Cytovene (ganciclovir) / Roche 
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  • ||||||||||  Cytovene (ganciclovir) / Roche
    Powassan Virus Infection Presenting as Rapidly Progressive Encephalitis and New-onset Refractory Status Epilepticus (NORSE) (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_4202;    
    CSF studies were notable for elevated protein and HHV-6 IgM antibodies and was empirically treated with Ganciclovir...While neuroinvasive Powassan virus remains a rare disease process, it should be considered on the differential for patients with NORSE in an endemic tick region. Additionally, it should be considered with isolated T2/FLAIR changes without diffusion restriction, particularly when the deep white matter structures are involved.
  • ||||||||||  Journal:  Cytomegalovirus Colitis in a Patient with Severe Treatment Refractory Ulcerative Colitis. (Pubmed Central) -  Mar 6, 2024   
    Additionally, it should be considered with isolated T2/FLAIR changes without diffusion restriction, particularly when the deep white matter structures are involved. We report a case of cytomegalovirus colitis in a pediatric patient with pancolitis who had been refractory to aminosalicylate, infliximab, and ustekinumab and was in clinical remission and with transmural response on upadacitinib...He developed an acute increase in symptoms and did not respond to therapy escalation with increased upadacitinib 45
  • ||||||||||  Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
    Journal, Surgery:  Herpes Simplex Keratitis as a Complication of Pterygium Surgery. (Pubmed Central) -  Feb 28, 2024   
    Timely diagnosis and treatment are crucial to prevent unfavorable outcomes. Consequently, routine corneal fluorescein staining, tear sIgA examination, and corneal scraping for polymerase chain reaction or next-generation sequencing of metagenomics should be performed in any suspected cases.
  • ||||||||||  Cytovene (ganciclovir) / Roche, Livtencity (maribavir) / Takeda, GSK
    Journal:  An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity. (Pubmed Central) -  Feb 24, 2024   
    In summary, the main experimental findings of this study are as follows: (1) the in vitro verification of CDK7 inhibition and selectivity that confirms the warhead covalent-binding principle (by CDK-specific kinase assays), (2) the highly pronounced antiviral efficacies of the hit compounds (in cultured cell-based infection models) with half-maximal effective concentrations that reach down to picomolar levels, (3) a particularly strong potency of compounds against strains and reporter-expressing recombinants of HCMV (using infection assays in primary human fibroblasts), (4) additional activity against further herpesviruses such as animal CMVs and VZV, (5) unique mechanistic properties that include an immediate block of HCMV replication directed early (determined by Western blot detection of viral marker proteins), (6) a substantial drug synergism in combination with MBV (measured by a Loewe additivity fixed-dose assay), and (7) a strong sensitivity of clinically relevant HCMV mutants carrying MBV or ganciclovir resistance markers. Combined, the data highlight the huge developmental potential of this host-directed antiviral targeting concept utilizing covalently binding CDK7 inhibitors.
  • ||||||||||  Cytovene (ganciclovir) / Roche, Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
    HIV Associated HHV6 Encephalitis (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_5968;    
    He was recently diagnosed with HIV and started on Biktarvy one week prior...Patient was started on empiric antibiotics and prophylactic azithromycin and trimethoprim/ sulfamethoxazole (TMP-SMX)...Most cases of HHV-6 encephalitis have occurred in allogeneic HCT recipients. In vitro studies have shown HHV-6 has susceptibility similar to CMV, which is why ganciclovir or foscarnet is recommended as treatment.
  • ||||||||||  Cytovene (ganciclovir) / Roche, Rituxan (rituximab) / Roche
    Is Therapeutic Plasma Exchange an Underused Treatment for Anti-melanoma Differentiation-Associated Gene 5 (MDA 5) Amyopathic Dermatomyositis (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_5890;    
    Case 50 year old Asian female undergoing evaluation for unknown rheumatologic disease on 60 mg of Prednisone daily admitted in transfer for acute respiratory distress syndrome (ARDS) and COVID-19...Rituxan was delayed due to reactivation of CMV viremia for which the patient was started on Ganciclovir with monitoring of CMV serum levels...She was maintained on Cellcept bid and was ultimately discharged from rehab to home and has been decannulated...This case displays the successful utilization of plasma exchange for refractory ILD in patients with Anti MDA 5 and possibly other underlying rheumatologic disease with lung involvement. Further research should be considered for defining timing and duration of treatment for plasma exchange.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    An Uncommon Presentation of a Common Bug: Legionella Pneumophila Pneumonia Progressing to Acute Respiratory Distress Syndrome (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_5881;    
    We diagnosed Legionnaire's disease progressing to ARDS as per the Berlin definition, enabling early pronation and ventilator management, along with rifampin addition to moxifloxacin given the clinical severity. Extending steroid treatment post clinical decline in our patient conferred benefit as early steroids administration reduces ventilation duration and overall mortality in moderate to severe ARDS.
  • ||||||||||  A Case of Idiopathic Pneumonia Syndrome in a Patient With Recent Stem Cell Transplant (San Diego Convention Center, Area H (Hall H, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_5651;    
    Early recognition and intervention are crucial for achieving favorable outcomes in these challenging cases. This also highlights the importance of treating possible infectious etiologies while awaiting workup and when unable to rule out certain infections.
  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Unmasking the Silent Threat: Cytomegalovirus Pneumonitis in a Patient With Pulmonary Sarcoidosis (San Diego Convention Center, Area H (Hall H, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_4076;    
    Case Presentation: A 51-year-old female with a history of pulmonary sarcoidosis treated with azathioprine and prednisone was hospitalized twice within one month...She was diagnosed with CMV pneumonitis and treated with ganciclovir for three weeks with clinical improvement...She is continued on prophylactic valganciclovir until glucocorticoids are completely weaned off...This case highlights the importance of considering CMV pneumonitis as a potential cause of severe respiratory failure in immunosuppressed individuals, despite its rarity. Timely recognition and targeted therapy are crucial for improving patient outcomes in such challenging clinical scenarios.
  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche, Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) / Gilead
    Cytomegalovirus Colitis Causing Hemorrhagic Shock and Ileocolic Intussusception in a Patient With Acquired Immunodeficiency Syndrome (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_3530;    
    The patient was started on broad-spectrum antibiotics, Genvoya and prophylaxis with atovaquone and azithromycin...Etoposide and dexamethasone were started for HLH...Blood transfusion with packed red blood cells, platelets and fresh frozen plasma was started and inotropic support with nor-epinephrine infusion was started...Ganciclovir was started for CMV colitis...Post-operatively, the patient improved remarkably and was discharged with itraconazole for disseminated histoplasmosis and valganciclovir for CMV colitis with outpatient clinic follow-up...The patient had a stormy course with multiple complications of disseminated histoplasmosis, HLH, and CMV Colitis, causing refractory lower gastrointestinal bleeding and ileocecal intussusception, for which the patient underwent right hemicolectomy. The multidisciplinary expert involvement and the timely intervention of the complications with rapid escalation to higher levels of care resulted in the successful outcome of the patient with a guarded prognosis.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    THE EFFICACY OF HAPLOID HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THE TREATMENT OF CHILDREN WITH DIAMOND-BLACKFAN ANEMIA (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2652;    
    Ciclosporin/tacrolimus, togethor with mycophenolate morphenate and methotrexate, were used to prevent graft versus host disease (GVHD)...Cytomegalovirus infection occurred in 3 patients and Epstein-Barr virus infection occurred in 1 patient after transplantation, and cured by ganciclovir treatment... Haplo-HSCT is an effective treament for pediatric patients with DBA and the conditioning regimen of Flu +Bu+ATG was recommended.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Cytovene (ganciclovir) / Roche
    SEVERE HHV-6 RELATED ENCEPHALITIS FOLLOWING ANTI-CD19 CAR-T TREATMENT: A CASE STORY FROM A POINT OF CARE PRODUCTION FACILITY (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2536;    
    Notably, in this case the initial number of cells in the apheresis product were very high, indicating a high proliferation capability of the harvested cells. Further, the patient had an unusual expansion of lymphocytes post infusion, however HHV-6 was not detectable in neither the pre-manufactured lymphocytes, nor in the pre-infusion CAR-T product.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    POSTTRANSPLANT COMPLICATIONS IN A CASE OF LATE-ONSET FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS TYPE 2 (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2285;    
    A notable proportion of patients experienced adverse events of myelosuppression and nephrotoxicity; these results are consistent with those from prior studies in this patient population Immunosuppression was switched to dexamethasone and cyclosporine in accordance with the HLH-2004 protocol...During that time, she suffered from a CMV infection for which she was treated with ganciclovir...Myeloablative conditioning with Busulfan (AUC 85-95), Fludarabine (160 mg/m
  • ||||||||||  PHYSICIAN PERSPECTIVES ON THE BURDEN AND CLINICAL MANAGEMENT OF CYTOMEGALOVIRUS (CMV) INFECTION IN TRANSPLANT RECIPIENTS IN CENTRAL AND EASTERN EUROPE (CLYDE) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2265;    
    Physicians reported intravenous ganciclovir and oral valganciclovir to be completely associated with rapid clearance of viraemia (32.3%) and convenient administration (37.8%), respectively, in transplant recipients with refractory PT-CMV infection...Approximately half of physicians reported having limited experience with newer anti-CMV options, such as treatment with maribavir (54.9%) and prophylaxis with letermovir (50.6%) (Figure 1)... This study provides real-world evidence from Central and Eastern Europe, bridging an existing knowledge gap and providing crucial epidemiological data on the prevalence, treatment practices and physicians
  • ||||||||||  PHYSICIAN PERSPECTIVES ON THE BURDEN AND CLINICAL MANAGEMENT OF CYTOMEGALOVIRUS (CMV) INFECTION IN TRANSPLANT RECIPIENTS IN CENTRAL AND EASTERN EUROPE (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2264;    
    Physicians reported intravenous ganciclovir and oral valganciclovir to be completely associated with rapid clearance of viraemia (32.3%) and convenient administration (37.8%), respectively, in transplant recipients with refractory PT-CMV infection...Approximately half of physicians reported having limited experience with newer anti-CMV options, such as treatment with maribavir (54.9%) and prophylaxis with letermovir (50.6%) (Figure 1)... This study provides real-world evidence from Central and Eastern Europe, bridging an existing knowledge gap and providing crucial epidemiological data on the prevalence, treatment practices and physicians
  • ||||||||||  Prevymis (letermovir) / Merck (MSD)
    OUTCOME OF THE USE OF LETERMOVIR AS PROPHYACTIC TREATMENT FOR HSCT RECIPIENTS: A SINGLE CENTER EXPERIENCE (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2148;    
    Treatment relies upon anti-CMV specific Immunoglobulin and antiviral drugs such as Ganciclovir, Foscavir or Cidofovir. The experience of our center shows an efficacy of the prophylactic use of letermovir in patients undergoing HSCT, even if it showed reactivation events which, overall, allowed effective therapeutic management with rapid resolution without complications.
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    MODIFIED GIAC CONDITIONING REGIMEN IN HAPLOIDENTICAL TRANSPLANT: SINGLE CENTRE STUDY (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2014;    
    HLA-mismatched/haploidentical HSCT was feasible with unmanipulated blood harvest in a modified GIAC conditioning regimen. Modified GIAC protocol for mismatched hematopoietic stem cell transplantation is relatively safe and efficient for patients with haematological malignancies
  • ||||||||||  Prevymis (letermovir) / Merck (MSD)
    LETERMOVIR AS TREATMENT AND SECONDARY PROPHYLAXIS OF CMV REACTIVATION IN LOW-WEIGHT PEDIATRIC PATIENTS (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_1917;    
    Due to the well-known toxicity of such drug, a switch to a better tolerated treatment was needed. The use of Letermovir once virological drop was achieved, showed to be safe and effective in inducing and maintaining CMV negativity, preventing further reactivation at the last available follow-up.
  • ||||||||||  EPIDEMIOLOGY OF VIRAEMIA IN CHILDREN UNDERGOING CORD BLOOD STEM CELL TRANSPLANT (CB-SCT) WITH NON-MALIGNANT DISEASES: A RETROSPECTIVE COHORT STUDY (CLYDE) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_1449;    
    Single anti-viral (ganciclovir/valganciclovir) was effective in 4/9 cases while Foscarnet was required as a second ant-viral agent in 5/9 cases...Four of these viremia episodes were treated with cidofovir, administered as 1 mg/kg three times a week therapy and oral brincidofovir was given successfully to one patient...Excellent response was seen as the child completely cleared EBV after a single dose of rituximab... This retrospective cohort from a single centre reports that despite T-cell depletion and with CB infused T-cells being na
  • ||||||||||  EPIDEMIOLOGY OF VIRAEMIA IN CHILDREN UNDERGOING CORD BLOOD STEM CELL TRANSPLANT (CB-SCT) WITH NON-MALIGNANT DISEASES: A RETROSPECTIVE COHORT STUDY (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_1448;    
    Single anti-viral (ganciclovir/valganciclovir) was effective in 4/9 cases while Foscarnet was required as a second ant-viral agent in 5/9 cases...Four of these viremia episodes were treated with cidofovir, administered as 1 mg/kg three times a week therapy and oral brincidofovir was given successfully to one patient...Excellent response was seen as the child completely cleared EBV after a single dose of rituximab... This retrospective cohort from a single centre reports that despite T-cell depletion and with CB infused T-cells being na