Recruiting

4

60

 

conbercept ;Lucentis

Shangdong Provincial Hospital; Shangdong Provincial Hospital, Shandong Nature Science Foundation

retina branch vein occlusion

 

 

Recruiting

4

36

 

subconjunctival injection conbercept ;subconjunctival injection 5-Fu

Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University, none

open angle glaucoma

 

 

Recruiting

4

48

 

subconjunctival injection of conbercept ;subconjunctival injection of 5-Fu

Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University, none

pterygium

 

 

Recruiting

4

120

 

Intravitreous injection of Conbercept 1 day before vitrectomy ;Intravitreous injection of Conbercept 3 days before vitrectomy ;Intravitreous injection of Conbercept 5 days before vitrectomy ;Intravitreous injection of Conbercept 7 days before vitrectomy ;Sham intravitreous injection of Conbercept 3 days before vitrectomy ;patients with macular hole receiving vitrectomy

The first affiliated hospital of Nanjing Medical University; The first affiliated hospital of Nanjing Medical University, National Key R&D Program of China (2017YFA0104101)

diabetic retinopathy

 

 

Not yet recruiting

4

40

 

intravitreal Conbercept injection ;intravitreal Conbercept injection

Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, Affiliated Hospital of Qingdao University

Branch Retinal Vein Occlusion

 

 

Not yet recruiting

4

300

 

Conbercept ;Ranibizumab

Guizhou Provincial People's Hospital; Guizhou Provincial People's Hospital, Independently

Age-related macular degeneration

 

 

Not yet recruiting

4

105

 

1+prn ;3+prn ;3+q2m

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 首都医科大学附属北京同仁医院

diabetic macular edema

 

 

Recruiting

4

100

 

Anti-vegf drugs were followed by PRP ;PRP, anti-vegf drug when necessary

Shandong Eye Institute; Shandong Eye Institute, Chengdu Kanghong Pharmaceutical Group Co.,Ltd.

diabetic retinopathy

 

 

Completed

4

500

 

Intravitreal injection of Conbercept Ophthalmic Injection ;Intravitreal injection of Conbercept Ophthalmic Injection

Peking University People's Hospital; Chengdu Kanghong Biotechnology Co., LTD, Chengdu Kanghong Biotechnology Co., LTD

Neovascular age-related macular degeneration

 

 

Not yet recruiting

4

105

 

intravitreal injection of Conbercept ;panretinal photocoagulation

Shanghai General Hospital; Shanghai General Hospital, Major clinical research project of Shanghai Shenkang hospital development center

diabetic retinopathy

 

 

Completed

4

140

 

Group 1 were treated with a T&E regimen and received intravitreal injection of Conbercept (0.5 mg); Group 2 were treated with a T&E regimen and received intravitreal injection of Aflibercept (2 mg)

The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, National Natural Science Founding of China(NO.81670881)

neovascular age-related macular degeneration

 

 

Recruiting

4

80

 

Joint injection ;Anti-VEGF therapy

Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Beijing Bethune Public Welfare Foundation

retinal vein occlusion

 

 

Not yet recruiting

4

516

 

Intravitreal injection of Conbercept before PPV + PPV ;Intravitreal injection of Conbercept at the end of PPV+PPV ;PPV without intravitreal injection of Conbercept

Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, China Ophthalmic Treatment Research Fund

Proliferative Diabetic retinopathy

 

 

Recruiting

4

58

RoW

Conbercept

Shanghai Eye Disease Prevention and Treatment Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Diabetic Macular Edema

12/24

07/25

Recruiting

4

104

 

Standard PRP therapy was followed by intravitreal injection (IVC) of compacept ;The standard PRP is given before intravitreal conbercept

The Second Affiliated Hospital of Xi'an Jiaotong University; 157 Xiwu Road, Xincheng District, self-funded

diabetic retinopathy

 

 

Recruiting

3

20

 

conbercept combined with Ozurdex ;conbercept

Department of Ophthalmology, Central Theater Command General Hospital,; Central Theater Command General Hospital of PLA, Self-raised funds

Central retinal vein occlusion

 

 

Enrolling by invitation

2/3

60

RoW

different degrees of adjustment of the injection interval, Modified Treat-and-Extend Regimens

First Affiliated Hospital of Chongqing Medical University

Exudative Age-Related Macular Degeneration

08/23

08/24

Completed

2

156

RoW

intravitreal injection of RC28-E, Conbercept

RemeGen Co., Ltd.

Diabetic Macular Edema

07/23

07/23

Recruiting

1

40

 

Phacoemulsification for cataract + intravitreal Conbercept injection ;Phacoemulsification for cataract

the 4th affiliated hospital of CMU; the 4th affiliated hospital of CMU, Conbercepts are provided by the Kanghong biological technology co.

cataract with diabetic macular edema

 

 

Completed

N/A

60

 

Intravitreal injection of anti-VEGF drugs

The First Hospital of Qiqihar; The First Hospital of Qiqihar, Self-financing

Proliferative Diabetic Retinopathy

 

 

Not yet recruiting

N/A

60

 

intravitreal urokinase combined with triamcinolone acetonide ;no interfere ;intravitreal injection of urokinase combined with conbercept

Xi'an 1st Hospital; Xi'an Fourth Hospital, self-financed

dense vitreous hemorrhage following various retinal disease

 

 

Recruiting

N/A

35

 

intravitreal Conbercept injection

Qingdao University Affiliated Hospital; Qingdao University Affiliated Hospital, Qingdao University Affiliated Hospital

branch retinal vein occlusion

 

 

Recruiting

N/A

20

 

subconjunctival conbercept injection 0.05 ml(10 mg/ml)

Eye & ENT Hospital of Fudan University; Eye & ENT Hospital of Fudan University, self-financing

ocular chemical injury.

 

 

Recruiting

N/A

40

 

intraocular injection of Conbercept(KH902) with a dose at 0.5mg at the time points of plaque removal and the month 1, 2, 5, 8, 11 after plaque removal

Beijing Tongren Hospital, Capital Medical University; Beijing Tongren Hospital, Capital Medical University, Management Committee of Bai Qiuen Foundation

Uveal Melanoma

 

 

Recruiting

N/A

30

 

intravitreal Conbercept injections

Zhongshan Ophthalimic Center; ZhongShan Ophthalimic Center, The department of macular disease, ZhongShan Ophthalimic Center

choroidal neovascularization secondary to rare macular diseases

 

 

Recruiting

N/A

90

 

intravitreal injection of conbercept/intravitreal injection of triamcinolone acetonide ;intravitreal injection of conbercept/intravitreal injection of triamcinolone acetonide

The second Hospital of Dalian Medical University; The second Hospital of Dalian Medical University, Bethune - Langmu Young and middle-aged ophthalmic research fund (Beijing Bethune Public Welfare Foundation, No.BJ-LM2015009L)

Retinal vein occlusion

 

 

Recruiting

N/A

120

 

vitrectomy ;intravitreal injection of conbercept combined with vitrectomy therapy according to iris fluorescein angiography ;intravitreal injection of conbercept combined with vitrectomy therapy

Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Hospital

proliferative diabetic retinopathy

 

 

Recruiting

N/A

40

 

Cyclosporine A eye drops 3 days before and 3months after glaucoma surgery ;Subconjunctiva injection of conbercept during glaucoma surgery

Eye and ENT Hospital of Fudan University; Eye and ENT Hospital of Fudan University, Self-funding

glaucoma

 

 

Recruiting

N/A

50

RoW

Conbercept and TA, Combined agents, Conbercept, Single agent

Zhongshan Ophthalmic Center, Sun Yat-sen University

Diabetes Mellitus, Type 2, Macular Edema

06/21

12/21

Not yet recruiting

N/A

300

 

conbercept ;Lucentis

Affiliate Eye hospital of Wenzhou Medical University; Peking University People's Hospital; Affiliate Eye hospital of Wenzhou Medical University, Chengdu Kanghong Biotechnology Co., Ltd.

Pathologic Myopia

 

 

Not yet recruiting

N/A

100

 

3+PRN (pro re nata) ;6+PRN(pro re nata)

Inner Mongolia Chaoju Eye Hospital; Inner Mongolia Chaoju Eye Hospital, Chengdu Kanghong Biotechnologies Co. Ltd

Diabetic macular edema

 

 

Enrolling by invitation

N/A

1000

RoW

Chengdu Kanghong Biotech Co., Ltd., Guangzhou Keli Medical Research Co., Ltd.

Retinopathy of Prematurity

10/22

10/22

Enrolling by invitation

N/A

226

RoW

intravitreal injection of conbercept, KH-902 (Chengdu Kanghong Biotech Co., Ltd., Sichuan, China), PRP

Sun Yat-sen University

Proliferative Diabetic Retinopathy

12/22

12/22

Recruiting

N/A

72

 

No intravitreal injection of conbercept during pars plana vitrectomy ;intravitreal injection of conbercept during pars plana vitrectomy

Tongji Hospital of Tongji University; Tongji Hospital of Tongji University, Study on the mechanism of metabolic time and pathway of different anti VEGF drugs in eyes (Project No.: QT1501)

diabetic retinopathy

 

 

Not yet recruiting

N/A

80

 

Intravitreal injection of Conbercept + Oral administration of Shenling Baizhu Powder ;Intravitreal injection of Conbercept

Guangdong Hospital of Traditional Chinese Medicine/ The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, National Natural Science Foundation of China (82074499)

Diabetic macular edema

 

 

Not yet recruiting

N/A

40

 

Intravitreal injection of Conbercept ;Intravitreal injection of Conbercept and Ozurdex

Shandong Eye Hospital Ethics Committee; Shandong Eye Hospital Ethics Committee, Natural Science Foundation of Shandong Province（ZR2021MH074）；National Natural Science Foundation of China Youth Foundation（82101164）

Retinopathy

 

 

Recruiting

N/A

102

RoW

Vitrectomy combined with ILM peeling, Conbercept intravitreal injection

Tianjin Medical University Eye Hospital

Diabetic Macular Edema, Pars Plana Vitrectomy, Conbercept

09/25

09/26

Recruiting

N/A

120

 

Anti-VEGF drug (ranibizumab, Aflibercept, or Conbercept) combined with dexamethasone implant in the baseline; After two weeks of anti-VEGF, then combined with dexamethasone implant ; After three injections of anti-VEGF treatment, then combined with dexamethasone implant

Nanning Aier Eye Hospital; Nanning Aier Eye Hospital

retinal vein occlusion secondary to macular edema

 

 

Not yet recruiting

N/A

150

 

Intraocular injection of conbercept (0.5 mg, 0.05 mL), an anti-VEGF fusion protein injection, will be performed once a month. Regarding the method, antibiotic eye drops are applied to the eyes 3 days before surgery to prevent infection. Pre-operative ocular ultrasound and dilated fundus examination are performed to determine whether there is a proliferative membrane in the retina that can cause retinal detachment, and the injection site should not be chosen at the proliferative membrane. The injection site is selected at 3.5 mm away from the corneal edge for the eyes without a lens and 4.0 mm away from the corneal edge for the eyes with the lens. The needle tip is beveled toward the direction of the optic nerve when injecting, and when removing the needle, the pinhole is clamped using microsurgery forceps for 5 seconds. Injections will be given as needed after 3 consecutive months. The indication for re-injection is the central macular thickness > 250 μm. ;Patients will undergo pan-retinal?photocoagulation using a 532 nm laser (Quantel Medical, France) in four sessions at an interval of 7 days. Pan-retinal photocoagulation will be performed as follows: green light at a wavelength of 532 nm is applied to disseminate photocoagulation from beyond the vascular arch of the macula to the periphery of the four quadrants, completed in 3-4 sessions, with a spot diameter of 200-300 μm, exposure time of 0.20-0.25 s, energy of 200-300 mW, class II-III spot, and 2000-2200 spot counts. All procedures will be performed by the same physician. ;Intraocular injection of conbercept (0.5 mg, 0.05 mL) will be given once a month for 3 consecutive months, during which pan-retinal photocoagulation will be performed 3-4 times in total.

Department of Ophthalmology, Affiliated Hospital of Beihua University; Department of Ophthalmology, Affiliated Hospital of Beihua University, This work was supported by Science and Technology Research Project of Jilin Provincial Department of Education (No. JJKH20220072KJ to XL) and Science and Technology Development Program of Jilin Province (No. 20200201495JC to YL).

diabetic macular edema

 

 

Not yet recruiting

N/A

60

 

3 times anti VEGF+1 time Ozurdex+1 time anti VEG; 3 times anti VEGF+1 time anti VEGF+1 time anti VEGF

Inner Mongolia Chaoju Eye Hospital; Inner Mongolia Chaoju Eye Hospital, Chengdu Kanghong Biotechnology Co., Ltd.

Diabetic macular edema (DME)

 

 

Recruiting

N/A

1000

RoW

Ranibizumab, Aflibercept, Conbercept

Wenbin Wei

Neovascular Age-related Macular Edema, Diabetic Macular Edema, Choroidal Neovascular Membrane, Non-proliferative Diabetic Retinopathy, Retinal Vein Occlusion, Proliferative Diabetic Retinopathy

01/23

05/23