- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
TENECTPLASE VERSUS ALTEPLASE (ePoster Area) - Apr 19, 2023 - Abstract #ESOC2023ESOC_552;
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Enrollment closed: CRAD-001-03: A Study of r-PA Treating Patients With Acute Ischemic Stroke?RAISE? (clinicaltrials.gov) - Apr 18, 2023
P3, N=1412, Active, not recruiting,
Trial completion date: Mar 2022 --> Mar 2026 | Trial primary completion date: Dec 2021 --> Dec 2025 Recruiting --> Active, not recruiting
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization (clinicaltrials.gov) - Apr 18, 2023
P=N/A, N=113035, Completed,
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | N=4000 --> 113035 | Trial completion date: Jun 2023 --> Mar 2023 | Trial primary completion date: Jun 2023 --> Mar 2023
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Review, Journal: Thrombolysis for acute ischaemic stroke: current status and future perspectives. (Pubmed Central) - Apr 18, 2023
The growing implementation of mobile stroke units and advanced neuroimaging could boost the number of patients who can receive intravenous thrombolysis by shortening onset-to-treatment times and identifying patients with salvageable penumbra. Continued improvements in this area will be essential to facilitate the ongoing research endeavors and to improve delivery of new interventions.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
New trial: DIVAr (clinicaltrials.gov) - Apr 12, 2023
P=N/A, N=300, Not yet recruiting,
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: Intravenous thrombolysis for mild stroke: NIHSS 3-5 Versus NIHSS 0-2. (Pubmed Central) - Apr 11, 2023
Minor stroke severity, non-disabling stroke and prior statin therapy were independent predictors for funcitonal outcomes at discharge. Further studies with large sample size are needed to confirm the findings.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Retrospective data, Journal: Comparison of dosing errors between tenecteplase and alteplase for management of acute ischemic stroke. (Pubmed Central) - Apr 4, 2023
Tenecteplase was associated with shorter door to needle times, which may be caused by simpler administration times. Institutions could consider strategies to mitigate dosing errors for thrombolytic therapies.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: In Silico Study of Different Thrombolytic Agents for Fibrinolysis in Acute Ischemic Stroke. (Pubmed Central) - Mar 30, 2023
While tenecteplase and alteplase have very similar thrombolysis efficacy, tenecteplase has a lower risk of ICH and better resistance to PAI-1. Among the four simulated drugs, reteplase has the slowest fibrinolysis rate, but fibrinogen concentration in systemic plasma is unaffected during thrombolysis.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Review, Journal: Successful mechanical thrombectomy in acute bilateral M1 middle cerebral artery occlusion: a case report and literature review. (Pubmed Central) - Mar 30, 2023
Intravenous alteplase thrombolysis can increase the risk of atrial thrombus shedding in patients with atrial fibrillation, so patients with acute bilateral MCA occlusion in the M1 segment chose direct MT or bridging therapy, which remains controversial, and the sequence of MT remains to be discussed. Nevertheless, early endovascular treatment can decrease the morbidity and mortality of such patients.
- |||||||||| Eraxis (anidulafungin) / RaQualia, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
SUCCESSFUL SALVAGE OF PERITONEAL DIALYSIS CATHETER IN CANDIDA PARAPSILOSIS PERITONITIS WITH ANTIFUNGAL AGENTS AND INTRA-CATHETER FIBRINOLYTICS () - Mar 28, 2023 - Abstract #ISNWCN2023ISN_WCN_1373;
He received 28-day in-patient antifungal therapy before he was discharged with 2-week oral voriconazole...This enables better antifungal penetration, fungi eradication and thus prevents relapsing or repeat fungal peritonitis. Conclusions Catheter salvage using multiple synergistic antifungal agents together with intra-catheter fibrinolytic locking protocol is a treatment option in selected group of patients.
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
COMBINED INTRAVITREAL ALTEPLASE, RANIBIZUMAB AND PNEUMATIC DISPLACEMENT WITH C3F8 IN SUBMACULAR HEMORRHAGE SECONDARY TO WET AMD () - Mar 27, 2023 - Abstract #COPHyEU2023COPHy_EU_208;
Combined intravitreal injection of alteplase, expansile gas and ranibizumab seems to be an effective approach to treat recent SMH in patients with exudative AMD. Compared with PPV approaches, it is less invasive, with a likely lower complication rate, and is more accessible since there is no need for a dedicated vitreorretinal surgery team
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
RETINAL HEMORRHAGES AFTER CARDIOPULMONARY RESUSCITATION: A CASE REPORT () - Mar 27, 2023 - Abstract #COPHyEU2023COPHy_EU_178;
We present a 26 years old woman with PE and cardiogenic shock leading to prolonged resuscitative measures. Adult presentation of Retinal Hemorrhages after CPR is uncommon, and there is little evidence in the literature, however, clinicians should be aware of visual symptoms reported for patients who survived resuscitation attempts, especially in the setting of coexisting risk factors as systemic coagulopathy
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: Stroke thrombolysis given by emergency physicians: The time is here. (Pubmed Central) - Mar 26, 2023
Sixteen patients were deemed eligible for IV alteplase with one hemorrhagic conversion (6.25%)...The concept of emergency physician SCs providing teleneurology consultation to other fellow emergency physicians was found to be feasible and safe. This model has the potential to be generalized not to just stroke champions, but to all emergency physicians to feel both confident and comfortable treating acute stroke patients.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
A Case of Rapidly Progressive Chronic Thromboembolic Pulmonary Hypertension (Walter E. Washington Convention Center, Area J, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8311;
Chronic pulmonary hypertension would explain why he was hemodynamically well compensated despite severely elevated pulmonary pressures. This case raises the importance of a standardized approach for long-term follow-up of patients with intermediate and high-risk pulmonary embolism for development of CTEPH.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
A Case of Severe Fusobacterium Necrophorum and Arcanobacterium Hemolyticus Pneumonia Complicated by Empyema, Pericardial Effusion, and Septic Shock in an Immunocompetent Patient (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8130;
In this case, the patient The empyema did not completely drain despite intrapleural instillation with dornase/alteplase and required two additional CT-guided chest tube placements...The patient was treated with piperacillin-tazobactam monotherapy followed by ampicillin-sulbactam monotherapy after pleural fluid culture speciation...He was discharged home on oral amoxicillin-clavulanate and pulmonary clinic follow-up in a month to determine the duration of therapy...On review of the literature, there is only one reported case of co-infection of F. necrophorum and A. hemolyticus presenting as Lemierre
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Tpa - Be Patient (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7978;
Introduction: We present a case of a right ventricle (RV) thrombus that persisted after alteplase(tPA) administration in a Covid19 positive patient that resolved over two weeks with anticoagulation...We describe a case that demonstrates that it could take up to 2 weeks for resolution of right heart thrombi. In critically ill patients that carry a high surgical risk who are hemodynamically stable, it may be a reasonable approach to follow clot in transit with anticoagulation and serial ECHOs post tPA administration.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Aspergillus a Rare Cause of Empyema (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7745;
Alteplase and Dornase was injected into the chest tube for five consecutive days with repeat CT imaging showing decreased volume of the loculated, left, pleural effusion and a grossly stable multifocal bibasilar consolidation...Current literature has shown this method can be an effective alternative treatment to antibiotics alone. In summary, in addition to medical management of Aspergillus empyema, surgical intervention may be needed to achieve infection control.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Xanthogranulomatous Pyelonephritis Leading to Empyema: A Renal Cell Carcinoma Mimic (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7739;
A left sided chest tube was placed and a 3 day course of intra-pleural alteplase and dornase alpha was utilized with improvement and eventual removal of the chest tube...Definitive treatment requires source control, which involves nephrectomy. Importantly for above patient, his medical decision makers elected to pursue comfort measures if malignancy was diagnosed, however diagnosis of XG diverted his medical course to full treatment of XG with eventual consideration for nephrectomy.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Pleuro-pulmonary Nocardiosis in a Patient With Monoclonal Gammopathy of Undetermined Significance (MGUS) (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7079;
Due to further respiratory deterioration, piperacillin-tazobactam was changed to meropenem, with subsequent transfer to ICU for ventilatory support.Discussion Pulmonary nocardiosis is traditionally thought of as an opportunistic infection with a reported mortality rate of 40-50%...Cell-mediated immunity is crucial in resisting nocardia species infection, though the mechanism remains unclear. Nocardiosis should be considered in the di?erential for patients presenting with community acquired or hospital acquired pneumonia, not responding to standard therapy, even amongst immunocompetent patients.Conclusion Clinicians should have a low threshold of suspicion for Nocardiosis in severely unwell patients with pneumonia refractory to standard ?rst-line therapies.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Paradoxical Improvement of Intraventricular Hemorrhage and Associated Hydrocephalus After Antithrombotics (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6638;
Here, the use of heparin and coagulopathy associated with cirrhosis likely contributed to the recanalization of the CSF pathway and resolution of hydrocephalus with subsequent clinical improvement. Hence in similar cases with grim prognosis and no other viable treatment, the use of anticoagulant could be considered however this will require further studies.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Plasminogen Activators Encapsulated Into Microfiber Carriers to Deliver and Support Sustainable Plasminogen Activation (Walter E. Washington Convention Center, Area J, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5641;
EStPA activates endogenous plasminogen in pleural fluid and slowly releases active tPA, thus supporting further plasminogen activation and fibrinolysis. While released tPA is not resistant to PAI-1, it may sustain intrapleural PA activity and support slow fibrinolysis during treatment of empyema.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Aspiration Pneumonia Complicated by Transdiaphragmatic Empyema Necessitans (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5483;
Despite antibiotic coverage with ampicillin-sulbactam, the patient continued to clinically deteriorate...He required three separate thoracostomy catheters into the empyema with multiple rounds of instilled alteplase and dornase-alfa...He was treated with a prolonged course of intravenous ceftriaxone and metronidazole followed by oral antibiotics with resolution of the empyema, discharging on hospital day 31.Discussion Empyema necessitans is a rare complication of a thoracic empyema...An exceedingly rare form of this complication is erosion through the diaphragm into the peritoneal space. Management of EN consists of tailored antibiotic therapy and some combination of source control with drainage or decortication.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Management of a Thrombus in Transit in a Patient With Gastric Cancer and Hepatic Abscess in a Resource-Poor Setting (Walter E. Washington Convention Center, Room 151 A (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_2408;
Treatment was started with enoxaparin, meropenem, and vancomycin...The patient received alteplase via a right internal jugular vein CVA...Although thrombolysis administered via CVA is an infrequent treatment option, it can be considered in a resource-poor setting. Its failure may require salvage surgery through emergent OHS and thrombectomy.
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Review, Journal: Treatment of acute stroke: Current practices and future horizons. (Pubmed Central) - Mar 21, 2023
Endovascular thrombectomy (EVT) has shown considerable efficacy for treating large-vessel occlusions and using CTP, patients can be selected for hours after symptom-onset if viable tissue remains. Further research is underway to determine if EVT can be used for medium vessel occlusions and for basilar artery thromboses as well as to determine whether an "EVT-alone" strategy is superior to "tPA + EVT" strategy.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: Effects of predictive nursing intervention on cognitive impairment and neurological function in ischemic stroke patients. (Pubmed Central) - Mar 16, 2023
Further research is underway to determine if EVT can be used for medium vessel occlusions and for basilar artery thromboses as well as to determine whether an "EVT-alone" strategy is superior to "tPA + EVT" strategy. Predictive nursing intervention is beneficial to improve the effects of thrombolytic therapy in patients with ischemic stroke, which improves the neurological, cognitive and motor functions of patients, and reduces the occurrence of complications, suggesting an important clinical application value.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Journal: Start, Stop, Continue? The Benefit of Overlapping Intravenous Thrombolysis and Mechanical Thrombectomy : A (Pubmed Central) - Mar 16, 2023
Predictive nursing intervention is beneficial to improve the effects of thrombolytic therapy in patients with ischemic stroke, which improves the neurological, cognitive and motor functions of patients, and reduces the occurrence of complications, suggesting an important clinical application value. The presented results support the approach of continuing and completing a
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