Cytovene (ganciclovir) / Roche 
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  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Engineered microtissues for the bystander therapy against cancer. (Pubmed Central) -  May 15, 2021   
    Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models...Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Impact of depletion of microglia/macrophages on regeneration after spinal cord injury. (Pubmed Central) -  May 15, 2021   
    To study the role of these cells in regeneration after spinal cord injury we used CD11b-herpes simplex virus thymidine kinase (HSVTK) (TK) transgenic mice, in which viral thymidine kinase activates ganciclovir toxicity in CD11b-expressing myeloid cells, including macrophages and microglia...We conclude that reducing numbers of CD11b-expressing cells improves locomotor recovery in the early phase after spinal cord injury, but does not affect recovery in the following 4 weeks. These observations point to differences in outcomes of astrocytic response and cholinergic innervation under CD11b cell ablation, which are, however, not reflected in the locomotor parameters analyzed at 5 weeks after injury.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Immunodeficiency and Thymoma: A Case Report on Good Syndrome, a Diagnosis Frequently Missed and Forgotten. (Pubmed Central) -  May 15, 2021   
    Intravitreal ganciclovir was administered in addition to intravenous systemic ganciclovir, which resulted in severe neutropenic sepsis...Clinical suspicion should be heightened in at-risk patients who present with multiple bouts of infection, particularly in thymoma cases with adult-onset immune dysfunction. It is of paramount importance to follow up those patients with annual clinical reviews and immunodeficiency screening.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. (Pubmed Central) -  May 15, 2021   
    Polymeric prodrug micelles with optimal features incorporated with HSV-tk encoding plasmids were cultivated with HT29 colorectal cancer cells and anticancer effectiveness was determined. Our results showed that prodrug GCV and HSV-tk cDNA encoded plasmid incorporated in GCV-PCL-chitosan polymeric nanocarriers could be delivered in a one-step manner to HT-29 cells and triggered high cytotoxicity.
  • ||||||||||  azathioprine / Generic mfg.
    Clinical, Journal:  CMV pneumonitis in a patient with Crohn's disease taking azathioprine. (Pubmed Central) -  May 15, 2021   
    This case study, therefore, makes the case for increased awareness of the possibility of, and recognition of CMV pneumonitis among healthcare professionals as a way of preventing significant morbidity and mortality. It also raises awareness of checking for slow metabolisers of azathioprine before initiation to look for individuals who may be at increased risk of azathioprine's adverse effects.
  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    [VIRTUAL] THE IMPACT OF PRETRANSPLANT IMMUNOMODULATORY DRUGS ON CMV REACTIVATION (Room-1) -  May 14, 2021 - Abstract #ICLLM2021ICLLM_82;    
    Our data suggests that MM patients treated with PI-based induction regimens at time of ASCT seem to have higher risk of developing symptomatic CMV reactivation andadding IMID to PI does not influence this. However, further studies on a largenumber of patients are warranted to clarify these findings
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Preclinical, Journal:  Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. (Pubmed Central) -  May 11, 2021   
    One construct delivered tumor necrosis factor (TNF), a purely cytotoxic gene for antitumor activity (RGD4C-AAVP-TNF); in the other construct, we delivered Herpes simplex virus thymidine kinase (HSVtk) for in tandem molecular-genetic imaging and targeted therapy (RGD4C-AAVP-HSVtk) utilizing ganciclovir (GCV) for a suicide gene therapy...We conclude that targeted AAVP constructs delivering either cytotoxic TNF or theranostic HSVtk followed by suicide gene therapy with GCV have comparable preclinical efficacy, at least in this standard experimental model. The results presented here provide a blueprint for future studies of targeted gene delivery against human glioblastomas and other brain tumors.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Chemo- and regioselective ring-opening of donor-acceptor oxiranes with N-heteroaromatics. (Pubmed Central) -  May 7, 2021   
    In the presence of 5 mol% of Y(OTf)3 as the catalyst, diverse N-heteroaromatics, including benzotriazoles, purines, substituted benzimidazole, imidazole and pyrazole, reacted well with various D-A oxiranes, providing acyclic nucleoside analogues containing a N-glycosidic bond in up to 97% yield and up to >95 : 5 regioselectivity. Through simple transformation, the Ganciclovir analogue could also be obtained.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, PK/PD data, Journal:  Population Pharmacokinetics of Ganciclovir in Critically Ill Patients. (Pubmed Central) -  May 6, 2021   
    CKD-EPI could partially explain the IIV, though a large part of the variability remains unclear. MCS suggested that recommended dose reductions for CKD-EPI <50 mL/min may lead to subtherapeutic plasma GCV levels in these patients.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Review, Journal:  Congenital Human Cytomegalovirus Infection Inducing Sensorineural Hearing Loss. (Pubmed Central) -  May 4, 2021   
    Ganciclovir, mainly used for antiviral therapy and behavioral prevention, can, to some degree, prevent congenital HCMV infection...Although some advancement has been made in diagnosing and treating SNHL, more improvement is needed. A comprehensive understanding of cytomegalovirus's pathogenesis is of key importance for preventing, diagnosing, and treating SNHL.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells. (Pubmed Central) -  May 4, 2021   
    Ganciclovir-treated CTH cells showed a decrease in UL69 gene detection and cellular proliferation...Finally, UL69 gene was detected in breast cancer biopsies. Our results indicate a close link between the UL69 gene detected in the HCMV-DB isolate used to infect HMECs, and the UL69 gene present in transformed CTH cells and tumor biopsies, further highlighting a direct role for HCMV in breast tumor development.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    [VIRTUAL] Design, Investigation and Delivery of Advanced trans-Splicing RNA for Suicide Gene Therapy () -  Apr 20, 2021 - Abstract #CSIFCS2020CSI_FCS_15;    
    As gene-directed enzyme prodrug therapy system we selected the Herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system...For targeted delivery in vivo, HCCtargeting vectors will be furnished with tri-antennary N-acetylgalactosamine (GalNAc3 ) residues. So far, our observations suggest that the amalgamation of the trans-splicing-based suicide technology with dumbbell vectors provides a powerful tool for specific destruction of aberrant target cells.
  • ||||||||||  Simulect (basiliximab) / Novartis, Cytovene (ganciclovir) / Roche
    [VIRTUAL] SUSTAINED BK VIRURIA: A FORGOTTEN ALLY FOR EARLY DIAGNOSIS OF BK VIRUS NEPHROPATHY IN KIDNEY TRANSPLANTATION () -  Apr 17, 2021 - Abstract #ISNWCN2021ISN-WCN_1287;    
    Immunosuppression (IS) consisted of Basiliximab, Tacrolimus (TAC), Mycophenolate Mofetil (MMF) and Prednisolone (PDN)...19,3 months after KT he had CMV infection treated with Ganciclovir and suspension of MMF...IS was changed to everolimus (EVR) and low dose TAC...Our study highlights the importance of BK viruria screening, and that BKVN should be considered in KT patients with allograft disfunction and persistent viruria, even without viremia. The early recognition of BK viruria could guide early therapeutic decisions with impact on the outcome of BKVN.
  • ||||||||||  hydroxychloroquine / Generic mfg., sirolimus / Generic mfg.
    [VIRTUAL] CYTOMEGALOVIRUS AND SARS-COV-2 COINFECTION IN KIDNEY TRANSPLANT RECIPIENT: A CASE REPORT () -  Apr 17, 2021 - Abstract #ISNWCN2021ISN-WCN_666;    
    Conclusions we report the first case of COVID-19 in kidney transplant patient in our country with excellent outcome despite the coinfection with SARS-COV-2 and Cytomegalovirus (CMV). So, it can be supposed that she might be protected by the antiviral therapy, ganciclovir or by the immunomodulatory effects of CMV.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma. (Pubmed Central) -  Apr 7, 2021   
    Following administration of the prodrug ganciclovir, residual tumor volumes in mice receiving GEM/tNSCs were reduced by 10-fold at day 35, and median survival was extended from 31 to 46 days. Taken together, these data begin to define design parameters for effective scaffold/tNSC composites and suggest a new approach to maximizing the efficacy of tNSC therapy in human patient trials.
  • ||||||||||  Cytovene (ganciclovir) / Roche, rimiducid (AP1903) / Bellicum
    Clinical, Journal, IO biomarker:  Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy. (Pubmed Central) -  Apr 7, 2021   
    Furthermore, high concentrations of GCV were toxic to cells not expressing HSV-TK, whereas AP1903 was bioinert. These results suggest that iCasp9/AP1903 is superior to HSV-TK/GCV in terms of both safety and efficacy when controlling the fate of GM-pMCs after priming antitumor immunity.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Topical Ganciclovir Reduces Viral Excretion in Mares With Equine Coital Exanthema. (Pubmed Central) -  Mar 23, 2021   
    We concluded that ganciclovir had an antiviral effect on EHV-3 replication when topically administered in mares showing clinical signs of ECE. Further trials should be performed to optimize the dose of the antiviral for a definitive formulation.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    [VIRTUAL] CMV ENCEPHALITIS IN A SLE FLARE (Mini-Orals Hall) -  Mar 19, 2021 - Abstract #ERAEDTA2021ERA_EDTA_1513;    
    These studies will be useful for establishing guidelines on the institution of prophylaxis or pre-emptive treatment of CMV infection in SLE patients. Protocols for screening and prevention in this population should be implemented to account for this emerging problem.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Trial completion date, Trial primary completion date:  CMV-CTL for the Treatment of CMV Infection After HSCT (clinicaltrials.gov) -  Mar 17, 2021   
    P4,  N=30, Recruiting, 
    Our findings suggest that the use of senolytic drugs can be a promising strategy for preventing the cognitive impairment associated with WBI. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  dexamethasone / Generic mfg.
    [VIRTUAL] A Rare Case of Latent Tuberculosis Reactivation in the Setting of COVID-19 Infection () -  Mar 14, 2021 - Abstract #ATS2021ATS_4717;    
    On admission, he began experiencing worsening hypoxia with exertion, and was started on remdesivir and dexamethasone for COVID-19 infection...Cytomegalovirus PCR was positive at 1486IU and was started on ganciclovir...Early research has shown that risk of death and recovery time with COVID-19 may be higher in patients with previous or active TB compared to those without. In patients with severe COVID-19 pneumonia and multiple risk factors for immunosuppression, latent TB reactivation should be considered in addition to secondary superinfection.
  • ||||||||||  Cytovene (ganciclovir) / Roche, Kineret (anakinra) / SOBI, Affibody
    [VIRTUAL] The COP Out Diagnosis: A Rare Case of CMV Pneumonitis and COVID19 Organizing Pneumonia () -  Mar 14, 2021 - Abstract #ATS2021ATS_3184;    
    After a prolonged hospital stay, the patient was discharged home with tapered prednisone and supplemental oxygen...Of note, this case demonstrates the perils of confounding diagnoses and anchoring bias as our patient likely failed to respond clinically to systemic steroid therapy for COP while secondarily infected with CMV. This case highlights the need to consider other possible confounders in the diagnostic differential for COVID19 sequalae when patients are not responding adequately to empiric treatment and to evaluate more histopathologic or post-mortem examinations of COVID19 patients.