Cytovene (ganciclovir) / Roche 
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 268 Diseases   30 Trials   30 Trials   2139 News 


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  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease. (Pubmed Central) -  Mar 2, 2020   
    Her fever and systemic symptoms improved rapidly with initiation of intravenous ganciclovir. She was transitioned to and maintained on oral valganciclovir until two and half months after discharge when her symptoms and lab abnormalities had fully subsided.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), fluconazole / Generic mfg.
    Journal:  Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery. (Pubmed Central) -  Feb 26, 2020   
    We compared the barrier properties of several RPE secondary cell lines (ARPE19, ARPE19mel, and LEPI) and both primary (hfRPE) and stem-cell derived RPE (hESC-RPE) cells by investigating the permeability of nine drugs (aztreonam, ciprofloxacin, dexamethasone, fluconazole, ganciclovir, ketorolac, methotrexate, voriconazole, and quinidine) across cell monolayers...Therefore, ARPE19, ARPE19mel, and hfRPE cells failed to form a tight barrier, whereas hESC-RPE and LEPI cells restricted the drug flux to a similar extent as bovine RPE-choroid. Therefore, LEPI and hESC-RPE cells are valuable tools in ocular drug discovery.
  • ||||||||||  Prevymis (letermovir) / Merck (MSD)
    Clinical, Journal:  Use of Letermovir as Salvage Therapy for Drug-resistant CMV Retinitis: A Case Series. (Pubmed Central) -  Feb 22, 2020   
    All patients improved clinically without known adverse drug events. However, three patients failed to maintain virologic suppression, including two patients who developed genotypically-confirmed resistance to letermovir while on therapy.
  • ||||||||||  Prevymis (letermovir) / Merck (MSD), Vistide (cidofovir) / Gilead
    Journal:  Letermovir (Prevymis) for CMV prophylaxis. (Pubmed Central) -  Feb 15, 2020   
    Thus, losartan has the potential to decrease TM fibrosis in patients with CMV-induced hypertensive anterior uveitis. No abstract available
  • ||||||||||  Foscavir (foscarnet) / Pfizer, Clinigen, Cytovene (ganciclovir) / Roche, Tamiflu (oseltamivir) / Gilead, Roche
    Loss of transgender identity following human herpesvirus-6 encephalitis () -  Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1161;    
    Conclusions : Loss of transgender identity in a patient with status epilepticus, bitemporal edema on MRI, and CSF positive for HHV-6. Also how recommended accommodations for transgender patients can be implemented in an inpatient rehabilitation facility.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with cytomegalovirus infection in a patient diagnosed with HIV infection: a case report. () -  Feb 11, 2020 - Abstract #ISPRM2020ISPRM_624;    
    At the end of the pharmacological therapy with Ganciclovir, the patient showed a decrease in pain intensity by 50% and improvement in gait pattern.Discussions : One of the manifestations of HIV infection in the nervous system is CIDP and several microorganisms are associated with that. This case with documented CMV infection associated with HIV infection too, showed clinical improvement after the use of ganciclovir as the main therapy, did not require the use of corticosteroids or immunotherapy as suggested in the current management guidelines, which shows complementary evidence of the use of other medications for treatment that neuropathy.Conclusions : The management of CIDP is mainly based on corticosteroids and immunotherapy according to the clinic guide, but this case shows the effectiveness to control the primary cause, such as coinfection with CMV in a patient with HIV infection.
  • ||||||||||  cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Roche, Biogen
    Clinical, Journal:  A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis. (Pubmed Central) -  Feb 9, 2020   
    The patient is dialysis dependent, unlike most previously described patients with atypical anti-GBM disease. The course was complicated by CMV pneumonitis, which contributed to the severity of the pulmonary manifestations and added diagnostic difficulty.
  • ||||||||||  Orencia (abatacept) / BMS, Vistide (cidofovir) / Gilead, sirolimus / Generic mfg.
    [VIRTUAL] SUCCESSFUL HSCT IN IMMUNE DISREGOLATORY DISEASES (ePoster Area) -  Feb 8, 2020 - Abstract #EBMT2020EBMT_2183;    
    The increasing control of post-transplant complications with the reduction of TRM also allows us to submit to HCST also pathologies that do not have an explicit indication. The outcome is one of better quality of life with the resolution of disabling symptoms.
  • ||||||||||  [VIRTUAL] EPIDEMIOLOGY, RISK FACTORS AND OUTCOMES OF CMV INFECTION IN ADULTS UNDERGOING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT (HCT): A SINGLE INSTITUTIONAL COHORT STUDY (ePoster Area) -  Feb 8, 2020 - Abstract #EBMT2020EBMT_1985;    
    From a retrospective cohort of 1,283 seropositive adults who underwent HCT at Stanford University from January 2009 to May 2019, we analyzed 1,107 adults after the exclusion of patients on letermovir (N=78), who received a second HCT (N=78), or were not screened (N=8)...From 2015-2017 umbilical cord blood (UCB) recipients received valacyclovir 2000 mg thrice daily...Median overall antiviral exposure through D+100 was 30 days (range 0-100); ganciclovir (54%) was the most common initial agent used [median exposure 24 days (range 1-92)] vs 39% valganciclovir [median 25d (1-93d)] vs 7% foscarnet [median 10d (0-53d)]... Despite effective preemptive therapy strategies, CMV infection remains a significant and common complication of HCT and to have a measurable impact on patients and healthcare system.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Human cytomegalovirus pneumonia in an immunocompetent patient: a very uncommon but treatable condition. (Pubmed Central) -  Feb 8, 2020   
    He made a rapid recovery after initiation of ganciclovir and has been doing well on follow-up visits...This article highlights the importance of considering CMV as a cause of pneumonia even in immunocompetent individuals, especially when the more common causes have been excluded. Early diagnosis allows prompt treatment and potentially complete recovery.
  • ||||||||||  Relenza (zanamivir) / GSK, Vaxart
    Journal:  Potential antiviral therapeutics for 2019 Novel Coronavirus (Pubmed Central) -  Feb 6, 2020   
    Drugs are possibly effective for 2019-nCoV include: remdesivir, lopinavir / ritonavir, lopinavir / ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics. (Pubmed Central) -  Feb 1, 2020   
    Here we have investigated and are reporting for the first time the effect of prodrug ganciclovir (GCV)-preloading (pre-treatment) in suicide gene therapy of cancer...These results suggest that preloading TK modified tumour cells with GCV needs further study to define the most effective strategy for an in vivo application to retain their bystander killing potential after exposure to lethal doses of GCV in vitro. This study highlights the promising possibility of improving the efficacy of pro-drug system to prevent any damage to the immune system and enhancing this type of suicide gene therapy of cancer, as well as the need for further studies to explore the discrepancies between in vitro and in vivo results.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  S-like phase CDKs stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription. (Pubmed Central) -  Jan 29, 2020   
    In this study, we demonstrated that CDK inhibitors induced de-stabilization of the vPIC component BDLF4, leading to a reduction in L gene expression and subsequently progeny production. Our findings suggest that CDK inhibitors may be a therapeutic option against beta- and gamma-herpesviruses in combination with existing inhibitors of herpesvirus lytic replication such as ganciclovir.
  • ||||||||||  Cytovene (ganciclovir) / Roche, Cubicin (daptomycin) / Merck (MSD), Zeftera (ceftobiprole) / Basilea
    Enrollment open:  TANDEM: Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC) (clinicaltrials.gov) -  Jan 27, 2020   
    P=N/A,  N=104, Recruiting, 
    Our findings suggest that CDK inhibitors may be a therapeutic option against beta- and gamma-herpesviruses in combination with existing inhibitors of herpesvirus lytic replication such as ganciclovir. Not yet recruiting --> Recruiting
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal, Oncolytic Virus, IO Biomarker:  Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase. (Pubmed Central) -  Jan 24, 2020   
    The engineering involves replacing the native thymidine kinase (VV-tk) gene, in a Wyeth strain vaccinia backbone, with the herpes simplex virus thymidine kinase (HSV-tk) gene, which allows for viral replication control via ganciclovir (GCV, an antiviral/cytotoxic pro-drug)...This is the first report of OTS-412, a VV-tk deleted OVV containing a mutant HSV-tk transgene, which demonstrates tumor selectivity and sensitivity to GCV. The HSV-tk/GCV combination provides a safety mechanism for future clinical applications of OTS-412.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Cytomegalovirus cholestasis in an immunocompetent host. (Pubmed Central) -  Jan 23, 2020   
    The diagnosis was retained on all clinico-pathologic data after eliminating the autoimmune, surgical and other infectious causes. Resolution of cholestasis has been observed with ganciclovir.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Preclinical, Journal:  Impact of Astrocyte Depletion upon Inflammation and Demyelination in a Murine Animal Model of Multiple Sclerosis. (Pubmed Central) -  Jan 18, 2020   
    Astrocyte depletion was induced by the intraperitoneal administration of ganciclovir during the early and late phase of TME...Furthermore, astrocyte depleted mice showed reduced inflammation and lower numbers of TMEV positive cells in the spinal cord. The present study indicates that astrocyte depletion in virus triggered CNS diseases contributes to a deterioration of clinical signs that are mediated by a dysfunction of perivascular astrocytes.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Inhibition of Cytomegalovirus Replication with Extended Half-Life Synthetic Ozonides. (Pubmed Central) -  Jan 17, 2020   
    In plaque reduction assays, OZ418 inhibited HCMV TB40 in a concentration-dependent manner as well as a ganciclovir (GCV)-resistant HCMV isolate...A parallel pharmacokinetic study with a single oral dose of OZ418 or AS showed a prolonged plasma half-life and higher unbound concentrations of OZ418 compared to AS. In summary, ozonides are proposed as potential therapeutics, alone or in combination with GCV, for HCMV infection in humans.
  • ||||||||||  Cytovene (ganciclovir) / Roche, azathioprine orodispersible / Generic mfg.
    Clinical, Journal:  Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis. (Pubmed Central) -  Jan 15, 2020   
    A bone marrow biopsy showed evidence of haemophagocytosis of platelets, neutrophils and erythrocytes. The azathioprine was stopped, and he received intravenous ganciclovir and corticosteroids with suppression of the CMV viral load and resolution of the HLH.
  • ||||||||||  valacyclovir / Generic mfg., Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Incidence and Impact of Cytomegalovirus in Hematopoietic Cell Transplant Recipients at a Single Center over the Last Decade (World Center Marriott - Palms & Cypress Foyers) -  Jan 14, 2020 - Abstract #TCTASTCTCIBMTR2020TCT_1317;    
    Umbilical cord blood (UCB) recipients received valacyclovir 2000 mg thrice daily...CONCLUSION Despite PET, CMV continues to have a measurable impact on HCT patients. Other analyses include the significance of low grade VL, area under the curve of DNAemia, peak viremia, transfusion requirements, infections, and relapse.
  • ||||||||||  Campath (alemtuzumab) / Sanofi, tacrolimus / Generic mfg., cyclophosphamide intravenous / Generic mfg.
    Parvovirus B19-Associated Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation (World Center Marriott - Palms & Cypress Foyers) -  Jan 14, 2020 - Abstract #TCTASTCTCIBMTR2020TCT_1315;    
    These two cases highlight the importance of including PVB19 PCR in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo-HSCT graft failure.