- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: In situ biodegradable crosslinking of cationic oligomer coating on mesoporous silica nanoparticles for drug delivery. (Pubmed Central) - Apr 19, 2017 In this study, we demonstrate a simple approach to developing mesoporous nanohybrids via a process of pre-drug loading (using doxorubicin (DOX) as a model drug) into mesoporous silica nanoparticles (MSN), followed by surface functionalization with a kind of cationic oligomer (low molecular weight polyethylene imine, LPEI) and in situ crosslinking by degradable N,N'-bis(acryloyl)cystamine (BAC)...The nanohybrids displayed a pH- and redox-dual sensitivity in DOX release under conditions that mimic intracellular reductive conditions and acidic tumor microenvironments. The nanohybrids can be effectively internalized into A549 cells (a carcinomic human alveolar basal epithelial cell line), resulting in a high DOX intracellular accumulation and an improved anticancer cytotoxicity when compared with free DOX, suggesting their high potential as a new platform for therapeutic delivery.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory. (Pubmed Central) - Apr 15, 2017 Doxorubicin (DOX) was then successfully loaded into SP and FA-SP NPs with a desirable loading content of 13.33% and 16.01%, respectively...In vivo, tumor accumulation and growth inhibitory were then examined using H22 tumor-bearing mice. All these results demonstrated that conjugation of FA can efficiently enhance SP-based NPs' tumor accumulation and antitumor effect.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Oncaspar liquid (pegaspargase) / Servier
Enrollment change, Trial termination, Trial primary completion date: NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma (clinicaltrials.gov) - Apr 11, 2017 P2, N=23, Terminated, Initiation date: Jun 2013 --> Dec 2013 N=72 --> 23 | Recruiting --> Terminated | Trial primary completion date: May 2027 --> Jun 2021
- |||||||||| thioguanine / Generic mfg.
Enrollment closed, Trial primary completion date: Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Apr 11, 2017 P3, N=600, Active, not recruiting, N=72 --> 23 | Recruiting --> Terminated | Trial primary completion date: May 2027 --> Jun 2021 Recruiting --> Active, not recruiting | Trial primary completion date: Nov 2019 --> Nov 2020
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: 3-Carboxyphenylboronic acid-modified carboxymethyl chitosan nanoparticles for improved tumor targeting and inhibitory. (Pubmed Central) - Apr 8, 2017 Doxorubicin (DOX) as a model drug was successfully encapsulated to give CM-DOX and CB-DOX NPs...CB-DOX NPs can deliver more drug than CM-DOX NPs, and retain for a long time in lung tissue, thus remarkably reducing the size of tumor mass of H22 metastasis lung tumor. All results demonstrate that the obtained NPs would be potentially useful as nano-scaled drug carriers in chemotherapy.
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Enrollment change, Trial primary completion date, Metastases: Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma (clinicaltrials.gov) - Apr 7, 2017 P2, N=18, Active, not recruiting, All results demonstrate that the obtained NPs would be potentially useful as nano-scaled drug carriers in chemotherapy. Recruiting --> Active, not recruiting | N=28 --> 18 | Trial primary completion date: Dec 2017 --> Dec 2018
- |||||||||| Vesanoid (tretinoin) / Roche, entinostat (SNDX-275) / Kyowa Kirin, Syndax Pharma
Journal: Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer. (Pubmed Central) - Apr 2, 2017 In this study, we found that combined treatment of TNBC xenografts with entinostat, ATRA, and doxorubicin (EAD) resulted in significant tumor regression and restoration of epigenetically silenced RAR-β expression...Finally, we demonstrate that patient-derived metastatic cells also responded to treatment with EAD. Collectively, our findings strongly suggest that entinostat potentiates doxorubicin-mediated cytotoxicity and retinoid-driven differentiation to achieve significant tumor regression in TNBC.
- |||||||||| sirolimus / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca(2+) in Human Cardiac Progenitor Cells. (Pubmed Central) - Apr 2, 2017 Additionally, DOXO significantly induced mTOR expression in hCPCs, and inhibition of mTOR signaling by rapamycin, a specific inhibitor, rescued DOXO-mediated autophagosome depletion in hCPCs with significant reduction of DOXO-mediated cytosolic Ca(2+) accumulation in hCPCs, and restored SMP30 and mTOR expression. Thus, DOXO-mediated hCPC toxicity is linked to Ca(2+)-related autophagy signaling, and inhibition of mTOR signaling may provide a cardio-protective effect against DOXO-mediated hCPC toxicity.
- |||||||||| Arzerra (ofatumumab) / Novartis, Genmab
Enrollment closed, Trial primary completion date, Combination therapy: Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma (clinicaltrials.gov) - Mar 30, 2017 P2, N=70, Active, not recruiting, Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2018 --> Jul 2019
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche, Zevalin (ibritumomab tiuxetan) / Servier, Aurobindo
Enrollment change, Trial primary completion date, Metastases: FOLL12: Study to Evaluate the Efficacy of Response-adapted Strategy in Follicular Lymphoma (clinicaltrials.gov) - Mar 27, 2017 P3, N=810, Recruiting, Trial primary completion date: Aug 2017 --> Aug 2018 N=602 --> 810 | Trial primary completion date: Dec 2016 --> Dec 2017
|