- |||||||||| Tembexa (brincidofovir oral) / SymBio Pharma, Vistide (cidofovir) / Gilead
Retrospective data, Review, Journal: Adenovirus diseases: a systematic review and meta-analysis of 228 case reports. (Pubmed Central) - Aug 4, 2021 Mortality rate was higher among patients with GI disease, pneumonia and disseminated disease. Our review clarified the current treatment of ADV infections, and more treatment required further investigation.
- |||||||||| Prevymis (letermovir) / Merck (MSD), Cytovene (ganciclovir) / Roche
[VIRTUAL] CMV Prophylaxis for Allogeneic HSCT Patients (CHANNEL A) - Jul 31, 2021 - Abstract #ICBMT2021ICBMT_83; However, upon the approval of letermovir and reimbursement in Korea, diverse clinical situations such as CMV blips, and CMV testing methods should be clarified. In this talk, I would be discussing the practical points for CMV prophylaxis with letermovir based on the pivotal study analysis.
- |||||||||| paclitaxel / Generic mfg.
Review, Journal: Mesenchymal Stem/Stromal Cell-Based Delivery: A Rapidly Evolving Strategy for Cancer Therapy. (Pubmed Central) - Jul 30, 2021 A large number of studies have focused on the MSC application as delivery vehicles for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), chemotherapeutic drug such as gemcitabine (GCB), paclitaxel (PTX), and doxorubicin (DOX), prodrugs such as 5-fluorocytosine (5-FC) and ganciclovir (GCV), and immune cell-activating cytokines along with oncolytic virus. In the current review, we evaluate the latest findings rendering the potential of MSCs to be employed as potent gene/drug delivery vehicle for inducing tumor regression with a special focus on the in vivo reports performed during the last two decades.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus ileitis with protein-losing enteropathy in an immunocompetent adult. (Pubmed Central) - Jul 28, 2021 She was successfully treated with medical treatments including intravenous injection of ganciclovir (GCV) (500 mg/day). We described an extremely rare case of CMV ileitis with PLE in an immunocompetent adult who was treated successfully with medical treatments, including GCV.
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Efficacy of small-dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR-UL112-3p expression. (Pubmed Central) - Jul 27, 2021 In conclusion, small-dose ganciclovir can better improve the liver function of the children, and downregulate miR-UL112-3p in them. The AUC, specificity, and sensitivity of miR-UL112-3p for predicting the efficacy of small-dose ganciclovir were 0.866, 73.77 and 84.62%, respectively, and the AUC, specificity, and sensitivityfor predicting the efficacy of conventional-dose ganciclovir were 0.837, 75.44 and 90.00%, respectively.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: Does ganciclovir exert retinal toxicity after multiple continuous intravitreal injections? (Pubmed Central) - Jul 22, 2021 In conclusion, NUDT15 is an important metabolizing enzyme for ACV and GCV, and NUDT15 variation contributes to inter-patient variability in their therapeutic effects. Ganciclovir-associated photoreceptor damage may induce abnormalities in retinal function in response to multiple continuous intravitreal ganciclovir injections at a relatively high dosage (3 mg/0.1 ml).
- |||||||||| Cytovene (ganciclovir) / Roche
[VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_5232; The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
- |||||||||| Cytovene (ganciclovir) / Roche
[VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_3052; The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
- |||||||||| Cytovene (ganciclovir) / Roche
[VIRTUAL] CMV DUODENITIS – A RARE CAUSE OF DUODENAL ULCERATION IN IMMUNE-COMPETENT HOST (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_1221; The patient was started on oral ganciclovir 900 mg daily for one week...CMV disease should be considered in the differential diagnosis in apparent immune-competent patients and if confirmed, a search for the underlying condition causing immune dysfunction must be made. The true burden of CMV disease in immune-competent patients remains largely unknown.
- |||||||||| Vistide (cidofovir) / Gilead
Journal: Antiviral Drugs Against Herpesviruses. (Pubmed Central) - Jul 15, 2021 The pyrophosphate analogue, foscarnet, and the nucleotide analogue, cidofovir, have been approved subsequently and constitute the second-line antiviral drugs...Recently, letermovir that targets the viral terminase complex was approved for the prophylaxis of human cytomegalovirus infections in hematopoietic stem cell transplant recipients. Other viral targets such as the protein kinase and the helicase-primase complex are also evaluated for the development of novel potent inhibitors against herpesviruses.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Journal: Human Adenovirus: An Unusual Causative Agent for Acute Retinal Necrosis Presented with Central Retinal Vascular Occlusion. (Pubmed Central) - Jul 11, 2021 Using digital PCR, we have developed a rapid, sensitive and accurate method for genotyping and quantification of the most prevalent mutations that cause human cytomegalovirus resistance to ganciclovir. HAdV known to cause acute epibulbar infections of the eye may also cause intraocular inflammation such as ARN.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal: Cytopathology of Vitreous Specimens in Acute Retinal Necrosis. (Pubmed Central) - Jul 10, 2021 The variability of the response to treatment in patients with ARN may reflect patient-to-patient differences in their antigen-specific immune response. Understanding the immunologic response associated with ARN may provide valuable information regarding the dosing and timing of treatment.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus skin disease in a kidney transplant patient. (Pubmed Central) - Jul 7, 2021 The patient was successfully treated with intravenous ganciclovir, followed by oral valganciclovir, with resolution of the skin changes. Persistent hydrocele with epididymitis on imaging suggests that this process may have been the source of the cutaneous cytomegalovirus infection.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Review, Journal: Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review. (Pubmed Central) - Jul 4, 2021 Physicians can select either of the agents, depending on the clinical situation; however, the selection may influence the cGVHD-related clinical course in HSCT recipients. Typical pathological features of cCMV infection are very common in renal tissue, but they do not seem to entail significant consequences at the anatomical or clinical levels.
- |||||||||| acyclovir / Generic mfg.
Clinical, Journal: Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6. (Pubmed Central) - Jul 1, 2021 The objective of this report is to highlight the importance of having multidisciplinary support, including basic medical sciences groups providing specific tests that are sometimes very difficult to get, which provides a benefit to patients in the well-aimed diagnosis as part of applied translational medicine. In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion.
- |||||||||| Cytovene (ganciclovir) / Roche
Journal: VZV meningoencephalitis treated with ganciclovir. (Pubmed Central) - Jun 30, 2021 In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion. No abstract available
- |||||||||| Cytovene (ganciclovir) / Roche
Clinical, Journal: Pathogen or bystander: clinical significance of detecting HHV-6 in pediatric CSF. (Pubmed Central) - Jun 24, 2021 FA-ME results led to discontinuation of empirical anti-viral in 12 patients and appropriate initiation of ganciclovir in 4 patients. In our institution, detection of HHV-6 using FA-ME led to faster establishment of disease etiology and optimization of antimicrobial therapy.
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