escitalopram / Generic mfg. 
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  • ||||||||||  citalopram / Generic mfg., sertraline / Generic mfg., escitalopram / Generic mfg.
    Journal:  A comparative analysis of selective serotonin reuptake inhibitors and fall risk in older adults. (Pubmed Central) -  May 19, 2022   
    These findings suggest a potential comparative safety benefit of sertraline compared to citalopram/escitalopram at high doses related to recurrent falls. Additional comparative studies of individual antidepressants may better inform fall risk management and prescribing for older adults.
  • ||||||||||  epinephrine / Generic mfg., escitalopram / Generic mfg.
    Journal:  The Serotonin Transporter Modulates the Kinetics and Quantal Size of Vesicular Fusion Events in Sympathoadrenal Chromaffin Cells. (Pubmed Central) -  May 14, 2022   
    ACCs synthesize and secrete catecholamines (epinephrine, norepinephrine) which mediate the physiological response to stress...In contrast, acute (minutes) or short-term (<6-8 hrs) treatment with escitalopram or 5-HT depletion had no effect...Treating ACCs with 5-HTP for 1-3 hrs had no effect but 24 hr treatment rescued the reduced spike charge seen in SERT knockout cells. Together, our data suggest that, following SERT-mediated uptake, intracellular 5-HT modulates the kinetics and thus fraction of secretory vesicle content that is released during a fusion event.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD), epacadostat (INCB024360) / Incyte
    IDO1 IS A PROMISING THERAPEUTIC TARGET TO TREAT PANCREATIC CANCER-ASSOCIATED DEPRESSION () -  May 10, 2022 - Abstract #APCM2022APCM_26;    
    These findings mirror results in patients with pancreatic cancer. Treatment of pancreatic cancer-bearing mice with epacadostat improved depressive-like behaviors and dramatically reduced serum kynurenine levels.
  • ||||||||||  escitalopram / Generic mfg.
    Journal:  Interesting presentation of postnatal depression and infant failure to thrive. (Pubmed Central) -  May 6, 2022   
    This case report is of a woman in her 30s, 10 months post partum who was referred to Mother Baby Unit at a tertiary hospital with depressive symptoms including lowered mood, reduced self-care and motivation despite initiation of escitalopram 3 months earlier...Surgical removal was successful which led to resolution of her depressive symptoms and improved parenting functioning. This case highlights the importance of considering organic causes of depression and non-organic causes of failure to thrive in infants.
  • ||||||||||  escitalopram / Generic mfg.
    Neuron-Derived Extracellular Vesicles and Antidepressant Response () -  May 6, 2022 - Abstract #SOBP2022SOBP_1264;    
    Samples were collected at two time points (baseline and after 8 weeks of follow-up) from depressed patients who responded (N=20) and did not respond (N=20) to escitalopram treatment, as well as controls (N=20)... Together, this study indicates that changes in peripherally isolated NDEV can act as both a clinically accessible and informative biomarker of ADT response specifically through size and cargo.
  • ||||||||||  escitalopram / Generic mfg.
    Defining Subtypes of Escitalopram Response Using Resting-State fMRI (Grand Salon C) -  May 6, 2022 - Abstract #SOBP2022SOBP_1234;    
    The results demonstrate the potential clinical and biological utility of predicting symptom-specific antidepressant response using RSFC. Future directions include clinical or reversetranslation, particularly regarding manipulating specific functional circuits for subtypes or symptoms
  • ||||||||||  duloxetine / Generic mfg., escitalopram / Generic mfg.
    Changes in Functional Connectivity in Remitters to CBT versus Pharmacotherapy for Depression (Grand Salon C) -  May 6, 2022 - Abstract #SOBP2022SOBP_1232;    
    Medication effects are broadly inhibitory. Remission achieved through CBT is assocaited with signfiicant increases in RSFC strength between networks involved in cognitive control and attention, providing biological support for the theorized mechanism of CBT.
  • ||||||||||  aripiprazole / Generic mfg., escitalopram / Generic mfg.
    ABCB1 Gene Variants and Antidepressant Response and Tolerability: A Systematic Review and Meta-Analysis Including Results From the CAN-BIND-1 Cohort (Churchill) -  May 6, 2022 - Abstract #SOBP2022SOBP_870;    
    From the CAN-BIND-1 sample, we observed an association between the ABCB1 rs2032582 (G2677T/A) SNP and percent MADRS improvement for major depressive disorder (MDD) patients treated with both escitalopram and aripiprazole (n=89, β= 6.06, p-value=0.0192). The present findings demonstrate that the ABCB1 G2677T/A SNP contributes to differences in antidepressant treatment outcomes, suggesting its potential for personalized antidepressant treatment therapy.
  • ||||||||||  escitalopram / Generic mfg.
    Predictors of Pharmacotherapy Outcomes for Body Dysmorphic Disorder: A Machine Learning Approach (Palomino Ballroom 4-10) -  May 6, 2022 - Abstract #ASCP2022ASCP_180;    
    Consistent with precision medicine initiatives in psychiatry, the current study provides a foundation for personalized pharmacotherapy strategies for patients with BDD. Learning Objectives To be able to discuss predictors of response, partial remission, and full remission with escitalopram treatment of body dysmorphic disorder.
  • ||||||||||  fluvoxamine / Generic mfg.
    Does Fluvoxamine Protect Patients With Obsessive-Compulsive Disorder Against COVID-19? () -  May 5, 2022 - Abstract #APA2022APA_888;    
    The study is limited by ascertainment bias from real-world diagnostic data. Moreover, the patients in the control group were on other psychotropics, including selective serotonin reuptake inhibitors and selective serotonin norepinephrine inhibitors, which could have provided some anti-inflammatory protection.
  • ||||||||||  lorazepam / Generic mfg., escitalopram / Generic mfg.
    Catatonia and Severe Schizophrenia in a 12-Year-Old With a Rare Genetic Mutation () -  May 5, 2022 - Abstract #APA2022APA_851;    
    This case illustrates the detailed management of rare early-onset catatonia and schizophrenia in a 12-year-old boy. Interestingly, it is the first case of these psychiatric disorders in a pediatric patient with progressive cognitive decline associated with a genetic mutation of unknown clinical significance.
  • ||||||||||  Z’s History - Challenges in Understanding the Relationship Between Covid 19 Pandemics and Mental Health Issues () -  May 5, 2022 - Abstract #APA2022APA_787;    
    Medications were changed to Escitalopram up to 20mg and Olanzapine up to 10mg, with improvement in psychotic symptoms and, to a lesser extent, also in depressive symptoms...2021; Gao et al, 2021), but Z''s case illustrates how, especially in countries with great social inequality , the relationship between COVID19 and mental disorders cannot be attributed only to the neuropsychiatric consequences of the disease (Deng et al, 2020; Tianchen Wu et al, 2021). Lack of social support, mourning, economic hardship, personal and social vulnerability of disadvantaged population in developing and underdeveloped countries are also factors to be surpassed in COVID19 pandemics and require social and political intervention, alongside with the medical-psychological treatment of individual cases.
  • ||||||||||  zonisamide / Generic mfg.
    Zonisamide-Induced Hallucinations in a Middle-Aged Woman () -  May 5, 2022 - Abstract #APA2022APA_730;    
    Reduced dosage or discontinuation of ZNS resolved AVH symptoms within one week. Given this patient’s history of seizure-related hallucinations, the causality of ZNS in generating these specific AVH symptoms is unclear, however, clinicians should be cognizant of this potential side-effect.
  • ||||||||||  The Roof Is on Fire! A Case of Antidepressant Induced Burning Mouth Syndrome () -  May 5, 2022 - Abstract #APA2022APA_685;    
    She was started on citalopram and remains psychiatrically stable with no symptoms of BMS...A limited number of cases of SSRI induced BMS have been reported in the literature associated with fluoxetine, sertraline, and venlafaxine...Our case illustrates a paradoxical role of antidepressants in BMS, and analyzes the use of SSRIs in both the treatment and induction of BMS symptoms. It is a welcome reminder to evaluate serotonergic agents in patients with new or worsening BMS symptomatology.
  • ||||||||||  Spravato (esketamine intranasal) / J&J
    The Rise of Psilocybin and Other Alternative Treatments for Depression: A Literature Review () -  May 5, 2022 - Abstract #APA2022APA_684;    
    In summary, none of the treatments discussed in this review are threatening the combination of SSRIs and psychotherapy as first-line treatment for MDD. However, they do have some unique properties that could possibly benefit patients who have exhausted other options or are acutely suicidal.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Psychiatric Comorbidities Associated With Postural Tachycardia Syndrome (POTS): Case Report and Literature Review () -  May 5, 2022 - Abstract #APA2022APA_608;    
    She was on Escitalopram, Bupropion, and Lamotrigine...Duloxetine and Venlafaxine are preferred due to dual action on serotonin and norepinephrine...The case highlights difficulties in choosing psychotropic medications for depression and anxiety, as these medications can lead to worsening of falls and syncope. However, certain combinations of medications and therapy can improve of quality of life.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg., escitalopram / Generic mfg.
    Nihilism, Neurocognition, and COVID: A Case of Acute Onset Cotard’s Syndrome () -  May 5, 2022 - Abstract #APA2022APA_572;    
    Escitalopram was added to treat depressed mood...Olanzapine was transitioned to risperidone to further address the delusions...As the pandemic continues, it is likely more instances of post-COVID psychiatric complications will manifest. In this poster, we discuss the presentation and treatment course for a case of post-COVID psychotic symptoms in a geriatric patient with minimal psychiatric history and highlight the importance of additional research to further determine possible neuropsychiatric sequelae of infection.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    New Onset Panic Disorder Following an Infection With COVID-19 () -  May 5, 2022 - Abstract #APA2022APA_570;    
    Despite the fact that the patient has been already on psychiatric medications (Gabapentin, Lorazepam, Amitriptyline and Escitalopram), in order to control her new condition, the medications were gradually tapered and changed to a different class of medications (Olanzapine and Duloxetine). Other case report studies with panic disorder onset following COVID-19 infection have also had positive outcomes with patients taking Vortioxetine (9), Paroxetine (10) and Sertraline (11).
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Lithium and Its Side Effects, a Case Study () -  May 5, 2022 - Abstract #APA2022APA_533;    
    He was initially started on Lithium over 30 years ago after experiencing an episode of paradoxical increased agitation when he took one dose of Ativan...At the time of this report, this patient has begun tapering off of Lithium and on an upward titration of Lamictal, off label, for the target symptom of irritability. Treatment goals for this patient include complete discontinuation of Lithium to avoid any further renal insult, regaining of his ability to concentrate his urine with resolution of Lithium induced nephrogenic diabetes insipidus, normalization of parathyroid stimulating hormone and secondarily normalization of calcium metabolism.
  • ||||||||||  Difficulties in Managing QTc Prolonging Medication in a Patient After Polymorphic Ventricular Tachycardia Arrest () -  May 5, 2022 - Abstract #APA2022APA_440;    
    At this time all QTc prolonging medications were stopped, including patient’s home quetiapine, fluoxetine, and gabapentin...Both antipsychotics and antidepressant medication have been associated with prolonged QTc, however these risks vary greatly by class and individual medication; for example, quetiapine has mixed results on its relation to QT prolongation and relationship to ventricular arrythmias, while in SSRIs the elevated risk is driven primarily by citalopram and escitalopram, with fluoxetine having little association...Studies suggest QTcF is a more accurate measurement than the commonly used QTcB, which overestimates QTc leading to unnecessary withholding of first-choice medication. In this poster, we discuss the importance and challenges of the management of QTc prolonging medication as well as interprofessional communication between services in patients who have recently experienced polymorphic ventricular tachycardia arrest.
  • ||||||||||  “It’s Not a Question of Whether It’ll Happen, but One of When?” Coping With Patient and Resident Suicide as a Trainee () -  May 5, 2022 - Abstract #APA2022APA_311;    
    He had occasional suicidal ideation although stated that he felt responsible for family and would not hurt himself; and was started on Lexapro, Vistaril and Buspar...He presented anxious, tense and tearful, and later endorsed suicidal thoughts so he was placed on constant observation and started on Abilify, Risperdal and Trazodone...He continued weekly outpatient visits where he continued to present with increased anxiety and clonazepam was started...Nevertheless, studies suggest that operationalized postvention programs that addresses medico-legal concerns, normalizes emotional responses and offers psychotherapy, process groups and connection with peers/faculty that had a similar experience, can strengthen suicide prevention, destigmatize the tragedy, and promote caregiver recovery in a more impactful way for residents than other less structured forms of support. Some guiding principles for these programs are: to decrease the feelings of isolation among resident physicians; to help trainees understand that bad patient outcomes do not equal personal failures; and to respond to this professional tragedy with kindness and support even if that takes more work and attention.
  • ||||||||||  cilostazol / Generic mfg.
    Trial completion:  The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. (clinicaltrials.gov) -  May 4, 2022   
    P=N/A,  N=80, Completed, 
    Some guiding principles for these programs are: to decrease the feelings of isolation among resident physicians; to help trainees understand that bad patient outcomes do not equal personal failures; and to respond to this professional tragedy with kindness and support even if that takes more work and attention. Active, not recruiting --> Completed
  • ||||||||||  Journal:  Dispensing patterns of mental health medications before and during the COVID-19 pandemic in Alberta, Canada: An interrupted time series analysis. (Pubmed Central) -  May 4, 2022   
    Initial increases in dispensing patterns of antidepressants may be attributed to a "stockpiling phenomenon" but the sustained higher levels of dispensing suggest an unfavorable shift in the population's mental health. Monitoring of medication dispensing patterns during COVID-19 may serve as a useful indicator of the population's mental health during the current pandemic and better prepare community pharmacists in future pandemic planning, medication dispensing strategies, and care of chronic medical conditions.
  • ||||||||||  aripiprazole / Generic mfg., escitalopram / Generic mfg.
    Review, Journal:  Treatment of Child Gratification Disorder. (Pubmed Central) -  May 3, 2022   
    In addition to parental education and behavioral therapy, escitalopram and aripiprazole can be used as treatment options for this issue. We need to perform well-designed randomized controlled trials to obtain adequate evidence on the efficacy of these measures.
  • ||||||||||  escitalopram / Generic mfg.
    Trial completion date, Trial primary completion date:  Impact of Escitalopram on Sperm DNA Fragmentation (clinicaltrials.gov) -  May 3, 2022   
    P2,  N=70, Recruiting, 
    Further studies are needed to confirm these results by investigating the therapeutic efficacy and safety profile of long-term antidepressant treatment of MDD with CC (Clinical Trial Registry, http://cris.nih.go.kr/cris/en/: KCT0002173). Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2022