- |||||||||| Foscavir (foscarnet) / Pfizer, Clinigen
Retrospective data, Journal: Recommended foscarnet dose is not associated with improved outcomes in cytomegalovirus salvage therapy. (Pubmed Central) - Jun 26, 2020
Nanoscale bubble-mediated suicide gene therapy system, bubble-LV5-YCD-TK/GCV/5-FC, acts as a novel therapeutic strategy for bladder cancer treatment. These findings suggest outcomes may be sensitive to other factors and underscore the need for further studies to improve understanding of foscarnet dosing in immunosuppressed patients.
- |||||||||| [VIRTUAL] DRESS to TEN: Multiple Drug Hypersensitivity Syndrome or CMV Reactivation? () - Jun 20, 2020 - Abstract #AADVMX2020AAD-VMX_286;
A 38-year-old female presented with facial and lip edema, non-blanching red patches and plaques involving 90% total body surface area (TBSA) following broad-spectrum antibiotics (cefepime/ceftriaxone/vancomycin/meropenem/micafungin/metronidazole) for necrotizing Klebsiella pneumonia/bacteremia in the setting of diabetic ketoacidosis and respiratory failure...Systemic corticosteroids were initiated with antibiotics (ciprofloxacin/metronidazole/piperacillin-tazobactam/vancomycin/ceftriaxone).The eruption was resolving until 16 days later, when patient developed acute full epidermal skin sloughing over 90%TBSA...Cyclosporine and intravenous immune globulin were initiated...Ganciclovir was started with initial improvement of diarrhea, however she continues to have a tumultuous hospital course...Although reports of overlap exist, there are scarce reports of discrete episodes of DRESS and TEN two weeks apart within one person. Our theory is that the continuation of antibiotics with potential cross-reactivity in the acute phase of DRESS may have induced a drug-elicited syndrome with hyperresponsiveness, compounded by CMV viral reactivation, and rendering the patient more susceptible to develop distinct severe drug reactions.
- |||||||||| Journal: New vaccines and antiviral drugs for cytomegalovirus. (Pubmed Central) - Jun 19, 2020
If there is evidence of control of CMV, this can be related to immune responses induced by the vaccine to define a correlate of protection. This review will summarise the published evidence available.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Golgi membrane protein GP73 modified-liposome mediates the antitumor effect of survivin promoter-driven HSVtk in hepatocellular carcinoma. (Pubmed Central) - Jun 19, 2020
Moreover, tail vein injection of GP73-HSVtk significantly suppressed the growth of xenograft tumors through an apoptosis-dependent pathway and extended the survival of tumor-bearing mice without damaging the mice liver functions. Taken together, this study demonstrates an effective cancer-specific gene therapy strategy using the herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene system for HCC that can be further developed for future clinical trials.
- |||||||||| Review, Journal: Recommendation of Antimicrobial Dosing Optimization During Continuous Renal Replacement Therapy. (Pubmed Central) - Jun 19, 2020
Here, we reviewed the literatures involving in new progresses of antimicrobial dosages, and complied the updated empirical dosing strategies based on CRRT modalities and effluent flow rates. The following antimicrobial agents were included for review: flucloxacillin, piperacillin/tazobactam, ceftriaxone, ceftazidime/avibactam, cefepime, ceftolozane/tazobactam, sulbactam, meropenem, imipenem, panipenem, biapenem, ertapenem, doripenem, amikacin, ciprofloxacin, levofloxacin, moxifloxacin, clindamycin, azithromycin, tigecycline, polymyxin B, colistin, vancomycin, teicoplanin, linezolid, daptomycin, sulfamethoxazole/trimethoprim, fluconazole, voriconazole, posaconzole, caspofungin, micafungin, amphotericin B, acyclovir, ganciclovir, oseltamivir, and peramivir.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Dual-vector prodrug activator gene therapy using retroviral replicating vectors. (Pubmed Central) - Jun 15, 2020
All combinations of the two prodrug activator genes produced synergistic cytocidal effects, but the combined effects of the different genes were significantly greater than those of the same genes when delivered by two different vectors. The present findings indicate the potential utility of dual-vector gene therapy using two different RRVs carrying different prodrug activator genes.
- |||||||||| Vistide (cidofovir) / Gilead
Clinical, Journal: Persistent primary cytomegalovirus infection in a kidney transplant recipient: Multi-drug resistant and compartmentalized infection leading to graft loss. (Pubmed Central) - Jun 15, 2020
To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied...The viral load failed to respond to foscavir, cidofovir and CMV-neutralizing immunoglobulins...Detailed monitoring in this patient demonstrated hallmarks of complicated CMV disease: (i) relatively rapid evolution of drug-resistant CMV mutants in the setting of persistent high blood viral loads, (ii) emergence of viral drug-resistance linked to acute graft rejection, (iii) transient and, thereafter, lack of response to various anti-CMV treatments, (iv) compartmentalization and heterogeneity of CMV viral populations, (v) possible differential ability of viral mutants to cause disease in the graft, and (vi) detection of minor viral variants by next generation sequencing. Translational research platforms that provide rapid molecular genotyping for detection of CMV drug-resistance are essential in guiding CMV disease management in high-risk transplant recipients.
- |||||||||| Imlygic (talimogene laherparepvec) / Amgen, Afinitor (everolimus) / Novartis
Preclinical, Journal, IO Biomarker: The Oncolytic Herpes Simplex Virus Talimogene Laherparepvec Shows Promising Efficacy in Neuroendocrine Cancer Cell Lines. (Pubmed Central) - May 31, 2020
Moreover, virostatic effects of ganciclovir (GCV) on replication of T-VEC were assessed and electron microscopic pictures were taken to comprehend viral envelopment and details of the replication cycle of T-VEC in human neuroendocrine cancer...On the other hand, GCV was shown to be able to limit replication of T-VEC, thus establishing an important safety feature for future treatments of NET/NEC patients. Taken together, T-VEC opens up a promising novel treatment option for NET/NEC patients, warranting its further preclinical and clinical development.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche, Rebif (human IFN-β-1a) / EMD Serono
[VIRTUAL] Epidemiology Cytomegalovirus Infection/Disease in Kidney Transplant Recipients: A Systematic Review of Observational Studies (Virtual) - May 29, 2020 - Abstract #ATC2020ATC_1290;
Our findings highlight that CMV infection/diseased occurred frequently even with similar preventive approaches. Wide variations in the incidence of CMV across studies could be due to differences in the underlying CMV definitions and time points of assessment suggesting the needs for standardizing CMV detection to appropriately quantify burden of CMV across the globe.
- |||||||||| Campath (alemtuzumab) / Sanofi, tacrolimus / Generic mfg.
[VIRTUAL] Graft versus Host Disease in a Liver Transplant Patient (Virtual) - May 29, 2020 - Abstract #ATC2020ATC_1014;
Ann Transplant 2012). It should be considered in patients presenting with skin lesions, fever, GI symptoms and a negative infectious work up.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Conditional Ablation of Reactive Astrocytes to Dissect Their Roles in Spinal Cord Injury and Repair. (Pubmed Central) - May 23, 2020
Here, we used a lentivirus-mediated herpes simplex thymidine kinase/ganciclovir (HSVtk/GCV) system to selectively kill scar-forming reactive proliferating astrocytes...Conditional ablation of reactive astrocytes in a mouse SCI model with crush injury impeded glial scar formation and resulted in widespread infiltration of inflammatory cells, increased neuronal loss, and severe tissue degeneration, which ultimately led to the failure of spontaneous functional recovery. These results suggest that reactive proliferating astrocytes play key roles in the healing process after SCI, shedding light on the potential benefit for the repair after central nervous system (CNS) injury.
- |||||||||| vancomycin / Generic mfg., Cytovene (ganciclovir) / Roche
Clinical, Review, Journal: Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit. (Pubmed Central) - May 22, 2020
Vancomycin-resistant enterococci bloodstream infections are also on the rise, as 20.5% of nosocomial enterococci are now vancomycin-resistant, changing empiric antibiotic selection...Finally, the incidence of emergence of ganciclovir-resistant cytomegalovirus infection in patients is 5-12%, requiring early recognition and change to alternative regimens in the case of poor response to therapy...Initial antibiotic treatment of these patients should cover both Gram-positive organisms, especially in the presence of intravascular catheters, and Gram-negative bacteria. Echinocandins like caspofungin should also be considered especially in critically ill patients, particularly if a patient has been on total parenteral nutrition or broad-spectrum antibiotics.
- |||||||||| [VIRTUAL] LETERMOVIR AS PRE-EMPTIVE THERAPY FOR RESISTANT CYTOMEGALOVIRUS INFECTION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION () - May 16, 2020 - Abstract #EHA2020EHA_2637;
Waiting for the approval of letermovir, ganciclovir plus foscarnet was initiated as a new line...In the reported case, after trying all the approved therapeutic options, letermovir was the only antiviral that achieved an effective and long-lasting response despite multiple episodes of GvHD that needed adjustment of the inmunosupressive therapy. In the setting of clinical resistance or when the drug is not used as prophylaxis, letermovir can lead to an optimal control of CMV DNAemia with a safety profile.
- |||||||||| cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] CYTOMEGALOVIRUS REACTIVATION IN PATIENTS WITH HAPLOIDENTICAL STEM CELLS TRANSPLANTATION: ONE CENTER EXPERIENCE () - May 16, 2020 - Abstract #EHA2020EHA_2622;
Methods We analyzed 60 patients who underwent haplo - TPH in our center, from January 2015 to December 2019 .All patients received high doses of cyclophosphamide (50mg / Kg on days + 3 and + 4 post-TPH), cyclosporine and mycophenolate mofetil as GvHD profilaxis...Preemptive therapy of CMV infections was valganciclovir (60 %) ganciclovir (25%) and foscarnet (15%), reaching a complete viral load clearance in 80 %, with a median time of response of 19 days (6-34) .Grade III – IV toxicity (mainly hematologic) was observed in 44,4 % (n= 12) treated with valganciclovir or ganciclovir...Only pre trasplantation CMV status was significantly asociated with CMV infection. Identification of high risk patients and new prophylactic strategies may impruve these results.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Review, Journal: Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives. (Pubmed Central) - May 14, 2020
The use of gene therapies and the disruption of different signaling pathways are currently being investigated. Research suggests that the combination of several methods increases treatment efficiency and the positive outcome in individual.
- |||||||||| Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
The diagnostic yield of bone marrow biopsy in patients with liver failure () - May 14, 2020 - Abstract #BSH2020BSH_398;
Both patients with hepatosplenic T‐cell lymphoma have died; 1 prior to chemotherapy and 1 patient died with from relapsed disease. Although we did not diagnose PTLD from the BMB, 8 (8%) patients subsequently received this diagnosis from another biopsy site. Four of the 8 patients have died. In the 4 patients diagnosed with an MPN, all 4 patients (4%) were treated with hydroxycarbamide. The 5 patients who had repeat BMBs were referred for possible HLH of which the diagnosis was subsequently made in 4. Overall, 42 (41%) patients have died. Although the majority of BMBs (75%) did not reveal a diagnosis, a haematological/immunological diagnosis was made in 25% of referrals. Therefore, a BMB remains an important investigation in patients with liver failure and cytopenias with a wide range of potential diagnoses that have implications for therapy.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Enhancers and Repressors of Immunotherapy: Translational Perspectives on Gene-Mediated Cytotoxic Immunotherapy () - May 9, 2020 - Abstract #ASGCT2020ASGCT_79;
Our data suggest that dexamethasone may decrease the efficacy of immunotherapy for glioma through impaired T cell function: this emphasizes the need in identifying alternatives to dexamethasone to prevent attenuated responses in immunotherapies. The combination of GMCI with ATRi however points to additional therapeutic benefit through enhanced cytotoxic efficacy, improved immunogenicity in vitro and increased long-term survival in vivo, making it a promising future approach for the treatment of glioblastoma.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: New treatments for cytomegalovirus in transplant patients. (Pubmed Central) - May 7, 2020
In summary, although options for prophylaxis and treatment against CMV have been somewhat limited to date, a number of new strategies are currently under development with several drugs in phase 3 trials. Therefore, the landscape of CMV management in kidney transplant recipients will be changing significantly in the coming years with the ultimate goal of safer and more effective therapies to combat CMV.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal, Adverse events: Evaluation of the Expression Time of Ganciclovir-Induced Adverse Events Using JADER and FAERS. (Pubmed Central) - May 7, 2020
Based on these findings, it concluded that the paying attention to signs of each ganciclovir-induced adverse event is required from the early phase after ganciclovir administration. However, in FAERS, development after a long-term course also accounted for 11%, suggesting that long-term periodic monitoring of adverse reactions would be also required.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase. (Pubmed Central) - May 2, 2020
HSVTK-transduced MSCs express the suicide gene and in prodrug ganciclovir (GCV) presence induced cell death by intracellular conversion of GCV to GCV-triphosphate...Efficient tumor cell killing of glioma cell lines and primary human glioblastoma cells mediated by HSVTK-MSC exosomes is reported. Exosomes produced by suicide gene transduced MSCs represent a new class of highly selective tumor cell targeted drug acting intracellular with curative potential.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Management and prevention of cytomegalovirus infection in paediatric hematopoietic stem cell transplant (HSCT) recipients: A binational survey. (Pubmed Central) - May 1, 2020
In the post-transplant post engraftment setting, all centres recommended using ganciclovir (5mg/kg/dose twice daily) as a first-line therapy for CMV reactivation or disease, with treatment duration of 14 days, provided declining CMV quantitative PCR...This study identifies areas of uniformity and others of great variability in prevention and management strategies for CMV in paediatric HSCT. Data on CMV infection and management in HSCT patients should be routinely collected as part of prospective trials to inform guidelines and improve prevention and treatment of this important complication.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication. (Pubmed Central) - May 1, 2020
Prophylactic or preventative treatment with antivirals, such as ganciclovir, reduces the occurrence of early onset HCMV disease...Here we demonstrate that HCMV replication is highly dependent on levels of the amino acid asparagine and that knockdown of a critical enzyme involved in asparagine synthesis results in severe attenuation of virus replication. These results suggest that reducing asparagine levels through dietary restriction or chemotherapeutic treatment could limit HCMV replication in patients.
- |||||||||| Livtencity (maribavir) / Takeda, GSK
Enrollment closed: SOLSTICE: Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir (clinicaltrials.gov) - Apr 22, 2020
P3, N=352, Active, not recruiting,
Local chemotherapeutics can help induce remission in vitreoretinal lymphoma. Recruiting --> Active, not recruiting
- |||||||||| Cytovene (ganciclovir) / Roche
Trial completion date, Trial primary completion date: CMV-CTL for the Treatment of CMV Infection After HSCT (clinicaltrials.gov) - Apr 20, 2020
P4, N=30, Recruiting,
Recruiting --> Active, not recruiting Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
|
