- |||||||||| buspirone/melatonin (BCI-952) / BrainCells
Enrollment open, Trial completion date, Trial primary completion date: Buspirone and Melatonin for Depression Following Traumatic Brain Injury (clinicaltrials.gov) - Apr 11, 2024
P4, N=10, Recruiting,
Not yet recruiting --> Recruiting | Trial completion date: Jul 2022 --> Jul 2026 | Trial primary completion date: Jul 2021 --> Jul 2026
- |||||||||| buspirone/melatonin (BCI-952) / BrainCells, lamotrigine liquid oral suspension / OWP Pharma
Medroxyprogesterone for Refractory Agitation in TBI and Parkinson’s Disease () - May 5, 2022 - Abstract #APA2022APA_549;
Psychiatric course of treatment included adequate trials of Quetiapine, Olanzapine, Buspirone, Melatonin, Valproic Acid, Trazodone, and varying levels of benzodiazepines...Due to severity of his Parkinson''s, Neurology was reluctant to make changes to Carbidopa-Levodopa 25-100 mg four times daily due to the overall motor benefit he experienced...As in the prior case, he was started on medroxyprogesterone IM 150 mg weekly and found benefit at 300 mg weekly, which allowed for discharge to memory care unit. While dopamine and D2-like receptor families have been associated with impulsive personality traits, these cases illustrate the potential for Medroxyprogesterone to target an alternative mechanism when agitation appears refractory to treatment, and changes to dopamine may be unable to be made.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg., Egis, memantine / Generic mfg.
Journal: The psychopharmacology of autism spectrum disorder and Rett syndrome. (Pubmed Central) - Apr 19, 2020
Experimental drug treatments for ASD include oxytocin and vasopressin, bumetanide, sulforaphane, nutritional supplements, memantine, and d-cycloserine. Work performed on syndromic forms, represents an important source of information for experimental therapies of ASD and knowledge of the unique mechanisms underlying autism in each individual patient may in the future pave the path to personalized drug treatments.
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