- |||||||||| Journal: Eptinezumab (Vyepti) for migraine prevention. (Pubmed Central) - Sep 16, 2020
These results suggest that certain 'β-blockers' have the potential to mitigate the negative psychological effects of traumatic events. No abstract available
- |||||||||| Journal: Drugs for hypertension. (Pubmed Central) - Sep 8, 2020
No abstract available No abstract available
- |||||||||| nadolol (INV102) / Chronic Airway Therap
Journal: Cardiac influence of the β3-adrenoceptor in the goldfish (Carassius auratus): a protective role under hypoxia? (Pubmed Central) - Aug 11, 2020
Under normoxia, the β3-AR-selective agonist BRL (10 to 10 mol l) elicited a concentration-dependent increase of contractility that was abolished by a specific β3-AR antagonist (SR; 10 mol l), but not by α/β1/β2-AR inhibitors (phentolamine, nadolol and ICI118,551; 10 mol l)...Under both normoxia and hypoxia, adenylate cyclase and cAMP were found to be involved in the β3-ARs-dependent downstream transduction pathway. Our findings suggest the presence of functional β3-ARs in the goldfish heart, whose activation modulates the basal performance and contributes to the hypoxia-dependent increase of contractility.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg., mexiletine / Generic mfg., Teva
[VIRTUAL] Viral Illness Precipitating Cardiac Arrest in a Patient with Congenital QT Prolongation (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4091;
Other treatment options include placement of ICD, mexiletine use, or left cardiac sympathetic denervation...Close monitoring of hospitalized individuals on QT prolonging medications is required to prevent TDP & cardiac arrest. Other than medications, electrolytes & congenital predisposition, acute viral illnesses can result in prolonged QT & predispose sudden cardiac arrest.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, Tenormin (atenolol) / AstraZeneca, sotalol / Generic mfg.
[VIRTUAL] A Unique Case of Treatment-Resistant Beta-Blocker Toxicity (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3043;
Due to its favorable dialyzability characteristics, hemodialysis can be used for beta-blocker toxicity which is resistant to conventional therapy as seen in our case. Additionally, other low lipid soluble and low protein binding beta-blockers namely nadolol and sotalol can also benefit from being dialyzable in the same way.
- |||||||||| nadolol (INV102) / Chronic Airway Therap
Preclinical, Journal: Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice. (Pubmed Central) - Jul 1, 2020
Chronic β-adrenergic receptor (β-AR) blockade with nadolol abrogated stress-induced alterations in tumor burden and cleaved caspase-3 expression, lung MDSC frequency, and exosomal TGF-β content...Unexpectedly, β-blockade in nonstressed mice increased lung metastatic lesions and splenic MDSC frequency, suggesting that in MMTV-PyMT mice, β-AR activation also inhibits tumor progression in the absence of stress exposure. Together, these results suggest stress exposure can act through β-AR signaling to slow primary tumor growth in MMTV-PyMT mice.
- |||||||||| PK/PD data, Journal: Pharmacokinetic variability of beta-adrenergic blocking agents used in cardiology. (Pubmed Central) - Apr 30, 2020
We have shown a high interindividual pharmacokinetic variability that varies markedly in different beta-adrenergic blocking agents; the extreme being steady state ratios as high as 30 in metoprolol. A more personalized approach to the medical treatment of patients may be obtained by combining known pharmacokinetic information about variability, pharmaco-genetics and -dynamics, and patient characteristics, to avoid adverse events or lack of treatment effect.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg.
Characterization Of The Calcium Release Channel Deficiency Syndrome Secondary To A Homozygous, Multi-exon Duplication In Ryr2 (Poster Hall) - Apr 22, 2020 - Abstract #RHYTHM2020RHYTHM_2312;
We demonstrate that the homozygous multi-exon RYR2 duplication-mediated CRCDS leads to a pathogenic substrate that is prone to DAD arrhythmic activity. While flecainide alone partially rescued the phenotype, both nadolol and propranolol were able to fully rescue the ISO treated patient iPSC-CMs by significantly reducing the arrhythmic activity of the cells below the baseline arrhythmic level of the control iPSC-CMs.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg.
Nadolol or Propranolol Are the ONLY Beta-Blockers That Should Be Used in LQT (Room 25) - Apr 22, 2020 - Abstract #RHYTHM2020RHYTHM_1479;
Furthermore there is a lack of clarity on why a given beta-blocker may be beneficial for certain pathogenic genotypes. To identify which beta-blockers should be used in LQT To identify which beta-blockers should absolutely not be used in LQT To understand when to change beta blockers in LQT To understand which beta blockers may be more genotype specific than others
- |||||||||| mexiletine / Generic mfg., Teva
Non-precision Medicine: Mexiletine Useful For More Than Just Long QT Syndrome Type 3 (Poster Hall) - Apr 22, 2020 - Abstract #RHYTHM2020RHYTHM_807;
Initially trialed on nadolol, she transitioned to propranolol due to side effects and nonadherence, but had a breakthrough syncopal event with a QTc >500 msec prompting ICD placement. Concomitant use of mexiletine for compound potassium channel mutations in LQTS2 and 5 was effective in shortening the QT interval and may provide an adjunctive approach to reduce clinical events.
- |||||||||| nadolol (INV102) / Chronic Airway Therap
Clinical, Journal: Death Associated With Nadolol for Infantile Hemangioma: A Case for Improving Safety. (Pubmed Central) - Apr 10, 2020
We suggest that if nadolol is selected for therapy, pediatricians should instruct parents to monitor their infants' bowel movements closely and encourage early intervention in the event of decreased stooling. This intervention may greatly improve the safety of nadolol in this vulnerable patient population.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, colchicine / Generic mfg.
Biomarker, Journal: Investigation mechanisms between normal, developing and regenerating livers for regenerative liver drug design. (Pubmed Central) - Apr 4, 2020
After that, we investigated the significant signal pathways and epigenetic modifications in the core GWGENs to identify potential biomarkers as drug targets. Result & A multimolecule drug consisting of sulmazole, clofibrate, colchicine, furazolidone, nadolol, eticlopride and felbinac is proposed to target on novel biomarkers for promoting hepatogenesis and liver regeneration.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg., mexiletine / Generic mfg., Teva
Viral Illness Precipitating Cardiac Arrest in a Patient with Congenital QT Prolongation (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_6522;
Other treatment options include placement of ICD, mexiletine use, or left cardiac sympathetic denervation...Close monitoring of hospitalized individuals on QT prolonging medications is required to prevent TDP & cardiac arrest. Other than medications, electrolytes & congenital predisposition, acute viral illnesses can result in prolonged QT & predispose sudden cardiac arrest.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, Tenormin (atenolol) / AstraZeneca, sotalol / Generic mfg.
A Unique Case of Treatment-Resistant Beta-Blocker Toxicity (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_5402;
Due to its favorable dialyzability characteristics, hemodialysis can be used for beta-blocker toxicity which is resistant to conventional therapy as seen in our case. Additionally, other low lipid soluble and low protein binding beta-blockers namely nadolol and sotalol can also benefit from being dialyzable in the same way.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg.
Journal: A personalized approach to long QT syndrome. (Pubmed Central) - Feb 20, 2020
LQTS is a model for effective collaboration between clinicians and basic scientists and between cardiologists and geneticists. Recent advances in the derivation of induced pluripotent stem cells from LQTS patients and creation of genetically engineered human models using clusters of regularly interspaced palindromic repeats (CRISPR/Cas9) will advance translational arrhythmia research and move us toward the goal of personalized medicine.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, propranolol / Generic mfg.
Simple library of Janus-dendrimers as dual delivery platform for small molecules, peptides and proteins (Commonwealth Hall A2, Loews Philadelphia) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_7936;
Figure 1. Cryo-TEM images of a) dendrimersome (scale bar 100 nm), b) supramolecular fibers (scale bar 100 nm), lower inset: SEM image of a vitrified gel (scale bar 1 µm), c) loading and release of propranolol from dendrimersomes, d) release of nadolol, gonadorelin (peptide) and HRP protein from 0.2 wt% supramolecular hydrogels.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis, nadolol (INV102) / Chronic Airway Therap, duloxetine delayed release / Generic mfg.
Journal: Amino acid chiral ionic liquids combined with hydroxypropyl-β-cyclodextrin for drug enantioseparation by capillary electrophoresis. (Pubmed Central) - Jan 12, 2020
A synergistic effect was observed when combining each chiral ionic liquid with hydroxypropyl-β-cyclodextrin in the case of the five compounds for which the cyclodextrin showed enantiomeric discrimination power when used as sole chiral selector (duloxetine, verapamil, terbutaline, econazole, sulconazole). Buffer concentration and pH, temperature and separation voltage were varied in order to optimize the enantiomeric separation of these five compounds using dual systems giving rise to resolutions ranging from 1.1 to 6.6.
- |||||||||| nadolol (INV102) / Chronic Airway Therap
[VIRTUAL] TO ICD OR NOT TO ICD: CLINICAL DECISION MAKING IN AN LONG QT SYNDROME MALE PATIENT (eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_5998;
History of cardiac arrest leaves no doubt regarding the use of ICDs to prevent sudden cardiac death in patients with LQTS. However, decisions regarding most patients with LQTS who have not experienced cardiac arrest must rely on risk-stratification methods using genotype-phenotype data.
- |||||||||| nadolol (INV102) / Chronic Airway Therap, sotalol / Generic mfg.
[VIRTUAL] ROLE OF SCN5A MUTATION T512I IN YOUNG PATIENT WITH RIGHT VENTRICULAR TACHYCARDIA AND CARDIOMYOPATHY (FIT Clinical Decision Making Moderated Poster Theater 1_eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_3456;
SCN5A mutations may present with ventricular arrhythmias and cardiomyopathy. Sodium channel blockade and electrophysiology study with endocardial and epicardial mapping can help differentiate this clinical entity from Brugada syndrome, which impacts counseling and pharmacotherapy while an ablative strategy may reduce arrhythmia burden and ICD shocks.
- |||||||||| Journal: Drugs for atrial fibrillation. (Pubmed Central) - Nov 18, 2019
Sodium channel blockade and electrophysiology study with endocardial and epicardial mapping can help differentiate this clinical entity from Brugada syndrome, which impacts counseling and pharmacotherapy while an ablative strategy may reduce arrhythmia burden and ICD shocks. No abstract available
- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Migraine Headache Prophylaxis. (Pubmed Central) - Nov 10, 2019
Acebutolol, oxcarbazepine, lamotrigine, and telmisartan are ineffective...The complementary treatments petasites, feverfew, magnesium, and riboflavin are probably effective. Nonpharmacologic therapies such as relaxation training, thermal biofeedback combined with relaxation training, electromyographic feedback, and cognitive behavior therapy also have good evidence to support their use in migraine prevention.
- |||||||||| tacrolimus / Generic Mfg.
Review, Journal: Update of green tea interactions with cardiovascular drugs and putative mechanisms. (Pubmed Central) - Oct 18, 2019
In these, the effect of GT or GT derivatives on drug exposure was mild to moderate, but a high inter-individual variability was observed. Further investigations, including studies on the effect of the dose and the time of GT intake are necessary to understand more in depth the clinical relevance of GT-CV drug interactions.
- |||||||||| ciprofloxacin / Generic Mfg., Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine
PATIENTS WITH DECOMPENSATED CIRRHOSIS ARE NOT RECEIVING THE MEDICATIONS THEY NEED WHILE RECEIVING MEDICATIONS THEY DO NOT NEED (Hynes Convention Center, Room 312) - Sep 29, 2019 - Abstract #AASLD2019AASLD_1363;
Many patients are taking medications that can cause further decompensation. Providers should carefully review all medications at each clinical opportunity for patients with decompensated cirrhosis.Table 1: Numbers and percentages of patients prescribed appropriate and potentially inappropriate medications during follow up periodDiuretics: Furosemide, Spironolactone, Bumetanide, Torsemide, Eplerenone, AmilorideNSAID: Non-steroidal anti-inflammatory drugNSBB (Non selective beta blocker): Carvedilol, Nadolol, PropranololPPI: Proton pump inhibitorAntibiotics: Sulfamethoxazole/Trimethoprim, Ciprofloxacin, Norfloxacin
- |||||||||| nadolol (INV 102) / Invion
BRASH SYNDROME: LOST IN PLAIN SIGHT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3366;
The diarrhea was thought to be iatrogenic as he was administered lactulose for bowel movement for encephalopathy...The effect may be seen more commonly with non-selective beta-blockers including nadolol...It is vital to recognize this syndrome as the patient might be initially treated with ACLS bradycardia protocol. Atropine might not correct the bradycardia and thus there might be undue utilization of transvenous pacing.
- |||||||||| nadolol (INV 102) / Invion
Retrospective data, Review, Journal: Interaction of herbal products with prescribed medications: A systematic review and meta-analysis. (Pubmed Central) - Aug 25, 2019
The study findings suggest that GT, SJW and EP perpetuate significant interactions with prescribed medications via CYP3A4 or OATP1A2. Our studies show that meta-analyses are important in the area of natural products to provide necessary information on their use in overall medication plans in order to avoid unintended interactions.
- |||||||||| nadolol (INV 102) / Invion, propranolol / Generic Mfg.
Patients with difficult to treat ascites and large varices (Hall 6) - Aug 18, 2019 - Abstract #UEGW2019UEGW_186;
Other studies have suggested that the deleterious effect of NSBB in patients with ascites occur with higher doses of NSBB (2, 7) and when NSBB are associated with a significant decrease in arterial blood pressure (2, 8). Given the benefit of NSBB, particularly in the setting of secondary prophylaxis of variceal hemorrhage where patients with ascites have a significantly better survival with combination EVL + NSBB compared to EVL alone (9), guidelines recommend that NSBB should not be avoided in patients with cirrhosis and ascites but that they should be used cautiously, starting at lower doses with dose/reduction or discontinuation if systolic blood pressure decreases to < 90 mmHg, serum sodium < 130 mEq/L or development of acute kidney injury (1, 10).
- |||||||||| Preclinical, Journal: Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties. (Pubmed Central) - Aug 16, 2019
This rapidly differentiating cell line will be an asset in ocular studies since it is easily maintained, it grows and differentiates quickly and does not require specialized culture conditions for differentiation. Thus, this cell line is suitable for both small scale assays and high throughput screening in drug discovery and development.
|
