| Fu Laimei (polyethylene glycol loxenatide) / Jiangsu Hansoh Pharma |
ChiCTR1900026514: Open clinical trial of once-weekly GLP-1 receptor agonist in the treatment of types 2 diabetes |
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| Not yet recruiting | 4 | 20 | | Polyethylene Glycol Loxenatide Injection 0.2mg qw s.c. | Shantou Longhu People's Hospital; Shantou Longhu People's Hospital, Shantou Longhu People's Hospital | Type 2 diabetes mellitus | | | | |
ChiCTR2100046845: Based on the renal ectopic fat deposition mediated chronic hypoxia injury, to explore the early renal protection of polyethylene glycol loxenatide in newly diagnosed type 2 diabetes patients |
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| Recruiting | 4 | 60 | | Received polyethylene glycol loxenatide ;Received Insulin glargine | Tianjin Medical University Chu Hisen-I Memorial Hospital; Tianjin Medical University Chu Hisen-I Memorial Hospital, China International Medical Exchange Foundation | Newly diagnosed type 2 diabetes | | | | |
ChiCTR2100049856: Effect and mechanism of polyethylene glycol Losenazeptide on cardiac microangiopathy in patients with type 2 diabetes mellitus complicated with massive albuminuria |
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| Not yet recruiting | 4 | 100 | | Polyethylene Glycol Loxenatide injection ;Linagliptin Tablets | Tianjin Medical University Chu Hsien-l Memorial Hospital; Tianjin Medical University Chu Hsien-l Memorial Hospital, China International Medical Foundation Special Fund for International Diabetes Exchange and Practice “SenMei China Diabetes Research Fund” | type 2 diabetes mellitus | | | | |
ChiCTR2200057800: The effect of polyethylene glycol loxenatide on body weight in overweight/obese patients with type 2 diabetes mellitus |
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| Not yet recruiting | 4 | 150 | | Polyethylene glycol loxenatide ;Metformin | Shandong Provincial Hospital; Shandong Provincial Hospital, China International Medical Exchange Foundation, International Diabetes Exchange and Practice special Fund, ‘’Simei China Diabetes Research Fund’’ Project | Type 2 Diabetes mellitus | | | | |
ChiCTR2100045569: Efficacy and safety of metformin in combination with polyethylene glycol loxenatide and canagliflozin in high-risk secondary prophylaxis patients with type 2 diabetes and kidney disease |
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| Not yet recruiting | 4 | 1000 | | Metformin + PEX-168 + canagliflozin ;Metformin + canagliflozin | Tianjin Medical University Zhu Xian Yi Memorial Hospital; Tianjin Medical University Zhu Xian Yi Memorial Hospital, Huilan Foundation | Type 2 Diabetes | | | | |
ChiCTR2100045608: Efficacy and safety of Polyethylene Glycol Loxenatide in combination with Canagliflozin in patients with type 2 diabetes mellitus at high risk for secondary prevention of heart and kidney disease |
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| Recruiting | 4 | 1000 | | Polyethylene Glycol Loxenatide + Canagliflozin ;Metformin+ Canagliflozin | West China Hospital Sichuan University; West China Hospital Sichuan University, Huilan Foundation | Type 2 Diabetes | | | | |
ChiCTR2200057155: Effects of polyethylene glycol losenatide injection and metformin on intestinal microbiota structure in overweight patients with type 2 diabetes mellitus |
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| Not yet recruiting | 4 | 40 | | Polyethylene glycol loxenatide injection ;Metformin | Beijing Hospital; Beijing Hospital, China International Medical Exchange Foundation, International Diabetes Exchange and Practice Special Fund, ‘’Sime China Diabetes Research Fund’’ | type 2 diabetes | | | | |
ChiCTR2300070919: Clinical study on the treatment of diabetic nephropathy with polyethylene glycol loxenatide |
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| Not yet recruiting | 4 | 80 | | Polyethlene glycol loxenatide ;SGLT-2 inhibitor | Sunshine Union Hospital; Sunshine Union Hospital, Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | diabetic nephropathy | | | | |
ChiCTR2300071939: Efficacy of Polyethylene Glycol Loxenatide combined with Exercise for sarcopenia in Type 2 Diabetes Patients:A randomized controlled trial |
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| Recruiting | 4 | 102 | | Glycol Loxenatide combined with Exercise ;Exercise | Tongji Hospital affiliated to Tongji Medical College of HUST ; Tongji Hospital affiliated to Tongji Medical College of HUST, Sen-Mei China Diabetes Research Fund | Sen-Mei China Diabetes Research Fund | | | | |
ChiCTR2100048253: Research on Psychiatric Disease and Metabolism of Medical Union in Huangpu District, Shanghai |
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| Not yet recruiting | 4 | 60 | | Polyethylene glycol loxenatide injection | Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, self-funded | endocrine metabolism diseases | | | | |
ChiCTR2200056410: A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Polyethylene Glycol Loxenatide on Cardiovascular Outcomes in Patients with Type 2 Diabetes (BALANCE-3) |
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| Not yet recruiting | 4 | 2006 | | polyethylene glycol loxenatide 0.2 mg ;Placebo | Tianjin Medical University Chu Hsien-I Memorial Hospital; Tianjin Medical University Chu Hsien-I Memorial Hospital, Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Type 2 Diabetes mellitus | | | | |
ChiCTR2400083620: Study for therapeutic effect and mechanism of glucagon like peptide-1 on the healing of diabetes foot ulcers through PI3K/Akt/FoxO1 signaling pathway |
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| Recruiting | 4 | 50 | | Routine dressing change and PEG-Loxenatide therapy; Routine dressing change | Tongji Hospital,Jiefang Road 1095 Wuhan, Hubei Province; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Senmei China Diabetes Research Fundation | diabetic foot ulcers | | | | |
ChiCTR2200055231: Observation on the clinical efficacy of polyethylene glycol loxenatide in the treatment of cerebral small vessel disease in patients with diabetes mellitus |
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| Recruiting | 3 | 110 | | Comprehensive management in accordance with the Chinese Diabetes Association guidelines for the prevention and treatment of type 2 diabetes, excluding the use of GLP-1R agonists or DDP-IV inhibitors ;Add loxenatide at a dose of 200ug, subcutaneously, once a week, or the maximum tolerated dose, under the premise of full management in the standard care group | Seventh Affiliated Hospital of Sun Yat-sen University; Seventh Affiliated Hospital of Sun Yat-sen University, 735 Plan of the Seventh Affiliated Hospital of Sun Yat-sen University | Diabetes | | | | |
NCT05172999: Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia |
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| Recruiting | 2/3 | 28 | RoW | levonorgestrel-releasing intrauterine system, MIRENA, Polyethylene Glycol Loxenatide, Fulaimei, PEX168 | Fudan University | Atypical Endometrial Hyperplasia, Obesity, Fertility Issues | 12/24 | 06/26 | | |
ChiCTR1800015049: An Open-label, Single-arm, Sequential study to evaluate the effect of Polyethylene Glycol Loxenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, on the pharmacokinetics and pharmacodynamics of warfarin in Healthy Chinese Volunteers |
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| Completed | 1 | 16 | | In this open-label, single-arm, two-treatment, sequential study, 16 healthy male subjects were administered warfarin (5 mg) alone on day 1. After a washout interval, subjects were Injected subcutaneously at 200 mcg per dose once a week for 14-42days with warfarin (5 mg) on day 44 in the other period. Ph | First Affiliated Hospital, College of Medicine, Zhejiang University; Jiangsu hausen Pharmaceutical Group Co., Ltd., Jiangsu hausen Pharmaceutical Group Co., Ltd. | Healthy Volunteers | | | | |
NCT06217887: Efficacy Comparison of Polyethylene Glycol Loxenatide and Gliclazide on the Brain Function in T2DM Patients |
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| Recruiting | N/A | 58 | RoW | loxenatide Group, metformin, Gliclazide Group | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Type 2 Diabetes Mellitus, Cognitive Function Abnormal | 02/24 | 06/24 | | |
ChiCTR2400087532: Effect of polyethylene glycol loxenatide treatment on body weight in patients with type 2 diabetes with different body mass index: a retrospective cohort study |
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| Not yet recruiting | N/A | 200 | | N/A; N/A | Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology; Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | type 2 diabetes | | | | |
ChiCTR2400086699: Efficacy and safety of polyethylene glycol loxenatide in combination with basal insulin in patients with type 2 diabetes mellitus: a retrospective cohort study |
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| Not yet recruiting | N/A | 200 | | none; none | The Third XiangYa Hospital of Central South University; The Third XiangYa Hospital of Central South University, None | Type 2 Diabetes | | | | |
ChiCTR2300073059: Effects of polyethylene glycol Losenatide on lipid metabolism and fat remodeling in elderly patients with type 2 diabetes |
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| Not yet recruiting | N/A | 56 | | Polyethylene glycol loxenatide ;Insulin glargine | Beijing Hospital; Beijing Hospital, China International Medical Exchange Foundation International Diabetes Exchange and Practice Fund | diabetes | | | | |
ChiCTR2300079158: Integration of Metabolomics and Multi-Modal fMRI Functional Imaging Techniques to Investigate the Role and Mechanisms of GLP-1 Receptor Agonist PEG-Loxenatide in Alleviating Early Damage in Diabetic Cardiomyopathy |
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| Recruiting | N/A | 120 | | Treatment of PEG-Loxenatide; Insulin glargine | Chu Hsien-lMemorial Hospital of TianjinMedical University; Chu Hsien-lMemorial Hospital of TianjinMedical University, China International Medical Foundation | diabetes | | | | |
ChiCTR2100052922: Effect of preoperative loxenatide on the prognosis of ultra-obese patients undergoing laparoscopic sleeve gastrectomy: a randomized controlled clinical study |
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| Recruiting | N/A | 207 | | polyethylene glycol loxenatide 400ug ;polyethylene glycol loxenatide 300ug ;none | The First Affiliated Hospital of Shandong First Medical University; The First Affiliated Hospital of Shandong First Medical University, Research hospital association of Shandong | Obesity | | | | |
