doxorubicin hydrochloride / Generic mfg. 
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  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial primary completion date:  Trial for Patients Not Qualifying for TT4 and TT5 Protocols Because of Prior Therapy (clinicaltrials.gov) -  Apr 19, 2017   
    P2,  N=100, Recruiting, 
    Therefore, this regimen achieved promising survival outcomes in high-risk DLBCL on long term follow-up, with manageable toxicity. Trial primary completion date: Mar 2017 --> Mar 2018
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  In situ biodegradable crosslinking of cationic oligomer coating on mesoporous silica nanoparticles for drug delivery. (Pubmed Central) -  Apr 19, 2017   
    In this study, we demonstrate a simple approach to developing mesoporous nanohybrids via a process of pre-drug loading (using doxorubicin (DOX) as a model drug) into mesoporous silica nanoparticles (MSN), followed by surface functionalization with a kind of cationic oligomer (low molecular weight polyethylene imine, LPEI) and in situ crosslinking by degradable N,N'-bis(acryloyl)cystamine (BAC)...The nanohybrids displayed a pH- and redox-dual sensitivity in DOX release under conditions that mimic intracellular reductive conditions and acidic tumor microenvironments. The nanohybrids can be effectively internalized into A549 cells (a carcinomic human alveolar basal epithelial cell line), resulting in a high DOX intracellular accumulation and an improved anticancer cytotoxicity when compared with free DOX, suggesting their high potential as a new platform for therapeutic delivery.
  • ||||||||||  Halpryza (rituximab biosimilar) / Innovent Biologics, Eli Lilly
    Enrollment open, Combination therapy:  A Study Comparing the Efficacy and Safety Between I-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients (clinicaltrials.gov) -  Apr 16, 2017   
    P3,  N=400, Recruiting, 
    The nanohybrids can be effectively internalized into A549 cells (a carcinomic human alveolar basal epithelial cell line), resulting in a high DOX intracellular accumulation and an improved anticancer cytotoxicity when compared with free DOX, suggesting their high potential as a new platform for therapeutic delivery. Not yet recruiting --> Recruiting
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory. (Pubmed Central) -  Apr 15, 2017   
    Doxorubicin (DOX) was then successfully loaded into SP and FA-SP NPs with a desirable loading content of 13.33% and 16.01%, respectively...In vivo, tumor accumulation and growth inhibitory were then examined using H22 tumor-bearing mice. All these results demonstrated that conjugation of FA can efficiently enhance SP-based NPs' tumor accumulation and antitumor effect.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), Oncaspar liquid (pegaspargase) / Servier
    Enrollment change, Trial termination, Trial primary completion date:  NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma (clinicaltrials.gov) -  Apr 11, 2017   
    P2,  N=23, Terminated, 
    Initiation date: Jun 2013 --> Dec 2013 N=72 --> 23 | Recruiting --> Terminated | Trial primary completion date: May 2027 --> Jun 2021
  • ||||||||||  thioguanine / Generic mfg.
    Enrollment closed, Trial primary completion date:  Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Apr 11, 2017   
    P3,  N=600, Active, not recruiting, 
    N=72 --> 23 | Recruiting --> Terminated | Trial primary completion date: May 2027 --> Jun 2021 Recruiting --> Active, not recruiting | Trial primary completion date: Nov 2019 --> Nov 2020
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    New trial, Combination therapy:  ISP-TACE Versus TACE for HCC With PVTT (clinicaltrials.gov) -  Apr 10, 2017   
    P=N/A,  N=126, Completed, 
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  3-Carboxyphenylboronic acid-modified carboxymethyl chitosan nanoparticles for improved tumor targeting and inhibitory. (Pubmed Central) -  Apr 8, 2017   
    Doxorubicin (DOX) as a model drug was successfully encapsulated to give CM-DOX and CB-DOX NPs...CB-DOX NPs can deliver more drug than CM-DOX NPs, and retain for a long time in lung tissue, thus remarkably reducing the size of tumor mass of H22 metastasis lung tumor. All results demonstrate that the obtained NPs would be potentially useful as nano-scaled drug carriers in chemotherapy.
  • ||||||||||  Trial initiation date:  Mature B-Cell Lymphoma And Leukemia Study III (clinicaltrials.gov) -  Apr 4, 2017   
    P2/3,  N=122, Recruiting, 
    Recruiting --> Active, not recruiting Initiation date: Jan 2009 --> Sep 2010
  • ||||||||||  Vesanoid (tretinoin) / Roche, entinostat (SNDX-275) / Kyowa Kirin, Syndax Pharma
    Journal:  Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer. (Pubmed Central) -  Apr 2, 2017   
    In this study, we found that combined treatment of TNBC xenografts with entinostat, ATRA, and doxorubicin (EAD) resulted in significant tumor regression and restoration of epigenetically silenced RAR-β expression...Finally, we demonstrate that patient-derived metastatic cells also responded to treatment with EAD. Collectively, our findings strongly suggest that entinostat potentiates doxorubicin-mediated cytotoxicity and retinoid-driven differentiation to achieve significant tumor regression in TNBC.
  • ||||||||||  sirolimus / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca(2+) in Human Cardiac Progenitor Cells. (Pubmed Central) -  Apr 2, 2017   
    Additionally, DOXO significantly induced mTOR expression in hCPCs, and inhibition of mTOR signaling by rapamycin, a specific inhibitor, rescued DOXO-mediated autophagosome depletion in hCPCs with significant reduction of DOXO-mediated cytosolic Ca(2+) accumulation in hCPCs, and restored SMP30 and mTOR expression. Thus, DOXO-mediated hCPC toxicity is linked to Ca(2+)-related autophagy signaling, and inhibition of mTOR signaling may provide a cardio-protective effect against DOXO-mediated hCPC toxicity.
  • ||||||||||  Rituxan (rituximab) / Roche
    Enrollment open:  Treatment and Natural History Study of Lymphomatoid Granulomatosis (clinicaltrials.gov) -  Mar 29, 2017   
    P2,  N=90, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2018 --> Jul 2019 Suspended --> Recruiting
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche, Zevalin (ibritumomab tiuxetan) / Servier, Aurobindo
    Enrollment change, Trial primary completion date, Metastases:  FOLL12: Study to Evaluate the Efficacy of Response-adapted Strategy in Follicular Lymphoma (clinicaltrials.gov) -  Mar 27, 2017   
    P3,  N=810, Recruiting, 
    Trial primary completion date: Aug 2017 --> Aug 2018 N=602 --> 810 | Trial primary completion date: Dec 2016 --> Dec 2017