| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe |
2018-004464-57: Solitaire™ With the Intention For Thrombectomy Plus Intravenous t-PA Versus DIRECT Solitaire™ Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke |
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| Ongoing | 4 | 404 | Europe, RoW | ActilyseInternational Non-Proprietary Name (INN): Alteplase, Powder for solution for infusion, ActilyseInternational Non-Proprietary Name (INN): Alteplase | Universtiy Hospital Bern, Klinik für Neurologie, Inselspital, Universitätsspital Bern, Medtronic | Acute Anterior Circulation Ischaemic Stroke, Acute Anterior Circulation Ischaemic Stroke, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04806373: Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis |
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| Completed | 4 | 27 | US | Cathflo Activase, Talc Slurry Pleurodesis, TSP | Memorial Healthcare System, Genentech, Inc. | Pleural Effusion | 12/23 | 12/23 | | |
2015-002657-36: Evaluation of Tenecteplase versus Alteplase for Stroke Thrombolysis (TASTE) Trial |
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| Ongoing | 3 | 1024 | Europe | Actilyse, Metalyse, Powder and solvent for solution for injection/infusion, Powder and solvent for solution for injection, Actilyse (Alteplase), Metalyse | University of Newcastle, National Health and Medical Research Council, Boehringer Ingelheim | Acute Ischaemic Stroke, Stroke or 'brain attack' caused by a clot, Diseases [C] - Nervous System Diseases [C10] | | | | |
2016-002075-10: ATTEST 2: A trial comparing the new "clot busting" drug treatment tenecteplase with standard "clot busting" treatment |
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| Ongoing | 3 | 1870 | Europe | Actilyse, Metalyse, Powder and solvent for solution for injection/infusion, Powder and solvent for solution for injection, Actilyse, Metalyse | NHS Greater Glasgow & Clyde, University of Glasgow, The Joint Stroke Association/ British Heart Foundation Award, Boehringer Ingelheim, | Acute ischaemic stroke, Stroke caused by a blood clot, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Terminated | 3 | 462 | Europe, US, RoW | CUSA-081, reteplase, Placebo, Alteplase | Chiesi Farmaceutici S.p.A. | Catheter Occlusion, Thrombosis | 06/23 | 07/23 | | |
| Completed | 3 | 1412 | RoW | Injection of recombinant human tissue plasminogen kinase derivatives, Reteplase, brand name: Ruitongli, r-PA, Recombinant human tissue plasminogen activator, Alteplase, brand name: Actilyse, rt-PA | Angde Biotech Pharmaceutical Co., Ltd., Beijing Tiantan Hospital | Acute Ischemic Stroke | 06/23 | 06/23 | | |
FORPE, NCT04688320: Massive Pulmonary Embolism: Trial of Non-immunogenic Recombinant Staphylokinase VS Alteplase |
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| Completed | 3 | 310 | RoW | Recombinant nonimmunogenic staphylokinase, Fortelyzin, Alteplase, Actillyze | Supergene, LLC | Massive Pulmonary Embolism | 07/23 | 07/23 | | |
ORIGINAL, NCT04915729: A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity |
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| Completed | 3 | 1490 | RoW | tenecteplase, alteplase | Boehringer Ingelheim | Stroke | 10/23 | 10/23 | | |
| Recruiting | 3 | 650 | Europe, Canada, RoW | Alteplase, Placebo | Assistance Publique - Hôpitaux de Paris, Johannes Gutenberg University Mainz, Life Sciences Research Partners (D Collen Research Foundation), Canadian Institutes of Health Research (CIHR), Instituto de Salud Carlos III, International Network of VENous Thromboembolism Clinical Research Networks, Boehringer Ingelheim | Pulmonary Embolism | 09/25 | 08/27 | | |
| Completed | 2 | 40 | US | Treatment-inhaled tPA, alteplase, Activase | University of Michigan, Genentech, Inc. | Plastic Bronchitis, Protein-Losing Enteropathies, Healthy | 03/21 | 06/23 | | |
RESET, NCT05188417: A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke |
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| Active, not recruiting | 2 | 266 | RoW | Tirofiban 0.05 MG/ML, Alteplase, 0.9% sodium chloride solution | GrandPharma (China) Co., Ltd. | Acute Ischemic Stroke | 03/23 | 06/23 | | |
NCT05395351: Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization |
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| Completed | N/A | 113035 | RoW | rt-PA | Boehringer Ingelheim | Stroke | 03/23 | 03/23 | | |
NCT06194968: Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study |
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| Recruiting | N/A | 1800 | RoW | Urokinase, Alteplase | The First Affiliated Hospital of Zhengzhou University, Techpool Bio-Pharma Co., Ltd. | Acute Ischemic Stroke | 11/25 | 12/26 | | |
