| aprepitant oral / Generic mfg. |
ChiCTR2400089337: An exploratory study of the efficacy and safety of aprepitant and ondansetron alone or in combination in the prevention of nausea and vomiting after thyroid cancer surgery |
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| Not yet recruiting | 4 | 600 | | 8 mg of ondansetron was administered orally 1 hour before anesthesia, followed by two doses of the drug at 8-hour intervals; Aprepitant 125 mg orally 1 hour before anesthesia and 80mg orally once daily on the morning of the 2nd and 3rd day after surgery (day 1 on the day of surgery); Aprepitant 125 mg plus 8 mg ondansetron was administered orally 1 hour before anesthesia, followed by ondansetron twice every 8 hours, and Aprepitant 80mg once daily on the morning of the 2nd and 3rd postoperative days (day 1 on the day of surgery). | First Affiliated Hospital of Zhengzhou University; First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital of Zhengzhou University | Thyroid cancer | | | | |
ChiCTR2300068304: A Randomized, Controlled, Non-Inferiority Study of Dexamethasone Combined with Granisetron Transdermal Patches Versus Dexamethasone Combined with NK-1 Receptor Antagonist and 5-HT3 Receptor Antagonist for Prevention of Chemotherapy-Induced Delayed Nausea and Vomiting |
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| Not yet recruiting | 4 | 178 | | Administer a piece of granisetron transdermal patch on the upper arm 24-48 h before chemotherapy on Day1 and retain it for 7 days; and intravenously inject dexamethasone 10 mg 30 minutes before chemotherapy ;Administer standard dose of 5-HT3 RA before chemotherapy on Day 1; intravenous inject dexamethasone 10mg 30 minutes before chemotherapy; orally administer aprepitant capsules 125 mg 1 h before chemotherapy on Day 1, 80 mg on Day 2 and Day 3 respectively | The Seventh Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, The Seventh Affiliated Hospital, Sun Yat-sen University | Chemotherapy-Induced Delayed Nausea and Vomiting | | | | |
APHYPAP, NCT03808805: Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms |
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| Recruiting | 3 | 80 | Europe | Aprepitant 80 mg, Hydroxyzine 25mg, Placebo of Hydroxyzine, Placebo of Aprepitant | University Hospital, Brest | Myeloproliferative Disorder, Aquagenic Pruritus | 11/21 | 01/22 | | |
NCT04912271: Granisetron Transdermal Patch for Prophylaxis of Delayed CINV |
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| Not yet recruiting | 3 | 140 | NA | Granisetron transdermal patch, sancuso, Palonosetron, Aprepitant, Fosaprepitant, Dexamethasone | Fudan University | Chemotherapy-induced Nausea and Vomiting (CINV) | 06/22 | 12/23 | | |
NCT04606264: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data |
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| Recruiting | 3 | 2500 | US | Neuraxial Analgesia, Intrathecal morphine/hydromorphone, IT morphine/hydromorphine, Regional Block 1: Paravertebral, Nerve Block, Perphenazine, Aprepitant, Dimenhydrinate, Ondansetron 4 MG, Dexamethasone, Regional Block 2: QL1 | Jennifer Holder-Murray, Berry Consultants | Perioperative Optimization | 06/25 | 06/25 | | |
PATROL-II, UMIN000038644: A multicenter phase II trial of the triplet antiemetic therapy with palonosetron, aprepitant and olanzapine for highly emetogenic chemotherapy in breast cancer |
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| Recruiting | 2 | 89 | Japan | Aloxi (palonosetron oral) - Helsinn, Otsuka, Roche, Eisai, Immedica, aprepitant oral - Generic mfg., olanzapine - Generic mfg. | Hoshi University; Division of Applied Pharmaceutical, University of Shizuoka, School of Pharmaceutical Sciences | Breast cancer;Oncology | | | | |
APHOS 3, NCT06462287: EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION |
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| Recruiting | 2 | 24 | Europe | Aprepitant 125 and 80Mg Oral Capsule, Placebo | University Hospital, Rouen | Apnea, Obstructive | 04/26 | 04/26 | | |
APRE-PONV, NCT06357234: Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery |
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| Not yet recruiting | 2 | 100 | NA | Aprepitant, Aprepitant oral suspension 20mg/ml, Placebo, Dextrose | IWK Health Centre | Spinal Fusion, Nausea and Vomiting, Postoperative, Anesthesia | 03/26 | 04/26 | | |
NCT03683225: A Study to Evaluate in Patients With Parkinsonian Type Disorders |
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| Active, not recruiting | 2 | 24 | US | CTC-413 | Chase Therapeutics Corporation | Idiopathic Parkinson Disease | 12/25 | 12/25 | | |
NCT06224894: The Effect of Music Therapy on Nausea, Vomiting and Anxiety Levels in Children |
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| Not yet recruiting | N/A | 80 | NA | Music Therapy, antiemetic treatment | Bilecik Seyh Edebali Universitesi | Music Therapy, Nausea, Anxiety, Cancer, Vomiting, Children, Only | 10/24 | 02/25 | | |
| Not yet recruiting | N/A | 600 | NA | Ondansetron 8mg, AD, Aprepitant 125 mg, AR | The First Affiliated Hospital of Zhengzhou University | Thyroid Cancer | 05/25 | 07/25 | | |
NCT06080880: Ondanstron Weekly vs Every 3 Weeks for Prevention of Nausea and Vomiting Induced by Chemotherapy Combined With PD-1 Blockade |
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| Recruiting | N/A | 98 | RoW | Ondansetron every 3 weeks, Aprepitant, Dexamethasone, Ondansetron weekly | Hubei Cancer Hospital | Nausea With Vomiting Chemotherapy-Induced | 11/25 | 11/27 | | |
ChiCTR2400087798: Efficacy of aprepitant combined with dual antiemetics in preventing postoperative nausea and vomiting after sleeve gastrectomy: A single-center, randomized controlled trial |
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| Recruiting | N/A | 276 | | Aprepitant capsules 80mg P.O. (4 hours preoperatively) + dexamethasone injection 10mg I.V. (at the start of surgery) + ondansetron injection 8mg I.V. (30 minutes prior to the end of surgery); Dexamethasone injection 10mg I.V. (at the start of surgery) + ondansetron injection 8mg I.V. (30 minutes prior to the end of surgery) | Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University; Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, self-financing | postoperative nausea and vomiting | | | | |
