- |||||||||| Visken (pindolol) / Novartis
Preclinical, Journal: Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study. (Pubmed Central) - May 10, 2024
Here we compare the efficacy of mirtazapine (MIR), pindolol (PIN), fluoxetine (FLX), risperidone (RIS), trazodone (TRZ), ziprasidone (ZPR), ondansetron (OND), yohimbine (YOH), or prazosin (PRZ), to reduce long-term cocaine-induced locomotor activity and the expression of cocaine-induced locomotor sensitization in rats...After each administration, locomotor activity for each animal was recorded for 30
- |||||||||| fluoxetine / Generic mfg.
Journal: Parietal-Frontal Pathway Controls Relapse of Fear Memory in a Novel Context. (Pubmed Central) - May 10, 2024
In addition, we found that parvalbumin-expressing interneurons controlled novel context-dependent fear renewal, which was blocked by the chronic administration of fluoxetine. Our findings highlight the PPC-to-ACC pathway in mediating the relapse of extinguished fear in novel contexts, thereby contributing significant insights into the intricate neural mechanisms that govern fear renewal.
- |||||||||| paroxetine / Generic mfg.
Trial completion date, Trial primary completion date: Effects of Paroxetine on Cardiovascular Function in Septic Patients (clinicaltrials.gov) - May 8, 2024
P2, N=92, Recruiting,
Data show tNAA is a potential marker for upper limb function. Trial completion date: Feb 2024 --> Jul 2024 | Trial primary completion date: Dec 2023 --> Jul 2024
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice. (Pubmed Central) - May 7, 2024
In addition, NSC689857 and fluoxetine coadministration produced additive antidepressant-like effects in non-stressed male mice...Administration of NSC689857 (5?mg/kg) also attenuated depression-like behaviors in male mice induced by chronic social defeat stress, suggesting therapeutic potential of NSC689857 in depression. Overall, these results suggest that NSC689857 is capable of exerting antidepressant-like effects in both non-stressed and chronically stressed mice.
- |||||||||| Journal: A case of Pitt-Hopkins syndrome: psychopharmacological approach for anxiety, insomnia, and agitation. (Pubmed Central) - May 3, 2024
After admission to our hospital, aripiprazole and hydroxyzine were prescribed for anxiety and ASD-related irritability...Hydroxyzine was stopped, and quetiapine was given to eliminate sleep disturbance...For the anxiety symptoms, escitalopram was prescribed...Patients with genetic syndromes may have various psychiatric complaints. Psychopharmacological interventions should be administered carefully for the side effects.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice. (Pubmed Central) - May 2, 2024
Group I: control (negative control) exposed to open-space forced swim test (OSFST) without any treatment, Groups II, III and IV received graded doses of Cinnamon 12.5, 25, and 50 mg/kg, group 5 (positive control) received fluoxetine 20 mg/kg orally...In conclusion, cinnamon has shown antidepressant-like effect in open-space forced swim-induced depression in mice. Keywords: Cinnamon, Depression, Cognitive impairment, Immobility time, Behavioural despair.
- |||||||||| fluoxetine / Generic mfg.
Journal: Polystyrene microplastics alter the trophic transfer and biotoxicity of fluoxetine in an aquatic food chain. (Pubmed Central) - Apr 24, 2024
In addition, the specific neurotransmission biotoxicity in fish induced by fluoxetine was mitigated by MPs, whilst the oxidative damage, apoptosis, and immune responses in zebrafish were reversely enhanced by MPs due to the stimulating effect. These findings highlight the alleviating effects of MPs on the trophic transfer and specific biotoxicity of fluoxetine in the food chain, providing new insights into the carrier effects of MPs in aquatic environments in the context of increasing global MP pollution.
- |||||||||| fluoxetine / Generic mfg.
Journal: Active microscopic colitis precipitated by fluoxetine. (Pubmed Central) - Apr 18, 2024
Some drugs have been described as triggers of colonic inflammation in predisposed individuals, while others may exacerbate microscopic colitis that evolves on its own. We present the case of a patient diagnosed with active microscopic colitis in relation to taking fluoxetine at high doses.
- |||||||||| Retrospective data, Review: Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis. (Pubmed Central) - Apr 18, 2024
Interestingly, commonly used synthetic drugs such as Fluoxetine, Escitalopram, Amitriptyline, Sertraline, Flupentixol and Melitracen, and Venlafaxine, not only appeared to be less effective than specific Chinese herbal medicines (Gan Mai Da Zao Decoction, Chaihu Jia Longgu Muli Decoction, Chai Hu Shu Gan San, Danzhi-Xiaoyao-San, and Xingnao Jieyu Decoction), but they were also related to substantially higher risk of adverse events...However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109.
- |||||||||| fluoxetine / Generic mfg.
Journal: Temperature-dependent toxicity of fluoxetine alters the thermal plasticity of marine diatoms. (Pubmed Central) - Apr 17, 2024
These findings emphasize the physiological impacts and ecological implications of fluoxetine on phytoplankton and underscore the significance of considering interactions between multiple environmental drivers when accessing the ecotoxicity of potential pollutants. The present study provides insights into crucial considerations for evaluating the impacts of pharmaceutical pollution on marine primary producers.
- |||||||||| ketamine / Generic mfg., fluoxetine / Generic mfg.
Behavioral and Neurochemical Effects of Increased MAOA Activity in the Prefrontal Cortex in Mice () - Apr 14, 2024 - Abstract #SOBP2024SOBP_1016;
In summary, regulating hippocampal SIK2 and CRTC1 participates in the antidepressant mechanism of paroxetine, extending the knowledge of its pharmacological targets. Our model provides the opportunities to cross-compare the effects of elevated MAOA in different cell types and brain regions (mPFC, hippocampus) on behavioural, biochemical, and neurochemical outcomes, and to directly test the hypothesis that elevated MAOA serves as a causal factor for treatment response.
- |||||||||| paroxetine / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Retrospective data, Journal: Evaluating the Use of Selective Serotonin Reuptake Inhibitors (SSRIs) and Male Infertility: A Critical Retrospective Study. (Pubmed Central) - Apr 13, 2024
Regarding the sperm analysis and the use of SSRIs, the impact of SSRIs use showed no significant differences in sperm liquefaction (p = 0.1), motility (p = 0.17), viscosity (p = 0.16), or count (p = 0.069) with escitalopram, fluoxetine, or paroxetine use; Our study showed no significant difference in the sperm analysis between the SSRI and non-SSRI cohorts. However, the relationship between SSRI use and sperm count warrants further investigation and consideration in clinical practice.
- |||||||||| venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Journal: Association of the Antidepressants and the Periodontal Status: An Original Research. (Pubmed Central) - Apr 10, 2024
Number, percentage, mean, and standard deviation were used to present the values. Results showed that antidepressants may be a risk factor for periodontal health, with increased periodontal parameters, and concluded that It is crucial to frequently check the periodontal health of depressed people using fluoxetine or venlafaxine since these drugs put good periodontal tissues at risk.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Trial primary completion date: Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders (clinicaltrials.gov) - Apr 10, 2024
P2, N=75, Recruiting,
Results showed that antidepressants may be a risk factor for periodontal health, with increased periodontal parameters, and concluded that It is crucial to frequently check the periodontal health of depressed people using fluoxetine or venlafaxine since these drugs put good periodontal tissues at risk. Trial primary completion date: Mar 2024 --> Nov 2024
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Drugs for bipolar disorder. (Pubmed Central) - Apr 9, 2024
Trial primary completion date: Mar 2024 --> Nov 2024 No abstract available
- |||||||||| Journal: Weak base drug-induced endolysosome iron dyshomeostasis controls the generation of reactive oxygen species, mitochondrial depolarization, and cytotoxicity. (Pubmed Central) - Mar 27, 2024
Atropine (anticholinergic), azithromycin (antibiotic), fluoxetine (antidepressant), metoprolol (beta-adrenergic), and tamoxifen (anti-estrogen) at pharmacologically and therapeutically relevant concentrations (1) de-acidified endolysosomes, (2) decreased Fe2+ levels in endolysosomes, (3) increased Fe2+ and ROS levels in cytosol and mitochondria, (4) induced mitochondrial membrane potential depolarization, and (5) increased cell death; effects prevented by the endocytosed iron-chelator deferoxamine. Weak-base pharmaceuticals induce lysosome-stress responses that may affect their safety profiles; a better understanding of weak-base drugs on Fe2+ interorganellar signaling may improve pharmacotherapeutics.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
Preclinical, Journal: Modulating gut microbiota improves neurological function and depressive symptoms in rats with post-stroke depression (Pubmed Central) - Mar 23, 2024
Factors regulating OLs might be biomarkers for early diagnosis and agents stimulating OLs warrant the development of anti-AD drugs. In PSD rats, TMAO/H2S ratio is correlated with neurological function score, immobility time in forced swimming and sugar water preference, and modulating intestinal flora can improve neurological function and depressive symptoms and improve the integrity of the blood-brain barrier.
- |||||||||| escitalopram / Generic mfg.
Enrollment change: Development and Application of Comprehensive Intervention Techniques for Adolescent Depression (clinicaltrials.gov) - Mar 22, 2024
P=N/A, N=100, Recruiting,
In PSD rats, TMAO/H2S ratio is correlated with neurological function score, immobility time in forced swimming and sugar water preference, and modulating intestinal flora can improve neurological function and depressive symptoms and improve the integrity of the blood-brain barrier. N=400 --> 100
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress. (Pubmed Central) - Mar 20, 2024
Indeed, we observed changes in several molecular key players of the hypothalamic pituitary adrenal axis, particularly influencing genomic effects mediated by the glucocorticoid receptor. This study highlights that prenatal FLX exposure influences the ability of adolescent male rats to respond to an acute challenge, thereby altering the functionality of the hypothalamic-pituitary-adrenal axis, and indicates that the prenatal manipulation may prime the response to challenging events during this critical period of life.
- |||||||||| Review, Journal: Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review. (Pubmed Central) - Mar 19, 2024
The following keywords were used to retrieve relevant case reports from PubMed: "antidepressant or antipsychotic drug or amitriptyline or bupropion or citalopram or desipramine or dosulepin or dothiepin or doxepin or escitalopram or fluoxetine or haloperidol or olanzapine or phenothiazine or quetiapine or risperidone or trazodone" and "lipid emulsion or Intralipid." Lipid emulsion treatment reversed the corrected QT interval prolongation and decreases in Glasgow Coma Scale scores caused by toxic doses of neuropsychiatric drugs, especially lipid-soluble drugs such as amitriptyline, trazodone, quetiapine, lamotrigine, and citalopram...Adjuvant lipid emulsion treatment contributed to the recovery of 98.30% of patients with neuropsychiatric drug-induced toxicity. However, further analyses using many case reports are needed to clarify the effects of lipid emulsion resuscitation.
- |||||||||| fluoxetine / Generic mfg.
Retrospective data, Journal: Individual patient data meta-analysis of the effects of fluoxetine on functional outcomes after acute stroke. (Pubmed Central) - Mar 18, 2024
It increased seizures, falls with injury, and bone fractures but reduced depression frequency at 6 months. Stroke Association, National Institute of Health Research, Australian Government National Health and Medical Research Council, Swedish Research Council, Swedish Heart-Lung Foundation, Swedish Brain Foundation, Swedish Society of Medicine, King Gustav V and Queen Victoria's Foundation of Freemasons and STROKE-Riksf
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda, Savella (milnacipran) / AbbVie, Pierre Fabre
Review, Journal: Update Lessons from PET Imaging Part II: A Systematic Critical Review on Therapeutic Plasma Concentrations of Antidepressants. (Pubmed Central) - Mar 18, 2024
For SNRIs, duloxetine, and venlafaxine, NETs are sufficiently occupied, well above the SERT efficacy threshold. For these drugs, a titration toward higher concentrations (within the recommended range) should be considered in case of no response at lower concentrations.
- |||||||||| clonazepam / Generic mfg., fluoxetine / Generic mfg.
Journal: Psychoactive substance consumption after the Fund (Pubmed Central) - Mar 17, 2024
The high public provision may have stifled significant consumption patterns of psychoactive drugs; however, peak consumption were observed in private retail, suggesting a modification in use patterns after the disaster. The decrease in consumption immediately after the event was probably related to lower care-seeking behavior on the part of the population, and significant peaks after the disaster may reflect economic consequences of it.
- |||||||||| fluoxetine / Generic mfg.
Journal: Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment. (Pubmed Central) - Mar 17, 2024
The decrease in consumption immediately after the event was probably related to lower care-seeking behavior on the part of the population, and significant peaks after the disaster may reflect economic consequences of it. Fluoxetine exhibited anti-inflammatory effects on intestinal mucosa via remodeling of the intestinal cells and macrophages, which reveals that fluoxetine is a promising therapeutic drug for the treatment of IBD and psychiatric comorbidities.
- |||||||||| fluoxetine / Generic mfg.
Review, Journal: Picornavirus 2C proteins: structure-function relationships and interactions with host factors. (Pubmed Central) - Mar 15, 2024
Additionally, we provide an overview of broad-spectrum antiviral drugs for treating various enterovirus infections, such as guanidine hydrochloride, fluoxetine, and dibucaine derivatives...The review underscores the need for further research to elucidate the precise mechanisms of action of 2C proteins and to identify additional host factors for potential therapeutic intervention. Overall, this review contributes to a deeper understanding of picornaviruses and offers insights into the antiviral strategies against these significant viral pathogens.
- |||||||||| hyoscine butylbromide oral / Generic mfg., fluoxetine / Generic mfg.
Journal: A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement. (Pubmed Central) - Mar 15, 2024
Furthermore, D01 reverses the long-term potentiation (LTP) inhibition induced by scopolamine. Taken together, our findings demonstrate that D01, a dual-target serotonin reuptake and M channel inhibitor, is highly effective in the treatment-resistant depression and cognitive deficits, thus holding potential for development as therapy of depression with cognitive deficits.
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