Cytovene (ganciclovir) / Roche 
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  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP). (Pubmed Central) -  Aug 6, 2021   
    Since the expression of BCRP was higher in MCF-7 cells than in MDA-MB-231 cells, and the cellular uptake of GCV and compound 1 was smaller but increased in the presence of BCRP-selective inhibitor (Fumitremorgin C) in MCF-7 cells, we concluded that the improved apoptotic effects of higher MTX exposure were raised mainly from the inhibition of BCRP-mediated efflux of MTX. However, the effects of GCV and its derivatives on MTX metabolism and the quantitative expression of MTX metabolizing enzymes in various cancer cells need to be studied more thoroughly in the future.
  • ||||||||||  Tembexa (brincidofovir oral) / SymBio Pharma, Vistide (cidofovir) / Gilead
    Retrospective data, Review, Journal:  Adenovirus diseases: a systematic review and meta-analysis of 228 case reports. (Pubmed Central) -  Aug 4, 2021   
    Mortality rate was higher among patients with GI disease, pneumonia and disseminated disease. Our review clarified the current treatment of ADV infections, and more treatment required further investigation.
  • ||||||||||  Prevymis (letermovir) / Merck (MSD), Cytovene (ganciclovir) / Roche
    [VIRTUAL] CMV Prophylaxis for Allogeneic HSCT Patients (CHANNEL A) -  Jul 31, 2021 - Abstract #ICBMT2021ICBMT_83;    
    However, upon the approval of letermovir and reimbursement in Korea, diverse clinical situations such as CMV blips, and CMV testing methods should be clarified. In this talk, I would be discussing the practical points for CMV prophylaxis with letermovir based on the pivotal study analysis.
  • ||||||||||  paclitaxel / Generic mfg.
    Review, Journal:  Mesenchymal Stem/Stromal Cell-Based Delivery: A Rapidly Evolving Strategy for Cancer Therapy. (Pubmed Central) -  Jul 30, 2021   
    A large number of studies have focused on the MSC application as delivery vehicles for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), chemotherapeutic drug such as gemcitabine (GCB), paclitaxel (PTX), and doxorubicin (DOX), prodrugs such as 5-fluorocytosine (5-FC) and ganciclovir (GCV), and immune cell-activating cytokines along with oncolytic virus. In the current review, we evaluate the latest findings rendering the potential of MSCs to be employed as potent gene/drug delivery vehicle for inducing tumor regression with a special focus on the in vivo reports performed during the last two decades.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Cytomegalovirus ileitis with protein-losing enteropathy in an immunocompetent adult. (Pubmed Central) -  Jul 28, 2021   
    She was successfully treated with medical treatments including intravenous injection of ganciclovir (GCV) (500 mg/day). We described an extremely rare case of CMV ileitis with PLE in an immunocompetent adult who was treated successfully with medical treatments, including GCV.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Does ganciclovir exert retinal toxicity after multiple continuous intravitreal injections? (Pubmed Central) -  Jul 22, 2021   
    In conclusion, NUDT15 is an important metabolizing enzyme for ACV and GCV, and NUDT15 variation contributes to inter-patient variability in their therapeutic effects. Ganciclovir-associated photoreceptor damage may induce abnormalities in retinal function in response to multiple continuous intravitreal ganciclovir injections at a relatively high dosage (3 mg/0.1 ml).
  • ||||||||||  voriconazole / Generic mfg.
    [VIRTUAL] CYTOMEGALOVIRUS INFECTION PRESENTING AS GASTRIC OUTLET OBSTRUCTION - AN UNUSUAL PRESENTATION (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_5234;    
    Complete symptomatic relief and serological response was reported after 2 weeks of therapy. Further hospitalisation course was uneventful and the patient was later discharged.To conclude, this case highlights gastric outlet obstruction as an unusual CMV related presentation in an immunocompromised setting.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    [VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_5232;    
    The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
  • ||||||||||  voriconazole / Generic mfg.
    [VIRTUAL] CYTOMEGALOVIRUS INFECTION PRESENTING AS GASTRIC OUTLET OBSTRUCTION - AN UNUSUAL PRESENTATION (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_3054;    
    Complete symptomatic relief and serological response was reported after 2 weeks of therapy. Further hospitalisation course was uneventful and the patient was later discharged.To conclude, this case highlights gastric outlet obstruction as an unusual CMV related presentation in an immunocompromised setting.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    [VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_3052;    
    The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
  • ||||||||||  voriconazole / Generic mfg.
    [VIRTUAL] CYTOMEGALOVIRUS INFECTION PRESENTING AS GASTRIC OUTLET OBSTRUCTION - AN UNUSUAL PRESENTATION (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_1223;    
    Complete symptomatic relief and serological response was reported after 2 weeks of therapy. Further hospitalisation course was uneventful and the patient was later discharged.To conclude, this case highlights gastric outlet obstruction as an unusual CMV related presentation in an immunocompromised setting.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    [VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_1221;    
    The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
  • ||||||||||  Vistide (cidofovir) / Gilead
    Journal:  Antiviral Drugs Against Herpesviruses. (Pubmed Central) -  Jul 15, 2021   
    The pyrophosphate analogue, foscarnet, and the nucleotide analogue, cidofovir, have been approved subsequently and constitute the second-line antiviral drugs...Recently, letermovir that targets the viral terminase complex was approved for the prophylaxis of human cytomegalovirus infections in hematopoietic stem cell transplant recipients. Other viral targets such as the protein kinase and the helicase-primase complex are also evaluated for the development of novel potent inhibitors against herpesviruses.
  • ||||||||||  Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Journal:  Human Adenovirus: An Unusual Causative Agent for Acute Retinal Necrosis Presented with Central Retinal Vascular Occlusion. (Pubmed Central) -  Jul 11, 2021   
    Using digital PCR, we have developed a rapid, sensitive and accurate method for genotyping and quantification of the most prevalent mutations that cause human cytomegalovirus resistance to ganciclovir. HAdV known to cause acute epibulbar infections of the eye may also cause intraocular inflammation such as ARN.
  • ||||||||||  Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
    Journal:  Cytopathology of Vitreous Specimens in Acute Retinal Necrosis. (Pubmed Central) -  Jul 10, 2021   
    The variability of the response to treatment in patients with ARN may reflect patient-to-patient differences in their antigen-specific immune response. Understanding the immunologic response associated with ARN may provide valuable information regarding the dosing and timing of treatment.
  • ||||||||||  Prevymis (letermovir) / Merck (MSD), Vistide (cidofovir) / Gilead, maribavir (TAK-620) / Takeda, GSK
    Clinical, Journal:  Letermovir and Maribavir for the Treatment and Prevention of Cytomegalovirus Infection in Solid Organ and Stem Cell Transplant Recipients. (Pubmed Central) -  Jul 9, 2021   
    The investigational agent maribavir has shown promise as pre-emptive treatment; in patients with refractory or resistant disease the emergence of resistance while on treatment has been observed and ongoing studies will define efficacy in this population. Both agents have unique mechanisms of action limiting cross resistance, and neither exhibit myelotoxicity or nephrotoxicity.
  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Cytomegalovirus skin disease in a kidney transplant patient. (Pubmed Central) -  Jul 7, 2021   
    The patient was successfully treated with intravenous ganciclovir, followed by oral valganciclovir, with resolution of the skin changes. Persistent hydrocele with epididymitis on imaging suggests that this process may have been the source of the cutaneous cytomegalovirus infection.
  • ||||||||||  Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
    Review, Journal:  Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review. (Pubmed Central) -  Jul 4, 2021   
    Physicians can select either of the agents, depending on the clinical situation; however, the selection may influence the cGVHD-related clinical course in HSCT recipients. Typical pathological features of cCMV infection are very common in renal tissue, but they do not seem to entail significant consequences at the anatomical or clinical levels.
  • ||||||||||  acyclovir / Generic mfg.
    Clinical, Journal:  Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6. (Pubmed Central) -  Jul 1, 2021   
    The objective of this report is to highlight the importance of having multidisciplinary support, including basic medical sciences groups providing specific tests that are sometimes very difficult to get, which provides a benefit to patients in the well-aimed diagnosis as part of applied translational medicine. In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  VZV meningoencephalitis treated with ganciclovir. (Pubmed Central) -  Jun 30, 2021   
    In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion. No abstract available
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Pathogen or bystander: clinical significance of detecting HHV-6 in pediatric CSF. (Pubmed Central) -  Jun 24, 2021   
    FA-ME results led to discontinuation of empirical anti-viral in 12 patients and appropriate initiation of ganciclovir in 4 patients. In our institution, detection of HHV-6 using FA-ME led to faster establishment of disease etiology and optimization of antimicrobial therapy.