- |||||||||| atomoxetine / Generic mfg.
Journal: Effect of biofeedback intervention on neurological characteristics of children with attention deficit hyperactivity disorder. (Pubmed Central) - Feb 28, 2024
fMRI results showed that the activity of the prefrontal, parietal, amygdala and hippocampus in the combined treatment group was significantly higher than that in the atomoxetine group (P<0.001). Biofeedback intervention can significantly improve the attention and behavior of ADHD children and positively regulate the neural activity in related brain areas on the basis of drug treatment, suggesting that biofeedback therapy can be considered as a potential effective non-drug treatment option for ADHD children.
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Journal: Continuation of Treatment in Children With ADHD: A Multicenter Turkish Sample Study. (Pubmed Central) - Jan 31, 2024
Other variables emerging as significant in the univariate model lost that significance in the multiple model. Understanding the variables associated with medication discontinuation in ADHD in different populations and taking these variables into account in the development of health policies, will be useful in improving the long-term devastating effects of the disorder.
- |||||||||| atomoxetine / Generic mfg.
Journal: Prescribed psychotropic medication patterns among treated Foster Care enrollees: a single institution study. (Pubmed Central) - Jan 26, 2024
Out of 569 distinct psychotropic medication treatment episodes within this cohort, the most frequent psychotropic classes prescribed were non-stimulant ADHD medications (alpha-agonists and atomoxetine, 31.5%), atypical antipsychotics (22.1%), antidepressants (20.6%), and stimulants (16.0%)...Despite this, 41% of the youth treated in this clinic received at least one prescription for psychotropic medication, and of those, 27.8% were prescribed more than one psychotropic medication at the same time. More studies are necessary to understand the underlying causes of high prevalence of concomitant medication use and prescribing practices of psychotropic medications use in foster care involved pediatric populations.
- |||||||||| atomoxetine / Generic mfg.
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Atomoxetine in Patients With Tourette's Syndrome (clinicaltrials.gov) - Jan 23, 2024
P2, N=5, Terminated,
The developed method is non-complex and can be effectively employed in the analytical practices of atomoxetine hydrochloride in pharmaceutical dosage forms. N=20 --> 5 | Trial completion date: Dec 2024 --> Jan 2024 | Recruiting --> Terminated | Trial primary completion date: Jun 2024 --> Jan 2024; experimental treatment (Atomoxetine) not available
- |||||||||| Review, Journal: Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions. (Pubmed Central) - Jan 15, 2024
Additionally, psychotropic drugs with different mechanisms of action have been approved to reduce associated symptoms and comorbidities, including aripiprazole, risperidone, and haloperidol for irritability and aggression, methylphenidate, atomoxetine, clonidine, and guanfacine for ADHD, and melatonin for sleep disturbances. The purpose of this review is to emphasize that it is imperative to develop objective, personalized diagnostic kits in order to tailor and individualize treatment strategies, as well as to describe the current pharmacological management options available in clinical practice and new prospects that may be helpful in managing ASD's core symptoms.
- |||||||||| droxidopa / Generic mfg., atomoxetine / Generic mfg.
Retrospective data, Journal, Surgery: Droxidopa or Atomoxetine for Refractory Hypotension in Critically Ill Cardiothoracic Surgery Patients. (Pubmed Central) - Dec 25, 2023
It could be an alternative for those who do not adhere to the standard available treatments for OSA. Droxidopa and atomoxetine are oral vasoactive agents with potential mechanisms to facilitate IV vasopressor weaning for patients in the ICU with hypotension refractory to midodrine, but further prospective research is needed.
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Journal: Association of Psychopharmacological Medication Preference with Autistic Traits and Emotion Regulation in ADHD. (Pubmed Central) - Dec 11, 2023
Multiple regression analyses revealed that non-acceptance of emotions predicted the switch to ATX while lack of emotional clarity predicted the maintenance of MTP therapy, rather than autistic traits. This study highlights emotion regulation difficulties and how different emotional profiles may influence medication selection in children with ADHD.
- |||||||||| atomoxetine / Generic mfg., donepezil / Generic mfg.
Journal: Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making. (Pubmed Central) - Dec 5, 2023
Interestingly, we observed both similar, unique, and interactive effects of attention and catecholaminergic neuromodulation on these behavioral, algorithmic, and neural markers of the decision-making process. Thereby, this study reveals an intricate relationship between attentional and catecholaminergic systems and advances our understanding about how these systems jointly shape various stages of perceptual decision-making.
- |||||||||| methylphenidate tablet / Generic mfg.
Journal: Methylphenidate-associated chest pain in a child. (Pubmed Central) - Dec 1, 2023
We then stopped the stimulant and changed his treatment to atomoxetine, after which he no longer had chest pain. In the following illustrated case, we will discuss the cardiac side effect of methylphenidate.
- |||||||||| atomoxetine / Generic mfg., chlorpromazine / Generic mfg.
Journal: Antipsychotic Medications and Mortality in Children and Young Adults. (Pubmed Central) - Nov 29, 2023
In this cohort study of more than 2 million children and young adults without severe somatic disease or diagnosed psychosis, antipsychotic treatment in doses of 100 mg or less of chlorpromazine equivalents or in children aged 5 to 17 years was not associated with increased risk of death. For doses greater than 100 mg, young adults aged 18 to 24 years had significantly increased risk of death, with 127.5 additional deaths per 100?000 person-years.
- |||||||||| atomoxetine / Generic mfg.
Clinical, Journal: The effect of atomoxetine on cognitive function in patients with multiple sclerosis. (Pubmed Central) - Nov 28, 2023
The results showed significant changes in cognitive levels before and after the use of atomoxetine and also in comparison to the placebo group (P < 0.05). This study showed that atomoxetine improved the cognitive domains after administration compared to placebo.
- |||||||||| atomoxetine / Generic mfg., bupropion / Generic mfg.
Review, Journal: Management Strategies for Borderline Personality Disorder and Bipolar Disorder Comorbidities in Adults with ADHD: A Narrative Review. (Pubmed Central) - Nov 25, 2023
The review highlights the effectiveness of specific medications, including psychostimulants, atomoxetine, and bupropion, as add-on therapies to mood-stabilizing treatments for addressing ADHD symptoms in patients with these comorbidities. Despite limited research, the review will address various pharmacological and psychotherapeutic approaches for managing comorbid ADHD and BPD, emphasizing the need for further investigations to better understand the unique needs of this patient population.
- |||||||||| atomoxetine / Generic mfg.
Journal: Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions. (Pubmed Central) - Nov 25, 2023
These data highlight a double dissociation between the behavioural effects of noradrenergic signaling across frontal regions with respect to risky choice and impulsive action. Given that the influence of noradrenergic manipulations on motor impulsivity could depend on baseline risk preference, these data also suggest that the noradrenaline system may function differently in subjects that are susceptible to the risk-promoting lure of win-associated cues.
- |||||||||| atomoxetine / Generic mfg.
Clinical, Journal: Assessment of probiotic strain (Pubmed Central) - Nov 14, 2023
P1
Given that the influence of noradrenergic manipulations on motor impulsivity could depend on baseline risk preference, these data also suggest that the noradrenaline system may function differently in subjects that are susceptible to the risk-promoting lure of win-associated cues. Lactobacillus acidophilus LB supplementation combined with atomoxetine for 3
- |||||||||| atomoxetine / Generic mfg., amphetamine / Generic mfg.
Amphetamine, but not atomoxetine, increases impulsive choice on a cue-guided delay discounting task (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9495;
Together, these findings suggest that amphetamine drives an increase in choice impulsivity and causes a general bias towards smaller/immediate rewards when cues signal delay duration, an effect that is likely not mediated by this drugs effects on noradrenergic transmission. More generally, these data highlight that the neurochemical mechanisms underlying impulsive choice may differ depending on whether information about delays to receiving rewards are internally mediated or signaled by external stimuli.
- |||||||||| atomoxetine / Generic mfg., fluoxetine / Generic mfg.
Amphetamine, punishment, and rewards:monoaminergic modulation of inhibitory impulse control (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9493;
In contrast, the 5-HT transporter blocker Fluoxetine (0,1, 0...0 mg/kg), thankfully, did not have any effects on behavioral control. These findings suggest increased monoamine transmission can markedly enhance the ability of cues signalling potential punishment to suppress impulsive reward-seeking under threat, which may be mediated by either NA or DA in a sex-dependent manner.
- |||||||||| Evaluation of Different Classes of Monoamine Uptake Inhibitors: Effects on Effort-based Choice (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_4005;
Furthermore, atypical DAT inhibitors such as modafinil and its analogs can effectively reverse these behavioral effects of TBZ...In the present studies, both the selective NET inhibitor atomoxetine and the NET/SERT inhibitor duloxetine failed to reverse the effort-related effects of TBZ, and in fact tended to further suppress lever pressing...Additionally, microdialysis methods are being used to assess the neurochemical effects of these different monoamine uptake inhibitors. Taken together with previous studies, the present results suggest that actions on DAT are critical for exerting pro-motivational effects in models of effort-based choice.
- |||||||||| atomoxetine / Generic mfg.
Enhancing noradrenergic activity using Atomoxetine improves olfactory discrimination learning in rats. (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_2192;
This study highlights the potential of ATM as a therapeutic intervention for AD by targeting the LC and enhancing NE transmission. As olfactory deficits are one of the earliest signs of AD, the improvement of odour discrimination learning by ATM has an implication for alleviating olfactory and other cognitive deficits in AD.
- |||||||||| NN1213 / Novo Nordisk, Intuniv (guanfacine XR) / Shionogi, Takeda
Trial completion: ADAPT: ADHD Medication and Predictors of Treatment Outcome (clinicaltrials.gov) - Oct 17, 2023
P=N/A, N=632, Completed,
In addition, this method is also applicable to the synthesis of natural product (R)-atomoxetine. Active, not recruiting --> Completed
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Review, Journal, Adverse events: An updated safety review of the current drugs for managing ADHD in children. (Pubmed Central) - Oct 16, 2023
Despite the availability of multiple stimulant and non-stimulant formulations, some individuals with ADHD may not tolerate available medications or attain satisfactory improvement. To satisfy unmet clinical needs, ADHD pharmaceutical research with stimulant and nonstimulant formulations targeting dopamine, norepinephrine and novel receptors is ongoing.
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Comparative Effectiveness and Pathways to Care: Opportunities and Pitfalls in Selection and Sequencing of ADHD Drug Treatments (Rhinelander South (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1365;
Conclusions Stimulants remain first-choice medications for ADHD. However, the findings that nonstimulants such as ATX may perform better when given as the first option and provide only minimal incremental benefit for individuals who fail stimulants, if confirmed, could have potentially important implications for personalizing ADHD treatment and refining treatment algorithms.
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Understanding the Impact of ADHD Familiality and Genetics on ADHD Medication Response and Optimization (Rhinelander South (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1364;
CYP2D6 poor metabolizers did not differ from other genotype groups in overall response. Conclusions Evidence is emerging that clinical factors and genetic markers (eg, DAT1 9/9) may be useful in predicting poor response or tolerability to medications, although clinical utility has yet to be established.
- |||||||||| Qelbree (viloxazine) / Supernus Pharma
Symposium 41 : Optimizing and Personalizing ADHD Treatment: What We Have Learned and Where Do We Need to Go (Rhinelander South (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1363;
He will then present data from several clinical trials, including unpublished data from the Methylphenidate Atomoxetine Treatment (MACRO) study examining genetic predictors of response...Nonstimulant response is influenced by genetic factors, prior treatment history, and signaled by early response. Conclusions A personalized approach to treatment should consider patient and parent preference, treatment history, severity of ADHD, and comorbidity pattern, while future prospective studies will evaluate the clinical utility of a data-driven approach.
- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg.
Effects of Methylphenidate and Atomoxetine Treatment on Improvement of Motor Coordination in Children With ADHD (Americas Hall II (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_561;
Conclusions Our results indicate that both methylphenidate and atomoxetine have a positive effect on motor coordination in children with ADHD. In addition, improvement in motor coordination with methylphenidate and atomoxetine treatment was associated with improvement in ADHD symptoms and neuropsychological tests.
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