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Biomarker, Trial completion, Trial completion date, Trial primary completion date: ENLIGHTEN: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression (clinicaltrials.gov) - Apr 4, 2024 P2, N=197, Completed, Recruiting --> Completed | Trial completion date: Jul 2024 --> Mar 2024 | Trial primary completion date: Jun 2024 --> Feb 2024
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Journal: Time-Course Transcriptome Analysis of Bacillus subtilis DB104 during Growth. (Pubmed Central) - Aug 26, 2023 However, the expression timing of the spore coat gene was only affected by the relevant sigma factor. This study can help to understand gene expression and regulatory mechanisms in B. subtilis species by providing an overall view of transcriptional changes during the growth of B. subtilis DB104.
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Journal: New robust subtilisins from halotolerant and halophilic Bacillaceae. (Pubmed Central) - Jun 5, 2023 This study can help to understand gene expression and regulatory mechanisms in B. subtilis species by providing an overall view of transcriptional changes during the growth of B. subtilis DB104. The protease genes were cloned and expressed in Bacillus subtilis DB104...
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Biomarker, Trial completion date, Trial initiation date, Trial primary completion date: ENLIGHTEN: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression (clinicaltrials.gov) - Apr 12, 2022 P2, N=180, Not yet recruiting, Not yet recruiting --> Recruiting Trial completion date: Apr 2024 --> Jul 2024 | Initiation date: Mar 2022 --> Jun 2022 | Trial primary completion date: Mar 2024 --> Jun 2024
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Journal: Decolorization of Acid Green 25 by Surface Display of CotA laccase on Bacillus subtilis spores. (Pubmed Central) - Jan 16, 2020 The optimum temperature for the decolorization of Acid Green 25 by the DB104 (pSDJH-EA) spore was found to be 50°C. Upon treatment with known laccase inhibitors, including EDTA, SDS, and NaN, the decolorization rate of Acid Green 25 by the DB104 (pSDJH-EA) spore decreased by 23%, 80%, and 36%, respectively.
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Journal: Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA. (Pubmed Central) - Nov 14, 2019 To this end, we cloned recombinant Bacillus subtilis spores pHY300PLK-cotg-dhaa-6his/DB104(FH01) for the delivery of DhaA from Rhodococcus rhodochrous NCIMB 13064...The hydrolyzing activity of DhaA displayed on spores towards the HD analog 2-chloroethyl ethylsulfide was 1.74 ± 0.06 U/mL (P < 0.01), with a specific activity was 0.34 ± 0.04 U/mg (P < 0.01). This is the first demonstration that DhaA displayed on the surface of B. subtilis spores retains enzymatic activity, which suggests that it can be used effectively in real-world applications including bioremediation of contaminated environments.
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