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144 Trials |
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144 Trials |  |
2302 News |  |
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- | lithium carbonate ER / Generic mfg.
Journal: Diagnostic trap: Lithium neurotoxicity with normal lithemia (Pubmed Central) - Sep 29, 2022
We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness caused by a supposed mismanagement of her treatment...The patient has been transferred to our nephrology department where she got two hemodialysis sessions conducting to clinical and biological improvement, confirming the diagnosis of lithium poisoning despite the normal blood levels. Later, she was transferred to the psychiatry department for follow-up and for treatment adjustment.
- | escitalopram / Generic mfg.
Journal: Genotyping of patients treated with selective serotonin reuptake inhibitors. (Pubmed Central) - Sep 29, 2022
Our findings demonstrate the low prevalence of the most favourable genotype combination for response to SSRIs. Genotype combinations probably contribute to the wide variation between individuals in the efficacy of these drugs and the fact that treatment does not produce the desired outcome in many patients.
- | aripiprazole / Generic mfg., escitalopram / Generic mfg.
Trial initiation date: Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia (clinicaltrials.gov) - Sep 29, 2022
P=N/A, N=252, Not yet recruiting, Sponsor: Peking University
Genotype combinations probably contribute to the wide variation between individuals in the efficacy of these drugs and the fact that treatment does not produce the desired outcome in many patients. Initiation date: Jun 2022 --> Oct 2022
- | escitalopram / Generic mfg.
Journal: Effect of Chaihu plus Longgu Muli decoction plus five-element music therapy in the treatment of cancer-related depression. (Pubmed Central) - Sep 29, 2022
Initiation date: Jun 2022 --> Oct 2022 Chaihu plus Longgu Muli decoction with five-element music therapy can effectively alleviate patients' cancer-related depression and improve their quality of life, which is worthy of promotion.
- || escitalopram / Generic mfg.
Review, Journal: Escitalopram should be investigated in anorexia nervosa: Rationale and review of mechanisms. (Pubmed Central) - Sep 29, 2022
Here, we present a short overview of pharmacological research in AN and discuss the theoretical rationale for escitalopram use in AN. We also call for double-blind, randomized, placebo-controlled trials to test whether this theoretical framework translates into clinical efficacy.
- || Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Review, HEOR: The impact of pharmacological and non-pharmacological interventions on physical health outcomes in people with mood disorders across the lifespan: An umbrella review of the evidence from randomised controlled trials. (Pubmed Central) - Sep 25, 2022
Evidence from this umbrella review has limitations, should consider evidence from other disorders and should be integrated with recent evidence from individual RCTs, and observational evidence. Effective treatments with either beneficial or physically neutral profiles should be prioritized.
- | Journal: Antidepressant medication prescribing patterns in Irish general practice from 2016 to 2020 to assess for long-term use. (Pubmed Central) - Sep 24, 2022
The high proportion of refill prescriptions demonstrates the long-term use of AD medications. This may be indicative of chronic depression or may highlight a lack of appropriate medication cessation strategies.
- ||| Retrospective data, Review, Journal, Adverse events: Unprescribed and unnoticed: Retrospective chart review of adverse events of interactions between antidepressants and over-the-counter drugs. (Pubmed Central) - Sep 23, 2022
The use of OTC drugs by the patients should be monitored. Pharmacokinetic interactions between nonprescribed medicines and antidepressants may increase concentration and severity of side effects of latter ones.
- clonazepam / Generic mfg., escitalopram / Generic mfg.
Excessive tearing; a paradoxical ocular manifestation of Parkinson’s disease (Poster Station: 4) - Sep 22, 2022 - Abstract #MDSCongress2022MDR_Congress_1399;
The increased tear production was suspected from autonomic dysfunction as similar as the pathophysiology of sialorrhea. In addition, the defective drainage was suspected from bradykinesia of orbicularis oculi muscle together with the ineffective and infrequent blinking from Parkinson’s disease.
- escitalopram / Generic mfg.
A patient with childhood-onset hearing loss and adult-onset ataxia was genetically diagnosed with Perrault syndrome 5 (Poster Station: 3) - Sep 22, 2022 - Abstract #MDSCongress2022MDR_Congress_413;
Early intellectual disability, gait disturbance associated with peripheral neuropathy, and cerebellar ataxia appeared in adulthood and cerebellar atrophy. Up to our knowledge this is the first case of multiple neurologic features of Perrault syndrome 5 in Korea.
- | escitalopram / Generic mfg.
Journal: Prediction of remission among patients with a major depressive disorder based on the resting-state functional connectivity of emotion regulation networks. (Pubmed Central) - Sep 21, 2022
The patients were treated with escitalopram for 12 weeks...URL: http://www.chictr.org.cn/showproj.aspx?proj=21377 . Registration number: ChiCTR-OOC-17012566.
- | Journal: Psychotropic medication in pregnancy and lactation and early development of exposed children. (Pubmed Central) - Sep 20, 2022
Psychotropic medication in the peripartum needs a balancing of risks and benefits and a continuous therapeutic drug monitoring (TDM) can be a guidance for clinicians to monitor drug alteration patterns, which are likely to occur due to physiological pregnancy-associated changes in pharmacokinetics. Accordingly, TDM can optimize a medication in pregnancy and lactation with the lowest but effective dose.
- | imipramine / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Preclinical, Journal: Decreased sensitivity to antidepressant drugs in Wistar Hannover rats submitted to two animal models of depression. (Pubmed Central) - Sep 17, 2022
Only s-ketamine and repeated imipramine were effective in WHR in a modified FST protocol. Altogether, these results indicate that WHR may be an interesting tool to investigate the mechanisms associated with the resistance to antidepressant drugs and identify more effective treatments.
- | Xatmep (methotrexate oral solution) / Azurity Pharma, Nexlizet (bempedoic acid/ezetimibe) / Esperion Therap, Otsuka, Daiichi Sankyo
New trial: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants (clinicaltrials.gov) - Sep 16, 2022
P=N/A, N=304, Recruiting, Sponsor: The Hospital for Sick Children
- |||| centanafadine SR (EB-1020) / Otsuka
Enrollment open, Monotherapy: JUNIPER: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder (clinicaltrials.gov) - Sep 15, 2022
P2, N=336, Recruiting, Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
Altogether, these results indicate that WHR may be an interesting tool to investigate the mechanisms associated with the resistance to antidepressant drugs and identify more effective treatments. Not yet recruiting --> Recruiting
- | clonazepam / Generic mfg., escitalopram / Generic mfg.
Preclinical, Journal: Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain. (Pubmed Central) - Sep 14, 2022
Pharmacological effects of escitalopram may be connected with local at least partially NPSR-related alterations in the NPS/NMU/NMUR2 gene expression at the level selected rat brain regions. A novel alternative mode of SSRI action can be therefore cautiously proposed.
- | aripiprazole / Generic mfg., escitalopram / Generic mfg.
Journal: Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study. (Pubmed Central) - Sep 14, 2022
Instead, ESC + ARI showed an association between CYP2D6 metabolizer group and ARI metabolite-to-drug ratio suggesting potential competition between ESC and ARI for CYP2D6. Our findings suggest that dosing based on CYP2C19 and CYP2D6 genotyping could improve safety and outcome in patients on ESC monotherapy.
- || Review: The efficacy of therapies for post-stroke depression in aging: An umbrella review. (Pubmed Central) - Sep 13, 2022
In addition, Acupuncture/EA+conventional, Escitalopram, Citalopram, Sertraline, and Fluoxetine showed no serious adverse events in PSD patients. Our study demonstrated that 11 treatment methods can effectively improve the condition of PSD patients.
- | escitalopram / Generic mfg.
Journal: Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter. (Pubmed Central) - Sep 12, 2022
SAP has been observed to be elevated in patients with depression, and higher SAP levels are associated with better response to the antidepressant escitalopram...SAP has complex effects on SERT levels and localization, thereby modulating the effect of SSRIs, which could partially explain clinical variability in antidepressant treatment response. These results add to our understanding of the mechanism for antidepressant drug action, and with further work could be of clinical utility.
- | Journal: Antidepressants Are Poor Inhibitors of Heat-Evoked Ion Currents Mediated by TRPM2. (Pubmed Central) - Sep 10, 2022
Whether or not TRPM2 may be a relevant target for antidepressants cannot be conclusively assessed by a single in vitro study, thus further studies are required along these lines. Nevertheless, future studies may get simplified by the novel approach we developed for in vitro pharmacological analysis of TRPM2.
- | lithium carbonate ER / Generic mfg.
Journal: Controversies In The Pharmacotherapy Of Adolescent Depression. (Pubmed Central) - Sep 10, 2022
Although no response to pharmacotherapy and psychotherapy may occur in up to 40% of depressed adolescents, possible predictors or mediators of poorer response in adolescents are uncertain, and only a few studies support possible treatment strategies. Finally, studies exploring the efficacy of antidepressants in specific depression subtypes, i.e., based on prevalent psychopathological dimensions (apathy, withdrawal, impulsivity), are warranted.
- || fluvoxamine / Generic mfg., doxepin / Generic mfg., escitalopram / Generic mfg.
Random question - My 23andme report says I’m a rapid metabolizer of CYP2C19 and have a decreased function of SLCO1B1. Does either of those interfere w #fluvoxamine in any negative way? The enzyme one includes Lexapro, Celexa & Silenor as medicines for me but is Fluvoxamine safe? (Twitter) - Sep 10, 2022
- | citalopram / Generic mfg., escitalopram / Generic mfg.
Journal: Skepticism about Recent Evidence That Psilocybin "Liberates" Depressed Minds. (Pubmed Central) - Sep 10, 2022
Here, we raise several issues with this paper, including inconsistencies in reports of the primary clinical outcome, statistical flaws including a one-tailed test, nonsignificant interaction, and regression to the mean, the ambiguity and overinterpretation of "resting state" data, and a missing reference for a conceptually similar study that exemplifies why a one-tailed test cannot be justified. Together, these issues make us question the uniqueness and impact of these findings, as well as the unwarranted media hype that they generated.
- ||||| centanafadine SR (EB-1020) / Otsuka
New P2 trial, Monotherapy: JUNIPER: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder (clinicaltrials.gov) - Sep 10, 2022
P2, N=336, Not yet recruiting, Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
- | psilocybin (COMP360) / Compass Pathways
Journal: The use of psilocybin for treatment-resistant depression (Pubmed Central) - Sep 7, 2022
In the phase 2 study of COMPASS Pathways, the psilocybin-COMP360 treatment led to a rapid response and remission as early as three weeks following the treatment for around one third of participants...Further research will reveal whether it will be granted a license to treat treatment-resistant depression in the near future. There remains an urgent need for novel treatments for those who do not respond to current antidepressant therapies.
- | psilocybin (COMP360) / Compass Pathways
Journal: Effects of psilocybin versus escitalopram on rumination and thought suppression in depression. (Pubmed Central) - Sep 7, 2022
There remains an urgent need for novel treatments for those who do not respond to current antidepressant therapies. These data provide further evidence on the therapeutic mechanisms of psilocybin and escitalopram in the treatment of depression.
- ||||| fluvoxamine / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Cytokine storm: fluvoxamine and escitalopram did not potently inhibit cytokine production, compared to fluoxetine. Overall, we suggest that fluoxetine may be the preferred SSRI for further evaluation as an agent to ameliorate cytokine storms. https://t.co/xTynQ6FuIb… (Twitter) - Sep 6, 2022
- | citalopram / Generic mfg., bupropion / Generic mfg., escitalopram / Generic mfg.
Journal: Effect of Antidepressants on Glucagon-Like Peptide-1 Receptor Agonist-Related Weight Loss. (Pubmed Central) - Sep 3, 2022
Antidepressants may diminish the weight loss effect of GLP-1 RAs. Additional research is needed to assess whether all GLP-1 RAs are affected similarly and the optimal weight loss strategies in patients receiving antidiabetic therapy with comorbid depression.
- | escitalopram / Generic mfg.
Journal: Protective Effect of Escitalopram on Hepatocellular Carcinoma by Inducing Autophagy. (Pubmed Central) - Sep 3, 2022
These findings provided evidence supporting the therapeutic potential of escitalopram for HCC. Both laboratory and nationwide population-based cohort evidence demonstrated the attenuated effects of escitalopram on HCC.
- ||| Selzentry (maraviroc) / ViiV Healthcare, escitalopram / Generic mfg.
@brucep13 Will ECT, TMS or Ketemine therapy help long covid anxiety and depression. I've been dealing with this for 9 months. Doctors don't acknowledge this can be from brain inflammation. I'm om maraviroc and statin but had to get on Lexapro and Seroquil out of desperation. (Twitter) - Sep 2, 2022
- | paroxetine / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Journal: SSRI antidepressants differentially modulate serotonin reuptake and release in Drosophila. (Pubmed Central) - Sep 2, 2022
Further, dynamic serotonin changes in Drosophila are similar to previous studies in mammals. This work establishes how antidepressants affect serotonin in real-time, which is useful for future studies that will investigate pharmacological effects of SSRIs with different genetic mutations in Drosophila.
- Yervoy (ipilimumab) / Ono Pharma, BMS
WITHDRAWN: Drugs Associated With Diabetes Insipidus- Disproportionality Analysis of Spontaneous Post-Marketing Case Reports Submitted to U.S. FDA Adverse Event Reporting System (In-person; Virtual) - Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_1687;
In this study, we have identified potential signals like desmopressin, remifentanil, thiopental, bromocriptine, and escitalopram with the highest PRR, ROR and 95% CI representing the significant association instigating DI. As causal relationships cannot be measured from this study, detailed evaluation and validation by the scientists further are required to acknowledge the healthcare professionals regarding the possible etiological aspects of DI, prescribing patterns, and hypotheses for future studies.
- amitriptyline / Generic mfg., sertraline / Generic mfg., escitalopram / Generic mfg.
Assessment of Consumption of Antidepressants in Ukraine Compared With Estonia (Virtual) - Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_1388;
Consumption in Estonia (32,3 DID) was 13.7 times more than in Ukraine. Escitalopram was the leader in amounts of consumption in both countries, but him consumption in Estonia was 10.9 times more.
- Trintellix (vortioxetine) / Lundbeck, Takeda
Most Common Treatments in Patients With Treatment Resistant Depression Based on European Cohort Study Real-World Evidence (Virtual) - Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_978;
Most received treatments were predominantly oral antidepressants, however, the third most received treatment was quetiapine, mainly used in clinical practice as an augmentation therapy, suggesting it is a routine treatment for patients with TRD. ACKNOWLEDGEMENTS: Editorial services (Costello Medical) and study funded by Janssen.
- | Retrospective data, Journal: Clinical significance of potential drug-drug interactions in older adults with psychiatric disorders: a retrospective study. (Pubmed Central) - Aug 30, 2022
However, many pDDIs may have no clinical significance in terms of ADR severity. Further research on assessing pDDIs, and possible measures to prevent serious ADRs induced by DDIs is needed to reduce the clinical significance of pDDIs.
- | escitalopram / Generic mfg.
New P2/3 trial: Home-TEA: Home Transcutaneous Electrical Acustimulation (TEA) (clinicaltrials.gov) - Aug 29, 2022
P2/3, N=160, Not yet recruiting, Sponsor: University of Michigan
- | escitalopram / Generic mfg.
Journal: Prediction of depression treatment outcome from multimodal data: a CAN-BIND-1 report. (Pubmed Central) - Aug 26, 2022
Present results are limited by lack of external validation. To achieve clinically meaningful prediction, the multimodal measurement should be scaled up to larger samples and the robustness of prediction tested in an external validation dataset.
- | escitalopram / Generic mfg.
Biomarker, Journal: Predicting escitalopram treatment response from pre-treatment and early response resting state fMRI in a multi-site sample: A CAN-BIND-1 report. (Pubmed Central) - Aug 25, 2022
These results appear contrary to findings from many smaller single-site studies, which report substantially higher predictive accuracies from models trained on only baseline resting state FC features, suggesting these models may not generalize well beyond data used for development. Further, these results indicate the potential value of collecting data both before and shortly after treatment initiation.
- ||| Retrospective data, Review, Journal, Adverse events: Risks of Digestive System Side-Effects of Selective Serotonin Reuptake Inhibitors in Patients with Depression: A Network Meta-Analysis. (Pubmed Central) - Aug 24, 2022
Fluoxetine exhibited distinct advantages compared to other SSRIs, while sertraline had the greatest likelihood of digestive system side effects. These findings will help doctors understand the relative advantages of various antidepressants.
- || citalopram / Generic mfg., escitalopram / Generic mfg.
Thank you, somehow I missed the table when looking at your article. There are a lot of them not working indeed. Quite interestingly, citalopram vs escitalopram. (Twitter) - Aug 24, 2022
- || escitalopram / Generic mfg.
Dr. Angela mam: Does Escitalopram has any such protective effect? Thank you. (Twitter) - Aug 24, 2022
- | Journal: Use of pharmacological treatment for posttraumatic stress disorder: Analysis of a psychiatric population in Switzerland and comparison with international guidelines. (Pubmed Central) - Aug 22, 2022
However, most of the antidepressants used were not recommended in the VA/DoD guidelines. Benzodiazepines and Z-drugs remained widely used, although they are not recommended.
- | escitalopram / Generic mfg.
Journal: The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: Serotonergic Psychedelic Treatments for Major Depressive Disorder. (Pubmed Central) - Aug 22, 2022
In Canada, as of 2022, psilocybin remains an experimental option that is only available through clinical trials or the special access program. As such, Canadian Network for Mood and Anxiety Treatments considers psilocybin an experimental treatment and recommends its use primarily within clinical trials, or, less commonly, through the special access program in rare, special circumstances.
- || escitalopram / Generic mfg.
Clinical, Journal: Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial. (Pubmed Central) - Aug 22, 2022
P4
The present trial is a randomized clinical trial that utilized H-MRS to examine Glx/GABA before and after 8 weeks of escitalopram or placebo...In light of variable findings in the literature and lack of association in our investigation, future directions should include evaluating glutamate and glutamine individually to shed light on the underpinnings of MDD severity. Advancing Personalized Antidepressant Treatment Using PET/MRI, ClinicalTrials.gov, NCT02623205.
- | escitalopram / Generic mfg.
Journal: Creatine@SiO @Fe O nanocomposite as an efficient sorbent for magnetic solid-phase extraction of escitalopram and chlordiazepoxide from urine samples through quantitation via HPLC-UV. (Pubmed Central) - Aug 22, 2022
Furthermore, the enrichment factors were found to be 79.8 and 92.7 for chlordiazepoxide and escitalopram, respectively. The method was successfully employed for the analysis of selected drugs in urine samples.
- | Retrospective data, Journal: QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes". (Pubmed Central) - Aug 22, 2022
Mirtazapine, amitriptyline, diphenhydramine, and trazodone were associated with prolonged QTc. Flecainide and methadone had the highest associated risk of life-threatening dysrhythmias.
- | escitalopram / Generic mfg.
Preclinical, Journal: The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non-stressed male rats. (Pubmed Central) - Aug 18, 2022
Only escitalopram 10 mg/kg improved synaptic excitability, as well as LTP induction and maintenance in non-stressed subjects even more than normal levels. However, under stress conditions, both escitalopram doses enhanced neural excitability and memory probably due to reduced serum corticosterone levels.
- furosemide / Generic mfg., desmopressin / Generic mfg., escitalopram / Generic mfg.
WATER INTOXICATION: A CASE OF HYPONATREMIA AND ACUTE RENAL FAILURE (Convention Center Exhibit Hall: Poster Area) - Aug 16, 2022 - Abstract #CHEST2022CHEST_2567;
Rhabdomyolysis markers should be closely monitored in patients with severe hyponatremia to avoid kidney damage, electrolyte abnormalities, and subsequent death. Collaborative management with Nephrology is warranted.
- | escitalopram / Generic mfg.
Journal: Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder. (Pubmed Central) - Aug 13, 2022
Collaborative management with Nephrology is warranted. Decreased resting-state regional activity of the left DLPFC and decreased plasma kynurenine levels may predict treatment response to escitalopram, suggesting that it may be involved in the pathophysiology of major depressive disorder in response to escitalopram treatment.
- | Januvia (sitagliptin) / Merck (MSD)
Journal: Evaluation of Manufacturer-to-Manufacturer Variability of Croscarmellose Sodium: Influence on the Dissolution of Sitagliptin Tablets (Water-Soluble Drug) and Escitalopram Tablets (Sparingly Soluble Drug). (Pubmed Central) - Aug 13, 2022
While with the highly water-soluble drug, increasing the concentration of low-swelling CCSs to 3 or 5% could improve the dissolution profiles; in the case of sparingly soluble drug, this was not possible. Therefore, functional differences between CCSs produced by various manufacturers are affected by the drug solubility and the ratio of the disintegrant used in the formulations.