Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe 
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  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment closed, Enrollment change:  Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke (clinicaltrials.gov) -  Jul 19, 2017   
    P3,  N=501, Active, not recruiting, 
    Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting | N=800 --> 501
  • ||||||||||  Pulmozyme (dornase alfa) / Roche, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    New P4 trial:  Fibrinolytic Therapy Versus Medical Thoracoscopy (clinicaltrials.gov) -  Jul 11, 2017   
    P4,  N=80, Not yet recruiting, 
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial completion, Trial primary completion date:  A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients (clinicaltrials.gov) -  Jun 15, 2017   
    P2a,  N=88, Completed, 
    N=64 --> 202 Active, not recruiting --> Completed | Trial primary completion date: Jul 2016 --> Jan 2016
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment open:  ERUPTE: A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism (clinicaltrials.gov) -  May 30, 2017   
    P2a,  N=108, Recruiting, 
    Improved stroke recognition and management of acute comorbidities may help to reduce door-to-needle times. Not yet recruiting --> Recruiting
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  Treatment Patterns and Short-Term Outcomes in Ischemic Stroke in Pregnancy or Postpartum. (Pubmed Central) -  May 27, 2017   
    Using data from the Get With the Guidelines-Stroke Registry to assemble the largest cohort of pregnant or postpartum ischemic stroke patients who had been treated with reperfusion therapy, we observed that pregnant or postpartum women had similarly favorable short-term outcomes and equal rates of total reperfusion therapy to nonpregnant women, despite lower rates of intravenous tissue plasminogen activator use. Future studies should identify the characteristics of pregnant and postpartum ischemic stroke patients who are most likely to safely benefit from reperfusion therapy.
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial primary completion date:  Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke (clinicaltrials.gov) -  May 22, 2017   
    P3,  N=800, Recruiting, 
    Future studies should identify the characteristics of pregnant and postpartum ischemic stroke patients who are most likely to safely benefit from reperfusion therapy. Trial primary completion date: Dec 2016 --> Mar 2018
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial termination:  PRISMS: A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke (clinicaltrials.gov) -  May 10, 2017   
    P3,  N=313, Terminated, 
    Trial primary completion date: Dec 2016 --> Mar 2018 Active, not recruiting --> Terminated; The study was terminated due to slow enrollment.
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial primary completion date:  Thrombolysis in Ischemic Spinal Cord Stroke (clinicaltrials.gov) -  Apr 13, 2017   
    P2,  N=12, Active, not recruiting, 
    Recruiting --> Suspended | Trial primary completion date: Dec 2016 --> Dec 2017 Trial primary completion date: Oct 2017 --> Oct 2018
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment closed, Enrollment change, Trial primary completion date:  Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy (clinicaltrials.gov) -  Mar 28, 2017   
    P=N/A,  N=50, Active, not recruiting, 
    Active, not recruiting --> Completed Recruiting --> Active, not recruiting | N=135 --> 50 | Trial primary completion date: May 2014 --> Dec 2017
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment closed, Enrollment change:  PRISMS: A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke (clinicaltrials.gov) -  Feb 23, 2017   
    P3,  N=313, Active, not recruiting, 
    Recruiting --> Active, not recruiting | N=200 --> 113 Terminated --> Active, not recruiting | N=948 --> 313
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial termination, Trial primary completion date:  PRISMS: A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke (clinicaltrials.gov) -  Feb 20, 2017   
    P3,  N=948, Terminated, 
    Terminated --> Active, not recruiting | N=948 --> 313 Recruiting --> Terminated | Trial primary completion date: May 2018 --> Apr 2017; The study was terminated due to slow enrollment.
  • ||||||||||  Pulmozyme (dornase alfa) / Roche, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial primary completion date:  Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) (clinicaltrials.gov) -  Feb 15, 2017   
    P3,  N=92, Recruiting, 
    Recruiting --> Terminated | Trial primary completion date: May 2018 --> Apr 2017; The study was terminated due to slow enrollment. Trial primary completion date: Dec 2016 --> Dec 2017
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment change, Trial termination:  TOACT: Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis (clinicaltrials.gov) -  Feb 14, 2017   
    P2/3,  N=67, Terminated, 
    Trial primary completion date: Dec 2016 --> Dec 2017 N=164 --> 67 | Recruiting --> Terminated
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment change, Trial primary completion date:  Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) (clinicaltrials.gov) -  Dec 13, 2016   
    P3,  N=4700, Recruiting, 
    Not yet recruiting --> Recruiting N=3300 --> 4700 | Trial primary completion date: Dec 2016 --> Dec 2018
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial initiation date, Trial primary completion date:  PHLO: Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial (clinicaltrials.gov) -  Nov 30, 2016   
    P3,  N=270, Not yet recruiting, 
    N=3300 --> 4700 | Trial primary completion date: Dec 2016 --> Dec 2018 Initiation date: Oct 2016 --> Jul 2017 | Trial primary completion date: Apr 2021 --> Apr 2022
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial initiation date:  INTRECIS: Intravenous Thrombolysis Registry for Chinese Ischemic Stroke Within 4.5 h Onset (clinicaltrials.gov) -  Nov 23, 2016   
    P=N/A,  N=3000, Not yet recruiting, 
    Initiation date: Oct 2016 --> Jul 2017 | Trial primary completion date: Apr 2021 --> Apr 2022 Initiation date: Aug 2016 --> Dec 2016
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Clinical:  PLATyPuS: Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis (clinicaltrials.gov) -  Oct 25, 2016   
    P2,  N=24, Not yet recruiting, 
    Initiation date: Aug 2016 --> Dec 2016 Initiation date: Nov 2016 --> Jun 2017 | Trial primary completion date: Dec 2020 --> Aug 2021
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial primary completion date:  ATTRACT: Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis (clinicaltrials.gov) -  Oct 11, 2016   
    P3,  N=692, Active, not recruiting, 
    Initiation date: Nov 2016 --> Jun 2017 | Trial primary completion date: Dec 2020 --> Aug 2021 Trial primary completion date: May 2016 --> Jan 2017
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment change, Trial withdrawal:  ACSSLAP: Acute Coronary Syndrome Sri Lanka Audit Project (clinicaltrials.gov) -  Oct 11, 2016   
    P=N/A,  N=0, Withdrawn, 
    Trial primary completion date: May 2016 --> Jan 2017 N=2380 --> 0 | Completed --> Withdrawn
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment open:  Optimal Coronary Flow After PCI for Myocardial Infarction - a Pilot Study (clinicaltrials.gov) -  Oct 9, 2016   
    P3,  N=80, Recruiting, 
    N=2380 --> 0 | Completed --> Withdrawn Not yet recruiting --> Recruiting
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Trial primary completion date:  Extending the Time for Thrombolysis in Emergency Neurological Deficits (clinicaltrials.gov) -  Sep 22, 2016   
    P3,  N=400, Recruiting, 
    Trial primary completion date: Dec 2015 --> Dec 2017 Trial primary completion date: Dec 2015 --> Dec 2017
  • ||||||||||  TNKASE (tenecteplase) / Roche, Boehringer Ingelheim, Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    New P3 trial:  ATTEST2: Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (clinicaltrials.gov) -  Jun 27, 2016   
    P3,  N=1870, Not yet recruiting, 
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment closed, Trial initiation date:  Thrombolysis in Ischemic Spinal Cord Stroke (clinicaltrials.gov) -  Apr 7, 2016   
    P2,  N=12, Active, not recruiting, 
    Not yet recruiting --> Recruiting | Phase classification: P4 --> PN/A Not yet recruiting --> Active, not recruiting | Initiation date: Oct 2014 --> Apr 2016
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment open, Trial initiation date, Trial primary completion date:  T-TIME: A Trial of Low-dose Adjunctive alTeplase During prIMary PCI (clinicaltrials.gov) -  Mar 30, 2016   
    P2,  N=618, Recruiting, 
    Not yet recruiting --> Active, not recruiting | Initiation date: Oct 2014 --> Apr 2016 Not yet recruiting --> Recruiting | Initiation date: Dec 2014 --> Mar 2016 | Trial primary completion date: Dec 2016 --> Feb 2018
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Enrollment closed, Trial primary completion date:  A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients (clinicaltrials.gov) -  Mar 23, 2016   
    P2a,  N=100, Active, not recruiting, 
    Not yet recruiting --> Recruiting | Initiation date: Dec 2014 --> Mar 2016 | Trial primary completion date: Dec 2016 --> Feb 2018 Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2016 --> Jul 2016