- |||||||||| Zortress (everolimus) / Novartis, Rituxan (rituximab) / Roche, Biogen
Clinical, Journal: Extreme hypercalcemia in a kidney transplant recipient. (Pubmed Central) - Apr 7, 2019
Despite all therapeutic interventions, the patient died of septic shock in the intensive care unit on the 10th day of emergency service admission. Importance of hemodialysis as an emergent treatment modality in extreme hypercalcemia, and unfavorable course of PTLD were underlined.
- |||||||||| doxorubicin hydrochloride / generics
Journal: INU-LA-PEG-FA coated SPIONs loading doxorubicin for solid tumour chemotherapy. (Pubmed Central) - Apr 7, 2019
...For this purpose, a dual targeted redox-responsive drug delivery system, prepared by coating superparamagnetic nanoparticles (SPIONs) with the amphiphilic copolymer INU-LA-PEG-FA and loading doxorubicin (DOXO-SPIONs) was investigated as tool for solid tumor chemotherapy...Accumulation by magnetic attraction was used as synergistic targeting strategy. Improved anticancer activity was demonstrated in mice by evaluating tumor volume reduction, immunohistochemical analyses and imaging properties using magnetic resonance imaging (MRI).
- |||||||||| doxorubicin hydrochloride / generics
Journal: Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging. (Pubmed Central) - Apr 7, 2019
Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.
- |||||||||| doxorubicin hydrochloride / generics
Clinical, Journal, Combination therapy: Efficacy and safety of transarterial chemoembolization with 70- to 150-μm drug-eluting beads alone or in combination with 100- to 300-μm drug-eluting beads. (Pubmed Central) - Apr 6, 2019
To evaluate the safety and efficacy of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma, a retrospective analysis of patients who underwent TACE utilizing up to one vial of LC BeadM1 (70-150 μm) embolics with doxorubicin was performed...The median progression-free survival was 282 days. In conclusion, drug-eluting bead TACE with 70- to 150-μm embolics alone or in combination with 100- to 300-μm embolics is safe and demonstrates good disease control, particularly with small, solitary tumors.
- |||||||||| doxorubicin hydrochloride / generics
Biomarker, Clinical, Journal, PARP Biomarker, IO Biomarker: MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy. (Pubmed Central) - Apr 5, 2019
...Direct inhibition of miR-7641 using a locked nucleic acid upregulated the expression of its target genes, sensitized cancer cells, and enhanced the efficiency of therapeutic agents such as doxorubicin...Thus, miR-7641 might be a clinically important cancer biomarker. Inhibition of miR-7641 expression could be an efficient treatment strategy for clinical patients.
- |||||||||| Zarzio (filgrastim biosimilar) / Novartis
Clinical, P3 data, Journal: Safety and efficacy of alternating treatment with EP2006, a filgrastim biosimilar, and reference filgrastim: a phase 3, randomised, double-blind clinical study in the prevention of severe neutropenia in patients with breast cancer receiving myelosuppressive chemotherapy. (Pubmed Central) - Apr 5, 2019
This phase III randomised, double-blind registration study in patients with breast cancer receiving (neo)adjuvant myelosuppressive chemotherapy (TAC; docetaxel + doxorubicin + cyclophosphamide) compares reference filgrastim, Neupogen® (Amgen), with two groups receiving alternating treatment with reference and biosimilar every other cycle...No neutralising antibodies were detected. There were no clinically meaningful results regarding efficacy, safety or immunogenicity when switching from reference to biosimilar filgrastim/EP2006, or vice versa.
- |||||||||| metformin / generics, doxorubicin hydrochloride / generics
Preclinical, Journal: Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. (Pubmed Central) - Apr 5, 2019
A three compound combination study found that enterolactone and metformin together in combination with relatively low concentrations of chemotherapeutic drugs were able to significantly decrease cancer cell viability, compared to low concentrations of the individual chemotherapeutic drug alone. Our in vitro evaluation suggests a future direction in improving chemotherapeutic efficacy in breast cancer by adjuvant therapy with the flaxseed lignans.
- |||||||||| fluorouracil / generics, doxorubicin hydrochloride / generics, cyclophosphamide intravenous / generics
Clinical, Journal: Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China. (Pubmed Central) - Apr 5, 2019
Our in vitro evaluation suggests a future direction in improving chemotherapeutic efficacy in breast cancer by adjuvant therapy with the flaxseed lignans. The diagnosis of PLS is difficult before operation due to its nonspecific manifestations, and the high survival rate can be achieved by radical resection with adjuvant chemotherapy.
- |||||||||| doxorubicin hydrochloride / generics
Journal: Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy. (Pubmed Central) - Apr 5, 2019
Moreover, the therapeutic potential of doxorubicin-loaded NKsome shows promising antitumor activity in vivo against MCF-7 induced tumor model. Overall results illustrate the therapeutic advantages of NK cell biomimicry capable of communicating like immune cells for cooperative drug delivery.
- |||||||||| cisplatin / generics, doxorubicin hydrochloride / generics
Preclinical, Journal, IO Biomarker: Naringenin palliates cisplatin and doxorubicin gonadal toxicity in male rats. (Pubmed Central) - Apr 5, 2019
Moreover, NG significantly decreased the testicular histopathological injury, and immunohistochemical expression of inducible nitric oxide synthase induced by CP and DX in rat testes. It was concluded that NG impeded gonadotoxicity of CP and DX in male rats by mitigating oxidative stress, nitrosative stress, inflammation, and apoptosis.
- |||||||||| doxorubicin hydrochloride / generics
Journal: A novel extracellular matrix-based leukemia model supports leukemia cells with stem cell-like characteristics. (Pubmed Central) - Apr 5, 2019
...When treated with a high-dose of doxorubicin, leukemia cells in DWJM demonstrated less apoptosis compared with cells in suspension...Leukemia cell culture in DWJM was associated with increased N-cadherin expression by flow cytometry. Our data suggest that DWJM could serve as an ECM-based model to study AML stem cell-like cell behavior and chemotherapy sensitivity.
- |||||||||| doxorubicin hydrochloride / generics
Journal: SDF-1-loaded PLGA Nanoparticles for the Targeted Photoacoustic Imaging and Photothermal Therapy of Metastatic Lymph Nodes in Tongue Squamous Cell Carcinoma. (Pubmed Central) - Apr 5, 2019
...Herein, we developed multifunctional targeted polymeric nanoparticles (NPs) loaded with indocyanine green (ICG) and doxorubicin (DOX) for the targeted photoacoustic imaging and photothermal ablation of oral cancer cells...The encapsulated drug (DOX) was released immediately after the liquid core was transformed into a gas via laser effects, which killed tumour cells while producing strong photoacoustic signals in vitro and in vivo. Thus, we concluded that the chemokine SDF-1 can be applied for the targeted chemotherapy of metastatic lymph nodes of oral squamous cell carcinoma (OSCC) and is more effective for treating oral cancer when combined with photothermal therapy than when used alone.
- |||||||||| doxorubicin hydrochloride / generics
Journal: Investigations into the DNA-binding mode of doxorubicinone. (Pubmed Central) - Apr 5, 2019
Study of the well-known DNA-intercalating agent, doxorubicin, and its aglycone, doxorubicinone, was undertaken using a variety of spectroscopic and calorimetric techniques. It was found that, despite conservation of the planar, aromatic portion of doxorubicin, the agylcone does not intercalate; it instead likely binds to the DNA minor-groove.
- |||||||||| doxorubicin hydrochloride / generics
Journal: Toxicological study of doxorubicin-loaded PLGA nanoparticles for the treatment of glioblastoma. (Pubmed Central) - Apr 5, 2019
Functional and morphological abnormalities caused by the nanoparticulate doxorubicin were dose-dependent and reversible. Altogether these results provide evidence that the PLGA-based nanoformulation not only might enable the broadening of the spectrum of doxorubicin activity but also an improvement of its safety profile.
- |||||||||| doxorubicin hydrochloride / generics
Journal: Co-delivery of hydrophobic and hydrophilic drugs by graphene decorated magnetic dendrimer. (Pubmed Central) - Apr 5, 2019
The cellular uptake images revealed higher drug internalization for co-loaded nanocarrier than the nanocarrier loaded with one drug alone. All of the results showed that the co-delivery of curcumin and doxorubicin by the presence nanocarrier was more effective in chemotherapy than the nanocarrier loaded with one drug.
- |||||||||| doxorubicin hydrochloride / generics
Journal: Biocompatibility studies of intravenously administered ionic-crosslinked chitosan-BSA nanoparticles as vehicles for antitumour drugs. (Pubmed Central) - Apr 5, 2019
In this study, a new alternative of ionic crosslinked nanoparticles (NPs) based on chitosan (C) and bovine serum albumin (A; BSA) was evaluated as drug delivery system for antitumour compounds (doxorubicin hydrochloride as a model)...In vivo results suggested that the selected proportions of chitosan-BSA created nonhemolytic and biocompatible stable NPs at the selected dose of 20mg/kg. Despite the different formulations, this study demonstrated that these NPs could serve as safe drug carriers in further in vivo investigations.
- |||||||||| avadomide (CC-122) / BMS
Enrollment closed, Enrollment change, Trial completion date, Combination therapy: Study of Safety and Efficacy of Avadomide (CC-122) Combined With RCHOP for Newly-diagnosed DLBCL With Poor Risk Factors (clinicaltrials.gov) - Apr 5, 2019
P1/2, N=35, Active, not recruiting,
These cells could mediate tumor formation, in addition to traditional ISCs. Recruiting --> Active, not recruiting | N=82 --> 35 | Trial completion date: May 2022 --> Jan 2021
- |||||||||| doxorubicin hydrochloride / generics
Journal: Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin. (Pubmed Central) - Apr 5, 2019
Taken together, inhibition of P-gp function and disruption of the metabolism of energy and related amino acids could be the key mechanisms by which UA could reverse the MDR. The findings also indicated that UA could be a potential alternative adjuvant antitumour herbal medicine to resensitize cells with MDR to chemotherapeutic agents.
- |||||||||| Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
Enrollment closed, Combination therapy: Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Apr 5, 2019
P2, N=60, Active, not recruiting,
Confocal laser scanning microscope and flow cytometry showed that the PMV nanogels exhibit an enhanced cellular uptake by tumor cells at pH 6.5 compared with pH 7.4, which allows for a severe cytotoxic effect of DOX-loaded PMV nanogels against tumor cells. Recruiting --> Active, not recruiting
- |||||||||| doxorubicin hydrochloride / generics
Journal: Dual-responsive molybdenum disulfide/copper sulfide-based delivery systems for enhanced chemo-photothermal therapy. (Pubmed Central) - Apr 5, 2019
...The resultant material has a particle size of approximately 115 nm, and can be loaded with doxorubicin (DOX) to a loading capacity of 162.3 mg DOX per g of carrier...Overall, the functionalized MoS material developed in this work exhibits great potential as an efficient system for dual responsive drug delivery and synergistic chemo-photothermal therapy. The route employed in our work thus provides a strategy to enhance photothermal efficacy for transition metal dichalcogenide drug delivery systems.
- |||||||||| doxorubicin hydrochloride / generics
Preclinical, Journal: Milk and kefir maintain aspects of health during doxorubicin treatment in rats. (Pubmed Central) - Apr 5, 2019
We observed no consistent protective effects with respect to heart dimensions and function. These findings suggest that long-term milk or kefir ingestion may be helpful in optimizing health before and during doxorubicin treatment.
- |||||||||| sotigalimab (APX005M) / Apexigen
Enrollment open, Combination therapy, Metastases: APX005M and Doxorubicin in Advanced Sarcoma (clinicaltrials.gov) - Apr 5, 2019
P2, N=27, Recruiting,
The constructed mesoporous FCA-SBA-15 composite material provides an integrated nanoplatform to exert controlled-delivery of anti-cancer drug molecules. Not yet recruiting --> Recruiting
- |||||||||| doxorubicin hydrochloride / generics
Journal: Framework nucleic acids as programmable carrier for transdermal drug delivery. (Pubmed Central) - Apr 5, 2019
Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers.
- |||||||||| aldoxorubicin (INNO-206) / NantWorks
Biomarker, Review, Journal: Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date. (Pubmed Central) - Apr 4, 2019
Despite the negative results from this Phase III study, the importance of anthracycline therapy in sarcoma management merits further investigation of the potential role of aldoxorubicin in this indication. Other avenues for progress include identification of sensitive histologies and biomarkers of activity, exploration of clinical niches without proven standard therapies, and exploration of alternate dosing strategies.
- |||||||||| doxorubicin hydrochloride / generics
Journal: 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body. (Pubmed Central) - Apr 4, 2019
...The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects...Problems related to blood clots, vein wall dissection, and other biocompatibility issues were not observed. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.
- |||||||||| paclitaxel / generics, doxorubicin hydrochloride / generics, cyclophosphamide intravenous / generics
Journal: Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer. (Pubmed Central) - Apr 4, 2019
These results support the hypothesis that PNA works through the inhibition of extracellular superoxide/ROS production leading to the conversion of 4T1 cells from a metastatic tumorigenic state to a cytostatic state. These findings support future clinical trials of PNA as an antimetastatic SOD3-mimetic drug to increase overall survival in TNBC patients.
- |||||||||| Adcetris (brentuximab vedotin) / Takeda, Pfizer
Enrollment closed: LCCC1637: BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma (clinicaltrials.gov) - Apr 4, 2019
P2, N=28, Active, not recruiting,
These findings support future clinical trials of PNA as an antimetastatic SOD3-mimetic drug to increase overall survival in TNBC patients. Recruiting --> Active, not recruiting
|
