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- voriconazole / Generic mfg.
PULMONARY ANGIOINVASIVE ASPERGILLOSIS IN A KIDNEY RECIPIENT: AN ATYPICAL CLINICAL PRESENTATION (Poster Area (Virtual)) - Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1339;
Invasive mycoses, associated with significant morbidity and mortality, are a frequent difficulty in solid organ transplantation. The clinical pictures differ and we could be faced with an atypical presentation which affects the therapeutic management.
- || Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Delayed graft function AND rejection are risk factors for cytomegalovirus breakthrough infection in kidney transplant recipients. (Pubmed Central) - Jan 20, 2022
These findings suggest that underexposure to ganciclovir occurs in patients with DGF. Prospective studies evaluating the added value of therapeutic drug monitoring to achieve target ganciclovir concentrations in patients with DGF are needed.
- | Cytovene (ganciclovir) / Roche
Journal: Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment. (Pubmed Central) - Jan 20, 2022
Background: Mesenchymal stem cells (MSCs) have been applied as a promising vehicle for tumour-targeted delivery of suicide genes in the herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir (GCV) suicide gene therapy against malignant gliomas...Outstanding tumour targeting and significantly prolonged survival with decreased tumour size were observed after the treatment using MFION-transfected MSCs in glioma model rats. Our results show that iron oxide nanoparticles have the potential to improve the suicide gene expression levels of transfected MSCs, while promoting the GJIC formation between MSCs and tumour cells, which enhances the sensitivity of glioma cells to HSV-tk/GCV suicide gene therapy.
- || methotrexate / Generic mfg.
Clinical, Journal: Immune Reconstitution Inflammatory Syndrome Associated with Pneumocystis Jirovecii Pneumonia and Cytomegalovirus Colitis in a Patient with Rheumatoid Arthritis. (Pubmed Central) - Jan 19, 2022
A 68-year-old woman presenting with rheumatoid arthritis was admitted due to pancytopenia caused by methotrexate...Subsequently, after treatment with leucovorin and trimethoprim-sulfamethoxazole, lung consolidation was found to be aggravated, along with a rapidly increasing leukocyte count...Both conditions were associated with immune reconstitution inflammatory syndrome caused by recovery from leukopenia. The patient was successfully treated with intravenous methylprednisolone pulse therapy and ganciclovir.
- || Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus Colitis in Immunocompetent and Immunocompromised Children: A 2-center Study. (Pubmed Central) - Jan 19, 2022
CMV colitis is a rare but overlooked cause of prolonged diarrhea in immunocompetent and immunocompromised children. CMV colitis might present without any ulcer formation at colonoscopy in infants.
- || Cytovene (ganciclovir) / Roche
Would use single Ganciclovir Tx. Watch out IRIS. (Twitter) - Jan 15, 2022
- || foscarnet / Generic mfg., Cytovene (ganciclovir) / Roche
Yes, use foscarnet and ganciclovir. Can stop foscarnet when confusion goes away. (Twitter) - Jan 15, 2022
- | doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects. (Pubmed Central) - Jan 14, 2022
In contrast, treatment with the cardiotoxic drug Dox induces, besides well-known adverse acute effects, long-term subclinical changes in the heart, especially of circadian clock genes. Since the circadian clock is known to impact on cardiac repair mechanisms, these changes may render the heart more sensitive to additional stress during lifetime, which, at least in part, could contribute to late cardiac toxicity.
- ||| Prevymis (letermovir) / Merck (MSD), Cytovene (ganciclovir) / Roche
Clinical: Patient is on high dose ganciclovir already and they added letermovir to that last week. (Twitter) - Jan 13, 2022
- ||| Cytovene (ganciclovir) / Roche
Clinical: The patient I switched off with CMV was complicated (more of a PNF/DGF that wasn’t improving) What about high dose ganciclovir? https://t.co/eQEja4XLQl (Twitter) - Jan 13, 2022
- ||| Prevymis (letermovir) / Merck (MSD), Cytovene (ganciclovir) / Roche, Nulojix (belatacept) / BMS
This is interesting. I’m dealing with this scenario now… refractory CMV viremia in a b/l lung on ganciclovir. Getting belatacept. On IVIG too. Transplant team added letermovir as an adjunct, which I didn’t think would help since VL > 1000s. https://t.co/lQarvKZ9fd (Twitter) - Jan 13, 2022
- || Cytovene (ganciclovir) / Roche
PK/PD data, Journal: Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar). (Pubmed Central) - Jan 12, 2022
The increased plasma concentration and prolonged elimination half-life of ganciclovir caused by ketoprofen may result in the prolonged duration of action and therapeutic effect of ganciclovir. However, the concomitant use requires determination of the pharmacokinetics of ketoprofen and the safety of both drugs.
- | NSC23766 / University of Oslo
Journal: NSC23766 and Ehop016 suppress herpes simplex virus-1 replication by inhibiting Rac1 activity. (Pubmed Central) - Jan 11, 2022
Our results showed that increased Rac1 activity facilitated HSV-1 replication and inhibition of Rac1 activity by NSC23766 and Ehop016 significantly reduced HSV-1 replication. Thus, we identified NSC23766 and Ehop016 as possessing potent anti-HSV-1 activities by suppressing the Rac1 activity, suggesting that Rac1 is a potential target for treating HSV-1-related diseases.
- | tacrolimus topical / Generic mfg.
Journal: Development of Cytomegalovirus Corneal Endotheliitis During Long-Term Topical Tacrolimus and Steroid Treatment for Chronic Ocular Surface Inflammatory Diseases. (Pubmed Central) - Jan 11, 2022
Topical steroids and immunosuppressants can induce fulminant CMV corneal endotheliitis with cataract progression and irreversible mydriasis. In these cases, early diagnosis and treatment, including topical 0.5% ganciclovir, glaucoma surgery, cataract surgery, and endothelial keratoplasty, are necessary for preserving the patient's vision.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: Continuous High-Dose (6 mg) vs. Low-Dose (3 mg) Intravitreal Ganciclovir for Cytomegalovirus Retinitis After Haploidentical Hematopoietic Stem Cell Transplantation: A Randomized Controlled Study. (Pubmed Central) - Jan 11, 2022
Continuous high-dose regimen was well tolerated and resulted in less intravitreal injections, with similar vision outcomes and safety profiles. The clinical course of CMVR after Haplo-HSCT was determined by its own nature at baseline and could not be modified by treatment protocols under consistent immune background.
- Prevymis (letermovir) / Merck (MSD)
[PRE-RECORD] Letermovir Prophylaxis for Cytomegalovirus Reactivation in Allogeneic Hematopoietic Cell Transplant Recipients: A Single Centre Experience (Salt Palace Convention Center Room 250 D) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_1396;
Pre-emptive management involves surveillance of CMV titres and treatment with val-/ganciclovir or foscarnet. Our single-centre study demonstrated that letermovir prophylaxis in high-risk alloHCT recipients for CMV reactivation significantly decreased the incidence of CMV reactivation as well as subsequent reactivations compared to those without letermovir, without an apparent impact on survival.
- Prevymis (letermovir) / Merck (MSD)
Letermovir As CMV Prophylaxis in a Pediatric Cohort: A Retrospective Analysis (Salt Palace Convention Center Hall A) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_1236;
Patient characteristics are described in Table 1. Apart from a 23 kg 4-year-old who received 240 mg daily, all patients received 480 mg daily for a mean daily dose of 10.1 mg/kg/day.
- Prevymis (letermovir) / Merck (MSD)
Extended Letermovir Prophylaxis Is Highly Effective Cytomegalovirus (CMV) Infection Prevention in Adult Cord Blood Transplantation (CBT) Recipients & Does Not Prevent Emergence of CMV-Specific Donor-Derived Immunity (Salt Palace Convention Center Hall A) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_1235;
It mitigates the high CMV infection burden, CMV-related mortality, & antiviral drug toxicities observed in seropositive adult CBT recipients managed preemptively during the first 6 months post-transplant. Our data highlights that extended LET prophylaxis for at least 6 months is beneficial in adult CBT.
- Prevymis (letermovir) / Merck (MSD)
Letermovir Prophylaxis in Pediatric Hematopoietic Stem Cell Transplant (HSCT) Recipients: A Single Institution Retrospective Series. (Salt Palace Convention Center Hall A) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_1232;
In our pediatric cohort, only two patients had CMV reactivation requiring treatment. Of these, patient 9 was extremely high risk for CMV reactivation due to CMV pneumonia with viremia in the 6 weeks prior to HSCT.
- Cytovene (ganciclovir) / Roche, Vistide (cidofovir) / Gilead, Livtencity (maribavir) / Takeda, GSK
Assessment of Discontinuations and Anti-Cytomegalovirus Treatment Switching in Post-Transplant Refractory/Resistant Cytomegalovirus Infections: Safety and Sensitivity Analyses from a Phase 3 Randomized Trial (Salt Palace Convention Center Hall A) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_1225;
P3
Conclusions The benefit of maribavir over IAT was observed for the primary endpoint of CMV viremia clearance at Wk 8 in sensitivity analyses regardless of early discontinuations or the need for alternative treatment . This study was funded by Takeda Development Center Americas, Inc.
- Cytovene (ganciclovir) / Roche
The Safety, Feasibility, and Efficacy of Ganciclovir Prophylaxis through Day +100 in Pediatric Allogeneic Stem Cell Transplantation (AlloSCT) Recipients: Bone Marrow Suppression Secondary to Ganciclovir May Limit Effectiveness (Salt Palace Convention Center Hall A) - Jan 9, 2022 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_906;
No other risk factors were associated with 1 yr OS or 1 yr NRM in the univariate analyses. Multivariate analysis is ongoing.
- | Cytovene (ganciclovir) / Roche
Journal: Infantile nephrotic syndrome secondary to cytomegalovirus infection in a 7-month-old girl: resolution with ganciclovir. (Pubmed Central) - Jan 7, 2022
At 18 months follow-up she remained well. Appropriate treatment of infantile nephrotic syndrome secondary to CMV should result in recovery.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: Molecular Epidemiology of Cytomegalovirus UL97 and UL54 variants in Taiwan. (Pubmed Central) - Jan 4, 2022
The proportion of antiviral resistance CMV strains within CMV DNAemia patients was 3.6%. With the information of polymorphism incidence in the UL54 and UL97 patients from our study, determination of the genetic profile of UL54 and UL97 among immunocompromised populations with refractory CMV infection is recommended.
- || Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Clinical, Journal: ENDOGENOUS ASPERGILLUS ENDOPHTHALMITIS IN AN IMMUNOCOMPETENT PATIENT WITH A REMOTE HISTORY OF PULMONARY TUBERCULOSIS. (Pubmed Central) - Dec 29, 2021
With the information of polymorphism incidence in the UL54 and UL97 patients from our study, determination of the genetic profile of UL54 and UL97 among immunocompromised populations with refractory CMV infection is recommended. To the best of our knowledge, this is the first reported case of Aspergillus endogenous endophthalmitis in an immunocompetent patient secondary to pulmonary changes that occurred from previously treated tuberculosis.
- | Cytovene (ganciclovir) / Roche
Journal, IO biomarker: A novel zeta-associated protein 70 homozygous mutation causing combined immunodeficiency presenting as neonatal autoimmune hemolytic anemia. (Pubmed Central) - Dec 29, 2021
Normal neonatal screening for SCID does not rule out the diagnosis of CID due to ZAP70 deficiency. This type of CID can present with autoimmunity as the sole initial manifestation of the disease.
- | Opsumit (macitentan) / Nippon Shinyaku, J&J
Journal: The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection. (Pubmed Central) - Dec 25, 2021
Ganciclovir and its pro-drug valganciclovir are the preferred drugs in use today for prophylaxis and treatment of viremic patients...We infected these cells with HCMV and treated them with the ETBR specific antagonist BQ788 or ETR antagonists that are approved by the FDA for treatment of pulmonary hypertension; macitentan, its metabolite ACT-132577, bosentan and ambrisentan, and as an anti-viral control, we used ganciclovir or letermovir...Of importance, macitentan also inhibited productive infection of a ganciclovir-resistant HCMV isolate. Our results suggest that binding or signaling through ETBR is crucial for viral replication, and that selected ETBR blockers inhibit HCMV infection.
- | Cytovene (ganciclovir) / Roche, brivudine (RP 101) / RESprotect, RedHill, SciClone
Journal: Neural Progenitor Cells Expressing Herpes Simplex Virus-Thymidine Kinase for Ablation Have Differential Chemosensitivity to Brivudine and Ganciclovir. (Pubmed Central) - Dec 24, 2021
Our findings demonstrate enhanced ablation efficiency and reduced bystander effects when targeting all rapidly dividing cells with combinatorial GCV and BVDU treatment. However, for use in loss of function studies, BVDU alone is optimal due to reduced nonselective cell ablation.
- | dexamethasone / Generic mfg.
Journal: Modifying gap junction communication in cancer therapy. (Pubmed Central) - Dec 23, 2021
However, for use in loss of function studies, BVDU alone is optimal due to reduced nonselective cell ablation. An enhancement of GJIC function by HDACi and ATRA increased cytotoxicity and could be effective in the presence of Dexamethasone, when combined with ATRA or VPA.
- Cytovene (ganciclovir) / Roche
HUMAN HERPESVIRUS-6 MENINGOENCEPHALITIS IN AN IMMUNOCOMPETENT MALE. (Carpenter Hall) - Dec 20, 2021 - Abstract #WSMRF2022WSMRF_298;
Conclusion HVV-6 meningoencephalitis is a serious but rare condition particularly in otherwise immunocompetent adults. Clinicians should be aware of this infection when initial work up is not diagnostic.
- || Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Clinical, Journal: Acute retinal necrosis with exudative retinal detachment in a child. (Pubmed Central) - Dec 17, 2021
In addition, she also received intravitreal ganciclovir 4 mg/0.1 mL three times under general anaesthesia. At her last follow-up, 3 years from her presentation, her right eye examination was within normal limits, and left eye showed thick vitreous bands with a posterior vitreous detachment, and left inferotemporal retinal scarring.
- || Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, PK/PD data, Journal: Population Pharmacokinetics and Bayesian Estimation of the Area Under the Concentration-Time Curve for Ganciclovir in Adult Chinese Renal Allograft Recipients After Valganciclovir Administration. (Pubmed Central) - Dec 17, 2021
The PPK model was acceptable and can describe the PK of GCV in Chinese renal transplant patients administered VGCV. The AUC of GCV in Chinese renal transplant patients can be calculated by a limited sampling strategy method.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: Epstein-Barr virus retinitis in an immunocompromised child: A case report. (Pubmed Central) - Dec 16, 2021
Epstein-Barr virus is rarely identified as a sole pathogen in retinitis. Peripapillary predilection might be another type of presenting feature apart from the more-commonly reported peripheral acute retinal necrosis.
- | Cytovene (ganciclovir) / Roche
Journal: Dose banding of intravenous ganciclovir: Banding scheme proposal and audit of toxicity and efficiency. (Pubmed Central) - Dec 16, 2021
Peripapillary predilection might be another type of presenting feature apart from the more-commonly reported peripheral acute retinal necrosis. Ganciclovir dose banding allows for efficient management of preparations without an increased risk of acute haematological side effects.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: Cytomegalovirus optic neuropathy in a young immunocompetent patient. (Pubmed Central) - Dec 16, 2021
Viral copies were detected in both blood and cerebrospinal fluid, as well as a high IgG titre and no evidence of immunosuppression was found. Clinical improvement was seen after high-dose corticosteroids and ganciclovir.
- | Cytovene (ganciclovir) / Roche, Livtencity (maribavir) / Takeda, GSK
Journal: Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing. (Pubmed Central) - Dec 16, 2021
The data indicate that mutations in the UL97 ATP binding region may arise in clinical specimens to affect the interpretation of ganciclovir and maribavir resistance. This region should now be included in the standard diagnostic genotyping of UL97, especially with the introduction of maribavir into therapeutic use.
- | Cytovene (ganciclovir) / Roche
Preclinical, Journal: Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model. (Pubmed Central) - Dec 16, 2021
Using mice that express a thymidine kinase (tk) "suicide gene" driven by the 3.6Col1a1 promoter (Col1-tk), proliferating osteoblast lineage cells can be ablated upon exposure to the nucleoside analog ganciclovir (GCV)...Our data indicates that suppression of proliferating osteoblast-lineage cells for at least 2?weeks after fracture blunts the formation and remodeling of a mineralized callus leading to a functional nonunion. We propose this as a new murine model of atrophic nonunion.
- | Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Journal: Cytomegalovirus mismatch after heart transplantation: Impact of antiviral prophylaxis and intravenous hyperimmune globulin. (Pubmed Central) - Dec 16, 2021
However, we did not observe differences in perioperative morbidity and mortality regarding CMV matching, which might be related to regularly administer prophylactic virostatics and additional CMV-IVIG for risk constellations. For high-risk constellation, long-term application of CMV-IVIG during the first year after transplant may be beneficial.
- Livtencity (maribavir) / Takeda, GSK
Healthcare Resource Utilization in Transplant Recipients with Cytomegalovirus Infection Refractory/Resistant to Treatment Receiving Maribavir Versus Investigator Assigned Therapy: Exploratory Analysis of a Phase 3 Trial (Salt Palace Convention Center Hall A) - Dec 3, 2021 - Abstract #TCTASTCTCIBMTR2022TCT_ASTCT_CIBMTR_207;
P3
Reducing hospitalizations is critical for alleviating disease burden to healthcare systems. This study was funded by Takeda Development Center Americas, Inc.
- Cytovene (ganciclovir) / Roche
Initial Cytomegalovirus Viral Load Increase in Solid Organ Transplant Patient Successfully Treated with Ganciclovir ([VIRTUAL]) - Dec 2, 2021 - Abstract #ASHP2021ASHP_123;
- || cyclosporine / Generic mfg.
Clinical, Journal: Cytomegalovirus-associated supraglottic mass in a patient on immunosuppressive therapy. (Pubmed Central) - Dec 2, 2021
After being given plasma exchange, pulses of methylprednisolone and a dose of cyclosporine for suspected ANCA (anti-neutrophilic cytoplasmic autoantibodies) vasculitis, she developed an obstructive supraglottic laryngeal mass that required a tracheostomy to bypass...The mass resolved after several weeks of intravenous ganciclovir therapy. This is an extremely unusual presentation of localised CMV disease, with only two or three similar cases having been reported worldwide.
- || Cytovene (ganciclovir) / Roche
Review, Journal: Microwave Freeze-thaw Technique for Injectable Drugs: A Review Updated from 1980 to 2021. (Pubmed Central) - Dec 1, 2021
Only three teams tested the long-term stability after the microwave freeze-thaw treatment, the first for ganciclovir after 7 days, the second for ceftizoxime after 30 days, and the third for 20 drugs after 11 to 70 days. This review can help Centralized Intravenous Additive Services take charge of the productions of ready-to-use injectable drugs.
- | Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Preclinical, Journal: In vitro efficacy of ganciclovir against feline herpesvirus type 1 and assessment of ocular tolerability in healthy cats. (Pubmed Central) - Nov 29, 2021
When applied q8h as a commercial 0.15% gel to a small group of cats with normal eyes, this medication was well tolerated. Taken together, these data suggest this medication warrants further investigation in cats with ocular disease caused by FHV-1.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: Impact of the use of nephrotoxic drugs in critically ill pediatric patients. (Pubmed Central) - Nov 29, 2021
Taken together, these data suggest this medication warrants further investigation in cats with ocular disease caused by FHV-1. It is necessary for intensivist physicians to have knowledge of the main nephrotoxic drugs to predict, reduce or avoid damage to their patients.
- | hydroxychloroquine / Generic mfg.
Journal: Severe herpes virus 6 interstitial pneumonia in an infant with three variants in genes predisposing to lung disease. (Pubmed Central) - Nov 29, 2021
HHV-6 infection should be considered in the differential diagnosis of late onset severe respiratory distress in neonates and the co-occurrence of genetic predisposing factors or modifiers should be tested by specific molecular techniques. The intensity of HHV-6 genome load in BAL fluid could be an indicator of the response to the antiviral therapy.
- || Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Clinical, Journal: Thoroughly Validated Bayesian Estimator and Limited Sampling Strategy for Dose Individualization of Ganciclovir and Valganciclovir in Pediatric Transplant Recipients. (Pubmed Central) - Nov 29, 2021
The intensity of HHV-6 genome load in BAL fluid could be an indicator of the response to the antiviral therapy. Three plasma samples collected at 1 h/2 h/3 h and 1 h/2 h/6 h post-dose for GCV and VGCV respectively, are sufficient to accurately determine GCV area under the concentration-time curve from 0 to 24 h for pharmacokinetic-enhanced therapeutic drug monitoring.
- | Cytovene (ganciclovir) / Roche
Preclinical, Journal: Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter. (Pubmed Central) - Nov 29, 2021
This study established pGFAP-HSVtk-P2A-EGFP plasmids that successfully ablated GFAP-positive glioblastoma cells, but left neuronal N2A cells intact. These data suggest that the neural differentiation of glioblastoma cells can be promoted by treatment with the HSVtk/GCV system.
- || foscarnet / Generic mfg.
Clinical, Journal: Glomerular and tubulointerstitial foscarnet nephropathy of kidney allograft with emphasis on ultrastructural findings: A case report. (Pubmed Central) - Nov 29, 2021
These data suggest that the neural differentiation of glioblastoma cells can be promoted by treatment with the HSVtk/GCV system. Transplant kidney biopsy remains the gold standard in distinguishing between foscarnet crystalline glomerular and/or tubulointerstitial lesions, and various forms of rejection and other causes of impaired renal function in transplant kidney.
- ||| foscarnet / Generic mfg., Cytovene (ganciclovir) / Roche
Treat bacterial sepsis, once cultures neg for 48 hours, proceed. Swap ganciclovir for foscarnet if CMV/renal function allow, watch closely - likely to be cytopenic for some time! (Twitter) - Nov 28, 2021
- Cytovene (ganciclovir) / Roche
Recurrent CMV Viremia Portends Poor Prognosis and Results in Significant Resource Utilization in Patients with Poor Graft Function Post Allogeneic Stem Cell Transplantation () - Nov 24, 2021 - Abstract #ASH2021ASH_6617;
Conclusion Patients with PGF and RP-CMV are at high risk of mortality as well as more lengthy hospital admissions of which CMV reactivation and CMV therapy is a potential contributor. Targeted use of novel therapies to prevent CMV reactivation in patients with PGF may improve both bone marrow function and survival leading to less resource utilization.
- || Cytovene (ganciclovir) / Roche
Clinical, Journal: The Effect of a Combined Ganciclovir, Methylprednisolone, and Immunoglobulin Regimen on Survival and Functional Outcomes in Patients With Japanese Encephalitis. (Pubmed Central) - Nov 24, 2021
TAGMIC treatment can reduce mortality due to severe Japanese encephalitis. The memory loss of surviving patients is mainly due to a disorder of the memory retrieval process, which may be related to the breakage of related fibre bundles.