liafensine (DB104) / Denovo 
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 5 Diseases   0 Trials   0 Trials   16 News 
  • ||||||||||  liafensine (DB104) / Denovo
    Journal:  Time-Course Transcriptome Analysis of Bacillus subtilis DB104 during Growth. (Pubmed Central) -  Aug 26, 2023   
    However, the expression timing of the spore coat gene was only affected by the relevant sigma factor. This study can help to understand gene expression and regulatory mechanisms in B. subtilis species by providing an overall view of transcriptional changes during the growth of B. subtilis DB104.
  • ||||||||||  liafensine (DB104) / Denovo
    Journal:  New robust subtilisins from halotolerant and halophilic Bacillaceae. (Pubmed Central) -  Jun 5, 2023   
    This study can help to understand gene expression and regulatory mechanisms in B. subtilis species by providing an overall view of transcriptional changes during the growth of B. subtilis DB104. The protease genes were cloned and expressed in Bacillus subtilis DB104...
  • ||||||||||  liafensine (DB104) / Denovo
    Journal:  Decolorization of Acid Green 25 by Surface Display of CotA laccase on Bacillus subtilis spores. (Pubmed Central) -  Jan 16, 2020   
    The optimum temperature for the decolorization of Acid Green 25 by the DB104 (pSDJH-EA) spore was found to be 50°C. Upon treatment with known laccase inhibitors, including EDTA, SDS, and NaN, the decolorization rate of Acid Green 25 by the DB104 (pSDJH-EA) spore decreased by 23%, 80%, and 36%, respectively.
  • ||||||||||  liafensine (DB104) / Denovo
    Journal:  Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA. (Pubmed Central) -  Nov 14, 2019   
    To this end, we cloned recombinant Bacillus subtilis spores pHY300PLK-cotg-dhaa-6his/DB104(FH01) for the delivery of DhaA from Rhodococcus rhodochrous NCIMB 13064...The hydrolyzing activity of DhaA displayed on spores towards the HD analog 2-chloroethyl ethylsulfide was 1.74 ± 0.06 U/mL (P < 0.01), with a specific activity was 0.34 ± 0.04 U/mg (P < 0.01). This is the first demonstration that DhaA displayed on the surface of B. subtilis spores retains enzymatic activity, which suggests that it can be used effectively in real-world applications including bioremediation of contaminated environments.
  • ||||||||||  liafensine (DB104) / Denovo
    Trial termination:  Long-term Safety and Tolerability of BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression (clinicaltrials.gov) -  Nov 3, 2013   
    P2,  N=789, Terminated, 
    This is the first demonstration that DhaA displayed on the surface of B. subtilis spores retains enzymatic activity, which suggests that it can be used effectively in real-world applications including bioremediation of contaminated environments. Recruiting --> Terminated; Failure to meet primary endpoint
  • ||||||||||  liafensine (DB104) / Denovo
    Trial completion:  Japanese Phase 1 Multiple Ascending Dose (MAD) Study (clinicaltrials.gov) -  Jan 31, 2013   
    P1,  N=57, Completed, 
    Recruiting --> Completed Recruiting --> Completed