- |||||||||| cyclophosphamide / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Evaluation of oral mucositis level and affecting factors in cancer patients receiving chemotherapy. (Pubmed Central) - Aug 20, 2024
In conclusion, nearly half of the patients (52%, n?=?128) receiving chemotherapy developed oral mucositis and of all patients of 35.5% had an oral mucositis score of 1 in the second round of chemotherapy. Patients those who had breast cancer, who received doxorubicin or cyclophosphamide chemotherapy protocols, and who had previously developed oral mucositis were found to have a higher rate of oral mucositis.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats. (Pubmed Central) - Aug 20, 2024
To mimic the typical clinical presentation of chemotherapy-induced HF in elder patients, we established an aged rat model in which restrictive cardiomyopathy with sequential HF was induced via consecutive doxorubicin injections...Additionally, we also evaluated the safety and feasibility of MISA intrapericardial delivery in a healthy porcine model with an intact immune system. In general, our data indicates that MISA has a strong potential for translation into large animal models and ultimately clinical applications for chemotherapy-induced HF prior to the final option of heart transplantation.
- |||||||||| datopotamab deruxtecan (DS-1062a) / Daiichi Sankyo, AstraZeneca
Rates of pathologic complete response (pCR) after datopotamab deruxtecan (Dato) in the neoadjuvant setting: Results from the I-SPY 2.2 trial (Barcelona Auditorium - Hall 2) - Aug 20, 2024 - Abstract #ESMO2024ESMO_3803;
P2
Patients who proceed to Block C receive doxorubicin + cyclophosphamide +/-pembro...Stomatitis and ocular toxicity were less common, mostly of lower grades. Conclusions Dato was particularly active in the HR(-)HER2(-)Im(-)DRD(-) signature, and was safe in other subtypes, in patients who followed the treatment strategy, highlighting the importance and benefit of adherence to protocol treatment recommendations.
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen
Enrollment closed, Combination therapy: AALL1731: A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia (clinicaltrials.gov) - Aug 19, 2024
P3, N=6720, Active, not recruiting,
Conclusions Dato was particularly active in the HR(-)HER2(-)Im(-)DRD(-) signature, and was safe in other subtypes, in patients who followed the treatment strategy, highlighting the importance and benefit of adherence to protocol treatment recommendations. Suspended --> Active, not recruiting
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Evaluation of in vitro anti-cancer potential and apoptotic profile of ethanolic plant extract of Wrightia tinctoria against oral cancer cell line. (Pubmed Central) - Aug 19, 2024
The control drug doxorubicin along with the test drug W. tinctoria was tested for anti-cancer potential by using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay and for apoptotic activity by using DNA fragmentation assay and western blotting assay...DNA fragmentation assay showed a ladder pattern when treated with 59 ?g/mL extract of W. tinctoria, and western blot analysis revealed the presence of cleaved caspase 3, confirming the apoptotic potential of the extract. The current study demonstrated that the plant extract has effective anti-cancer and apoptotic potential and can be used as a natural source for the production of new anti-cancer and cytotoxic agents against oral cancer.
- |||||||||| digoxin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Actively Targeting Redox-Responsive Multifunctional Micelles for Synergistic Chemotherapy of Cancer. (Pubmed Central) - Aug 19, 2024
Accordingly, we synthesized a digoxin-modified novel multifunctional redox-responsive disulfide-linked poly(ethylene glycol-b-poly(lactic-co-glycolic acid) copolymer (Bi(Dig-PEG-PLGA)-S2) for the targeted and controlled release of doxorubicin (DOX) in cancer cells. In addition, the release of DOX demonstrated the redox-responsive behavior of the micelles, with approximately 89.41
- |||||||||| Herceptin (trastuzumab) / Roche, Perjeta (pertuzumab) / Roche, Rituxan (rituximab) / Roche
Journal: Synchronous Invasive Ductal Carcinoma of Breast and Diffuse Large B-cell Lymphoma: A Case Report. (Pubmed Central) - Aug 19, 2024
She was given three cycles of rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone (R-CHOP) protocol...She was recommended weekly paclitaxel for 12 cycles and trastuzumab and pertuzumab for 1 year...Biopsy of metastatic sites should be done wherever possible. All histopathologies should be reviewed thoroughly before treatment initiation, as they may significantly alter patient management.
- |||||||||| Review, Journal, Adverse events: Mitigating Cardiotoxicity Associated with Anticancer Drugs: An Updated Systematic Review. (Pubmed Central) - Aug 19, 2024
Pharmacological interventions, including candesartan and carvedilol, have shown potential in reducing early DOX-induced subclinical cardiotoxicity (DISC)...Combination therapy with lisinopril and bisoprolol effectively preserved the LVEF...This systematic review underscores the promise of exercise and pharmacological interventions for preserving cardiac function in cancer patients receiving chemotherapy. These findings have significant implications for enhancing the quality of care for cancer patients.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Polyphenol (-)-Epigallocatechin Gallate (EGCG) mitigated kidney injury by regulating metabolic homeostasis and mitochondrial dynamics involvement with Drp1-mediated mitochondrial fission in mice. (Pubmed Central) - Aug 17, 2024
The study aimed to examine effects of (-)-epigallocatechin-3-gallate (EGCG) on energy metabolism and mitochondrial dynamics in mouse model of renal injury caused by doxorubicin (DOX)...Moreover, changing glycolysis into mitochondrial oxidative phosphorylation was observed, evidenced by controlling activities of malate dehydrogenase (MDH) and hexokinase (HK) in EGCG+DOX groups when compared to DOX group, indicating that reprogramming energy metabolism was linked to EGCG-induced renal protection in mice. Therefore, EGCG was demonstrated to have a protective effect against kidney injury by reducing oxidative damage, metabolic disorders, and mitochondrial dysfunction, suggesting that EGCG has potential as a feasible strategy to prevent kidney injury.
- |||||||||| Folotyn (pralatrexate) / Aurobindo, Beleodaq (belinostat) / Aurobindo, Assertio, Adcetris (brentuximab vedotin) / Takeda, Pfizer
Review, Journal: Peripheral T-cell lymphoma: From biology to practice to the future. (Pubmed Central) - Aug 17, 2024
Edits of the front-line regimens, often called CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-plus approaches, look more like CHOP-minus strategies, as the toxicity of five-drug regimens often reduces the dose intensity of the added 'novel' drug, nullifying any hope of an advance...Herein, we analyze PTCL through a 2025 lens, highlighting and underscoring walls that have impeded progress. We will critically explore all the clues and the panoramic view of PTCL research.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: The caspase-activated DNase promotes cellular senescence. (Pubmed Central) - Aug 17, 2024
Inducers of cellular senescence, such as oncogenic RAS, type-I interferon, and doxorubicin treatment, also depend on CAD presence for senescence induction...We further investigate the contribution of CAD to senescence in vivo and find substantially reduced signs of senescence in organs of ageing CAD-deficient mice. Our results show that CAD-induced DNA damage in response to various stimuli is an essential contributor to cellular senescence.
- |||||||||| Adcetris (brentuximab vedotin) / Takeda, Pfizer
Journal: Mycosis fungoides refractory to treatment - importance of a multidisciplinary approach. (Pubmed Central) - Aug 17, 2024
This protocol effectively controlled MF, which previous protocols had failed to do. The diagnosis by the dental team was essential for therapeutic change and improvement of the patient's clinical condition without the need for invasive medical procedures.
- |||||||||| doxorubicin hydrochloride / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Journal: Vitamin D ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model via enhancement of the antioxidant defense and minimizing mitochondrial dysfunction. (Pubmed Central) - Aug 17, 2024
However, the combination of vitamin D with celecoxib and celecoxib?+?doxorubicin caused a significant reversal of deformity in paws and limbs, increased pressure in the eye, blindness, and animal death, as well as cardiotoxicity, oxidative stress, and mitochondrial parameters. This study proved for the first time the beneficial effect of vitamin D on celecoxib-induced cardiotoxicity, which is aggravated in the presence of doxorubicin through the maintenance of mitochondrial functions and its antioxidant potential.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Doxorubicin alters G-protein coupled receptor-mediated vasocontraction in rat coronary arteries. (Pubmed Central) - Aug 17, 2024
This study proved for the first time the beneficial effect of vitamin D on celecoxib-induced cardiotoxicity, which is aggravated in the presence of doxorubicin through the maintenance of mitochondrial functions and its antioxidant potential. The vasocontractile responses by activation of endothelin receptor type A (ETA) and type B (ETB), serotonin receptor 1B (5-HT1B) and thromboxane A2 prostanoid receptor (TP) were investigated by a sensitive myography using specific agonists, while the specificity of the GPCR agonists was verified by applying selective antagonists (i.e. ETA and ETB agonist?=?10-?14-10-?7.5 M endothelin-1 (ET-1); ETA antagonist?=?10
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Biomarker, Review, Journal: Precision Treatment of Anthracycline-Induced Cardiotoxicity: An Updated Review. (Pubmed Central) - Aug 16, 2024
And we systematically discuss current prevention and treatment strategies and novel pathogenesis-based therapies for AIC: 1) dose reduction and change; 2) altering drug delivery methods; 3) antioxidants, dexrezosen, statina, RAAS inhibitors, and hypoglycemic drugs; 4) miRNA, natural phytochemicals, mesenchymal stem cells, and cardiac progenitor cells. We also offer a fresh perspective on the management of AIC by outlining the current dilemmas and challenges associated with its prevention and treatment.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Preparation of double-loaded bitter ginseng derivative B21-DOX liposomes co-modified with SP94 and BR2 ligand and its in vitro anti-hepatocarcinogenic effect. (Pubmed Central) - Aug 16, 2024
To construct a novel liposomal drug delivery system co-modified with SP94 and BR2 ligands, encapsulating both the bitter ginseng derivative B21 and doxorubicin (DOX), to achieve superior anti-tumour efficacy and reduced toxic side effects...The results indicated that SP94/BR2-B21/DOX-LP exhibited enhanced targeting and cytotoxicity compared to single-ligand modified and unmodified liposomes, with the combined encapsulation of B21 and DOX showing synergistic anti-hepatocarcinogenic effects. SP94/BR2-B21/DOX-LP liposomes represent a promising targeted drug delivery system for hepatocellular carcinoma, offering improved membrane penetration, enhanced therapeutic efficacy, and reduced systemic toxicity.
- |||||||||| abiraterone acetate / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications. (Pubmed Central) - Aug 14, 2024
Compound 4 also showed a synergic effect with doxorubicin in osteosarcoma cell lines; specifically, the effect is correlated with AKR1C3 expression. In this research work, therefore, the use of AI allowed the identification of a new structure as an AKR1C3 inhibitor and its potential to enhance the effect of chemotherapeutics.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Ginsenoside Rg3 combined with near-infrared photothermal reversal of multidrug resistance in breast cancer MCF-7/ADR cells. (Pubmed Central) - Aug 14, 2024
Adriamycin (ADR) is a frequently employed chemotherapeutic agent for the management of breast cancer...This was achieved by reversing the expression of drug resistance-associated proteins, while also inhibiting cell proliferation, migration, and epithelial-mesenchymal transition (EMT) processes via attenuation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway transduction. Ginsenoside Rg3 combined with near-infrared photothermal therapy (NIR) effectively reverses multidrug resistance in breast cancer MCF-7/ADR cells, providing a new therapeutic strategy for breast cancer drug resistance.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Improvement photothermal property of MoS2/Fe3O4/GNR nanocomposite in cancer treatment. (Pubmed Central) - Aug 13, 2024
The objective of the present study was to develop a novel molybdenum disulfide/iron oxide/gold nanorods (MoS2/Fe3O4/GNR) nanocomposite (MFG) with different concentrations of AgNO3 solution (MFG1, MFG2, and MFG3) for topical doxorubicin (DOX) drug delivery...Finally, results revealed when DOX loading increased in nanocomposite, then cell viability was decreased in it. Therefore, these properties make MFG3 nanocomposite a good candidate for photothermal therapy and drug loading.
- |||||||||| daunorubicin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Conjugating Daunorubicin and Doxorubicin to GTP by Formaldehyde to Overcome Drug Resistance. (Pubmed Central) - Aug 13, 2024
Our results also indicate that these daunorubicin/doxorubicin-GTP conjugates bind to DNA via intercalation. Furthermore, we observed rapid accumulation of these conjugates in human cancer cells and observed cytotoxic effects in both doxorubicin-sensitive SK-OV-3 and doxorubicin-resistant NCI/ADR-RES cells, suggesting that these daunorubicin and doxorubicin derivatives can overcome doxorubicin resistance.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: In Vitro and In Vivo Biological Evaluation of Novel 1,4-Naphthoquinone Derivatives as Potential Anticancer Agents. (Pubmed Central) - Aug 13, 2024
Notably, compound 5v displayed a greater cytotoxic effect on MCF-7 cells compared to the standard drug doxorubicin...Finally, a computational modelling study was conducted on four protein receptors, namely ER, EFGR, BRCA1, and VEFGR2. The findings highlight the importance of the aminonaphthoquinone moiety, amide linkage, and propyl thio moiety in enhancing the anticancer properties.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Self-assembled hollow CuS@AuNRs/PDA nanohybrids with synergistically enhanced photothermal efficiency. (Pubmed Central) - Aug 13, 2024
The excellent adhesion performance and strong negative charge of PDA ensure a high doxorubicin hydrochloride (DOX) loading efficiency of 96.08% for HCuS@AuNRs/PDA...In vitro cell viability results confirm that HCuS@AuNRs/PDA could efficiently kill tumor cells under the dual effect of acidic media and NIR laser. This study presents a novel nanocarrier with synergistically enhanced NIR photothermal responsiveness and high drug loading capacity, which provides a versatile platform in intelligent drug release and photothermal therapy.
- |||||||||| digoxin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Mechanical Stretch Induces Senescence of Lung Epithelial Cells and Drives Fibroblast Activation by Paracrine Mechanisms. (Pubmed Central) - Aug 12, 2024
Finally, the senolytic effects of digoxin were tested in these models...This stretch-induced senescence has specific features compared to senescence induced by doxorubicin...These results suggest that lung fibrosis in response to mechanical stretch may be caused by the paracrine effects of senescent cells. This pathogenetic mechanism can be pharmacologically manipulated to improve lung repair.
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