- |||||||||| doxycycline / Generic mfg.
Journal: HDAC Inhibitor Abrogates LTA-Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis. (Pubmed Central) - Jul 4, 2021
The LTA-stimulated human PMCs and intrapleural doxycycline-injected rats were pretreated with or without the pan-HDACi, m-carboxycinnamic acid bis-hydroxamide (CBHA), then PAI-1 and collagen expression and activated signalings in PMCs, and morphologic pleural changes in rats were measured...Conclusively, CBHA abrogates LTA-induced PAI-1 and collagen expression in PMCs and attenuates experimental pleural fibrosis. PAI-1 inhibition by HDACi may confer potential therapy for pleural fibrosis.
- |||||||||| doxycycline / Generic mfg.
Journal, HEOR: Modeling the Cost-Effectiveness of Interventions to Prevent Plague in Madagascar. (Pubmed Central) - Jul 4, 2021
Sensitivity analyses support expanded access to antibiotic treatment and leave open the possibility that mass distribution of doxycycline prophylaxis or mass distribution of malathion could be cost-effective. Our analysis highlights the potential for rapid expansion of access to doxycycline upon recognition of plague outbreaks to cost-effectively prevent future large-scale plague outbreaks and highlights the importance of intervention timing.
- |||||||||| doxycycline / Generic mfg.
Journal: Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine. (Pubmed Central) - Jul 3, 2021
In the present study, we measured indices of peripheral neuropathy in the doxycycline (DOX)-inducible HIV-TAT (iTAT) transgenic mouse and investigated the therapeutic efficacy of a selective muscarinic subtype-1 receptor (MR) antagonist, pirenzepine (PZ)...These studies demonstrate that TAT expression disrupts mitochondria and induces indices of sensory and motor peripheral neuropathy and that MR antagonism may be a viable treatment for HIV-DSP. However, some indices of neuropathy in the DOX-inducible TAT transgenic mouse model can be ascribed to DOX treatment rather than TAT expression and data obtained from animal models in which gene expression is modified by DOX should be accompanied by appropriate controls and treated with due caution.
- |||||||||| doxycycline / Generic mfg.
Journal: A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways. (Pubmed Central) - Jul 3, 2021
We found the translational balance to be conserved in mammalian cells upon inhibiting mitochondrial translation pharmacologically with doxycycline. Lastly, extending this in vivo, doxycycline repressed cytosolic translation in the livers of germ-free mice. These data demonstrate that inhibiting mitochondrial translation initiates an atf-5/ATF4-dependent cascade leading to coordinated repression of cytosolic translation, which could be targeted to promote longevity.
- |||||||||| doxycycline / Generic mfg.
Journal: Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cells. (Pubmed Central) - Jul 3, 2021
Here, in contrast to loss-of-function experiments, we implemented a gain-of-function approach by generating a doxycycline-inducible transgenic mouse model that enables spatial and temporal overexpression of Cxcl12...Here, using this model, we demonstrated that CXCL12 influences trafficking, proliferation and radioresistance of hematopoietic stem cells and progenitors. These findings are important for understanding hematopoietic development, cancer and transplantation therapies.
- |||||||||| doxycycline / Generic mfg.
Journal: Tinidazole: Another Therapeutic Option for Syphilis? (Pubmed Central) - Jul 2, 2021
It is possible that tinidazole has the same bactericidal action on spirochetes other than Borrelia, such as Treponema pallidum, explaining its rapid therapeutic action on the lesions of early syphilis. Whether this action could be confirmed by studies on larger series of patients, tinidazole might be considered in case of allergy to penicillin or other antibiotics usually prescribed in syphilis.
- |||||||||| doxycycline / Generic mfg.
Journal: Transcription factor overexpression drives reliable differentiation of retinal pigment epithelium from human induced pluripotent stem cells. (Pubmed Central) - Jul 2, 2021
Here, we report a robust, scalable method to generate iPSC-RPE using doxycycline-inducible expression of eye field transcription factors OTX2, PAX6 and MITF paired with RPE-permissive culture media...Further, these RPE monolayers display functionality features including light absorption via pigmentation, polarity-driven fluid transport, and phagocytosis. With this method, we achieve a highly efficient and easily scalable differentiation without the need for mechanical isolation or enrichment methods, generating RPE cultures applicable for in vitro studies.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Beta-cell-specific expression of NOX5 aggravates high fat diet-induced impairment of islet insulin secretion in mice. (Pubmed Central) - Jul 1, 2021
Here, we sought to characterize regulation of NOX5 expression in human islets in vitro and to uncover the relevance of NOX5 in islet function in vivo using a novel mouse model expressing NOX5 in doxycycline-inducible, β-cell-specific manner (RIP/rtTA/NOX5 mice)...Decreased insulin secretion was most distinct in response to theophylline stimulation suggesting impaired cAMP-mediated signaling due to increased phophodiesterase activation. Our data provide the first insight into the complex regulation and function of NOX5 in islets implying an important role for NOX5 in δ-cell mediated intra-islet crosstalk in physiological circumstances but also identifying it as an aggravating factor in β-cell failure in diabetic conditions.
- |||||||||| doxycycline / Generic mfg.
Journal: Mononeuritis multiplex secondary to Lyme neuroborreliosis. (Pubmed Central) - Jul 1, 2021
A 6-week course of doxycycline was initiated with gradual resolution of pain and improved power...This case report identifies a peripheral nerve syndrome of a mononeuritis multiplex secondary to LNB in the absence of CSF pleocytosis with excellent outcome following antibiotic treatment. Peripheral nervous system manifestations of Lyme borreliosis can mimic a vasculitic neuropathy and therefore should be considered in individuals presenting with a painful mononeuritis multiplex.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline-doped membranes induced osteogenic gene expression on osteoblastic cells. (Pubmed Central) - Jul 1, 2021
Peripheral nervous system manifestations of Lyme borreliosis can mimic a vasculitic neuropathy and therefore should be considered in individuals presenting with a painful mononeuritis multiplex. Doxycycline doped membranes may be a potential candidate for use in GBR procedures in several challenging pathologies, including periodontal diseases.
- |||||||||| doxycycline / Generic mfg.
Journal: Targeting RLIP with CRISPR/Cas9 controls tumor growth. (Pubmed Central) - Jun 30, 2021
Inducible Cas9/sgRNA-transduced BC cells without doxycycline treatment did not exhibit altered cell survival or proliferation in vitro or in vivo. Our study provides proof-of-concept that the CRISPR/Cas9 system can be utilized to target RLIP in vitro and in vivo.
- |||||||||| Taltz (ixekizumab) / Eli Lilly, Japan Tobacco
Clinical, Journal: Remission of Refractory PASH Syndrome Using Ixekizumab and Doxycycline. (Pubmed Central) - Jun 30, 2021
The findings provide a potential approach using doxycycline at 37°C to preserve chondrocyte viability in fresh OC grafts for treatment of articular cartilage lesions. No abstract available
- |||||||||| Clinical, Observational data, Journal: Antibiotic resistant Cutibacterium acnes among acne patients in Jordan: a cross sectional study. (Pubmed Central) - Jun 30, 2021
The findings of this study demonstrate the distribution of antibiotic resistance of C. acnes towards used antibiotics and emphasizes the influence of antibiotic consumption on development of antibiotic resistance. The similar pattern of resistance between skin bacteria tested in this study highlights the genetic transfer of resistance between skin commensals including S. aureus and S. epidermidis hence promoting its circulation in the community.
- |||||||||| doxycycline / Generic mfg.
Journal: Lyme disease: "End of the debate?" (Pubmed Central) - Jun 30, 2021
Treatment is based on doxycycline for 14 days in early forms (radiculitis), or 28 days in late forms (arthritis)...The prevalence of a diffuse polyalgia syndrome (fibromyalgia) following Lyme disease does not seem to differ much from that in the general population. It is not improved by prolonged antibiotic therapy, which is therefore not recommended.
- |||||||||| doxycycline / Generic mfg.
Biomarker, Preclinical, Journal: Autophagy Promotes Cigarette Smoke-Initiated and Elastin-Driven Bronchitis-Like Airway Inflammation in Mice. (Pubmed Central) - Jun 30, 2021
Short CS exposure rapidly induced expression of matrix metallopeptidase 12 (MMP12) in alveolar macrophages, and treatment of doxycycline, a pan metalloproteinase inhibitor, during CS exposure effectively attenuated the ensuing elastin-induced airway inflammation in mice...These data, taken together, demonstrate that autophagy mediates both the CS-initiated MMP12 activation in macrophages and subsequent airway epithelial injury, eventually contributing to development COPD-like airway inflammation. This study reemphasizes that inhibition of autophagy as a novel therapeutic strategy for CS-induced COPD.
- |||||||||| ampicillin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Review, Journal: A systematic review of case reports of hepatic actinomycosis. (Pubmed Central) - Jun 30, 2021
HA should be considered in patients with a subacute or chronic inflammatory process of the liver. With accurate and timely diagnosis of infection, extensive surgery can be prevented.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Case report: first symptomatic Candidatus Neoehrlichia mikurensis infection in Slovenia. (Pubmed Central) - Jun 29, 2021
Due to the obscurity of the pathogen, diagnostic workup in CNM is prolonged and challenging. More awareness is need about this emerging infectious disease in countries with high prevalence of tick-borne diseases as standard microbiological methods are not successful in confirming the diagnosis.
- |||||||||| hydroxychloroquine / Generic mfg., ceftriaxone / Generic mfg.
Retrospective data, Journal: Granulomatous lung disease and immune reconstitution inflammatory syndrome in Whipple's disease. (Pubmed Central) - Jun 28, 2021
Treatment with ceftriaxone resulted in clinical deterioration with fever, arthritis and recurrent pleuritis consistent with immune reconstitution inflammatory syndrome. Dose increase of glucocorticoids and therapy rotation to doxycycline and hydroxychloroquine resulted in rapid clinical improvement.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline, an Antibiotic or an Anti-inflammatory Agent? The Most Common Uses in Dermatology. (Pubmed Central) - Jun 26, 2021
Because of doxycycline's ability to inhibit the molecular pathways associated with certain processes, this antibiotic can be used to treat hair follicle diseases, granulomatous diseases, and vascular proliferation, among other conditions. The main properties of doxycycline and its many applications in dermatology make this drug one that specialists should become familiar with.
- |||||||||| doxycycline / Generic mfg.
Journal: Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration. (Pubmed Central) - Jun 26, 2021
We show that reduced EEG spectral power precedes reductions in sleep and home cage locomotor activity in a mouse model of tauopathy. The data shows increasing mutant tau changes sleep architecture, EEG properties, behaviour and cognition, which suggest tau-related effects on sleep architecture in patients with neurodegenerative diseases.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Severe Leptospirosis in a Mexican Woman. (Pubmed Central) - Jun 26, 2021
The information presented in this study may help in the identification of pathology caused by spirochetes. This case report is the first to present a case of severe leptospirosis in Sonora, México.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: Octenidine/carbenicillin GUMBOS as potential treatment for oropharyngeal gonorrhoea. (Pubmed Central) - Jun 26, 2021
This case report is the first to present a case of severe leptospirosis in Sonora, México. Antimicrobial GUMBOS synthesized in this study could be used as an adjunctive treatment approach to current drug therapies for oropharyngeal gonorrhoea infection control and prevention.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: A Case of Anaplasmosis during a Warm Minnesota Fall. (Pubmed Central) - Jun 26, 2021
He was empirically with doxycycline and had rapid improvement in his symptoms...Ixodes ticks are known to be sensitive to temperature and humidity, which likely contributed to increased tick activity, leading to disease transmission. This case highlights the importance for clinicians to be aware of local weather patterns and how this might influence seasonal disease presentations.
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