Lodopin (zotepine) / Astellas 
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 4 Diseases   0 Trials   0 Trials   26 News 
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Lodopin (zotepine) / Astellas, Serlect (sertindole) / Lundbeck, Abbott
    Retrospective data, Review, Adverse events:  Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis. (Pubmed Central) -  Nov 3, 2023   
    Almost all antipsychotics were associated with dose-dependent EPS with varied degrees and the maximum ORs ranged from OR?=?1.57 95%CI [0.97, 2.56] for aripiprazole to OR?=?7.56 95%CI [3.16, 18.08] for haloperidol at 30?mg/d...There was very low quality of findings for cariprazine, iloperidone, and zotepine, and no data for clozapine...In conclusion, we found that the risk of EPS increases with rising doses and differs substantially in magnitude among antipsychotics, yet exceptions were quetiapine and sertindole with negligible risks. Our data provided additional insights into the current DR therapeutic window for EPS.
  • ||||||||||  Lodopin (zotepine) / Astellas, Serlect (sertindole) / Lundbeck, Abbott
    Retrospective data, Review, Journal:  Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic review and dose-response meta-analysis. (Pubmed Central) -  Jun 19, 2023   
    We obtained data on all antipsychotics except clozapine and zotepine. In patients with acute exacerbations of chronic schizophrenia, from moderate to high certainty of evidence, our analysis showed that sertindole and quetiapine carried negligible risks for akathisia across examined doses (flat curves), while most of the other antipsychotics had their risks increase initially with increasing doses and then either plateaued (hyperbolic curves) or continued to rise (monotonic curves), with maximum ORs ranging from 1.76 with 95% Confidence Intervals [1.24, 2.52] for risperidone at 5.4
  • ||||||||||  Lodopin (zotepine) / Astellas
    Retrospective data, Review, Journal:  Long-term efficacy of antipsychotic drugs in initially acutely ill adults with schizophrenia: systematic review and network meta-analysis. (Pubmed Central) -  May 9, 2023   
    In terms of overall symptoms, olanzapine was on average more efficacious than ziprasidone (standardized mean difference, SMD=0.37, 95% CI: 0.26-0.49), asenapine (SMD=0.33, 95% CI: 0.21-0.45), iloperidone (SMD=0.32, 95% CI: 0.15-0.49), paliperidone (SMD=0.28, 95% CI: 0.11-0.44), haloperidol (SMD=0.27, 95% CI: 0.14-0.39), quetiapine (SMD=0.25, 95% CI: 0.12-0.38), aripiprazole (SMD=0.16, 95% CI: 0.04-0.28) and risperidone (SMD=0.12, 95% CI: 0.03-0.21)...The differences between olanzapine and lurasidone, amisulpride, perphenazine, clozapine and zotepine were either small or uncertain...Concerning weight gain, the impact of olanzapine was higher than all other antipsychotics, with a mean difference ranging from -4.58 kg (95% CI: -5.33 to -3.83) compared to ziprasidone to -2.30 kg (95% CI: -3.35 to -1.25) compared to amisulpride. Our data suggest that olanzapine is more efficacious than a number of other antipsychotic drugs in the longer term, but its efficacy must be weighed against its side effect profile.
  • ||||||||||  Lodopin (zotepine) / Astellas
    Review, Journal:  Onset of Action of Selected Second-Generation Antipsychotics (Pines)-A Systematic Review and Meta-Analyses. (Pubmed Central) -  Jan 22, 2023   
    The summarized effect across all included pines administered as immediate-release formulations showed a statistically significant effect at week 1 (SMD, -0.20 [CI95% -0.28, -0.13]), which increased until week 3 (SMD, -0.42 [CI95% -0.50, -0.34]), after which the effect leveled off (week 6: SMD, -0.53 [CI95% -0.62, -0.44]). The sensitivity analyses of the individual pines confirm this finding, although data sparsity increases variability and limits conclusiveness of these analyses.
  • ||||||||||  Lodopin (zotepine) / Astellas
    PK/PD data, Journal:  Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics. (Pubmed Central) -  May 30, 2022   
    In vivo anti-schizophrenic activity was conducted using catalepsy test scores, the formulation showed better efficacy via the intranasal route; furthermore, there was no inflammation or hemorrhage in the nasal cavity. The results concluded that the ZTP microemulsion as a safe and effective strategy could greatly enhance brain distribution by intranasal administration.
  • ||||||||||  blonanserin / Generic mfg.
    Journal:  The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression. (Pubmed Central) -  Feb 25, 2022   
    Furthermore, changes in HbA1c levels 6 mo after the initiation of zotepine treatment were significantly higher than those following blonanserin and haloperidol treatments...Our study indicated that the type of antipsychotic had a greater affect on the incidence of hyperglycemic progression than the daily dose of antipsychotics or their number. Among these, zotepine was most likely to increase the incidence of hyperglycemic progression, suggesting the need for caution when these antipsychotics are prescribed.
  • ||||||||||  risperidone / Generic mfg., amisulpride / Generic mfg., ziprasidone / Generic mfg.
    Clinical, Journal:  Factors associated with laxative use in schizophrenia patients treated with second-generation antipsychotics. (Pubmed Central) -  Jan 18, 2022   
    In contrast, sulpiride was least associated with laxative use among all SGAs...Laxative use is common in schizophrenia patients treated with SGAs. For clinically significant constipation, switching to an SGA with a lower risk for constipation, and decreasing the doses of SGAs and anticholinergics should be considered.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Preclinical, Journal:  Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles. (Pubmed Central) -  Dec 16, 2021   
    The remaining nine antipsychotics (pipamperone (a butyrophenone), sulpiride, sultopride, tiapride, nemonapride (benzamides), risperidone, paliperidone (SDAs), aripiprazole, and brexpiprazole (dopamine partial agonists)) did not inhibit ACh-induced contractions at concentrations up to 10 M. These findings suggest that chlorpromazine, levomepromazine, zotepine, olanzapine, quetiapine, and clozapine should be avoided by elderly people with urinary disorders.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Essential role of the C148 - C227 disulphide bridge in the human 5-HT homodimeric receptor. (Pubmed Central) -  Dec 2, 2020   
    However, fluorescence microscopy showed that these mutations hindered receptor trafficking to the cell membrane. These results illustrate the importance of the disulphide bridge between TM-3 and ECL-2 in maintaining the correct 5-HT receptor conformation to allow ligand binding and migration of the homodimeric receptor to the cell membrane.
  • ||||||||||  Preclinical, Journal:  In vitro effects of antipsychotics on mitochondrial respiration. (Pubmed Central) -  Sep 2, 2020   
    Mitochondrial respiratory rate was significantly inhibited by all tested APs, except for olanzapine...Due to the complicated processes associated with mitochondrial activity, it is necessary to measure not only the effect of the drug on individual mitochondrial enzymes but also the respiration rate of the mitochondria or a similar complex process. The experimental approach used in the study can be applied to mitochondrial toxicity testing of newly developed drugs.
  • ||||||||||  Saphris (asenapine) / Lundbeck, Meiji Seika, AbbVie, olanzapine / Generic mfg., clozapine / Generic mfg.
    [VIRTUAL] Onset of antipsychotic action of selected second-generation antipsychotics - A systematic review and meta-analyses (Poster Area) -  Aug 5, 2020 - Abstract #ECNP2020ECNP_798;    
    By including sequential data only, the summary estimates did not change to a significant degree for any of the antipsychotics. Conclusions : Our results indicate that the initial antipsychotic effect of -pine antipsychotics appears within week one-three of treatment and that maximal effect appears within three weeks of treatment.
  • ||||||||||  Lodopin (zotepine) / Astellas
    Preclinical, Journal:  Intranasal Zotepine Nanosuspension: intended for improved brain distribution in rats. (Pubmed Central) -  Apr 12, 2020   
    ZTP-NS was successfully developed, characterized and found that nanosuspension is a favorable approach for intranasal delivery of zotepine. Graphical abstract Graphical abstract representing zotepine drawbacks, nanosuspension preparation, characterization and pharmacokinetic study in rats.
  • ||||||||||  sertraline / Generic mfg.
    [VIRTUAL] The clinical case of a 53-year-old-woman with atypical cognitive symptoms. (Station 11) -  Feb 20, 2020 - Abstract #EPA2020EPA_652;    
    Cognitive complaints, especially in younger patients with no family history of neurodegenerative diseases, can be challenging and need a multidisciplinary approach. The correct diagnosis is essential and implies different psychopharmacological approaches, family education and care planning.
  • ||||||||||  Lodopin (zotepine) / Astellas
    Enrollment change, Trial termination:  Risperidone and Zotepine in the Treatment of Delirium (clinicaltrials.gov) -  Feb 17, 2020   
    P4,  N=5, Terminated, 
    The correct diagnosis is essential and implies different psychopharmacological approaches, family education and care planning. N=60 --> 5 | Recruiting --> Terminated; inadequate participant
  • ||||||||||  risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg., quetiapine / Generic Mfg.
    Retrospective data, Review, Journal:  Antipsychotic drug use and pneumonia: Systematic review and meta-analysis. (Pubmed Central) -  Nov 2, 2019   
    Exposure to both first-generation antipsychotics and second-generation antipsychotics is associated with an increased pneumonia risk. Clinicians need to be vigilant for the occurrence of pneumonia in patients commencing antipsychotics, especially those with other risk factors for pneumonia including older age, chronic respiratory disease, cerebrovascular disease, dysphagia and smoking.
  • ||||||||||  Clinical, Review, Journal:  Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. (Pubmed Central) -  Aug 17, 2019   
    Although the current evidence of the efficacy and tolerability of AAPs in the treatment of delirium is limited and the heterogeneity of the data precluded a meta-analysis, olanzapine and quetiapine seem to be adequate alternatives to haloperidol, especially in patients who are vulnerable for extrapyramidal symptoms, who require sedation or who have a history of haloperidol intolerance. Evidently, larger-scale RCTs are urgently required.