- |||||||||| nadolol (INV 102) / Invion
Massive Hematochezia Due to Bleeding Cecal Varices in a 35-Year-Old (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2084;
She had no further bleeding and was started on Nadolol for further reduction in portosystemic pressure...In our case, the decision to pursue TIPS was made due to complicated superior mesenteric artery anatomy precluding coil embolization. Aggressive resuscitation and collaboration between gastroenterology, surgery, and radiology made for a successful outcome for this young patient.
- |||||||||| nadolol (INV 102) / Invion
Clinical, Journal: Interplay Between Genetic Substrate, QTc Duration, and Arrhythmia Risk in Patients With Long QT Syndrome. (Pubmed Central) - Jul 28, 2019
Aggressive resuscitation and collaboration between gastroenterology, surgery, and radiology made for a successful outcome for this young patient. The study provides an estimator of risk of LAEs in LQTS that allows a granular estimate of 5-year arrhythmic risk and demonstrate the superiority of nadolol in reducing the risk of LAEs in LQTS.
- |||||||||| Procoralan (ivabradine) / Amgen, Servier, Ono Pharma
Clinical, Journal: Efficacy of ivabradine to control ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia. (Pubmed Central) - May 31, 2019
In these 2 patients Ivabradine in combination with Nadolol or flecainide was well tolerated and successfully suppressed non-sustained polymorphic ventricular tachycardia and couplets. Thus, Ivabradine could limit the use of implantable cardioverter-defibrillators or left cardiac sympathetic denervation in CPVT patients with uncontrollable ventricular arrhythmias.
- |||||||||| carbamazepine / generics, ibuprofen / generics
Journal: Sorption and degradation of contaminants of emerging concern in soils under aerobic and anaerobic conditions. (Pubmed Central) - Apr 26, 2019
The degradation behavior of the target compounds varied in relation to soil and compound physicochemical properties as well as the microbial activities (e.g., 220 ppm of CH were produced in anaerobic experiments) and aeration of the tested soils. Overall, the poor adsorption and relative persistence of sucralose and carbamazepine suggests that both may be used as potential tracers for soil and groundwater contamination.
- |||||||||| nadolol oral (INV102 oral) / Chronic Airway Therap
Journal: Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor. (Pubmed Central) - Mar 14, 2019
The number of CD34+ HSCs increased with exercise after the placebo and bisoprolol trials, but not the nadolol trial, suggesting β2-AR signaling mediated the mobilization of CD34+ cells [Placebo: 2.10 ± 1.16 (207± 69.2%), Bisoprolol 1.66 ± 0.79 (+163 ± 29%), Nadolol: 0.68 ± 0.54 (+143 ± 36%) Δcells/µL]. We conclude that the mobilization of CD34+ HSCs with exercise is not dependent on circulating G-CSF and is likely due to the combined actions of β2-AR signaling and hemodynamic shear stress.
- |||||||||| nadolol oral (INV102 oral) / Chronic Airway Therap
Enrollment closed: Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol, in Mild Asthma (clinicaltrials.gov) - Nov 10, 2015
P2, N=60, Active, not recruiting,
We conclude that the mobilization of CD34+ HSCs with exercise is not dependent on circulating G-CSF and is likely due to the combined actions of β2-AR signaling and hemodynamic shear stress. Recruiting --> Active, not recruiting
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