Strada (ademetionine) / MSI Methylation Sciences 
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 5 Diseases   0 Trials   0 Trials   23 News 
  • ||||||||||  Strada (ademetionine) / MSI Methylation Sciences
    Clinical, Journal:  Early score fluctuation and placebo response in a study of major depressive disorder. (Pubmed Central) -  Mar 25, 2021   
    We examined the effect of early score fluctuation during a 2-week double-blind placebo lead-in period in a phase II, double-blind, placebo-controlled trial of adjunctive s-adenosyl methionine (MSI-195) in MDD subjects who had had an inadequate response to ongoing antidepressant treatment...A reliable baseline measure is an asset for signal detection. These post-hoc findings suggest that study designs that anticipate and attempt to manage early response prior to randomization may yield more meaningful outcome data for trials of MDD and possibly other disorders as well.
  • ||||||||||  Adomet (S-adenosyl-L-methionine) / Abbott, Strada (ademetionine) / MSI Methylation Sciences
    Journal:  An augmentation study of MSI-195 (S-adenosylmethionine) in Major Depressive Disorder. (Pubmed Central) -  Sep 14, 2019   
    P2
    These post-hoc findings highlight the inherent challenges encountered for subject selection in double-blind, placebo controlled trials and compel further investigation of enrollment criteria and moderating factors that affect treatment. The favorable safety profile and clinical benefit observed with MSI-195 in the 1st half of this study warrant further investigation in MDD.
  • ||||||||||  Strada (ademetionine) / MSI Methylation Sciences
    Trial completion, Enrollment change, Trial primary completion date:  Add-On Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) for Patients With Major Depressive Disorder (MDD) (clinicaltrials.gov) -  Mar 19, 2016   
    P2,  N=376, Completed, 
    The favorable safety profile and clinical benefit observed with MSI-195 in the 1st half of this study warrant further investigation in MDD. Active, not recruiting --> Completed | N=286 --> 376 | Trial primary completion date: Jun 2015 --> Sep 2015