doxorubicin hydrochloride / Generic mfg. 
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  • ||||||||||  deferiprone / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression. (Pubmed Central) -  Sep 20, 2024   
    Transcriptomic data from patients with different etiologies demonstrated the relevance of iron accumulation in the progression of liver chronic damage and fibrosis, correlating with a SASP-related gene signature and pivotal hallmarks of fibrotic changes. Altogether, our study establishes iron accumulation as a clinically exploitable driver to attenuate pathological senescence in hepatocytes.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  IKK?-STAT3-S727 axis: a novel mechanism in DOX-induced cardiomyopathy. (Pubmed Central) -  Sep 20, 2024   
    Doxorubicin (DOX) is an effective chemotherapeutic drug, but its use can lead to cardiomyopathy, which is the leading cause of mortality among cancer patients...In conclusion, the IKK?-STAT3-S727 signaling pathway was found to play a crucial role in DOX-induced cardiomyopathy. Targeting this pathway could be a promising therapeutic strategy for treating DOX-related heart failure.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Trigonelline alkaloid is effective in preventing doxorubicin-induced lung damage. (Pubmed Central) -  Sep 20, 2024   
    In contrast, TRIG pretreatment partially suppressed apoptosis and decreased inflammation by blocking the activation of the MAPK/NF-?B pathway, lowering IL-6 levels, and protecting the lung from apoptotic cell death. Assessing TRIG's effectiveness in lung tissue injury, this study may be a crucial first step.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Drug Binding and Delivery with Supramolecular System Based on Sodium Carboxymethylcellulose and Viologen Calix[4]resorcinol. (Pubmed Central) -  Sep 20, 2024   
    When there is excess of macrocycle, the nanoparticles bind lipophilic oleic acid, and when there is excess of polymer, they bind hydrophilic doxorubicin...The nanoparticles of triple composition (polymer/macrocycle/drug) have a more effective penetration ability into these cells than those of double composition (polymer/drug). The presented results are the first step towards the creation of new nanotechnologies to improve the bioavailability and delivery of bioactive components.
  • ||||||||||  cyclophosphamide / Generic mfg., paclitaxel / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Pneumocystis jirovecii Pneumonia in Patients Treated for Solid Organ Malignancy. (Pubmed Central) -  Sep 19, 2024   
    Although this approach leads to improved disease-free and overall survival, it has also been associated with an increased risk of developing Pneumocystis jirovecii pneumonia. Further research involving patients receiving dose-dense chemotherapy regimens is needed to determine their risk of developing opportunistic infections and whether that risk warrants changes in clinical management.
  • ||||||||||  Journal:  Recurrent Intracranial Ewing Sarcoma. (Pubmed Central) -  Sep 19, 2024   
    Treatments are individualized based on the patient's response to treatment and the decisions of tumor boards. Patients with rare tumors such as Ewing sarcoma benefit from multidisciplinary collaboration, resulting in improved quality of care and treatment outcomes.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Nanocarrier-based drug delivery system with dual targeting and NIR/pH response for synergistic treatment of oral squamous cell carcinoma. (Pubmed Central) -  Sep 15, 2024   
    Thus, a novel dual-targeted nano-loading system, DOX@GO-HA-HN-1 (GHHD), was created for synergistic chemotherapy and PTT by the co-modification of carboxylated graphene oxide (GO) with hyaluronic acid (HA) and HN-1 peptide and loading with the anticancer drug doxorubicin (DOX)...In addition, chemo-photothermal combination therapy for cancer treatment was realized by causing cell apoptosis under the irradiation of 808-nm laser. In summary, the application of GHHD to chemotherapy combined with photothermal therapy for OSCC is shown to have important potential as a means of combatting the low accumulation of single chemotherapeutic agents in tumors and drug resistance generated by single therapeutic means, enhancing therapeutic efficacy.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Cancer cell-derived exosome based dual-targeted drug delivery system for non-small cell lung cancer therapy. (Pubmed Central) -  Sep 15, 2024   
    We successfully promoted the targeted delivery of anti-drug doxorubicin (DOX) at the cellular levels by combining the homing targeted ability of exosomes with the magnetic targeted ability of SPIONs...It was found that exosome-SPIONs (Exo-SPIONs) loaded with DOX exhibited optimal tumor tissue delivery and tumor suppression in the presence of an external magnetic field, and reduced the toxicity of the DOX to normal tissues. The constructed "dual-targeting" anti-cancer drug delivery platform holds promise for targeted chemotherapy for NSCLC.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Incorporation of CuS nanorods in polyelectrolyte multilayer microcapsules improved cancer cell cytotoxicity and signal intensity in ultrasound imaging. (Pubmed Central) -  Sep 15, 2024   
    In this study, we have developed poly(allylamine) hydrochloride (PAH)/dextran sulfate (DS) polyelectrolyte MCs capable of carrying doxorubicin (DOX) for targeted cancer therapy and ultrasound imaging...Further, the capsules showed better echogenicity than that of control PAH/DS MCs when imaged under medical ultrasound-scanning system. Hence, the MCs demonstrated in this study have huge potential for targeted cancer theranostics by offering an option to image the cancer cells during the treatment period.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  Self-assembled metal-polyphenolic based multifunctional nanomedicine to improve therapy treatment of pancreatic cancer by inhibition of glutamine metabolism. (Pubmed Central) -  Sep 15, 2024   
    Herein, we propose an effective assembly strategy to synthesize a novel metal-polyphenolic based multifunctional nanomedicine (Fe-DBEF) containing Pluronic F127 stable ferric ion crosslinked epigallocatechin gallate (EGCG) nanoparticles loaded with GLS1 inhibitor bis-2-(5-phenylacetamino-1,3,4-thiadiazole-2-yl) ethyl sulfide (BPTES) and chemotherapy drug doxorubicin (DOX)...Additionally, excessive ROS production also aggravates DNA damage caused by DOX, synergistically sensitizing chemotherapy and promoting apoptosis for efficient treatment of pancreatic cancer. Overall, our findings suggest that inhibiting glutamine metabolism to increase the sensitivity of chemotherapy/CDT using metal-polyphenolic based multifunctional nanomedicine provides a promising combination of multiple therapeutic means for treating pancreatic cancer.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity. (Pubmed Central) -  Sep 15, 2024   
    In summary, our findings underscore the pivotal role of the P62-autophagy pathway in SLC7A11 degradation, modulating ferroptosis to exacerbate DIC. This finding offers significant insights into the underlying molecular mechanisms of DOX-induced ferroptosis and identifies new targets for reversing DIC.
  • ||||||||||  bleomycin / Generic mfg., cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification. (Pubmed Central) -  Sep 15, 2024   
    Knockdown of TAPBP inhibited the JAK/STAT/MICB signaling pathway in CC cells and upregulated certain immune genes including ISG15, IRF3, PTPN6, and HLA-A. These findings offer insights into the involvement of genetic variations in TAPBP in the development and progression of CC.
  • ||||||||||  verapamil / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Lathyrane diterpenoids with multidrug resistance reversal activity from the tubers of Euphorbia antiquorum. (Pubmed Central) -  Sep 15, 2024   
    Their reversal ability against P-glycoprotein-mediated multidrug resistance (MDR) in MCF-7/ADR cell line was then evaluated, and 15 ones exhibited moderate MDR reversal activity with reversal fold falling in the range of 1.12-13.15. The most active euphorantester B could effectively increase the sensitivity of MCF-7/ADR cell to adriamycin comparably to the reference drug verapamil.
  • ||||||||||  cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin. (Pubmed Central) -  Sep 14, 2024   
    Furthermore, MTT cell viability assays revealed that the enhanced DNA-damaging capability of complex 1 resulted in superior cytotoxicity and selectivity against human cancer cells compared to cisplatin, doxorubicin, or their combination. Overall, the development of this amphiphilic Pt(IV)-doxorubicin conjugate represents a new form of combination therapy with improved therapeutic efficacy.
  • ||||||||||  Journal, IO biomarker:  Design, Synthesis, and Anticancer and Antibacterial Activities of Quinoline-5-Sulfonamides. (Pubmed Central) -  Sep 14, 2024   
    All the compounds were also tested against reference strains Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 and representatives of multidrug-resistant clinical isolates of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis...Its efficacies were comparable to those of cisplatin/doxorubicin and oxacillin/ciprofloxacin...In additional tests, compound 3c decreased the expression of H3, increased the transcriptional activity of cell cycle regulators (P53 and P21 proteins), and altered the expression of BCL-2 and BAX genes in all cancer lines. The unsubstituted phenolic group at position 8 of the quinoline is the key structural fragment necessary for biological activity.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Biomarker, Journal:  Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer. (Pubmed Central) -  Sep 14, 2024   
    Doxorubicin (DOX), a commonly used anticancer agent, causes cardiotoxicity that begins with the first dose and may progress to heart failure years after treatment...We demonstrate that circulating levels of PGLYRP1, CAMP, MMP9, and CEACAM8 can predict the cardiotoxicity of DOX. This novel finding may be of value in the early identification of patients at risk for cardiotoxicity.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Preclinical, Journal:  Aerobic Exercise Attenuates Doxorubicin-Induced Cardiomyopathy by Suppressing NLRP3 Inflammasome Activation in a Rat Model. (Pubmed Central) -  Sep 14, 2024   
    While regular exercise did not entirely prevent DOX-induced hypotension, our findings demonstrate that it confers protection against DOX-induced cardiotoxicity by suppressing NLRP3 inflammasome activation in the heart, underscoring its anti-inflammatory role. Further research should explore the temporal dynamics and interactions among exercise, pyroptosis, and other pathways in DOX-induced cardiotoxicity to enhance translational applications in cardiovascular medicine.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Biomarker, Journal, Tumor microenvironment:  Synergistic Photothermal Therapy and Chemotherapy Enabled by Tumor Microenvironment-Responsive Targeted SWCNT Delivery. (Pubmed Central) -  Sep 14, 2024   
    After doxorubicin hydrochloride (DOX), used as the model drug, was loaded by CNT carriers, functional nano-delivery systems (HD/CNTs-SS-ICG@DOX) were developed...The in vivo antitumor activity results in tumor-bearing model mice, further verifying that HD/CNTs-SS-ICG@DOX inhibited tumor growth most significantly by mediating a synergistic effect between chemotherapy and PTT, while various functional nanosystems have shown good biological tissue safety. In conclusion, the composite CNT delivery systems developed in this study possess the features of high biocompatibility, targeted delivery, and responsive drug release, and can achieve the efficient coordination of chemotherapy and PTT, with broad application prospects in cancer treatment.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal, PD(L)-1 Biomarker, IO biomarker:  PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients. (Pubmed Central) -  Sep 14, 2024   
    In U2OS cells, PAK4 was involved in the stabilization of PD-L1 from ubiquitin-mediated proteasomal degradation and the in vivo infiltration of immune cells such as regulatory T cells and PD1-, CD4-, and CD8-positive cells in mice tumors. In conclusion, this study suggests that PAK4 is involved in the progression of osteosarcoma by promoting proliferation, invasion, and resistance to doxorubicin and stabilized PD-L1 from proteasomal degradation.
  • ||||||||||  cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal, Surgery:  Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Sarcomatosis. (Pubmed Central) -  Sep 14, 2024   
    In conclusion, this study suggests that PAK4 is involved in the progression of osteosarcoma by promoting proliferation, invasion, and resistance to doxorubicin and stabilized PD-L1 from proteasomal degradation. (3) Ten patients with a median age of 46.1 years (range: 23-77 years) with metachronous (40%) or synchronous (60%) peritoneal sarcomatosis from six different tumor entities were treated according to tumor board recommendation using CRS and HIPEC with cisplatin and doxorubicin over 60 min at 42.0
  • ||||||||||  cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  The synergistic mechanisms of propofol with cisplatin or doxorubicin in human ovarian cancer cells. (Pubmed Central) -  Sep 14, 2024   
    In summary, repurposing propofol could provide novel insights into the existing chemotherapy strategies for ovarian cancer. It holds promise for overcoming resistance to cisplatin or doxorubicin and may potentially reduce the required chemotherapy dosages and associated side effects, thus improving treatment outcomes.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg., trimetazidine / Generic mfg.
    Journal:  An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress. (Pubmed Central) -  Sep 14, 2024   
    Accordingly, the treatment with the lipid oxidation inhibitor Trimetazidine concomitantly with stressful stimuli limits ROS accumulation and prevents long-term heart dysfunction. These findings disclose a physiologic mechanism of metabolic regulation in the heart and demonstrate that a timely restriction of lipid metabolism represents a potential therapeutic strategy to improve cardiac resilience to stress.
  • ||||||||||  doxorubicin hydrochloride / Generic mfg.
    Journal:  In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy. (Pubmed Central) -  Sep 14, 2024   
    The reaction temporarily impaired the phase separation of histones in vitro, favoured the initiation of liquid-liquid phase separation within cells and led to the formation of biomolecular condensates that were sufficiently large to be retained within tumour cells. The controlled formation of biomolecular condensates as drug reservoirs within cells may offer new options for boosting the efficacies of cancer therapies.