fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  Identifying and Treating Depression in Hemodialysis Patients (clinicaltrials.gov) -  Sep 29, 2022   
    P4,  N=96, Recruiting, 
    It has been shown that the simultaneous and effective treatment performance for micropollutants makes the membrane bioreactor system a promising wastewater treatment process. Trial completion date: Nov 2023 --> Mar 2023 | Trial primary completion date: Nov 2023 --> Jan 2023
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Chronic fluoxetine treatment of socially isolated rats modulates prefrontal cortex proteome. (Pubmed Central) -  Sep 29, 2022   
    Flx treatment in CSIS rats downregulated protein involved in oxidative phosphorylation, such as complex III and manganese superoxide dismutase, and upregulated vesicle-mediated transport and synaptic signaling proteins in the cytosol, and neuronal calcium-binding protein 1 in NSM. Our study identified PFC modulated proteins and affected biochemical pathways that may represent potential markers/targets underlying CSIS-induced depression and effective Flx treatment, and highlights the role of protein systems involved in NSM and various metabolic pathways potentially involved in neuronal plasticity.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  3D ex vivo tissue platforms to investigate the early phases of influenza A virus- and SARS-CoV-2-induced respiratory diseases. (Pubmed Central) -  Sep 24, 2022   
    We observed efficient viral replication, associated with the release of inflammatory cytokines and the induction of an antiviral interferon response, comparable to ex vivo infection in human lung explants. Endolysosomal entry could be confirmed as a potential host target for pharmacological intervention, and the potential repurposing potentials of fluoxetine and interferons for host-directed therapy previously seen in vitro could be recapitulated in the ex vivo model.
  • ||||||||||  Januvia (sitagliptin) / Merck (MSD)
    Review, Journal:  Recent progress in the chemistry of β-aminoketones. (Pubmed Central) -  Sep 23, 2022   
    Also, the synthesis of the investigated compounds is accomplished by condensation reactions, from propargylic alcohols, reductive hydroamination, alkylation, carbonylative coupling, and acid hydrolysis of metal complexes. The aim of this review is to provide details for the synthesis of piperidines, morpholinones, piperazinones, dihydroxy-2-oxopyrroles, spirocyclic systems, imidazolines, indolizines, pyrido-isoindoles, aminoalcohols, metal complexes, fluoxetine, sotolon, (S)-ketamine, indolines, and benzoazepinones.
  • ||||||||||  risperidone / Generic mfg., fluoxetine / Generic mfg.
    Functional movement disorder with mixed phenotype in a child with Asperger’s syndrome (Poster Station: 13) -  Sep 22, 2022 - Abstract #MDSCongress2022MDR_Congress_597;    
    It is observed from unbiased molecular dynamics simulations that the two aforementioned molecules form a noncovalent complex spontaneously and the calculated binding free energy is in agreement with the literature. We describe a novel case of AS associated with functional tremor, functional limb weakness and functional tics.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice. (Pubmed Central) -  Sep 21, 2022   
    The positive control group was intraperitoneally injected with a tricyclic antidepressant (Fluoxetine, as tricyclic antidepressant), the control group was given ddHO, and the test substance groups were administered test samples once daily for 21 days...Notably, in the positive control and the medium- and high-dose groups, brain-derived neurotrophic factor (BDNF) increase by more than in the control group. In summary, medium and high dose of extract of chlorella and lion's mane mushroom could improve depression behavior in animals and have the potential to be antidepressant health care products.
  • ||||||||||  remdesivir / Generic mfg., fluvoxamine / Generic mfg., fluoxetine / Generic mfg.
    Review, Journal:  Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use. (Pubmed Central) -  Sep 21, 2022   
    If successful, these drugs can substantially reduce hospitalization and mortality rates, as well as allow for fully outpatient treatment for mild-to-moderate infections. Thus, repositioning SSRIs can provide benefits when faced with a rapidly evolving pandemic such as COVID-19.
  • ||||||||||  fluoxetine / Generic mfg., ibuprofen / Generic mfg.
    Preclinical, Journal:  Resolvin D5 disrupts anxious- and depressive-like behaviors in a type 1 diabetes mellitus animal model. (Pubmed Central) -  Sep 15, 2022   
    To conclude, RvD5 presents a preventive therapeutic potential in impairing the development of the emotional complications resulting from T1DM. This potential may be related to its protective profile, as demonstrated in this study by its pro-resolutive action on neuroinflammation in the hippocampus and prefrontal cortex.
  • ||||||||||  clarithromycin / Generic mfg., fluoxetine / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Pharmaceutical pollution of hospital effluents and municipal wastewaters of Eastern Canada. (Pubmed Central) -  Sep 14, 2022   
    Distribution coefficients (K) and particle-associated fractions (Φ) indicate that pharmaceuticals tend to have better affinity to suspended solids in hospital wastewater than in municipal wastewaters. The results also bring arguments for at source treatment of these specific effluents before their introduction into urban wastewater systems.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes. (Pubmed Central) -  Sep 14, 2022   
    This study established two depressive mouse models by maternal separation (MS) or lipopolysaccharide (LPS) administration, and added fluoxetine treatment group respectively for comparison...Overall, LPS induced stronger system inflammation, while MS impaired the function of HPA axis and 5-HT system. Our results will contribute to a deeper understanding of the pathophysiology of different stress-induced depression and will also help researchers select appropriate models of depression for their own needs.
  • ||||||||||  Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
    Journal:  Fluoxetine and Molnupiravir: A Synergistic Combination for COVID-19 Treatment? (Pubmed Central) -  Sep 13, 2022   
    Our results will contribute to a deeper understanding of the pathophysiology of different stress-induced depression and will also help researchers select appropriate models of depression for their own needs. No abstract available
  • ||||||||||  venlafaxine / Generic mfg., fluoxetine / Generic mfg.
    Review, Journal:  Interventions for Co-occurring Cannabis Use and Depression. (Pubmed Central) -  Sep 11, 2022   
    However, the conclusions of this review are limited because of the small number of studies and their low quality. Higher-quality research is required to evaluate the effectiveness of CBT, MI, and other interventions for comorbid cannabis use and depression.
  • ||||||||||  Journal:  Antidepressants Are Poor Inhibitors of Heat-Evoked Ion Currents Mediated by TRPM2. (Pubmed Central) -  Sep 10, 2022   
    Whether or not TRPM2 may be a relevant target for antidepressants cannot be conclusively assessed by a single in vitro study, thus further studies are required along these lines. Nevertheless, future studies may get simplified by the novel approach we developed for in vitro pharmacological analysis of TRPM2.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Controversies In The Pharmacotherapy Of Adolescent Depression. (Pubmed Central) -  Sep 10, 2022   
    Although no response to pharmacotherapy and psychotherapy may occur in up to 40% of depressed adolescents, possible predictors or mediators of poorer response in adolescents are uncertain, and only a few studies support possible treatment strategies. Finally, studies exploring the efficacy of antidepressants in specific depression subtypes, i.e., based on prevalent psychopathological dimensions (apathy, withdrawal, impulsivity), are warranted.
  • ||||||||||  fluoxetine / Generic mfg.
    The Use of Red Blood Cell Exchange to Treat Methemoglobinemia in a Young Woman With Serotonin Syndrome ([IN-PERSON]) -  Sep 8, 2022 - Abstract #CAP2022CAP_1060;    
    She developed hyperreflexia and ocular clonus concerning for serotonin syndrome—she was prescribed fluoxetine—precluding additional methylene blue...She continued to improve and was discharged on hospital day 10. Although there are currently no guidelines for therapeutic apheresis in the setting of methemoglobinemia, this case highlights its potential use in patients for whom methylene blue treatment is insufficient or contraindicated.
  • ||||||||||  fluoxetine / Generic mfg.
    The Use of Red Blood Cell Exchange to Treat Methemoglobinemia in a Young Woman With Serotonin Syndrome ([IN-PERSON]) -  Sep 8, 2022 - Abstract #CAP2022CAP_334;    
    She developed hyperreflexia and ocular clonus concerning for serotonin syndrome—she was prescribed fluoxetine—precluding additional methylene blue...She continued to improve and was discharged on hospital day 10. Although there are currently no guidelines for therapeutic apheresis in the setting of methemoglobinemia, this case highlights its potential use in patients for whom methylene blue treatment is insufficient or contraindicated.
  • ||||||||||  Enrollment change, Trial completion date, Trial primary completion date:  Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV) (clinicaltrials.gov) -  Sep 8, 2022   
    P2,  N=1500, Recruiting, 
    Although there are currently no guidelines for therapeutic apheresis in the setting of methemoglobinemia, this case highlights its potential use in patients for whom methylene blue treatment is insufficient or contraindicated. N=750 --> 1500 | Trial completion date: Aug 2023 --> Aug 2024 | Trial primary completion date: Aug 2023 --> Aug 2024
  • ||||||||||  fluoxetine / Generic mfg.
    Prozac??? (Twitter) -  Sep 6, 2022