doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  Osteoblastic Wnt1 regulates periosteal bone formation in adult mice. (Pubmed Central) -  Jun 22, 2021   
    In this model, the Cre recombinase expression is suppressed by administering doxycycline (Dox) in drinking water...Mechanisticly, this was due to impaired periosteal bone formation. Based on our data, in addition to its essential role in early skeletal growth, Wnt1 is an important regulator of modeling-based bone formation and cortical thickness in adult mice.
  • ||||||||||  Nuzyra (omadacycline) / Paratek
    Preclinical, Journal:  In Vitro Susceptibility Testing of Omadacycline against Nontuberculous Mycobacteria (NTM). (Pubmed Central) -  Jun 22, 2021   
    In this study, the in vitro potency of omadacycline, a new tetracycline derivative, was tested against 111 isolates of NTM...massiliense (3), Mycobacterium chelonae (15 isolates), Mycobacterium immunogenum (7 isolates), the Mycobacterium fortuitum group, including six doxycycline-resistant isolates (12 isolates), and the Mycobacterium mucogenicum group, including four doxycycline-resistant isolates (10 isolates)...While there was no trailing observed in SGM, omadacycline MICs were higher (MIC range 8->16 μg/ml, N = 41) as previously noted with tigecycline. This study supports further research of omadacycline including clinical trials for the treatment of RGM infections, especially M. abscessus.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Isolation, identification and biological characteristics of Mycoplasma bovis in yaks. (Pubmed Central) -  Jun 22, 2021   
    The isolates were found resistant to macrolides, aminoglycosides and lincomycin at various degrees, but they were sensitive or moderately sensitive to doxycycline and kanamycin under antimicrobial susceptibility analysis. In conclusion, the results provided certain reference for the follow-up research and guiding for the treatment of M. bovis in yaks.
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Burkholderia ubonensis high-level tetracycline resistance is due to efflux pump synergy involving a novel TetA(64) resistance determinant. (Pubmed Central) -  Jun 22, 2021   
    TetA(64) does not efflux minocycline, tigecycline, and eravacycline...It is present in some major cystic fibrosis pathogens, like B. cenocepacia, but absent from others like B. multivorans The tetR(64)-tetA(64) genes are located in a region of chromosome 1 that is highly conserved in Burkholderia Because there is no evidence for transposition, the tetR(64)-tetA(64) genes may have been acquired by homologous recombination after horizontal gene transfer. Although Burkholderia species contain a resident multi-component efflux pump that allows them to respond to tetracyclines up to a certain concentration, the acquisition of the single-component TetA(64) by some species likely provides the synergy that these bacteria need to defend against high tetracycline concentrations in niche environments.
  • ||||||||||  doxycycline / Generic mfg.
    Clinical, Journal:  Feasibility of an inhaled antibiotic/adjuvant dry powder combination using an experimental design approach. (Pubmed Central) -  Jun 22, 2021   
    In this context, we have recently identified a new polyamino-isoprenyl derivative NV716 able to potentiate, at a very low concentration the activity of doxycycline against resistant P. aeruginosa bacterial strains by increasing its intracellular concentration...Under these conditions, the best formulation was defined by combining the optimal factors leading to the best aerodynamic properties' values (the lowest MMAD (Mass Median Aerodynamic Diameter) and the highest FPF (Fraction of Fine Particles)) without even using sophisticated engineering techniques. Finally, our results suggest that these molecules could be successfully delivered at the requested concentration in the lungs and then able to decrease drug consumption as well as increase treatment efficacy.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders. (Pubmed Central) -  Jun 22, 2021   
    Fibroblasts are transduced with two lentiviruses: hTERT to immortalize the primary culture and a tet-inducible MYOD, which upon the addition of doxycycline, induces the conversion of fibroblasts into myoblasts and then mature myotubes, which express late differentiation markers. This quick transdifferentiation protocol represents a powerful tool to investigate pathological mechanisms and to investigate innovative gene-based or pharmacological biotherapies for neuromuscular disorders.
  • ||||||||||  ceftriaxone / Generic mfg.
    Review, Journal:  Urethritis: Rapid Evidence Review. (Pubmed Central) -  Jun 22, 2021   
    Patients treated for a sexually transmitted infection should have repeat screening in three months, with shared decision-making about future screening intervals. Patients treated for urethritis should abstain from sex for seven days after the start of treatment, until their partners have been adequately treated, and until their symptoms have fully resolved.
  • ||||||||||  doxycycline / Generic mfg.
    Trial completion, Enrollment change, Head-to-Head:  Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis (clinicaltrials.gov) -  Jun 16, 2021   
    P3,  N=121, Completed, 
    Expanded and improved gonococcal AMR surveillance in Kyrgyzstan is crucial. Active, not recruiting --> Completed | N=250 --> 121
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  A drug cocktail for protecting against ischemia-reperfusion injury. (Pubmed Central) -  Jun 16, 2021   
    Previously, we have shown that pretreatment of the hearts by co-administration of sub-threshold concentrations of doxycycline, a matrix metalloproteinase (MMPs) inhibitor, ML-7 an inhibitor of myosin light-chain kinase (MLCK) and L-NAME a non-selective NOS inhibitor protects the heart against I/R injury...This pre-treatment resulted in full protection of contractility, decreased production of iNOS and ADMA and normalized the bioavailability of NO in the I/R hearts. Thus, the formulated drug cocktail protects the heart from I/R injury.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg.
    Clinical, Journal:  Travel-associated multidrug-resistant organism acquisition and risk factors among US military personnel. (Pubmed Central) -  Jun 16, 2021   
    Thus, the formulated drug cocktail protects the heart from I/R injury. Incident colonization with MDR organisms occurs at a lower rate in this military population compared to civilian travelers, with no identified modifiable risk factors, with highest incidence of ESBL acquisition observed after South Asia travel.
  • ||||||||||  cefixime / Generic mfg., doxycycline / Generic mfg.
    Clinical, Journal:  A case of infective colitis due to Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver occult metastases: a case report. (Pubmed Central) -  Jun 16, 2021   
    Incident colonization with MDR organisms occurs at a lower rate in this military population compared to civilian travelers, with no identified modifiable risk factors, with highest incidence of ESBL acquisition observed after South Asia travel. This case report should make clinicians reflect on how complex the differential diagnosis between microliver abscesses and metastasis could be and the possibility of bacteriaemia by Y. enterocolitica even without iron overload conditions.
  • ||||||||||  doxycycline / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Clinical, Retrospective data, Journal:  Diagnosis and treatment of Chlamydia psittaci pneumonia: experiences of 8 cases (Pubmed Central) -  Jun 16, 2021   
    Moxifloxacin and/or doxycycline were administered after diagnosis, and the course of treatment lasted from 14 to 21 days.Chest CT showed absorption of lesions following treatment Chlamydia psittaci pneumonia showed certain characteristics, including high fever with pulmonary patchy consolidation, and normal white blood cell count. Molecular diagnostic methods such as mNGS could lead to rapid diagnosis and treatment which can shorten the course of hospitalization and thus improve prognosis.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Journal:  EXPRESS: Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy. (Pubmed Central) -  Jun 16, 2021   
    Interference due to the tetracycline class was revealed through in vitro experimentation to cause an apparent decrease in the sampleâs net bilirubin absorbance(NBA); the presence of xanthochromia on visual inspection was, however, conserved.Conclusions The problem of CSF absorbance curve interference might be more common than previously suspected. Due to the potential NBA- lowering effect of tetracyclines, the author recommends visual examination of CSF samples in every case.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Doxycycline Therapy for Abdominal Aortic Aneurysm: Inhibitory Effect on Matrix Metalloproteinases. (Pubmed Central) -  Jun 16, 2021   
    The result of our study supports the effect of doxycycline in preventing the growth of small AAAs. We conclude that therapeutic treatment with doxycycline in patients with small AAAs can prevent the growth of aneurysms, life-threatening aneurysm rupture, and reduce the need for expensive, invasive treatment.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    [VIRTUAL] AN IMMUNOCOMPROMISED WOMAN WITH LEFT EYE VISUAL LOSS () -  Jun 14, 2021 - Abstract #CSCTRMWAFMR2021CSCTR-MWAFMR_57;    
    Case Presentation An 86-year-old woman with a history significant for Sjogren’s disease, ILD on immunosuppression with hydroxychloroquine and prednisone, chronic hypoxic respiratory failure requiring 3L of oxygen, diabetes mellitus who came from an ophthalmology clinic to be evaluated for vision problems in her left eye for four days...Since admission, the patient was started on meropenem...The patient was discharged home after 18 days of hospitalization on amikacin, imipenemCilastatin and fluconazole with significant improvement in her vision on follow-up one month after...The firstline treatment is trimethoprim sulfamethoxazole, which use in our patient was limited due to side effects and later switched to doxycycline, which has not been reported in the literature to be effective in ophthalmic nocardiosis, resulting in a worsening of her left eye disease...Ophthalmic nocardiosis is extremely rare, and vision loss as the first isolated symptom will certainly make diagnosis even more difficult. Early detection and correct diagnosis allow the start of appropriate therapy, which will contribute significantly to the health of the patient.
  • ||||||||||  doxycycline / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetics of doxycycline in dogs. (Pubmed Central) -  Jun 12, 2021   
    Early detection and correct diagnosis allow the start of appropriate therapy, which will contribute significantly to the health of the patient. No abstract available
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors. (Pubmed Central) -  Jun 12, 2021   
    In this study, the TRACT assay technology was applied to NET expressed in a doxycycline-inducible HEK 293 JumpIn cell line...The inhibitory potencies of several reported NET inhibitors from the TRACT assay showed positive correlation with those from an established fluorescent substrate uptake assay. These findings demonstrate the suitability of the TRACT assay for HTS characterization and screening of NET inhibitors and provide a basis for investigation of other solute carrier transporters with label-free biosensors.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Helicobacter Pylori Eradication Therapy: Still a Challenge. (Pubmed Central) -  Jun 12, 2021   
    Patient compliance to the treatment can only be ensured by medicines with fewer adverse effects. In our study, levofloxacin-based triple, concomitant, and standard triple regimens with probiotics are maximally acceptable treatments.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Microbial and chemical pollutants on the manure-crops pathway in the perspective of "One Health" holistic approach. (Pubmed Central) -  Jun 11, 2021   
    Manure-supplemented soil was characterised by a high concentration of doxycycline and enrofloxacin...The high abundance of integrase genes and ARGs and their reciprocal correlations with HMs pose a serious risk of the rapid spread of antibiotic resistance in the environment. Moreover, unusual dependencies between integrase genes and selected ARGs indicate the possibility of changes in the mobility nature of genetic elements.
  • ||||||||||  cephalexin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
    Trial completion date, Trial primary completion date:  Effects of Treatments on Atopic Dermatitis (clinicaltrials.gov) -  Jun 10, 2021   
    P2,  N=130, Recruiting, 
    In addition, the PDP was able to generate real-world evidence for drug safety. Trial completion date: Dec 2022 --> Jan 2024 | Trial primary completion date: Jan 2022 --> Jan 2024
  • ||||||||||  rifampicin / Generic mfg.
    Journal:  Whole-genome Sequencing of Rough Brucella melitensis in China Provides Insights into its Genetic Features. (Pubmed Central) -  Jun 10, 2021   
    Moreover, as there was no significant difference in rifampicin, doxycycline and streptomycin susceptibility between the smooth and rough B. melitensis strains, treatment of brucellosis was not affected by strain type. This study provided important information for understanding the genetics and evolution of rough B. melitensis in China.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Clinical, Journal:  An immunocompromised woman in her twenties with abdominal pain and vaginal discharge. (Pubmed Central) -  Jun 10, 2021   
    This study provided important information for understanding the genetics and evolution of rough B. melitensis in China. It is important to consider opportunistic microbes in immunocompromised patients, as they might pose a major diagnostic challenge and require the involvement of several specialties.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Doxycycline aggravates granulomatous inflammation and lung microstructural remodeling induced by Schistosoma mansoni infection. (Pubmed Central) -  Jun 10, 2021   
    Together, our findings indicated that Dox aggravated granulomatous inflammation, accelerating lung microstructural remodeling by downregulating MMP-1 and MMP-2 activity without impair neutrophils and macrophages recruitment or elastase activity. Thus, Dox potentiates inflammatory damage associated with lung fibrosis, elastin depletion and massive alveolar collapse, profoundly subverting lung structure in S. mansoni-infected mice.
  • ||||||||||  tetracycline / Generic mfg.
    Review, Journal:  Can tetracyclines ensure help in multiple sclerosis immunotherapy? (Pubmed Central) -  Jun 10, 2021   
    Many of the drugs used to treat MS have severe side effects and are costly. Tet, on the other hand, are a safe and inexpensive class of drugs that can modulate the immune response in MS patients.