- |||||||||| Journal: Engineering Low Volume Resuscitants for the Prehospital Care of Severe Hemorrhagic Shock. (Pubmed Central) - Jul 22, 2024
We demonstrate that a radiant star poly(glycerol monomethacrylate) polymer did not interfere with coagulation while successfully correcting metabolic deficit and resuscitating animals from hemorrhagic shock to the desired mean arterial pressure range for DCR - correcting a 60% total blood volume (TBV) loss when given at only 10% TBV. This highly portable and non-coagulopathic resuscitant has profound potential for application in trauma medicine.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Journal: Transition of (Pubmed Central) - Aug 8, 2023
In this swine model of NCTH, hemodynamics and survival were improved when the REBOA balloon was transitioned from zone 3 to zone 1 during an impending cardiovascular collapse. Furthermore, these improved outcome data support the pursuit of additional research into mitigating ischemia-reperfusion insult to the abdominal viscera while still providing excellent resuscitative support, such as intermittent or partial REBOA.
- |||||||||| tranexamic acid oral / Generic mfg., Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Preclinical, Journal: Characterization of Combined Blast- and Fragment-Induced Pelvic Injuries and Hemostatic Resuscitation in Rabbits. (Pubmed Central) - Mar 2, 2023
Furthermore, these improved outcome data support the pursuit of additional research into mitigating ischemia-reperfusion insult to the abdominal viscera while still providing excellent resuscitative support, such as intermittent or partial REBOA. We herein established in rabbits a blast- and fragment-induced pelvic injury animal model that exhibited high reproducibility, and we demonstrated that hemostatic resuscitation plus DCS was effective in improving the outcome.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Preclinical, Journal: Serum from rats subjected to traumatic brain injury and hemorrhagic shock induces profound endothelial barrier dysfunction. (Pubmed Central) - May 14, 2022
These results suggest that exposure to CCI-HS leads to production of humoral factors causing early and late-phase barrier disruptive effects in lung vascular endothelium. While thrombin-PAR1 signaling has been identified as mechanism of acute EC permeability increase by CCI-HS serum, the factor(s) defining long-term EC barrier disruption in CCI-HS model remain to be determined.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Journal: Fluid Resuscitation in Tactical Combat Casualty Care; TCCC Guidelines Change 21-01. 4 November 2021. (Pubmed Central) - Jan 7, 2022
Presently, an expanding body of literature suggests that fluid resuscitation strategies for casualties in hemorrhagic shock that include the prehospital use of cold-stored or fresh whole blood when available, or blood components when whole blood is not available, are superior to crystalloid and colloid fluids. On the basis of this recent evidence, the Committee on Tactical Combat Casualty Care (TCCC) has conducted a review of fluid resuscitation for the combat casualty who is in hemorrhagic shock and made the following new recommendations: (1) cold stored low-titer group O whole blood (CS-LTOWB) has been designated as the preferred resuscitation fluid, with fresh LTOWB identified as the first alternate if CS-LTOWB is not available; (2) crystalloids and Hextend are no longer recommended as fluid resuscitation options in hemorrhagic shock; (3) target systolic blood pressure (SBP) resuscitation goals have been redefined for casualties with and without traumatic brain injury (TBI) coexisting with their hemorrhagic shock; and (4) empiric prehospital calcium administration is now recommended whenever blood product resuscitation is required.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Unraveling the Cytoprotective Effects of Valproic Acid: A Transcriptomics Meta-Analysis of Transfusion Strategies for Hemorrhagic Shock and Traumatic Brain Injury (GWCC - Hall B5, Level 1) - Nov 5, 2021 - Abstract #ASH2021ASH_4917;
These genes are involved in a variety of biological processes such as cell division, neurogenesis, coagulation, cytoskeleton, and inflammation. These results suggest that VPA treatment may promote an environment that favors the restoration of hemostasis, production of new neurons, removal of damaged cells, and attenuation of inflammation.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Preclinical, Journal: Efficacy of past, present, and future fluid strategies in an improved large animal model of non-compressible intra-abdominal hemorrhage. (Pubmed Central) - Sep 30, 2021
Survival data support the movement away from HEX toward NS and, preferably, FWB in clinical practice and translational animal modeling. The presented model allows for future research including basic science, as well as translational studies of novel diagnostics, therapeutics, and devices.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Journal: Effects of Early Altitude Exposure on the Open Abdomen After Laparotomy in Trauma. (Pubmed Central) - Jul 31, 2020
Contrary to our hypothesis, we found that AE in those animals with open abdomens is relatively safe with no difference in mortality compared to those with closed abdomens. However, given the physiologic and inflammatory changes observed in animals with open abdomens, further evaluation is necessary prior to definitive recommendations regarding the safety or downstream effects of exposure to AE prior to definitive abdominal closure.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, Lineage Cell Therap
Preclinical, Journal: Early Identification of Acute Lung Injury in a Porcine Model of Hemorrhagic Shock. (Pubmed Central) - Jun 11, 2020
Our study demonstrates the reproducibility of a porcine model of hemorrhagic shock that is consistent with physiologic changes in humans in hemorrhagic shock. Pulmonary neutrophil infiltration may serve as an early marker for ALI; however, the practicality of this finding has yet to be determined.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, BioTime
Clinical, Journal: Efficacy of the Abdominal Aortic Junctional Tourniquet-Torso Plate in a Lethal Model of Noncompressible Torso Hemorrhage. (Pubmed Central) - Jun 30, 2019
A future multi-functional resuscitative fluid including an asanguineous, oncotic, non-oxygen carrying component to facilitate intra-vascular volume expansion and a component with synthetic coagulation factors and fibrinogen to deter coagulopathy may show equivalence to whole blood. The AAJT-TP did not provide any survival benefit compared with Hextend alone in this model of noncompressible torso hemorrhage.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, BioTime
Journal: Thromboelastographic analysis of novel polyethylene glycol based low volume resuscitation solutions. (Pubmed Central) - Apr 24, 2019
Hydroxocobalamin restored blood pressure more effectively than no treatment and as effectively as hydroxyethyl starch but did not adversely affect coagulation. In conclusion, PEG-20k based LVR solutions produced a dose-dependent minor hypocoagulative state, possibly associated with changes in clot propagation and platelet function, which can be reversed by dose reduction in concentration while providing superior LVR, microvascular rescue, and lactate clearance compared to saline or starch.
- |||||||||| Hextend (6% hetastarch in lactated electrolyte) / Korea Kolmar, Pfizer, BioTime
Clinical, Journal: Efficacy of the perfluorocarbon dodecafluoropentane as an adjunct to pre-hospital resuscitation. (Pubmed Central) - Apr 23, 2019
DDFPe administration with FFP does not improve survival or enhance tissue oxygenation. However, given similar survival rates of Hextend and FWB, there is evidence that an ideal MRF should contain an element of volume expansion to enhance oxygen delivery.
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