||||| imipramine / Generic mfg., fluoxetine / Generic mfg.
Journal, Epigenetic controller: Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior. (Pubmed Central) - Mar 18, 2022
Rosmarinic acid, a phenolic compound that increases SUV39H1 expression, reverses stress-induced changes of SUV39H1, Mkp-1, and Bdnf expression in the hippocampus via an overlapping but distinct mechanism from those of fluoxetine and imipramine and produces anti-depressive effects. These results suggest that aging increases susceptibility to stress via downregulation of SUV39H1 and resulting changes in SUV39H1-regulated signaling pathways in the hippocampus.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring. (Pubmed Central) - Mar 15, 2022
Using this model, we show that the maternal depressive-like state induced by social isolation can be partially rescued by chronic treatment with the selective serotonin reuptake inhibitor, fluoxetine (FLX)...Taken together, our findings suggest that the presence of a depressive-like state during preconception and pregnancy has sex-dependent consequences on brain and behavioral functions in the offspring. At the same time, our study highlights that FLX treatment in dams with a depression-like state can prevent abnormal behavioral development in the offspring.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice. (Pubmed Central) - Mar 15, 2022
Repeated stimulation prompted a persistent increase in grooming that could be reversed by fluoxetine treatment, a first-line drug therapy for OCD...Finally, circuit and functional mapping of STN neurons showed that these effects are mediated via projections to the globus pallidus/entopeduncular nucleus and substantia nigra reticulata. Altogether, these data identify Gabrr3 neurons as a key population in mediating the beneficial effects of STN modulation thus providing potential cellular targets for PD and OCD drug discovery.
- |||||||||| fluoxetine / Generic mfg.
Journal: Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. (Pubmed Central) - Mar 15, 2022
Strikingly, treatment of Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors...Finally, injection of recombinant Cbln2 protein into the dorsal raphe of Cbln2 KO mice largely reversed their compulsive behaviors. Taken together, our results show that Cbln2 controls compulsive behaviors by regulating serotonergic circuits in the dorsal raphe.
- |||||||||| fluoxetine / Generic mfg.
Journal: Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity. (Pubmed Central) - Mar 15, 2022
Visual cortical plasticity induced by fluoxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant, was lost in mice with reduced expression of TrkB in PV interneurons...In addition, decreased expression and puncta of Synaptotagmin2 (Syt2), a presynaptic marker of PV interneurons involved in Ca-dependent neurotransmitter release, suggests lower inputs onto pyramidal neurons suppressing feed-forward inhibition. Together, the results provide mechanistic insights into how TrkB activation in PV interneurons orchestrates the activity of cortical networks and mediating antidepressant responses in the adult brain.
- |||||||||| naltrexone / Generic mfg., fluoxetine / Generic mfg.
Journal, IO biomarker: Integrative genomic analysis of a novel small nucleolar RNAs prognostic signature in patients with acute myelocytic leukemia. (Pubmed Central) - Mar 15, 2022
In the subsequent targeted drug screening using CMap, we also identified six drugs that can be used for AML targeted therapy, they were alimemazine, MG-262, fluoxetine, quipazine, naltrexone and oxybenzone. In conclusion, our current study was constructed an AML prognostic signature based on the 14 prognostic snoRNAs, which may serve as a novel prognostic biomarker for AML.
- |||||||||| fluoxetine / Generic mfg., escitalopram / Generic mfg.
PK/PD data, Journal: Selective Serotonin Reuptake Inhibitor Pharmacokinetics During Pregnancy: Clinical and Research Implications. (Pubmed Central) - Mar 15, 2022
This perspective examines the impact of pharmacokinetic genes-related to CYP activity on SSRI pharmacokinetics during pregnancy. Through a simulation-based approach, plasma concentrations for SSRIs metabolized primarily by CYP2C19 (e.g., escitalopram) and CYP2D6 (e.g., fluoxetine) are examined and the implications for dosing and future research are discussed.
- |||||||||| amitriptyline / Generic mfg., duloxetine / Generic mfg.
Journal: Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress. (Pubmed Central) - Mar 15, 2022
Additionally, all of the other three monoamine-based antidepressants, the fluoxetine of selective serotonin reuptake inhibitors, the amitriptyline of tricyclic agents, and the moclobemide of MAOs, increased ASPA expression in CeA. Together, these results indicate that increasing ASPA to hydrolyze NAA in CeA is a common mechanism of gastroprotective effects against stress exerted by monoamine-based antidepressants, and ASPA is a shared target more than monoamine regulation for this kind of drugs.
- |||||||||| fluoxetine / Generic mfg.
Journal: Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test. (Pubmed Central) - Mar 12, 2022
Together, these results indicate that increasing ASPA to hydrolyze NAA in CeA is a common mechanism of gastroprotective effects against stress exerted by monoamine-based antidepressants, and ASPA is a shared target more than monoamine regulation for this kind of drugs. In conclusion, this work shows that increased hippocampal HO-1 content and activity mediate the antidepressant-like effect of UA in the TST.
- |||||||||| ibuprofen / Generic mfg.
Journal: Heart rate as an early warning parameter and proxy for subsequent mortality in Danio rerio embryos exposed to ionisable substances. (Pubmed Central) - Mar 11, 2022
Moreover, the observed pH-dependent effects were strongly associated with log D and thus, likely driven by differences in uptake (toxicokinetic) rather than internal (toxicodynamic) processes. Prospectively, the a priori consideration of pH-dependent effects of ionisable substances might make testing at different pH levels redundant, while the endpoint of mortality might even be replaced by a reliable sublethal proxy that would reduce the exposure, accelerating the evaluation process.
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