- |||||||||| cisplatin / Generic mfg., albumin-bound paclitaxel / Generic mfg.
Enrollment closed, Enrollment change, Trial completion date, Metastases: Nab-PIPAC: PIPAC With Nab-paclitaxel and Cisplatin in Peritoneal Carcinomatosis (clinicaltrials.gov) - May 23, 2024 P1, N=18, Active, not recruiting, No abstract available Recruiting --> Active, not recruiting | N=36 --> 18 | Trial completion date: Mar 2024 --> Dec 2024
- |||||||||| Onivyde (nanoliposomal irinotecan) / Servier, Ipsen
Review, Journal: Update on management of pancreatic cancer: a literature review. (Pubmed Central) - May 21, 2024 Radical surgery itself is not enough for prolong survival. The improvement of chemotherapy, target agents and immunotherapy with multidisciplinary approach will be the only solution for improvement of survival outcome and quality of life for patients with pancreatic cancer.
- |||||||||| Loqtorzi (toripalimab-tpzi) / Shanghai Junshi Biosci, Coherus Biosci
Trial completion date: NeoTENNIS: Neoadjuvant Dose-dense EC Followed by ABX With PD-1 for Triple Negative Breast Cancer Patients (clinicaltrials.gov) - May 21, 2024 P2, N=70, Active, not recruiting, The improvement of chemotherapy, target agents and immunotherapy with multidisciplinary approach will be the only solution for improvement of survival outcome and quality of life for patients with pancreatic cancer. Trial completion date: Dec 2023 --> Dec 2025
- |||||||||| irinotecan / Generic mfg., albumin-bound paclitaxel / Generic mfg., gemcitabine / Generic mfg.
Journal: Failure to Undergo Resection Following Neoadjuvant Therapy for Resectable Pancreatic Cancer: A Secondary Analysis of SWOG S1505. (Pubmed Central) - May 16, 2024 Failure to undergo resection following NT was relatively common among patients with potentially resectable PDAC and associated with worse survival. Although few predictive factors were identified in this secondary analysis of the SWOG S1505 randomized trial, further research must focus on risk factors for severe toxicities during NT that preclude surgical resection so that patient-centered interventions can be delivered or alternate treatment sequencing can be recommended.
- |||||||||| Loqtorzi (toripalimab-tpzi) / Shanghai Junshi Biosci, Coherus Biosci
Review, Journal, Metastases: TORCHLIGHT trial, brightening the life of more patients with advanced triple-negative breast cancer. (Pubmed Central) - May 16, 2024 TORCHLIGHT trial, as the name of it, like a torch to more patients with advanced TNBC, lighting up their lives. We described the design background of TORCHLIGHT trial and reviewed primary trials of PD-1 or PD-L1 inhibitor in advanced TNBC both domestically and internationally.
- |||||||||| Enrollment closed, Trial completion date, Trial primary completion date, Metastases: Modified FOLFIRINOX Alternated With Biweekly Gemcitabine Plus Nab-Paclitaxel Untreated Pancreatic Cancer (clinicaltrials.gov) - May 15, 2024
P2, N=30, Active, not recruiting, However, further prospective studies are needed to verify it. Recruiting --> Active, not recruiting | Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Jun 2024 --> Sep 2024
- |||||||||| budigalimab (ABBV-181) / AbbVie, revdofilimab (ABBV-368) / AbbVie, giloralimab (ABBV-927) / AbbVie
Trial completion date, Trial primary completion date, Metastases: A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (clinicaltrials.gov) - May 12, 2024 P1, N=150, Active, not recruiting, Besides, a significant association was identified between the expression levels of TLR3 and RET and the PFS in patients. Trial completion date: Nov 2023 --> Sep 2024 | Trial primary completion date: Nov 2023 --> Sep 2024
- |||||||||| Endostar (recombinant human endostatin) / Simcere
Journal: Acute cardiac tamponade after Endostar treatment of non-small cell lung cancer: A case report. (Pubmed Central) - May 10, 2024 This review article summarizes the current evidence and discusses future prospects for treatment strategies for NSCLC patients complicated with IP, severe COPD, and TB. Medical professionals should remain vigilant for the potential, albeit rare, risk of Endostar inducing acute pericardial tamponade, a severe and potentially fatal complication.
- |||||||||| fludarabine IV / Generic mfg., cyclophosphamide / Generic mfg., albumin-bound paclitaxel / Generic mfg.
Enrollment change, Trial completion date, Trial primary completion date, CAR T-Cell Therapy, Metastases: Pan-T Booster Co-expressing MSLN CAR T Cell Therapy in Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - May 10, 2024 P1/2, N=15, Recruiting, Not yet recruiting --> Recruiting | Initiation date: Dec 2023 --> Mar 2024 N=30 --> 15 | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2024 --> Dec 2025
- |||||||||| Anniko (penpulimab) / Akesobio, Sino Biopharm, Focus V (anlotinib) / Advenchen, Sino Biopharm
Trial completion, Trial completion date, Combination therapy, Metastases: PAAG: A Study of Penpulimab and Anlotinib Plus Nab-paclitaxel and Gemcitabine for Metastatic Pancreatic Cancer. (clinicaltrials.gov) - May 9, 2024 P2, N=66, Completed, Trial completion date: Aug 2024 --> Aug 2025 | Trial primary completion date: Aug 2024 --> Aug 2025 Recruiting --> Completed | Trial completion date: Dec 2024 --> May 2024
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