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70 Trials |  |
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- | fluoxetine / Generic mfg.
Trial completion date, Trial primary completion date: Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal Trauma (clinicaltrials.gov) - Nov 7, 2022
P1, N=150, Recruiting, Sponsor: University of Florida
Trial completion date: Jun 2022 --> Jun 2024 | Trial primary completion date: Jun 2022 --> Jun 2024
- fluoxetine / Generic mfg.
EFFICACY OF FLUOXETINE IN POST-STROKE ANXIETY-PROSPECTIVE RANDOMIZED OPEN BLINDED ENDPOINT (PROBE) STUDY (GALLERY) - Nov 7, 2022 - Abstract #WSC2022WSC_1389;
In this first randomized trial of Fluoxetine in post stroke patients, we did not see any significant difference in the anxiety scores between intervention and control arm. There were no significant side effects which led to drug withdrawal or non-compliance.
- | fluoxetine / Generic mfg.
Journal: Conserved and distinct functions of the autism-related chromatin remodeler CHD8 in embryonic and adult forebrain neurogenesis. (Pubmed Central) - Nov 5, 2022
Treatment with an FDA approved antidepressant fluoxetine partially rescues the adult neurogenesis defects in CHD8-mutants. Thus, our findings help resolve CHD8 functions throughout life during embryonic and adult neurogenesis, and point to a potential avenue to promote neurogenesis in CHD8 deficiency.
- | Retrospective data, Journal: Predictors of response to pharmacotherapy in children and adolescents with psychiatric disorders: A combined post hoc analysis of four clinical trial data. (Pubmed Central) - Nov 5, 2022
Thus, our findings help resolve CHD8 functions throughout life during embryonic and adult neurogenesis, and point to a potential avenue to promote neurogenesis in CHD8 deficiency. Allocation to active drugs, female sex, and early improvement may predict treatment response to pharmacotherapy among children and adolescents with psychiatric disorders.
- || phenytoin / Generic mfg., fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: Drug-induced cutaneous pseudolymphoma: A systematic review of the literature. (Pubmed Central) - Nov 5, 2022
In conclusion, anti-hypertensives, anti-convulsants, monoclonal antibodies and anti-depressants are the most common drugs responsible for CPL. It mostly presents in middle-aged patients with almost no gender difference as pruritic papules, nodules and plaques.
- | fluoxetine / Generic mfg.
Trial completion, Enrollment change: FLOW: Fluoxetine Opens Window to Improve Motor Recovery After Stroke (clinicaltrials.gov) - Nov 4, 2022
P2, N=52, Completed, Sponsor: University Health Network, Toronto
It mostly presents in middle-aged patients with almost no gender difference as pruritic papules, nodules and plaques. Active, not recruiting --> Completed | N=176 --> 52
- | fluoxetine / Generic mfg.
Preclinical, Journal: Achyranthes aspera ameliorates stress induced depression in mice by regulating neuroinflammatory cytokines. (Pubmed Central) - Nov 4, 2022
Mice were intraperitoneally injected with A. aspera extract (2.5, 5 and 10 mg/kg) or fluoxetine (10 mg/kg) or betaine (20 mg/kg) once daily during day 15-28 of the CUMS protocol...A. aspera treatment decreased the elevated plasma corticosterone and reversed the effect of CUMS on TNF-α, Il-6 and BDNF immunocontent in mice. The results of the present study suggest A. aspera as a promising indigenous medicine for stress associated neurobehavioral and comorbid complications.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Ameliorated Neurogenesis Deficits in Dentate Gyrus May Underly the Pronounced Antidepressant Effect of TREK-1 Potassium Channel Blockade in Rats with Depressive-like Behavior. (Pubmed Central) - Nov 4, 2022
Indeed, the neotype TREK-1 potassium channel blocker expressed an earlier and pronounced antidepressant manifestation compared to the traditional selective serotonin-reuptake inhibitors fluoxetine. We therefore conclude that the administration of TREK-1 potassium channel antagonism can reverse the depressive deficits caused by chronic stress quickly via regulation of adult hippocampal neurogenesis.
- | fluoxetine / Generic mfg.
Journal: Mechanism of visible light enhances microbial degradation of Bisphenol A. (Pubmed Central) - Nov 4, 2022
Moreover, the bacteria showed well degradation ability to various pharmaceutically active but nonbiodegradable compounds including diclofenac and fluoxetine, with a removal rate of 88 % and 20 %, respectively. Our study revealed the organic pollutant transformation pathway under the combined action of light and microorganisms, providing new insights into the microbial treatment of aromatic hydrocarbon pollutants.
- | fluoxetine / Generic mfg.
Phase classification: Poststroke Depression in Hemorrhagic Stroke (clinicaltrials.gov) - Nov 3, 2022
P2, N=224, Recruiting, Sponsor: University of Washington
Our study revealed the organic pollutant transformation pathway under the combined action of light and microorganisms, providing new insights into the microbial treatment of aromatic hydrocarbon pollutants. Phase classification: P1 --> P2
- | fluoxetine / Generic mfg.
Journal: Ecotoxicological assessment of the effects of fluoxetine on Daphnia magna based on acute toxicity, multigenerational reproduction effects, and attraction-repellence responses. (Pubmed Central) - Nov 3, 2022
This effect might be related to the fact that the organisms in the contaminated treatment began their first reproduction earlier, when compared to that in the control treatments. In conclusion, this study discusses an identified hazard for aquatic biota due to the fluoxetine attraction effect and a predictive assessment of the consequences expected if its indiscriminate use increases.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice. (Pubmed Central) - Nov 1, 2022
The anxiolytic effect of KRG was comparable to that of fluoxetine, a reference drug clinically used for anxiety disorders...Enhanced BDNF expression by KRG in the hippocampus was also indicated to mediate the anxiolytic action of KRG in immobilized mice. KRG exhibited the anxiolytic effect in immobilized mice by multiple mechanisms of action, involving enhanced serotonin and GABA transmissions and BDNF expression.
- || PK/PD data, Journal: Prediction of Basic Drug Exposure in Milk using a Lactation Model Algorithm integrated within a Physiologically Based Pharmacokinetic Model. (Pubmed Central) - Nov 1, 2022
Integration of the lactation model within PBPK models facilitates prediction of drug exposure in breast milk. The developed model can inform the design of lactation studies and assist with the neonatal risk assessment after maternal exposure to such environmental chemicals or basic drugs which diffuses passively into the milk.
- fluoxetine / Generic mfg.
Imaging Brain SV2A Density Measured With [11C]UCB-J μPET as a Readout Of Depression and Antidepressant Response in a Mouse Model of Depression (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_710;
Synaptic plasticity might contribute to the neurobiological substrate of depression and may be a target for the management of therapy efficacy. Further investigations using an immunohistochemical study of synaptogenesis is currently ongoing for a better characterization of the biological meaning of this change in [11C]UCB-J binding.
- fluoxetine / Generic mfg., tianeptine / Generic mfg.
Tianeptine Improves Anticipation for Reward in a Mouse Model of Early Developmental Exposure to Fluoxetine (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_511;
We expand on this phenotype to show these effects also include reward anticipation, while reward learning and hedonic perception remains intact. Our results also demonstrate that these deficits in motivation and reward anticipation in PN FLX animals are resistant to subsequent FLX administration in adulthood.
- Nuplazid (pimavanserin) / Acadia Pharma
Pimavanserin Treatment Increases Plasma Brain-Derived Neurotrophic Factor Levels in Rats (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_478;
In chronic treatment studies described above, both Pimavanserin and Fluoxetine significantly increased plasma levels of proBDNF as compared to vehicle group. The observed increases in plasma mBDNF levels following chronic Pimavanserin treatment suggest the neuroprotective potential of Pimavanserin in the long-term treatment management of PDP in addition to its antipsychotic effects.
- fluoxetine / Generic mfg.
Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_402;
Our data suggest that the short-term effect of ketamine vs midazolam on Y-BOCS may be influenced by baseline inhibitory cognitive control, such that greater control (less Stroop interference for color-naming) predicted greater benefit from ketamine vs midazolam. Our data may accord with published findings suggesting that Stroop task performance moderates the effectiveness of other OCD treatment modalities (e.g., cognitive behavioral therapy vs fluoxetine).
- ketamine / Generic mfg., desipramine / Generic mfg., fluoxetine / Generic mfg.
Psychedelics Show an Antidepressant Biosignature but a Sustained Response (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_41;
Previous studies in postmortem brain and in platelets showed that this biomarker was enriched in lipid rafts from depressed subjects and reverted toward control values after effective treatment (as indicated by HAM-D). The similarities and differences in the actions of these drugs at the cellular level may lead to a better molecular understanding of the distinct kinetic features of their actions.
- | fluoxetine / Generic mfg.
Preclinical, Journal: 18β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats. (Pubmed Central) - Oct 30, 2022
18βGA (10, 20, and 50 mg/kg) or fluoxetine was given once daily (from day 30 to day 36)...Furthermore, BDNF and TrkB proteins were down-regulated in CUMS group, which was increased to varying degrees by 18βGA at doses of 20 and 50 mg/kg. Therefore, 18βGA ameliorates depressive-like behavior persuaded by chronic unpredictable mild stress, decreases neuroinflammation, liver biomarkers, stress hormones, and improves body weight, brain neurotransmitter concentration via activating on BDNF/TrkB signaling pathway in both PFC and hippocampus in rats.
- |||| Preclinical: Fluvoxamine, DHEA? "the order of affinity for sigma-1 receptors is as follows: fluvoxamine > sertraline > fluoxetine > escitalopram > citalopram >> paroxetine." "Furthermore, fluvoxamine, donepezil, and DHEA, improved cognitive deficits in mice" https://t.co/tuYyvnDzDy (Twitter) - Oct 29, 2022
- | methylphenidate tablet / Generic mfg., fluoxetine / Generic mfg.
Journal: Combined chronic oral methylphenidate and fluoxetine treatment during adolescence: Effects on behavior. (Pubmed Central) - Oct 29, 2022
These behavioral results characterize the long-term effects of these drugs (orally administered) that are widely co-administered and co-misused and provide important insight into the potential neurobiological and neurochemical effects. Future research will determine the potential risks of the long-term use of MP and FLX together.
- || fluoxetine / Generic mfg.
CBD oil is The Cure For Cancer God Goven Plant is Prozac for me (Twitter) - Oct 29, 2022
- | fluoxetine / Generic mfg.
Preclinical, Journal: Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart. (Pubmed Central) - Oct 29, 2022
Fluoxetine (SERT inhibitor), decynium-22 (PMAT inhibitor), or their mixture was locally administered by reverse-microdialysis for 60 min...Decynium-22 and the mixture did not change dialysate 5-HIAA concentration, which were not affected by pargyline. Both SERT and PMAT regulate myocardial interstitial 5-HT levels by its uptake; however, 5-HT uptake via PMAT leads to 5-HT metabolism by MAO.
- | Journal, PARP Biomarker: Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. (Pubmed Central) - Oct 28, 2022
Furthermore, it was found that 5-FU + thioridazine and 5-fluorouracil (5-FU) + sertraline can synergistically induce a reduction in the viability of human colorectal adenocarcinoma cell line (HT-29)...Furthermore, it is also demonstrated that PPT1 may have an important role in the mechanism of action of these combinations, as demonstrated by their ability to decrease PPT1 expression. These results support the use of antimalarial and central nervous system (CNS) drugs in combination regimens with chemotherapeutic agents; nevertheless, additional studies are recommended to further explore their complete mechanisms of action.
- | Journal: Analysis of Antidepressants Utilization for Patients Visiting Psychiatric Out-Patient Clinic in a Tertiary Care Hospital. (Pubmed Central) - Oct 28, 2022
Sertraline, paroxetine, and desvenlafaxine, were used in adequate doses (PDD: DDD between 1 and 1.1), and fluoxetine, duloxetine, amitriptyline, imipramine, and mirtazapine, were used in inadequate doses (PDD: DDD <0.5). Our study findings reveal the need for continuous assessment of antidepressants medications usage in a hospital set up.
- | fluoxetine / Generic mfg.
Biomarker, Journal: Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling. (Pubmed Central) - Oct 28, 2022
We identified several differences in protein expression and phosphorylation in the dorsolateral prefrontal cortex (DLPFC) and cingulate cortex (CC) that correlated with impulsivity in animals, suggesting that the GABAergic synapse pathway may be affected by fluoxetine treatment. Biomarkers in combination with the identified pathways contribute to a better understanding of the mechanisms underlying the chronic effects of fluoxetine after discontinuation in children.
- || fluoxetine / Generic mfg.
Review, Journal: Advantages and Disadvantages of Using St. John's Wort as a Treatment for Depression. (Pubmed Central) - Oct 28, 2022
More prospective studies will help us better understand its efficacy in mild and moderate depression and its ability to serve as a long-term agent. Considering its mechanism of action, its role in relieving patients suffering from an anxiety disorder is also worth considering.
- | Journal: Acute and chronic ecotoxicological effects of pharmaceuticals and their mixtures in Daphnia similis. (Pubmed Central) - Oct 27, 2022
Finally, the chronic assays performed with the quaternary mixture indicated the presence of a hormetic effect at low concentrations. In sum, the present study demonstrated that the effects of individual pharmaceuticals can underestimate the risk level of these contaminants in the environment.
- || fluoxetine / Generic mfg.
PK/PD data, Journal: Fluoxetine pharmacokinetics and tissue distribution quantitatively supports a therapeutic role in COVID-19 at a minimum dose of 20 mg per day. (Pubmed Central) - Oct 26, 2022
Conclusion. Overall, with a minimum treatment period of 10-days and a minimum dose of 20 mg/day, this study corroborates in vitro studies reporting fluoxetine inhibiting SARS-CoV-2 titers and also multiple observational clinical studies showing therapeutic benefit of fluoxetine in COVID-19 patients.
- || Clinical, Journal: Trends in prescription of psychotropic medications to children and adolescents in Australian primary care from 2011 to 2018. (Pubmed Central) - Oct 26, 2022
General practitioner prescribing of melatonin, antipsychotics, antidepressants and attention deficit hyperactivity disorder medications to under-19-year-olds increased markedly from 2011 to 2018. Although benzodiazepine and Z-drug prescriptions declined, this was offset by a substantial increase in melatonin prescribing.
- || lovastatin / Generic mfg., imipramine / Generic mfg., fluoxetine / Generic mfg.
Retrospective data, Review, Journal: Potential effects of commonly applied drugs on neural stem cell proliferation and viability: A hypothesis-generating systematic review and meta-analysis. (Pubmed Central) - Oct 25, 2022
Previous studies revealed preliminary evidence that the anti-depressants fluoxetine and imipramine may affect NSC viability and proliferation...Although the data available in the literature is limited, there are clear indications for an impact of commonly applied drugs, in particular statins, on NSC function. Considering the modes of action of the respective drugs, we reveal plausible mechanisms by which this impact may be mediated, creating a testable hypothesis, and providing insights into how future confirmative research on this topic may be conducted.
- | fluoxetine / Generic mfg., duloxetine / Generic mfg.
Journal: Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants. (Pubmed Central) - Oct 25, 2022
PGMs provided clinically meaningful predictions in samples of depressed children and adolescents treated with fluoxetine or duloxetine. Future work should augment PGMs with biological data for refined predictions to guide the selection of pharmacological and psychotherapeutic treatment in children and adolescents with depression.
- | Journal: The modifying effect of the serum-to-dialysate potassium gradient on the cardiovascular safety of SSRIs in the hemodialysis population: a pharmacoepidemiologic study. (Pubmed Central) - Oct 25, 2022
The serum-to-dialysate potassium gradient may modify the association between higher versus lower QT-prolonging SSRI use and SCD among people receiving HD. Minimizing the potassium gradient in the setting of QT-prolonging medication use may be warranted.
- | fluoxetine / Generic mfg., quetiapine / Generic mfg.
Journal: Use of extracorporeal membrane oxygenation in massive amlodipine overdose. (Pubmed Central) - Oct 25, 2022
Both patients improved drastically once perfusion to vital organs was maintained by ECMO and eventually survived with good neurological outcomes and preserved cardiac contractility on discharge. This case report supports the growing evidence that although ECMO support represents a potentially life-saving salvage therapy for refractory poisoning-induced shock, escalation to ECMO must be considered and instituted early before irreversible multi-organ failure sets in to ensure good clinical outcomes.
- || fluoxetine / Generic mfg.
Preclinical, Retrospective data, Review, Journal: Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis. (Pubmed Central) - Oct 25, 2022
These results suggest that although chronic fluoxetine treatment proves positive effects in animal models of depression, it may simultaneously increase anxiety in adolescent animals in a dose-related manner. Although the clinical implications of the data should be interpreted with extreme caution, adolescent patients under fluoxetine treatment should be closely monitored.
- || Savella (milnacipran) / AbbVie, Pierre Fabre
PK/PD data, Review, Journal: Comorbid epilepsy and depression-pharmacokinetic and pharmacodynamic drug interactions. (Pubmed Central) - Oct 25, 2022
Animal data indicate that chronic administration of antidepressants could reduce (mianserin, trazodone) or potentiate the anticonvulsant activity of some antiepileptics (fluoxetine, reboxetine, venlafaxine). There are also examples of neutral interactions (milnacipran).
- | Journal: Contaminants of emerging concerns (CECs) in a municipal wastewater treatment plant in Indonesia. (Pubmed Central) - Oct 23, 2022
The study demonstrates the importance of conventional WWTPs in reducing the concentrations of CECs to minimize their aquatic contamination risk. The findings are relevant for countries, such as Indonesia, with limited resources for advanced centralized wastewater treatments, and which are exploring the efficacy of centralized WSP against the existing decentralized treatments.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Boophone disticha attenuates five day repeated forced swim-induced stress and adult hippocampal neurogenesis impairment in male Balb/c mice. (Pubmed Central) - Oct 22, 2022
The antidepressant effects of BD were comparable to those of fluoxetine, but unlike fluoxetine, BD did not show any anxiogenic effects, suggesting better pharmacological functions. In conclusion, our study shows that BD exerted antidepressant-like effects in 5d-RFSS mice, mediated in part by normalizing brain corticosterone and BDNF levels.
- | fluoxetine / Generic mfg.
Journal: Bespoke library docking for 5-HT receptor agonists with antidepressant activity. (Pubmed Central) - Oct 22, 2022
Notably, neither had psychedelic activity, in contrast to classic 5-HTR agonists, whereas both had potent antidepressant activity in mouse models and had the same efficacy as antidepressants such as fluoxetine at as low as 1/40th of the dose. Prospects for using bespoke virtual libraries to sample pharmacologically relevant chemical space will be considered.
- | fluoxetine / Generic mfg.
Journal: Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment. (Pubmed Central) - Oct 22, 2022
Fluoxetine also scored well and a theoretical combination of fluoxetine and exercise reversed 549 AD genes...Comparisons of the AD portrait to a recent depression portrait revealed a high congruence of downregulated genes in both. Together, the AD portrait provides a new platform for understanding AD and identifying potential treatments for AD.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. (Pubmed Central) - Oct 22, 2022
The FOSB immunoreactivity was almost completely abolished in the hippocampus of the deprived mice. This study showed that FOSB and H3K9ac were modulated in a territory-specific manner by early life adversities and later life stress interacting with the effect of fluoxetine therapy supporting the reliability of our model.
- || fluvoxamine / Generic mfg., fluoxetine / Generic mfg.
Clinical data, Retrospective data, Review, Journal: The effect of selective serotonin and norepinephrine reuptake inhibitors on clinical outcome of COVID-19 patients: A systematic review and meta-analysis. (Pubmed Central) - Oct 22, 2022
According to this study's results, SSRI/SNRIs may be effective in reducing mortality of COVID-19 patients, suggesting the superiority of fluvoxamine to fluoxetine. The safety profile and affordable cost of SSRI/SNRIs for a short-term use may be other reasons to propose them as beneficial medications in preventing mortality in COVID-19.
- | imipramine / Generic mfg., venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. (Pubmed Central) - Oct 21, 2022
Vitamin B6 efficiently prevented BCG sickness and depression that was comparable to common antidepressant drugs. Therefore, B6 supplement for preventing depression in high-risk individuals is suggested for further clinical research.
- | olanzapine / Generic mfg., fluoxetine / Generic mfg.
Journal: Olanzapine add-on treatment promotes neuronal differentiation of neural stem cells compared with fluoxetine alone. (Pubmed Central) - Oct 21, 2022
The combination of olanzapine and fluoxetine has no profound effect on NSCs proliferation compared with fluoxetine alone, but olanzapine add-on treatment produces a greater number and percentage of differentiated neurons from NSCs. Further investigations are needed to explore the underlying mechanisms of the increased neurogenesis caused by the combination of olanzapine with fluoxetine.
- | New trial: Electronic Training of Elderly Depression With Cognitive Impairment (clinicaltrials.gov) - Oct 20, 2022
P=N/A, N=128, Recruiting, Sponsor: Capital Medical University
- | fluoxetine / Generic mfg.
Journal: Investigation of effects of fluoxetine on the bronchial smooth muscles by the isolated organ bath system. (Pubmed Central) - Oct 20, 2022
In conclusion, fluoxetine had no contractile effect on ASM in isolated organ bath systems. Future studies are needed to evaluate the effects of oral usage of fluoxetine on the bronchial muscle in different experimental models to explain the adverse/beneficial effects of fluoxetine in the subjects, especially with respiratory conditions.
- || Retrospective data, Review, Journal: Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review. (Pubmed Central) - Oct 20, 2022
All nine drugs can relieve the pain of CPSP patients to different degrees; among them pregabalin and gabapentin have the most significant effect, and gabapentin and pregabalin also have the most adverse reactions. In the future, more multicenter, large sample, double-blind clinical randomized controlled trials need to be carried out to supplement and demonstrate the results of this study.
- || fluoxetine / Generic mfg.
THAT is the most laughable thing @KatieRebecca47 ever tipped me off to That and the Prozac use (Twitter) - Oct 20, 2022
- || Retrospective data, Review: Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis. (Pubmed Central) - Oct 19, 2022
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
- | Journal: Trajectories of Depressive and Anxiety Symptoms Across Pregnancy and Postpartum in Selective Serotonin Reuptake Inhibitor-Treated Women. (Pubmed Central) - Oct 19, 2022
Two of the four anxiety trajectories were stable, including Asymptomatic and Minimal, while the third, termed Breakthrough, was ascending with increasing symptoms and the fourth trajectory, described as Mild, had descending symptoms. Screening for anxiety with depression for pregnant women will yield a comprehensive view of psychiatric symptoms and treatment targets in perinatal women.