- |||||||||| fluoxetine / Generic mfg.
Review, Journal: Effects of fluoxetine on fish: What do we know and where should we focus our efforts in the future? (Pubmed Central) - Oct 19, 2022
We conclude that environmentally relevant concentrations of fluoxetine (e.g., from 0.00345 μg/L) produced adverse effects and often this concentration range is not addressed in conventional environmental risk assessment strategies. Its environmental persistence and ionizable properties reinforce the need for standardized testing with representative aquatic models, targeting endpoints sensitive to the specific mode of action of fluoxetine, in order to assess and rank its actual environmental risk to aquatic ecosystems.
- |||||||||| fluoxetine / Generic mfg.
Equipercentile Linking of Suicidal Ideation Questionnaire-Jr and the Clinical Global Impression Scale for Treatment of Adolescent Depression () - Oct 19, 2022 - Abstract #AACAP2022AACAP_829;
Methods We examined the Treatment for Adolescents with Depression Study (TADS), which was a 12-week trial in which subjects were randomized to fluoxetine (FLX), CBT, FLX and CBT combined (COMB), and clinical management with placebo (PBO) treatment...Conclusions Our results demonstrated that there is a clinically and statistically significant relationship between SIQ-Jr and CGI-I. These findings can be utilized in the further use of CGI-I for global and symptoms assessment to evaluate suicidality in clinical settings.
- |||||||||| fluoxetine / Generic mfg.
Triple Threat: Physical Symptoms, Humiliation/Rejection, and Perfectionism as Predictors or Moderators of Adolescent Depression Treatment Outcomes () - Oct 19, 2022 - Abstract #AACAP2022AACAP_705;
Participants included 439 adolescents, aged 12 to 17 years, who were randomly assigned to 4 treatment arms: fluoxetine, CBT, combined fluoxetine and CBT, and placebo, over a period of 36 weeks...Conclusions Increased physiological symptoms merit treatment via either singular CBT or SSRI or combined CBT and SSRI intervention. Further, the MASC emerged as a robust metric for identifying co-occurring anxiety symptoms in depressed adolescents.
- |||||||||| fluoxetine / Generic mfg., escitalopram / Generic mfg.
Use of Psychopharmacology and Neurotherapeutics in Treatment-Resistant Adolescent Depression (Virtual) - Oct 19, 2022 - Abstract #AACAP2022AACAP_589;
Having options for treatment after SSRI monotherapy does not result in remission of symptoms, which is an important part of caring for youth with depression. Findings in this lecture will inform practitioners about options for the teenagers in their practice.
- |||||||||| Know Your CYPs! Meaningful Cytochrome p450 Interactions in the Treatment of Psychosis () - Oct 19, 2022 - Abstract #AACAP2022AACAP_286;
Some CYP1A2 substrates include olanzapine, clozapine, propranolol, and caffeine...Conclusions Many medications prescribed for patients experiencing early psychosis have important cytochrome p450 interactions. Knowledge of these interactions is important for providers at all levels.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda, Viibryd (vilazodone) / AbbVie
Clinical Pharmacogenetic Guideline Updates for Antidepressants () - Oct 19, 2022 - Abstract #AACAP2022AACAP_58;
Data evaluations by CPIC provide evidence grading and recommendations regarding whether important PK or PD genes should be considered if PGx information is available. CPIC and FDA evidence evaluations are helpful resources for the interpretation of pharmacogenetic information for commonly used antidepressants.
- |||||||||| sertraline / Generic mfg., fluoxetine / Generic mfg.
Treating the depression or the disease? Pseudo-Trial with the UK MS Register (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_1310;
There was a significant difference in worsening (p=0.028); notably fluoxetine was more likely to have worse outcomes and Sertraline better outcomes compared to control. Preliminary studies in repurposing antidepressants to treat the symptoms of MS in this 'pseudo-trial' show a promising signal for further testing Sertraline in clinical trials.
- |||||||||| fluoxetine / Generic mfg.
Journal: Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model. (Pubmed Central) - Oct 18, 2022
We also evaluated the influence of exposure to fluoxetine, a well-known antidepressant, on the behavior of reserpine-exposed animals...Physical exercise was able to prevent the changes in dopamine and serotonin levels, reinforcing that the preventive effect promoted by physical exercise is related to the modulation of neurotransmitter levels. Our findings showed that reserpine was effective in the induction of a putative depression model in zebrafish and that physical exercise may be an alternative to prevent the effects induced by reserpine.
- |||||||||| progesterone / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. (Pubmed Central) - Oct 18, 2022
PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids...A radioimmunoassay was utilized for estradiol (E2) and progesterone (P) measurements...Furthermore, suppression of TSPO or the BDNF‑mTOR pathway partially reversed the effects of paeoniflorin on depression‑like behaviors, hormone levels, and inflammatory cytokine release. Paeoniflorin may improve symptoms of PPD by regulating the TSPO and BDNF‑mTOR pathways, indicating that paeoniflorin may be an effective anti‑PPD and antidepressant drug, providing evidence for the future treatment of PPD.
- |||||||||| Calcium Channel Blocker Toxicity () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1301;
HELPFUL DETAILS:PMH: TIAs- Previous QTc prolongation on ECG -Ulcerative Colitis -OA -Takayasu's Disease - Trigeminal Neuralgia - Migraines - Seizure disorder.Rx:Clopidogrel 75mg OD Lansoprazole 30mg OD Atorvastatin 40mg ODFluoxetine 20mg OD Gabapentin 300mg BD Lamotrigine 50mg OD Ramipril 5mg OD Sodium Valproate 200mg BD Verapamil 320mg TDS Sumatriptan PRN ON EXAMINATION:A – Patent , Pt talking...S1+S2+0 D- GCS 14/15 E3, S5, M6, PEARLA BM 5.4, Temp 36.2 Lactate 4.2 Bloods and VBG done.12 - Lead ECG performed DIFFERENTIALS:- Inferior myocardial infarction.- AV-nodal blocking drugs (e.g., calcium-channel blockers, beta-blockers, digoxin)- Electrolyte imbalance...Hypotension should first be treated with intravenous fluids. Later interventions may include calcium, insulin/dextrose and vasopressors.-There is no “magic bullet” antidote for CCB poisoning, so a very high risk of mortality.Disposition:- Any patient manifesting calcium channel toxicity needs HDU/ ICU level care.Patient Monitoring:- 4 - 12 hours if standard release verapamil or diltiazem- 16 - 24 hours if SR verapamil or diltiazemLEARNING POINTS:- The exact timing of when high dose insulin euglycaemic therapy should be given in the stepwise approach is uncertain.- Echocardiography and invasive monitoring are helpful to assess the cardiovascular manifestations of calcium channel toxicity.- vasopressors are more likely to be useful if vasodilation is significant whereas insulin and inotropes are more likely to be beneficial when there is impaired contractility.
- |||||||||| Calcium Channel Blocker Toxicity () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1300;
HELPFUL DETAILS:PMH: TIAs- Previous QTc prolongation on ECG -Ulcerative Colitis -OA -Takayasu's Disease - Trigeminal Neuralgia - Migraines - Seizure disorder.Rx:Clopidogrel 75mg OD Lansoprazole 30mg OD Atorvastatin 40mg ODFluoxetine 20mg OD Gabapentin 300mg BD Lamotrigine 50mg OD Ramipril 5mg OD Sodium Valproate 200mg BD Verapamil 320mg TDS Sumatriptan PRN ON EXAMINATION:A – Patent , Pt talking...S1+S2+0 D- GCS 14/15 E3, S5, M6, PEARLA BM 5.4, Temp 36.2 Lactate 4.2 Bloods and VBG done.12 - Lead ECG performed DIFFERENTIALS:- Inferior myocardial infarction.- AV-nodal blocking drugs (e.g., calcium-channel blockers, beta-blockers, digoxin)- Electrolyte imbalance...Hypotension should first be treated with intravenous fluids. Later interventions may include calcium, insulin/dextrose and vasopressors.-There is no “magic bullet” antidote for CCB poisoning, so a very high risk of mortality.Disposition:- Any patient manifesting calcium channel toxicity needs HDU/ ICU level care.Patient Monitoring:- 4 - 12 hours if standard release verapamil or diltiazem- 16 - 24 hours if SR verapamil or diltiazemLEARNING POINTS:- The exact timing of when high dose insulin euglycaemic therapy should be given in the stepwise approach is uncertain.- Echocardiography and invasive monitoring are helpful to assess the cardiovascular manifestations of calcium channel toxicity.- vasopressors are more likely to be useful if vasodilation is significant whereas insulin and inotropes are more likely to be beneficial when there is impaired contractility.
- |||||||||| Calcium Channel Blocker Toxicity () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1299;
HELPFUL DETAILS:PMH: TIAs- Previous QTc prolongation on ECG -Ulcerative Colitis -OA -Takayasu's Disease - Trigeminal Neuralgia - Migraines - Seizure disorder.Rx:Clopidogrel 75mg OD Lansoprazole 30mg OD Atorvastatin 40mg ODFluoxetine 20mg OD Gabapentin 300mg BD Lamotrigine 50mg OD Ramipril 5mg OD Sodium Valproate 200mg BD Verapamil 320mg TDS Sumatriptan PRN ON EXAMINATION:A – Patent , Pt talking...S1+S2+0 D- GCS 14/15 E3, S5, M6, PEARLA BM 5.4, Temp 36.2 Lactate 4.2 Bloods and VBG done.12 - Lead ECG performed DIFFERENTIALS:- Inferior myocardial infarction.- AV-nodal blocking drugs (e.g., calcium-channel blockers, beta-blockers, digoxin)- Electrolyte imbalance...Hypotension should first be treated with intravenous fluids. Later interventions may include calcium, insulin/dextrose and vasopressors.-There is no “magic bullet” antidote for CCB poisoning, so a very high risk of mortality.Disposition:- Any patient manifesting calcium channel toxicity needs HDU/ ICU level care.Patient Monitoring:- 4 - 12 hours if standard release verapamil or diltiazem- 16 - 24 hours if SR verapamil or diltiazemLEARNING POINTS:- The exact timing of when high dose insulin euglycaemic therapy should be given in the stepwise approach is uncertain.- Echocardiography and invasive monitoring are helpful to assess the cardiovascular manifestations of calcium channel toxicity.- vasopressors are more likely to be useful if vasodilation is significant whereas insulin and inotropes are more likely to be beneficial when there is impaired contractility.
- |||||||||| Calcium Channel Blocker Toxicity () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1298;
HELPFUL DETAILS:PMH: TIAs- Previous QTc prolongation on ECG -Ulcerative Colitis -OA -Takayasu's Disease - Trigeminal Neuralgia - Migraines - Seizure disorder.Rx:Clopidogrel 75mg OD Lansoprazole 30mg OD Atorvastatin 40mg ODFluoxetine 20mg OD Gabapentin 300mg BD Lamotrigine 50mg OD Ramipril 5mg OD Sodium Valproate 200mg BD Verapamil 320mg TDS Sumatriptan PRN ON EXAMINATION:A – Patent , Pt talking...S1+S2+0 D- GCS 14/15 E3, S5, M6, PEARLA BM 5.4, Temp 36.2 Lactate 4.2 Bloods and VBG done.12 - Lead ECG performed DIFFERENTIALS:- Inferior myocardial infarction.- AV-nodal blocking drugs (e.g., calcium-channel blockers, beta-blockers, digoxin)- Electrolyte imbalance...Hypotension should first be treated with intravenous fluids. Later interventions may include calcium, insulin/dextrose and vasopressors.-There is no “magic bullet” antidote for CCB poisoning, so a very high risk of mortality.Disposition:- Any patient manifesting calcium channel toxicity needs HDU/ ICU level care.Patient Monitoring:- 4 - 12 hours if standard release verapamil or diltiazem- 16 - 24 hours if SR verapamil or diltiazemLEARNING POINTS:- The exact timing of when high dose insulin euglycaemic therapy should be given in the stepwise approach is uncertain.- Echocardiography and invasive monitoring are helpful to assess the cardiovascular manifestations of calcium channel toxicity.- vasopressors are more likely to be useful if vasodilation is significant whereas insulin and inotropes are more likely to be beneficial when there is impaired contractility.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology. (Pubmed Central) - Oct 14, 2022
After the administration of LBRD (90 g/kg) and fluoxetine (2 mg/kg) for 14 days, we assessed behaviour and the levels of neurotransmitter, inflammatory cytokine and circulating stress hormone...Followed by LBRD treatment, the main metabolites in prefrontal tissue were contributed to retrograde endocannabinoid signalling, glycerophospholipid metabolism, glycosylphosphatidylinositol-anchor biosynthesis, autophagy signal pathway, etc. LBRD were effective at increasing neurotransmitter, attenuating proinflammatory cytokine and regulating glycerophospholipid metabolism and glutamatergic synapse, thereby ameliorating depressive phenotypes. This research will offer reference for elucidating the metabolomic mechanism underlying novel antidepressant agents contained LBRD formula.
- |||||||||| mirtazapine / Generic mfg., fluoxetine / Generic mfg.
One Not So Salty Lady (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2327;
Lab studies were not consistent with SIADH, but improved with treatment for SIADH. It is important to understand the balance of aldosterone and ADH in a patient with hyponatremia as it guides treatment.
- |||||||||| olanzapine / Generic mfg., fluoxetine / Generic mfg.
A Case of Obsessive Compulsive Disorder with Surgical Complications (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1430;
olanzapine 10mg/daily and buspirone 30mg/daily were added for augmentation...Liaison psychiatry should be given more importance in order to provide early diagnosis and treatment in OCD patients especially when symptoms are related to somatic functions. Strategies to strengthen communication with other medical branches for early detection and referral for psychiatric treatment are needed.Interventions to increase mental health literacy skills to reduce DUI and to enhance mental health- seeking behavior should be implemented.
- |||||||||| Systematic review treatments for Autism Spectrum Disorder. (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1357;
There is evidence that demonstrates the effects of Memantine on behavioral symptoms and attention problems in children with ASD (Aguirre, C.G.; Ruelas, J.M. and Samuano, M., 2016).In addition to pharmacological treatment, there are support resources in educational planning, based on the dimensions of the I.D.E.A. and elaborated based on the dimensions established in the Autistic Spectrum Inventory (Rivière, 1997, 2002), defining the following elements for each of the dimensions and levels:· Priority intervention objectives.· Basic Methodological strategies, with their bibliographic reference.· Resources for the intervention: Downloadables of own elaboration, commercial materials that contribute to the development of capacities, related bibliographic resources.
- |||||||||| Metronidazole-induced mania – a case report (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1337;
The Case Report ed, of a 50-year-old woman with no known history of mental illness, and a manic episode concomitant with metronidazole administration, points to the likely possibility of an induction of symptoms. Even though the patient was previously medicated with fluoxetine 20mg daily, she has been so for the past 20 years without any adverse effects.
- |||||||||| aripiprazole / Generic mfg., memantine / Generic mfg., fluoxetine / Generic mfg.
Treating obsessive-compulsive symptoms in autism spectrum disorder: new perspectives (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1207;
Adapted-CBT and function-based CBT show promising Result s, with the use of medication functioning as a potential mediator. Novel therapeutic strategies, namely the potential role of glutamatergic medication, need further studies.
- |||||||||| fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Suicidal behaviors – risk factors in patients with schizophrenia (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1088;
Having side effects of neuroleptics like sialorrhea and dyslipidemia was a significant risk of suicidal behavior( p<10-3). Conclusion : Suicidal behavior is a serious problem and the most common cause of death among patients with schizophrenia. Thus, it should be investigated among all patients with schizophrenia and measures should be taken in order to prevent this behavior.Preventing suicidal behaviors in schizophrenia involves the identification of risk factors and early treatment of the mental disease.
- |||||||||| fluoxetine / Generic mfg., lurasidone / Generic mfg.
Augmentation strategy fluoxetine and lurasidone in the treatment of obsessive-compulsive disorder with comorbid restrictive anorexia nervosa – a case report (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_920;
Lurasidone is a second-generation antipsychotic with good efficacy and lower metabolic and cardiovascular side effects if compared with other SGAs, but there is currently brief experience about its use in treatment of OCD, especially whereas comorbid anorexia nervosa- restrictive type (AN-r) is present. Objective: This Case Report presents the effect of augmentation strategy with lurasidone (37 mg daily bedtime) in a 45-years old woman with a relapse episode of severe OCD with comorbid AN-r, previously treated with combined fluoxetine and olanzapine treatment, subsequently interrupted. During the first visit to our psychiatric clinic the patient was provided self- and hetero-administered assessment with Yale-Brown Obsessive Compulsive Scale (Y-BOCS-II), Clinical Global Impression-Severity (CGI-S), Symptom Checklist-90 (SCL-90) and Eating Disorder Inventory-3 (EDI-3)...The management of this clinical case demonstrates a possible indication of lurasidone as augmentation strategy in tr-OCD. Nevertheless, further longitudinal and real-world effectiveness studies are needed to confirm effectiveness in attenuating OC symptomatology, in tr-OCD and whereas a comorbid AN-r is present.
- |||||||||| agomelatine / Generic mfg.
Agomelatine in children and adolescents with moderate to severe major depressive disorder: an open-label extension study (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_670;
Safety data for adolescents were similar to the overall population. Conclusion : Agomelatine for up to 104W was associated with continuous improvement in depressive symptoms, whatever the treatment received during the double-blind primary phase. Although additional studies are needed to further investigate the clinical relevance of the improvement, these findings suggest long-term benefits of agomelatine in a pediatric population with moderate-to-severe MDD.
- |||||||||| CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability: clinical study on 102 inpatients (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_525;
Therefore, it is likely that SM group does not receive the appropriate treatment under standard psychiatric practice, which is in most cases unaware of the patients’ CYP2C19 genotype. Even though this study does not have sufficient power for an unequivocal Conclusion related to the need of pre-emptive CYP2C19 genotyping of antidepressant treated patients, it contributes to the body of already existing evidence on the clinical usefulness of CYP2C19 genotyping in psychiatry.
- |||||||||| A case of neuroacanthocytosis presented with depression and suicidal thoughts (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_449;
She had been followed up with the diagnosis of recurrent depression for over 5 years in another centre and her last treatment regimen was fluoxetine 20 mg/daily and lamotrigine 75 mg/daily.On admission, her lips were swollen and ecchymotic due to the biting behaviour...Peripheral blood smear showed acanthocytes in 40-50% of the field.The patient was put on risperidone 2 mg/daily, escitalopram 10 mg/daily and quetiapine 50 mg/daily with the diagnosis of neuroacanthocytosis accompanied by depression...Even though there is no curative treatment for neuroacanthocytosis; symptomatic treatment plays a major role in maintaining quality of life [4]. In Conclusion , in individuals presenting with movement disorders and psychiatric conditions, a peripheral smear for acanthocyte screening must be considered.
- |||||||||| samidorphan (ALKS 33) / Alkermes
Review, Journal: Pharmacological interventions for prevention of weight gain in people with schizophrenia. (Pubmed Central) - Oct 11, 2022
Interpretation of this result and those for other agents, is limited by the small number of studies, small sample size, and short study duration. In future, we need studies that are adequately powered and with longer treatment durations to further evaluate the efficacy and safety of interventions for managing weight gain.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study. (Pubmed Central) - Oct 11, 2022
The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1β, IL-6, TNF-α, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Enrollment closed, Trial completion date, Trial primary completion date, Head-to-Head: VESPA: Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment (clinicaltrials.gov) - Oct 11, 2022
P4, N=362, Active, not recruiting,
The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model. Unknown status --> Active, not recruiting | Trial completion date: Jan 2020 --> Sep 2023 | Trial primary completion date: Jul 2019 --> Feb 2023
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