- |||||||||| ampicillin / Generic mfg., amoxicillin / Generic mfg.
Journal: Prevalence and characterization of antibiotic resistance genes and integrons in Escherichia coli isolates from captive non-human primates of 13 zoos in China. (Pubmed Central) - Oct 2, 2021
The E. coli isolates mainly showed resistance to tetracycline (tetracycline 62.71%, doxycycline 61.11%), β-lactams (ampicillin 54.27%, amoxicillin 52.36%), and sulfonamide (trimethoprim-sulfamethoxazole 36.78%)...Significant positive associations were observed among integrons and antibiotics, of which the strongest association was observed for integrons / Gentamicin (OR, 2.642) and integrons / Cefotaxime (OR, 2.512)...Our results indicate a high diversity of antibiotic resistance phenotypes in non-human primate E. coli isolates, which carry multiple ARGs and integrons. Corresponding preventive measures should be taken to prevent the spread of integron-mediated ARGs in non-human primates and their living environments in zoos.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg., minocycline / Generic mfg.
Journal, Adverse events: Psychosis as an adverse effect of antibiotics. (Pubmed Central) - Oct 1, 2021
Conversely, the tetracycline antibiotic minocycline has been associated with improvements in psychopathology in patients with psychotic disorders...Fifteen antibiotics were associated with a significantly increased odds of psychosis (OR = 1.67-9.48), including penicillins, fluoroquinolones, macrolides, cephalosporins, and doxycycline...Future studies in this area are needed to identify specific underlying biological mechanisms that contribute to these associations. Findings may also inform on clinical decisions regarding the selection of antibiotic therapy in vulnerable patient populations.
- |||||||||| acetazolamide / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Intracranial Hypertension due to Acne Treatment () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4545;
Several medicines –among which tetracyclines- have been associated with induced intracranial pressure and in most cases resolves after stopping the treatment...She was admitted to the neurology ward and had lumbar puncture and acetazolamide treatment...The successful management of this condition consists in rapid cessation of the drug. Prompt cessation of doxycycline treatment along with specific therapy can prevent progression of the intracranial hypertension and minimise the danger of permanent visual impairment.
- |||||||||| acetazolamide / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Intracranial Hypertension due to Acne Treatment () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4544;
Several medicines –among which tetracyclines- have been associated with induced intracranial pressure and in most cases resolves after stopping the treatment...She was admitted to the neurology ward and had lumbar puncture and acetazolamide treatment...The successful management of this condition consists in rapid cessation of the drug. Prompt cessation of doxycycline treatment along with specific therapy can prevent progression of the intracranial hypertension and minimise the danger of permanent visual impairment.
- |||||||||| acetazolamide / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Intracranial Hypertension due to Acne Treatment () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4543;
Several medicines –among which tetracyclines- have been associated with induced intracranial pressure and in most cases resolves after stopping the treatment...She was admitted to the neurology ward and had lumbar puncture and acetazolamide treatment...The successful management of this condition consists in rapid cessation of the drug. Prompt cessation of doxycycline treatment along with specific therapy can prevent progression of the intracranial hypertension and minimise the danger of permanent visual impairment.
- |||||||||| acetazolamide / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Intracranial Hypertension due to Acne Treatment () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4542;
Several medicines –among which tetracyclines- have been associated with induced intracranial pressure and in most cases resolves after stopping the treatment...She was admitted to the neurology ward and had lumbar puncture and acetazolamide treatment...The successful management of this condition consists in rapid cessation of the drug. Prompt cessation of doxycycline treatment along with specific therapy can prevent progression of the intracranial hypertension and minimise the danger of permanent visual impairment.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
SARS-COV2 infection associated with inappropriate ADH secretion syndrome () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2269;
His history of illness goes back to a week marked by asthenia with dyspnea, the patient was put on vitamin therapy and azithromycin before the suspicion of a covid infection, but the evolution was marked by the worsening of the symptoms hence his admission...The course of action was to correct the blood serum rate according to a rapid protocol with water restriction, the patient was also put on an antibiotic such as doxycycline and vitamin therapy as well as adequate anticoagulation... SARS-COV2 infection is a pathology characterized by an important clinical polymorphism even of an ionic metabolic order at which may be related to an inappropriate syndrome of ADH secretion secondary to this viral infection
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
SARS-COV2 infection associated with inappropriate ADH secretion syndrome () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2268;
His history of illness goes back to a week marked by asthenia with dyspnea, the patient was put on vitamin therapy and azithromycin before the suspicion of a covid infection, but the evolution was marked by the worsening of the symptoms hence his admission...The course of action was to correct the blood serum rate according to a rapid protocol with water restriction, the patient was also put on an antibiotic such as doxycycline and vitamin therapy as well as adequate anticoagulation... SARS-COV2 infection is a pathology characterized by an important clinical polymorphism even of an ionic metabolic order at which may be related to an inappropriate syndrome of ADH secretion secondary to this viral infection
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
SARS-COV2 infection associated with inappropriate ADH secretion syndrome () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2267;
His history of illness goes back to a week marked by asthenia with dyspnea, the patient was put on vitamin therapy and azithromycin before the suspicion of a covid infection, but the evolution was marked by the worsening of the symptoms hence his admission...The course of action was to correct the blood serum rate according to a rapid protocol with water restriction, the patient was also put on an antibiotic such as doxycycline and vitamin therapy as well as adequate anticoagulation... SARS-COV2 infection is a pathology characterized by an important clinical polymorphism even of an ionic metabolic order at which may be related to an inappropriate syndrome of ADH secretion secondary to this viral infection
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
SARS-COV2 infection associated with inappropriate ADH secretion syndrome () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2266;
His history of illness goes back to a week marked by asthenia with dyspnea, the patient was put on vitamin therapy and azithromycin before the suspicion of a covid infection, but the evolution was marked by the worsening of the symptoms hence his admission...The course of action was to correct the blood serum rate according to a rapid protocol with water restriction, the patient was also put on an antibiotic such as doxycycline and vitamin therapy as well as adequate anticoagulation... SARS-COV2 infection is a pathology characterized by an important clinical polymorphism even of an ionic metabolic order at which may be related to an inappropriate syndrome of ADH secretion secondary to this viral infection
- |||||||||| Journal: Rosacea. (Pubmed Central) - Oct 1, 2021
Oral doxycycline 40 mg modified release can be used as monotherapy or in combination with other treatments for recalcitrant disease. Further understanding of the pathogenesis of rosacea could allow identification and targeted avoidance of triggers and the development of new treatment modalities.
- |||||||||| hydroxychloroquine / Generic mfg.
Clinical, Review, Journal: Q Fever Endocarditis: A Review of Local and all Reported Cases in the Literature. (Pubmed Central) - Oct 1, 2021
Serological diagnosis is key in Q fever endocarditis and possible risk factors exist such as male gender, pre-existing valvular conditions and contact with animals or travel. Native valve endocarditis and treatment with drugs other than doxycycline and hydroxychloroquine increase the risk of death.
- |||||||||| amoxicillin / Generic mfg.
Journal: An integrated modelling approach to derive the grey water footprint of veterinary antibiotics. (Pubmed Central) - Oct 1, 2021
The overall Vecht catchment's GWF is estimated at 250,000 m yr, resulting from doxycycline (81% and 19% contribution from the German and Dutch catchment part respectively). Uncertainty ranges of several orders of magnitude, as well as several remaining limitations to the presented IMA, underscore the importance to further develop and refine the approach.
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status. (Pubmed Central) - Sep 30, 2021
Besides the symptomatic mainstay clinical therapeutic approach, only Remdesivir has been approved by the FDA...In this review, we have precisely compiled the efforts to curb the disease and discussed the clinical findings of Ivermectin, Doxycycline, Vitamin-D, Vitamin-C, Zinc, and cannabidiol and their combinations. Additionally, the correlation of these molecules on the prophylactic and diseased ministration against COVID-19 has been explored.
- |||||||||| doxycycline / Generic mfg.
Journal, Heterogeneity: Microwave-Assisted, One-Pot Synthesis of Doxycycline under Heterogeneous Catalysis in Water. (Pubmed Central) - Sep 29, 2021
The present work focuses on the microwave-assisted hydrogenolysis of oxytetracycline to selectively produce α-doxycycline. Although the combination of microwave irradiation and a heterogeneous rhodium catalyst provided good conversions, the selective synthesis of active α-doxycycline was only achieved when an oxytetracycline-cyclodextrin complex was used as the starting material, giving the desired product at 34.0% yield in a one-step reaction under very mild conditions.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline Attenuates Cancer Cell Growth by Suppressing NLRP3-Mediated Inflammation. (Pubmed Central) - Sep 29, 2021
Doxycycline also decreased proliferation and caused cell death through apoptosis, a response that differed to the LPS-Nigericin mediated pyroptosis. Our findings suggest that doxycycline inhibits LPS priming of NLRP3 and reduces tumor progression through early apoptosis in cancer.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Retrospective data, Journal: Current Evidence on the Antimicrobial Treatment and Chemoprophylaxis of Human Leptospirosis: A Meta-Analysis. (Pubmed Central) - Sep 29, 2021
On the other hand, neither doxycycline nor penicillin, nor azithromycin have shown statistically significant differences in preventing symptomatic infection. Well-designed clinical trials, including other antibiotics such as quinolones or aminoglycosides, are urgently needed to improve our understanding of the treatment for this infection, which continues to be a neglected disease.
- |||||||||| tetracycline / Generic mfg.
Journal: Pollution Characteristics and Risk Assessment of Tetracycline Antibiotics in Farmland Soil in Yinchuan (Pubmed Central) - Sep 29, 2021
The average risk values of OTC, TC, CTC, and DOC in farmland soils were 0.14, 0.69, 0.14, and 1.02, respectively. TC and DOC represented a high level of risk in 23.26% and 6.98% of the samples, respectively, which requires particular attention.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Clinical, Journal: Identification of risk factors associated with antimicrobial resistance in equine fecal Escherichia coli isolates. (Pubmed Central) - Sep 29, 2021
TetA is also 8 times more likely to be found in horses that were fed a natural diet compared to other horses that were fed manufactured/ processed feed. In conclusion, E. coli bacterium can harbor high resistance to different classes of antimicrobials which increases the risk of potential uncontrolled transmission of the multi-drug resistant E. coli bacterium to veterinarians and horse handlers, as well as to the equine population itself.
- |||||||||| doxycycline / Generic mfg.
Journal: Toxic epidermal necrolysis induced by doxycycline. (Pubmed Central) - Sep 29, 2021
In conclusion, E. coli bacterium can harbor high resistance to different classes of antimicrobials which increases the risk of potential uncontrolled transmission of the multi-drug resistant E. coli bacterium to veterinarians and horse handlers, as well as to the equine population itself. No abstract available
- |||||||||| doxycycline / Generic mfg.
Doxycycline (Twitter) - Sep 27, 2021
- |||||||||| doxycycline / Generic mfg.
Journal: The impact of endotrophin on the progression of chronic liver disease. (Pubmed Central) - Sep 26, 2021
We used a doxycycline (Dox)-inducible liver-specific ETP-overexpressing mouse model on a NAFLD-prone (liver-specific SREBP1a transgenic) background...Our data revealed that ETP can act as a "second hit" during the progression of NAFLD and can play an important role in the development of NASH and hepatocellular carcinoma (HCC). These observations firmly link elevated levels of ETP to chronic liver disease.
- |||||||||| tetracycline / Generic mfg.
Preclinical, Journal: A novel plasmid from Aerococcus urinaeequi of porcine origin co-harboring the tetracycline resistance genes tet(58) and tet(61). (Pubmed Central) - Sep 26, 2021
Reduced susceptibility to doxycycline was observed in S. aureus RN4220 harboring tet(61) when an extra tet(58) was expressed. Plasmid pT4303 was electrotransformed into S. aureus RN4220, E. faecalis JH2-2, S. suis BAA and E. coli DH5α and conferred tetracycline resistance (MIC ≥ 16) in both Gram-positive and Gram-negative bacteria, assuming that it might serve as a vehicle for the dissemination of the tetracycline resistance genes tet(61) and tet(58).
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline-Induced Gastric Perforation. (Pubmed Central) - Sep 24, 2021
There is a paucity of literature describing life-threatening complications from doxycycline-induced mucosal injury, such as hemorrhage and perforation. We present the first case report describing a gastric perforation from doxycycline use.
- |||||||||| dimethyl fumarate / Generic mfg.
[VIRTUAL] Novel Fumarate Prodrug Rescues Cardiomyopathy and Motor Function in Friedreich's Ataxia (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_2843;
To suppress FXN expression, FXNKD mice were fed doxycycline chow and cardiac function was examined by in-vivo echocardiography. Because cardiomyopathy is the usual lethal event in FA, we suggest that nicotinamidated monomethyl fumarate is more potent drug compared to DMF and could improve the quality of life in FA affected individuals.
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