- |||||||||| doxorubicin hydrochloride / Generic mfg.
3D printed Biosponge adsorbers for capturing chemotherapy drugs before they spread through the body (In-person; Galerie 6 (New Orleans Marriott)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_1941;
The surface of porous cylinders was coated with an ion-containing nanostructured block polymer which is responsible for capturing doxorubicin, a widely used chemotherapy drug with significant toxic side effects...Additional improvement may be obtained by changing the chemical composition of the selective membrane layer and controlling the lattice structure and size with elastomers. The proposed approach can help patients fight cancer.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Functionalization of framboidal boronic acid nanoparticles via aqueous Suzuki-Miyaura coupling reactions for drug delivery applications (In-person; Hall B, Room 8 (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_507;
Using this catalyst system, we show that BNPs can be functionalized with carboxylic acids, aldehyde and hydrazide groups while keeping their original framboidal morphology. Furthermore, the potential of the functionalized BNP in drug delivery applications is demonstrated by conjugating the hydrogen sulfide (H2S)-releasing compound anethole dithiolone to carboxylic acid-functionalized BNPs and doxorubicin to hydrazide-functionalized BNPs.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Construction of an Injectable Composite Double-Network Hydrogel as a Liquid Embolic Agent. (Pubmed Central) - Mar 12, 2024
A two-dimensional nanosheet, i.e., layered double hydroxide (LDH), was incorporated into the network through physical interactions which led to serious reduction of yield stress for the injection of the hydrogel and the capacity for loading therapeutic agents like indocyanine green (ICG) and doxorubicin (DOX) for the functions of photothermal therapy (PTT) and chemotherapy...These characteristics met the requirements of arterial interventional embolization, which was demonstrated by renal embolism operation on rabbits, and meanwhile favored the inhibition of subcutaneous tumor growth on an animal model. Therefore, this work makes a breakthrough in the case of largely reducing the embolism risks, thus affording a novel generation for interventional embolization.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: iRGD-targeted Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Delivery. (Pubmed Central) - Mar 11, 2024
We then show that iRGD-targeted PhMV loaded with the chemotherapeutic doxorubicin shows increased potency in a murine flank xenograft model of cancer. Our results validate that PhMV-like nanoparticles can be targeted to tumors through iRGD-peptide conjugation and suggest that iRGD-PhMV provides a promising platform for the targeted delivery of molecular cargo to tumors.
- |||||||||| Journal: A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer. (Pubmed Central) - Mar 11, 2024
Many drugs are employed to give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites (5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin); such treatment is associated with significant adverse effects...The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumor cells in vitro with relevant mechanistic visualization...In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another study, CTS was used in the synthesis of SeNPs and then situated into CTS/citrate gel, resulting in Se loaded nanoparticles. These formulations were found to be more successful in cancer treatment.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Exosomal miR-122-3p represses the growth and metastasis of MCF-7/ADR cells by targeting GRK4-mediated activation of the Wnt/?-catenin pathway. (Pubmed Central) - Mar 11, 2024
This study was to reveal the correlation of miR-122-3p expression with BC metastasis and Adriamycin (ADM) resistance and its mechanism of inhibiting BC metastasis...Data from xenograft experiments further suggest that excess miR-122-3p and MCF-7-derived exosomes inhibit the growth and metastasis of MCF-7/ADR cancer cells in vivo. In conclusion our data reveal that exosomal miR-122-3p may negatively regulate BC growth and metastasis, potentially serving as a diagnostic and druggable target for BC treatment.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal, PARP Biomarker: USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy. (Pubmed Central) - Mar 11, 2024
In conclusion, these findings suggest that Dox promotes DIC progression by activating USP36-mediated PARP1 deubiquitination. This novel USP36/PARP1 axis may play a significant regulatory role in the pathogenesis of DIC.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release. (Pubmed Central) - Mar 8, 2024
Using multiple physicochemical characterization techniques, we demonstrate that poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) scaffolds can be efficiently modified with a coumarin derivative, doxorubicin, and camptothecin small molecule drugs...In addition, we report the pharmacokinetics, biodistribution, and antitumor efficacy of a PVDMA-based polymer for the first time, demonstrating unique accumulation patterns based on the administration route (i.e., intravenous vs oral), efficient tumor uptake, and tumor growth inhibition in 4T1 orthotopic triple negative breast cancer (TNBC) xenografts. This work establishes the utility of PVDMA as a versatile chemical platform for producing polymer-drug conjugates with a tunable, stimuli-responsive delivery.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Engineered triphenylphosphonium-based, mitochondrial-targeted liposomal drug delivery system facilitates cancer cell killing actions of chemotherapeutics. (Pubmed Central) - Mar 8, 2024
The resultant PCDA-TPP and PCDA-DAN conjugates were incorporated into a 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-based lipid bilayer, and these modified liposomes (Lip-DT) were studied for their cellular toxicity, mitochondrial targeting ability, and efficacy in delivering the drug Doxorubicin (Dox) to human colorectal carcinoma (HCT116) and human breast (MCF7) cancer cells in vitro...The ability of Lip-DT-Dox to trigger cellular toxicity in both HCT116 and MCF7 cancer cells was comparable to the known cell-killing actions of the unencapsulated drug (Dox). The findings in this study reveal a promising approach where conventional liposome-based drug delivery systems can be rendered mitochondria-specific by incorporating well-known mitochondriotropic moieties onto the surface of the liposome.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Review, Journal: Revisiting luteolin: An updated review on its anticancer potential. (Pubmed Central) - Mar 8, 2024
It exhibits antioxidant properties and can be given to patients receiving Doxorubicin (DOX) chemotherapy to prevent the development of unexpected adverse reactions in the lungs and hematopoietic system subjected to DOX...Accordingly, this review covers the recent literature related to the use of luteolin against different types of cancer, along with the mechanisms of action. In addition, the review highlights luteolin as a complementary medicine for preventing and treating cancer.
- |||||||||| Rituxan (rituximab) / Roche
TUBULOINTERSTITIAL NEPHRITIS AND ACUTE RENAL FAILURE: A CASE OF PRIMARY RENAL LYMPHOMA (TUE-234; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1903;
This entity is characterized by an infiltration of inflammatory cells in the renal interstitial area. Renal biopsy remains as the gold standard to diagnose this entity in where probable cause can be guided with the type of inflammatory cells involved.
- |||||||||| Rituxan (rituximab) / Roche
TUBULOINTERSTITIAL NEPHRITIS AND ACUTE RENAL FAILURE: A CASE OF PRIMARY RENAL LYMPHOMA (TUE-233; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1902;
This entity is characterized by an infiltration of inflammatory cells in the renal interstitial area. Renal biopsy remains as the gold standard to diagnose this entity in where probable cause can be guided with the type of inflammatory cells involved.
- |||||||||| Rituxan (rituximab) / Roche
FROM HODGKIN'S LYMPHOMA TO NEPHROTIC SYNDROME: A DIAGNOSTIC PUZZLE UNVEILED (SAT-260; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1649;
Additionally, it is remarkable how the patient's systemic response to steroids was swift. At the renal level, we believe that the presence of fibrillary and immunotactoid patterns secondary to IgG4RD contributed to the persistent proteinuria and subsequent renal failure.
- |||||||||| Rituxan (rituximab) / Roche
Drug-Induced Acute Interstitial Nephritis (TUE-102; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1144;
It should be considered even in the absence of clinical or laboratory signs of hypersensitivity. Prompt discontinuation of any suspected medication and corticosteroid therapy remain the appropriate management to improve prognosis.
- |||||||||| ifosfamide / Generic mfg.
RARE KIDNEY COMPLICATIONS WITH IFOSFAMIDE: INSIPIDUS DIABETES AND KIDNEY TUBULAR ACIDOSIS (TUE-051; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_704;
Although infrequent, these adverse effects require vigilant monitoring, particularly concerning dose, treatment duration, and patient's renal status. Early diagnosis and effective management of these complications are crucial, underscoring importance of renal monitoring as an integral component of clinical management when using this chemotherapeutic agent.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
ATYPICAL HEMOLYTIC SYNDROME INDUCED BY PEMBROLIZUMAB. MANAGEMENT AND OUTCOMES (SUN-005; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_688;
Contrary to the prior reports of Pembrolizumab related MAHA and HLH, use of corticosteroids and PLEX was not effective presumably due to the different mechanisms of immune injury. Prompt response to Eculizumab with complete renal and hematologic recovery points to the novel pathway of how Pembrolizumab can affect the immune system on the level of complement regulatory proteins.
- |||||||||| cisplatin / Generic mfg., cyclophosphamide / Generic mfg., doxorubicin hydrochloride / Generic mfg.
A Case of Thymoma-associated Paraneoplastic Encephalitis with Identification of a Novel Neuronal Antibody (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3542;
Patients with subacute onset of neurological decline may need evaluation for autoimmune encephalitis and paraneoplastic syndromes. With ongoing rapid expansion of antibody detection capabilities, it's important to describe phenotype-specific presentations of paraneoplastic encephalitis that may aid early detection of malignancy.
- |||||||||| cyclophosphamide / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Angioimmunoblastic T Cell Lymphoma Presenting as Subacute Sensorimotor Peripheral Neuropathy (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3493;
Patient was started on infusions of doxorubicin and cyclophosphamide. This case highlights the importance of establishing a broad differential and diagnostic workup for rapidly progressive neuropathy with unique features.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: Oxidized cellulose-filled double thermo/pH-sensitive hydrogel for local chemo-photothermal therapy in breast cancer. (Pubmed Central) - Mar 7, 2024
The composite hydrogel incorporated with tempo-oxidized cellulose nanofiber (TOCN), polyvinyl alcohol (PVA) and a polydopamine (PDA) coating for photothermal therapy (PTT) triggered in situ release of doxorubicin (DOX) drug was utilized to optimize postoperative strategies of malignant tumors inhibition...Then the TOCN/PVA7-PDA@DOX hydrogel is implanted into the tumor resection cavity for local in vivo chemo-photothermal synergistical therapy to ablate residue tumor tissues. Overall, this work suggests that such a chemo-photothermal hydrogel delivery system has great potential as a promising tool for the postsurgical management of breast cancer.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Opdivo (nivolumab) / Ono Pharma, BMS
Journal, PD(L)-1 Biomarker, IO biomarker: Primary pulmonary histiocytic sarcoma with high PD-L1 expression benefited from immunotherapy: A case report and bioinformatic analysis. (Pubmed Central) - Mar 7, 2024
Here, we report a 45-year-old man who was diagnosed with primary pulmonary histiocytic sarcoma with systemic metastases, with partial remission (PR) treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but it relapsed soon after therapy above. Following that, we found that the genetic alteration of PD-L1 was associated with poor prognosis in sarcoma patients in terms of overall survival (OS) (p?=?1.51?
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Journal: A Fe(III) intercalated clay nanoplatform for combined chemo/chemodynamic therapy. (Pubmed Central) - Mar 7, 2024
A Fe(III) intercalated montmorillonite nanoplatform (Fe-MMT) was engineered for doxorubicin (DOX) loading. The constructed Fe-MMT/DOX nanoplatform could not only improve the production of H2O2 to enhance chemodynamic therapy but interfere with DNA damage repair to amplify the efficacy of DOX, proving an ideal combination of chemotherapy and chemodynamic therapy.
- |||||||||| Verzenio (abemaciclib) / Eli Lilly
Preclinical, Journal, Combination therapy, PARP Biomarker: Combination therapy application of Abemaciclib with Doxorubicin in triple negative breast cancer cell line MDA-MB-231. (Pubmed Central) - Mar 6, 2024
For this reason, in this study, we aimed to determine the impact of the combined use of the CDK4/6 inhibitors ABE and DOX on the cytotoxicity, apoptotic homeostasis, alterations in antioxidative mechanisms, and the molecular pathways that they utilize. Our results showed that when used in combination, Doxorubicin and Abemaciclib showed a synergistic effect on TNBC cell line MDA-MB-231.
- |||||||||| cyclophosphamide / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Deconvolution of breast cancer dissemination and therapy resistance via single-cell transcriptional lineage tracing (Section 11) - Mar 5, 2024 - Abstract #AACR2024AACR_9767;
scRNAseq analyses of pro-metastatic, circulating and metastatic clones is ongoing.Our preliminary data showed that all the dominant clones in the metastatic lungs are also found as CTCs in the bloodstream, thus suggesting that all pro-metastatic cells are also capable of surviving in the bloodstream and reinforcing our concept of pro-metastatic clone. This approach led us to gain a complete overview around clonal and transcriptional evolution of breast cancer dissemination.
- |||||||||| Applications of a novel fibrous extracellular matrix for advanced in vitro cancer models (Section 6) - Mar 5, 2024 - Abstract #AACR2024AACR_9715;
The primary cells from human tumors formed cell clusters resembling the original tumor tissue's structure. In conclusion, the novel micro-fibrous scaffold, closely mimicking natural extracellular matrixes, promotes significant cell-to-cell and cell-to-matrix interactions, while also facilitating cell growth over extended periods providing a more physiologically relevant platform for evaluating drug responses for various cancer cell types, further showing the importance of 3D culture systems in cancer research.
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