- |||||||||| Herceptin (trastuzumab) / Roche, Perjeta (pertuzumab) / Roche
Trial primary completion date: Paclitaxel + Trastuzumab + Pertuzumab as Pre-Op for Inflammatory BrCa (clinicaltrials.gov) - Sep 10, 2018 P2, N=23, Active, not recruiting, Trial completion date: Nov 2018 --> Nov 2019 | Trial primary completion date: Nov 2018 --> Nov 2019 Trial primary completion date: Jun 2018 --> Dec 2018
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Enhanced Drug Delivery to the Skin Using Liposomes. (Pubmed Central) - Sep 4, 2018 In an in vivo model, LTSLs containing doxorubicin (dox) as a marker were administered intravenously to rats that were exposed locally to mild hyperthermia...Development of more hydrophilic immunosuppressants in the future would increase the applicability of this system in the treatment of rejection reactions in vascularized composite allotransplantation. The treatment of other skin condition might be another potential application.
- |||||||||| Matulane (procarbazine hydrochloride) / Leadiant Biosci
Enrollment closed, Enrollment change, Trial primary completion date: Procarbazine Hydrochloride Capsule (Natulan (clinicaltrials.gov) - Sep 4, 2018 P=N/A, N=92, Active, not recruiting, The treatment of other skin condition might be another potential application. Not yet recruiting --> Active, not recruiting | N=184 --> 92 | Trial primary completion date: Feb 2020 --> Dec 2018
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Does doxorubicin survive thermal ablation? Results of an ex vivo bench top study. (Pubmed Central) - Sep 2, 2018 Contrary to the initial hypothesis, tissue DOX concentration progressively decreased after MWA of longer ablation times. These results suggest that TACE followed by ablation may result in lower intratumoral DOX than would otherwise be anticipated for TACE alone.
- |||||||||| Imbruvica (ibrutinib) / AbbVie, J&J
Trial primary completion date, Combination therapy: SELENE : A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma (clinicaltrials.gov) - Aug 31, 2018 P3, N=403, Active, not recruiting, Completed --> Terminated; The study was terminated due to lack of accrual. Trial primary completion date: Jul 2019 --> Jul 2020
- |||||||||| Arenegyr (NGR-hTNF) / AGC Biologics
Trial completion, Trial completion date, Trial primary completion date, Combination therapy, Metastases: NGR007: Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Metastatic Small Cell Lung Carcinoma (clinicaltrials.gov) - Aug 29, 2018 P2, N=28, Completed, Active, not recruiting --> Completed | Trial completion date: Jun 2017 --> May 2016 Active, not recruiting --> Completed | Trial completion date: Jun 2016 --> Nov 2015 | Trial primary completion date: Jun 2016 --> Nov 2015
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Enrollment closed: ReChiVe: Prospective Multicentric Evaluation of a Bladder Preservation Strategy (clinicaltrials.gov) - Aug 29, 2018 P2, N=77, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Jun 2016 --> Nov 2015 | Trial primary completion date: Jun 2016 --> Nov 2015 Recruiting --> Active, not recruiting
- |||||||||| Herceptin (trastuzumab) / Roche, Perjeta (pertuzumab) / Roche
Trial completion date, Combination therapy, Metastases: BERENICE: A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer (clinicaltrials.gov) - Aug 29, 2018 P2, N=401, Active, not recruiting, Recruiting --> Active, not recruiting Trial completion date: Dec 2020 --> Aug 2020
- |||||||||| Lartruvo (olaratumab) / Eli Lilly
Trial completion, Trial completion date, Combination therapy, Monotherapy: A Study of Olaratumab (LY3012207) in Participants With Soft Tissue Sarcoma (clinicaltrials.gov) - Aug 24, 2018 P1b, N=40, Completed, Not yet recruiting --> Recruiting | Initiation date: Mar 2018 --> Aug 2018 Active, not recruiting --> Completed | Trial completion date: Jun 2019 --> Jul 2018
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Trial completion, Enrollment change, Trial completion date: Lenalidomide and R-CHOP in B-cell Lymphoma (clinicaltrials.gov) - Aug 23, 2018 P1/2, N=108, Completed, Active, not recruiting --> Completed Active, not recruiting --> Completed | N=30 --> 108 | Trial completion date: Jan 2012 --> Nov 2015
- |||||||||| Oncaspar liquid (pegaspargase) / Servier
Trial completion date: Treatment of Acute Lymphoblastic Leukemia in Children (clinicaltrials.gov) - Aug 21, 2018 P3, N=800, Active, not recruiting, Trial completion date: Jun 2022 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2019 Trial completion date: Jun 2018 --> Jun 2019
- |||||||||| Lartruvo (olaratumab) / Eli Lilly
Trial completion date, Metastases: A Study of Olaratumab in Japanese Participants With Advanced Cancer (clinicaltrials.gov) - Aug 16, 2018 P1, N=18, Active, not recruiting, Trial completion date: Apr 2018 --> Dec 2018 | Trial primary completion date: Apr 2018 --> Dec 2018 Trial completion date: Sep 2018 --> Mar 2019
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, P2 data, Journal: R-CHOP, radioimmunotherapy, and maintenance rituximab in untreated follicular lymphoma (SWOG S0801): a single-arm, phase 2, multicentre study. (Pubmed Central) - Aug 16, 2018 P2 However, most discontinuations occurred during maintenance therapy, suggesting that rituximab over a 4-year span is not feasible for many patients. Nonetheless, this sequential therapeutic strategy resulted in good overall outcomes for patients, including a low incidence of early disease progression.
- |||||||||| Nerofe (84AA-API 14AA) / Immune System Key
New P1 trial, Combination therapy, Metastases: Safety and Efficacy of IV Nerofe (clinicaltrials.gov) - Aug 15, 2018 P1b, N=24, Not yet recruiting,
- |||||||||| Yondelis (trabectedin) / Otsuka, PharmaMar, Valeo Pharma, J&J, Lartruvo (olaratumab) / Eli Lilly
Trial completion date, Trial initiation date, Trial primary completion date, Combination therapy, Metastases: Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent Leiomyosarcoma (clinicaltrials.gov) - Aug 14, 2018 P1, N=30, Not yet recruiting, N=27 --> 0 | Not yet recruiting --> Withdrawn Trial completion date: Jul 2022 --> Oct 2022 | Initiation date: Jul 2018 --> Oct 2018 | Trial primary completion date: Jul 2020 --> Oct 2020
- |||||||||| Aranesp (darbepoetin alfa) / Amgen, Kyowa Kirin
Trial completion date, Trial primary completion date: Erythropoietin for Management of Anemia Caused by Chemotherapy (clinicaltrials.gov) - Aug 8, 2018 P2, N=53, Active, not recruiting, Trial completion date: Sep 2018 --> Sep 2019 | Trial primary completion date: Sep 2018 --> Sep 2019 Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018
- |||||||||| Lartruvo (olaratumab) / Eli Lilly
Enrollment closed, Trial completion date, Combination therapy, Monotherapy: A Study of Olaratumab (LY3012207) in Participants With Soft Tissue Sarcoma (clinicaltrials.gov) - Aug 8, 2018 P1b, N=40, Active, not recruiting, Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018 Completed --> Active, not recruiting |Trial completion date: Jul 2018 --> Jun 2019
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