- |||||||||| Rituxan (rituximab) / Roche, Rituxan Hycela (rituximab/hyaluronidase) / Biogen, Roche, Halozyme
Trial completion, Combination therapy: A Study of Subcutaneous Versus Intravenous MabThera/Rituxan (Rituximab) in Combination With CHOP Chemotherapy in Patients With Previously Untreated CD20-Positive Diffuse Large B-Cell Lymphoma (clinicaltrials.gov) - May 18, 2017 P3, N=572, Completed, Recruiting --> Active, not recruiting | N=194 --> 38 Active, not recruiting --> Completed
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: Prospective Study of FLT PET for Early Interim Response Assessment in Advanced Stage B-cell Lymphoma. (Pubmed Central) - May 11, 2017 (18)F-FLT PET after 1-2 cycles of chemotherapy predicts PFS and OS, and a negative (18)F-FLT iPET result may potentially help design risk-adapted therapies in patients with aggressive lymphomas. In contrast, the positive predictive value of (18)F-FLT iPET remains too low to justify changes in patient management.
- |||||||||| Adcetris (brentuximab vedotin) / Takeda, Pfizer, Matulane (procarbazine hydrochloride) / Leadiant Biosci
Enrollment open, Metastases: Uni-Koeln-1762: HD21 for Advanced Stages (clinicaltrials.gov) - May 11, 2017 P3, N=1500, Recruiting, Changes in volumes, strain, and ventricular-arterial coupling were consistently associated with concurrent and subsequent LVEF declines and recovery across therapies. Not yet recruiting --> Recruiting
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Stimuli-responsive nanocomposites for magnetic targeting synergistic multimodal therapy and T1/T2-weighted dual-mode imaging. (Pubmed Central) - May 5, 2017 Anticancer drug doxorubicin hydrochloride (DOX)-loaded photothermal nanocomposite MnFe2O4@mSiO2 with magnetic targeting and T1/T2-weighted dual-mode magnetic resonance imaging of MnFe2O4 core and NIR/pH-coupling sensitive mesoporous silica shell nanocarriers was designed and synthesized successfully...The lower pH can also promote DOX releasing from mesoporous layer to enhance tumor inhibitory effect. It is confirmed that biocompatible DOX-MnFe2O4@mSiO2 nanocomposites can act as a potential multifunctional platform for effective magnetic targeting photothermal/chemo dual-modal synergistic therapies with enhanced anti-tumor efficacy and T1/T2-weighted dual modes magnetic resonance imaging (MRI) applications in vivo.
- |||||||||| Trial completion, Enrollment change: PETAL: Positron Emission Tomography Guided Therapy of Aggressive Non-Hodgkin's Lymphomas (clinicaltrials.gov) - May 4, 2017
P3, N=1073, Completed, It is confirmed that biocompatible DOX-MnFe2O4@mSiO2 nanocomposites can act as a potential multifunctional platform for effective magnetic targeting photothermal/chemo dual-modal synergistic therapies with enhanced anti-tumor efficacy and T1/T2-weighted dual modes magnetic resonance imaging (MRI) applications in vivo. Active, not recruiting --> Completed | N=696 --> 1073
- |||||||||| Matulane (procarbazine hydrochloride) / Leadiant Biosci
Enrollment closed: HD17 for Intermediate Stage Hodgkin Lymphoma (clinicaltrials.gov) - May 3, 2017 P3, N=1100, Active, not recruiting, N=10 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Active, not recruiting
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: External Magnetic Field Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles. (Pubmed Central) - May 1, 2017 Our work demonstrated that larger Fe3O4 nanoparticles, with a diameter of up to 310 nm, exhibited the best magnetic-targeting efficiency mediated by an external MF and the strongest antitumor efficacy from combination photothermal-chemotherapy. Our results could serve as a valuable reference for the future design of MNPs and their targeted delivery via the modulation of an external MF.
- |||||||||| methotrexate / Generic mfg., doxorubicin hydrochloride / Generic mfg., vincristine / Generic mfg.
Biomarker, Journal: Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study. (Pubmed Central) - May 1, 2017 Children were more likely to die when inadvertently overdosed by more than 115% of the correct dose of cyclophosphamide (a HR=1.43 [0.84 to 2.43]), or doxorubicin (a HR=1.25, [0.66 to 2.35]), compared to those receiving accurate doses of the respective agent in this setting. This study codifies risk factors associated with poor outcomes for eBL patients in Africa and provides a benchmark by which to assess improvements in survival for new chemotherapeutic approaches.
- |||||||||| metformin / Generic mfg., doxorubicin hydrochloride / Generic mfg., vincristine / Generic mfg.
Trial initiation date, Combination therapy: Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) (clinicaltrials.gov) - Apr 28, 2017 P1, N=14, Active, not recruiting, Trial primary completion date: Mar 2017 --> Jun 2018 Initiation date: Mar 2011 --> Jul 2011
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche, Imbruvica (ibrutinib) / AbbVie, J&J
New P1/2 trial: Ibrutinib, Bortezomib and Rituximab-CHOP for the Treatment of Elderly Patients With CD20+ DLBCL, IPI ? 2 (clinicaltrials.gov) - Apr 26, 2017 P1/2, N=60, Recruiting,
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells. (Pubmed Central) - Apr 26, 2017 Active targeting and active targeting in combination with endo-lysosomal escape have been demonstrated to be the primary function for a nanocarrier against doxorubicin-sensitive and doxorubicin-resistant MCF-7 cells, respectively. These results indicate that the rational design of multifunctional nanocarriers for cancer therapy needs to consider the heterogeneous cancer cells and the primary function needs to be integrated to achieve effective payload delivery.
- |||||||||| Trial primary completion date, Metastases: Combination Chemotherapy, Amifostine, and Peripheral Stem Cell Transplantation in Treating Patients With Stage II, Stage III, or Stage IV Breast Cancer (clinicaltrials.gov) - Apr 25, 2017
P=N/A, N=15, Active, not recruiting, These results indicate that the rational design of multifunctional nanocarriers for cancer therapy needs to consider the heterogeneous cancer cells and the primary function needs to be integrated to achieve effective payload delivery. Trial primary completion date: Mar 2017 --> Jan 2018
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Trial completion, Trial initiation date, Trial primary completion date: Acute Exercise Cardioprotection From Doxorubicin (clinicaltrials.gov) - Apr 24, 2017 P2, N=24, Completed, Trial primary completion date: Dec 2016 --> Aug 2017 Recruiting --> Completed | Initiation date: Jun 2014 --> Jan 2016 | Trial primary completion date: Dec 2015 --> May 2016
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Biomarker, Journal: Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin. (Pubmed Central) - Apr 22, 2017 These findings suggest that deguelin has potent anticancer effects against pancreatic cancer and potentiates the anti-cancer effects of doxorubicin. These findings provide evidence that combined treatment with deguelin and doxorubicin represents an effective strategy for treating pancreatic cancer.
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