- |||||||||| Cytovene (ganciclovir) / Roche
Preclinical, Journal: Proliferating osteoblasts are necessary for maximal bone anabolic response to loading in mice. (Pubmed Central) - Mar 12, 2021
We utilized 3.6Col1a1-tk mice in which replicating osteoblast lineage cells can be ablated in an inducible manner using ganciclovir (GCV)...Loading-induced lamellar bone formation was diminished but not prevented in experimental mice. We conclude that osteoblast proliferation induced by mechanical loading is a critical source of bone forming osteoblasts for maximal lamellar formation and is essential for woven bone formation.
- |||||||||| foscarnet / Generic mfg., Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Retrospective data, Journal, HEOR: Clinical and Economic Burden of Pre-emptive Therapy of Cytomegalovirus Infection in Hospitalized Allogeneic Hematopoietic Cell Transplant Recipients. (Pubmed Central) - Mar 11, 2021
The average cost amongst the 19 US cancer centers, including our institution, was $42,327 with major disparities in cost and clinical outcomes. PET for CMV infection is associated with high economic burden in allo-HCT recipients.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Necrotizing retinitis in a patient with syphilis: A case report. (Pubmed Central) - Mar 10, 2021
However, whenever ARN is clinically suspected, empiric treatment against herpetic viruses should be promptly administered while awaiting further infectious disease study results. Recognition of syphilitic retinitis and prompt initiation of intravenous penicillin is of critical important for clinicians.
- |||||||||| Cytovene (ganciclovir) / Roche
[VIRTUAL] Coinfection with COVID-19 and Cytomegalovirus in Kidney Transplant Recipients – A Case Series () - Mar 2, 2021 - Abstract #NKFSCM2021NKF-SCM_534;
Patient was admitted to ICU due to worsening respiratory status and Ganciclovir-resistant CMV pneumonitis, for which high dose Ganciclovir was given...CONCLUSION The COVID-19 and CMV coinfection can lead to variable disease severity among DDKT recipients and can be treated with combined antiviral and immunosuppressive regimen. A high index of suspicion for coinfection is warranted in immunocompromised patients with atypical or prolonged respiratory failure.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus retinitis in a patient of granulomatosis with polyangiitis on long-term immunosuppressants. (Pubmed Central) - Mar 2, 2021
He was treated with intravitreal ganciclovir injections. Subsequently, the retinitis lesions regressed and BCVA in the right eye improved to 20/40.This case report elaborates on the risks of the development of opportunistic ocular infections in patients receiving long-term systemic immunosuppressants and the need for regular ocular examinations in such cases.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: (Iso)Quinoline-Artemisinin Hybrids via Click Chemistry: Highly Potent Agents against Viruses. (Pubmed Central) - Feb 25, 2021
The most active hybrid 1 (EC50 = 0.22 µM) is 25 times more potent than its parent compound artesunic acid (EC50 = 5.41 µM) and 12 times more efficient than the standard drug ganciclovir (EC50 = 2.6 µM). Interestingly, hybrid 1 shows also inhibitory activity against hepatitis B virus in vitro (EC50 (HBeAg) = 2.57 µM).
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus Infection in Postrenal Transplant Recipients: 18 Years' Experience From a Tertiary Referral Center. (Pubmed Central) - Feb 24, 2021
CMV infection is quite prevalent in RTR, and early detection and immediate treatment or prophylaxis is of utmost importance. qRT-PCR is the gold standard and preferred over other methods; however pp65Ag assay still holds its importance in low-economic countries and populations where CMV infection is more prevalent and financial constraints are a major limitation.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Re-discussion on the diagnosis and treatment of cytomegalovirus hepatitis in children (Pubmed Central) - Feb 14, 2021
Therefore, a comprehensive scientific understanding of cytomegalovirus hepatitis requires an understanding of the basic knowledge of cytomegalovirus infection. Concurrently, it is necessary to standardize the indications of antiviral treatment in combination with the child's age, immune status and other potential diseases to avoid the abuse of antiviral drugs.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation. (Pubmed Central) - Feb 12, 2021
Concurrently, it is necessary to standardize the indications of antiviral treatment in combination with the child's age, immune status and other potential diseases to avoid the abuse of antiviral drugs. In patients mechanically ventilated for ≥ 96 h with CMV reactivation in blood, preemptive ganciclovir did not improve the outcome.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal, IO biomarker: Immuno-informatics approach to design a multi-epitope vaccine to combat Cytomegalovirus infection. (Pubmed Central) - Feb 7, 2021
Considering the recent reports of emergence of Ganciclovir drug resistance, vaccine development is the need of an hour...The overall results obtained indicated the vaccine to be immunogenic, non-allergic, had high population coverage, high affinity and stability with the immune receptor, had efficient expression in host E. coli and was effective in stimulating different immune cell types like T helper, T cytotoxic, B cells, dendritic cells, macrophages and interleukins. The proposed vaccine construct is expected to be highly efficacious and needs to be carried forward by the vaccinologists to test its efficacy in lab settings.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Development of iRGD-Modified Peptide Carriers for Suicide Gene Therapy of Uterine Leiomyoma. (Pubmed Central) - Feb 7, 2021
TheHSV-1thymidine kinase encoding plasmid delivery to PANC-1pancreatic carcinoma cells and primary UL cells resulted in significant suicide gene therapy effects. Subsequent ganciclovir treatment decreased cells proliferative activity, induced of apoptosis and promoted cells death.The obtained results allow us to concludethatthe developed RGD1-R6 carrier can be considered a promising candidate for suicide gene therapy of uterine leiomyoma.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, PK/PD data, Journal: Population Pharmacokinetics and Dose Optimization of Ganciclovir in Critically Ill Children. (Pubmed Central) - Feb 5, 2021
A population pharmacokinetic model of intravenous ganciclovir for critically ill children with cytomegalovirus infection was successfully developed. Results showed that underdosing of ganciclovir was relatively common in critically ill pediatric patients, and model-based approaches should be applied in the optimizing of empiric dosing regimens.
- |||||||||| Cytovene (ganciclovir) / Roche, Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz
[VIRTUAL] EBV COLITIS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENT WITH APLASTIC ANEMIA (ePoster Area) - Feb 4, 2021 - Abstract #EBMT2021EBMT_2811;
The differential diagnosis is between massive mucositis, aGvHD and CMV infections, but also EBV-related lesions should be considered, expecially in patient previously treated with intense immunosuppressive therapies. Endoscopic evaluation with byoptic samples should be performed in order to recognize pathological entity.
- |||||||||| Cytovene (ganciclovir) / Roche, Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz
[VIRTUAL] EBV COLITIS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENT WITH APLASTIC ANEMIA (ePoster Area) - Feb 4, 2021 - Abstract #EBMT2021EBMT_2810;
The differential diagnosis is between massive mucositis, aGvHD and CMV infections, but also EBV-related lesions should be considered, expecially in patient previously treated with intense immunosuppressive therapies. Endoscopic evaluation with byoptic samples should be performed in order to recognize pathological entity.
- |||||||||| Cytovene (ganciclovir) / Roche, Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz
[VIRTUAL] EBV COLITIS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENT WITH APLASTIC ANEMIA (ePoster Area) - Feb 4, 2021 - Abstract #EBMT2021EBMT_2809;
The differential diagnosis is between massive mucositis, aGvHD and CMV infections, but also EBV-related lesions should be considered, expecially in patient previously treated with intense immunosuppressive therapies. Endoscopic evaluation with byoptic samples should be performed in order to recognize pathological entity.
- |||||||||| Cytovene (ganciclovir) / Roche, Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz
[VIRTUAL] EBV COLITIS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENT WITH APLASTIC ANEMIA (ePoster Area) - Feb 4, 2021 - Abstract #EBMT2021EBMT_2808;
The differential diagnosis is between massive mucositis, aGvHD and CMV infections, but also EBV-related lesions should be considered, expecially in patient previously treated with intense immunosuppressive therapies. Endoscopic evaluation with byoptic samples should be performed in order to recognize pathological entity.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: A school-aged boy with nephrotic syndrome with cough for one month and shortness of breath for half a month (Pubmed Central) - Feb 3, 2021
After anti-infective therapy with sulfamethoxazole/trimethoprim and ganciclovir and respiratory support, the child still experienced progressive aggravation of dyspnea and tension pneumothorax, and extracorporeal membrane oxygenation (ECMO) was given on day 13 of invasive ventilation...The child was followed up for 6 months after discharge, and there was a significant improvement on lung CT, without organ dysfunction. It is concluded that Pneumocystis jirovecii pneumonia is a potential lifethreatening infection for children with low immunity, and that ECMO can effectively improve the prognosis of children with severe respiratory distress syndrome.
- |||||||||| Journal: Advances in the Development of Therapeutics for Cytomegalovirus Infections. (Pubmed Central) - Feb 2, 2021
First, the deployment of ganciclovir and valganciclovir for both the prevention and treatment of CMV infections and disease in transplant recipients has been further improved with the licensure of the efficacious and less toxic letermovir...Thus, an important lesson learned from studies in both populations is the need for new antiviral agents and the necessity for combination therapies as has been shown to be beneficial in the treatment of HIV infections, among others. The development of monoclonal antibodies, sirtuins, and cyclopropovir may provide new treatment options.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Retrospective data, Journal: Cytomegalovirus infection in AIDS patients. An illustrative case series. (Pubmed Central) - Jan 30, 2021
The predominant clinical manifestation in our series was gastrointestinal. A CMV VL cutoff level of CMV VL of 3,800 copies / mL is useful to discriminate infected patients from those with CMV related disease.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Clinical, imaging, endoscopic findings, and management of patients with CMV colitis: a single-institute experience. (Pubmed Central) - Jan 26, 2021
Imaging and endoscopic findings can mimic inflammatory, ischemic, and infectious colitides. However, CMV colitis should be included in the differential diagnosis in immunocompromised adults who present to emergency department with bloody stools, acute abdominal pain or diarrhea, and have bowel wall thickening and pericolonic stranding on imaging.
- |||||||||| Cytovene (ganciclovir) / Roche
Preclinical, Journal: Validation of an assay for quantifying ganciclovir in dried blood spots. (Pubmed Central) - Jan 23, 2021
GCV concentrations determined in DBS agreed well with GCV concentrations observed in serum. The assay was successfully applied to patient samples, and will be used to support pharmacokinetic studies in an ongoing clinical trial of VGC in infants with CMV-mediated hearing loss.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: A Case of Cytomegalovirus Reactivation after Chemoradiotherapy for Esophageal Cancer (Pubmed Central) - Jan 22, 2021
He discharged our hospital while the steroid dose was reduced and valganciclovir continued administrating...This is a rare case of CMV reactivation due to immunosuppression caused by steroids therapy during CRT against esophageal cancer. We should be aware of CMV infection during CRT and steroid therapy.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Observational data, Journal: Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study. (Pubmed Central) - Jan 21, 2021
Hematological adverse events, i.e., neutropenia, were noted in a minority of cases (4.4%). Our study demonstrates the benefits and safety aspects of treating symptomatic and asymptomatic children with cCMV even beyond the recommended neonatal period.What is Known:• Valganciclovir treatment of symptomatic congenital cytomegalovirus (cCMV) disease, commenced during the neonatal period, is beneficial in improving hearing and developmental outcome.• However, data of treatment started beyond the neonatal period is lacking.What is New:• Our study demonstrates the benefits of treating symptomatic children with cCMV as well as asymptomatic children that develop late-onset hearing loss even beyond the recommended neonatal period.• This was true for symptomatic children who presented > 4 weeks as well as to those were asymptomatic at birth but experienced late hearing deterioration.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Review, Journal: Management of cytomegalovirus corneal endotheliitis. (Pubmed Central) - Jan 15, 2021
There is no consensus on the management of CMV endotheliitis. Further studies are much needed to elucidate the optimal treatment modality, regime, and duration in the treatment and prophylaxis of CMV endotheliitis.
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