- |||||||||| levofloxacin / Generic mfg., nitazoxanide / Generic mfg., moxifloxacin intravenous / Generic mfg.
LEVOFLOXACIN VERSUS MOXIFLOXACIN IN NITAZOXANIDE-BASED QUADRUPLE THERAPY AS A FIRST- AND SECOND-LINE TREATMENT FOR HELICOBACTER PYLORI INFECTION. A RANDOMIZED, COMPARATIVE, MULTICENTER STUDY (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1298;
Nai?ve patients were randomized into three groups according to treatment regimens: levofloxacin, nitazoxanide, doxycycline, and lansoprazole (LNDL); moxifloxacin, nitazoxanide, doxycycline, and lansoprazole (MNDL); or amoxicillin, clarithromycin, and lansoprazole (ACL) for 14 days. levofloxacin- and moxifloxacin-containing nitazoxanide-based regimens exhibit substantial efficacy for the eradication of both nai?ve and resistant H. pylori infections over a 14-day course with a considerable safety profile.
- |||||||||| Sovaldi (sofosbuvir) / Gilead
THE CHALLENGES OF TREATMENT OF PATIENT WITH HEPATITIS C VIRUS ASSOCIATED CIRRHOSIS AND SPINAL BRUCELLOSIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_963;
levofloxacin- and moxifloxacin-containing nitazoxanide-based regimens exhibit substantial efficacy for the eradication of both nai?ve and resistant H. pylori infections over a 14-day course with a considerable safety profile. Many drugs can be used for the management of Brucellosis but Gentamycin and Streptomycin were contraindicated in decompensated cirrhosis, the patient was allergic to Sulfamethoxazole, Rifampicin can
- |||||||||| doxycycline / Generic mfg.
SYPHILITIC HEPATITIS: A RARE CASE OF HEPATIC INJURY FROM A COMMONLY TRANSMITTED VENEREAL DISEASE (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_953;
The patient was started on doxycycline due to a history of hypersensitivity allergic reactions from penicillin and experienced significant recovery of symptoms and aminotransferases on subsequent laboratory follow ups. Our case highlights a novel and unorthodox treatment strategy employed in the management of syphilitic hepatitis.
- |||||||||| Remicade (infliximab) / J&J
INFLIXIMAB TREATMENT FOR CROHN (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_892;
Our case highlights a novel and unorthodox treatment strategy employed in the management of syphilitic hepatitis. Demodicosis should be taken into account in patients treated with biological medications and presenting atypical inflammatory skin lesions.
- |||||||||| Stelara (ustekinumab) / J&J, Cubicin (daptomycin) / Merck (MSD), Entyvio (vedolizumab) / Takeda
CHALLENGES IN MANAGING RECURRENT EPHEMERAL ERUPTIONS IN CROHN (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_879;
IBD can be associated with neutrophilic dermatoses and its diagnosis can be challenging. This case reports an CD-associated erythema nodosum-like neutrophilic dermatosis, underscoring its complex approach and management.Note: We are submitting this case with iconography as it underscores a rare IBD manifestation.
- |||||||||| prednisolone / Generic mfg., doxycycline / Generic mfg.
Journal: Surgical management of unilateral restrictive strabismus in an 8-month-old dog. (Pubmed Central) - Jul 17, 2024
EOM has been shown to also present unilaterally and it can progress to strabismus if not promptly recognised and treated with systemic steroids. Surgical management can restore vision when severe strabismus results in visual deprivation.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Review, Journal: Free water surface constructed wetlands: review of pollutant removal performance and modeling approaches. (Pubmed Central) - Jul 17, 2024
Various modeling approaches (i.e., black-box and process-based) were comprehensively reviewed, revealing the need for including the internal process mechanisms related to the biological processes along with plants spp., that supported by a further research with field study validations. This work presents a state-of-the-art, systematic, and comparative discussion on the efficiency of FWSCWs in removing different pollutants, main design factors, the vegetation, and well-described models for performance prediction.
- |||||||||| doxycycline / Generic mfg.
Journal: Strain-level variations of Dirofilaria immitis microfilariae in two biochemical assays. (Pubmed Central) - Jul 17, 2024
This work presents a state-of-the-art, systematic, and comparative discussion on the efficiency of FWSCWs in removing different pollutants, main design factors, the vegetation, and well-described models for performance prediction. These assays provide a greater understanding of the biochemical variation among isolates of D. immitis, which can be exploited in the future to develop in vitro diagnostic tests capable of differentiating susceptible and resistant isolates.
- |||||||||| Review, Journal: Occurrence of pharmaceuticals in Latin America: case study on hazard assessment and prioritization in Costa Rica. (Pubmed Central) - Jul 16, 2024
The prioritization approach (which included the Frequency of Appearance (FoA), the Frequency of PNEC exceedance (FoE), and the Extent of predicted no-effect concentration (PNEC) exceedance (EoE)), showed a critical list of nine pharmaceuticals: caffeine, diphenhydramine, acetaminophen, lovastatin, gemfibrozil, ciprofloxacin, ibuprofen, doxycycline and norfloxacin. These compounds should be taken into account as a first concern during the implementation of environmental policies related to pharmaceutical products in the region.
- |||||||||| doxycycline / Generic mfg., gentamicin sulfate / Generic mfg., nitrofurantoin / Generic mfg.
Review, Journal: Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review. (Pubmed Central) - Jul 15, 2024
Mesenchymal stem cells and platelet-rich plasma were the most studied, with the latter showing considerable promise in improving biomechanical properties in hernia repair. Further investigations are needed to ascertain their definitive use in humans.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: A case report of donovanosis in HIV-positive female. (Pubmed Central) - Jul 11, 2024
She was treated with doxycycline 100 mg twice daily and azithromycin 1 g once weekly for 3 weeks and further azithromycin 1 g weekly for the next 9 weeks till complete healing of the lesion. Due to the rarity of this condition in our region, we present this case of donovanosis in an HIV-positive female patient.
- |||||||||| Journal: An investigation of the transmission of Actinobacillus pleuropneumoniae within vertically integrated systems using whole genome sequencing. (Pubmed Central) - Jul 10, 2024
On the other hand, using CLSI clinical breakpoints (CBPs), concordance was acceptable for florfenicol and enrofloxacin and not evaluated for doxycycline, oxytetracycline, trimethoprim-sulfamethoxazole (T/S), and amoxicillin because no CBP are available for them. Finally, WGS has demonstrated the clonality between isolates that shared a common origin (grandmother's farm) and resistance phenotype, suggesting vertical transmission of this pathogen and supporting the use of the epidemiological approach as a good criterion to optimise the antimicrobial use.
- |||||||||| hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
Journal: Q fever presenting as splenic infarct without endocarditis. (Pubmed Central) - Jul 10, 2024
However, the presence of these antibodies has been associated with increased risk of complications. Further investigation into the management of patients with Q fever associated hypercoagulability is needed.
- |||||||||| doxycycline / Generic mfg., amoxicillin / Generic mfg.
Preclinical, Journal: Assessment of Antimicrobial Therapy in Eradicating Chlamydia muridarum in Research Mice: Immune Status and its Impact on Outcomes. (Pubmed Central) - Jul 9, 2024
All immunocompetent and NOD.SCID mice were negative for Cm by PCR 14 days post-treatment, remained clinically normal and had no evidence of Cm infection at necropsy, all NSG mice remained Cm positive and were euthanized. While these findings highlight the difficulties in eradicating Cm from highly immunodeficient mice, eradication of Cm from immunocompetent or moderately immunocompromised mice with antibiotics is feasible.
- |||||||||| doxycycline / Generic mfg.
Journal: A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. (Pubmed Central) - Jul 6, 2024
Furthermore, our results reveal a close transcriptional and proteomic alignment between the iECs generated via our method and primary ECs, confirming the biological relevance of the differentiated cells. The high efficiency and effectiveness of our induction methodology pave the way for broader application and accessibility of iPSC-derived ECs in scientific research, offering a valuable tool for investigating endothelial biology and for the development of EC-based therapies.
- |||||||||| doxycycline / Generic mfg.
FOXI1 deletion alters ion transport and cellular composition in an iPSC-based airway system (153 A-C) - Jul 4, 2024 - Abstract #NACFC2024NACFC_256;
Additionally, ionocytes influence cell lineage fate in the respiratory epithelium. Future studies will validate these findings using FOXI1-overexpressing iPSC-derived airway models and assess whether WT ionocytes can rescue aberrant chloride transport in CF epithelial cells and epithelium and alters airway cell composition and function.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg.
Journal: A Rare Case of Brucellosis with Multivalvular Endocarditis and Complete Heart Block. (Pubmed Central) - Jul 4, 2024
Future studies will validate these findings using FOXI1-overexpressing iPSC-derived airway models and assess whether WT ionocytes can rescue aberrant chloride transport in CF epithelial cells and epithelium and alters airway cell composition and function. This report has drawn attention to multivalvular involvement and cardiac rhythm abnormalities in Brucellosis (in this case, A.V. dissociation was present) because early diagnosis and treatment can cause a significant decrease in morbidity as well as mortality by appropriate treatment.
- |||||||||| doxycycline / Generic mfg.
Journal: Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26. (Pubmed Central) - Jul 3, 2024
To identify novel genes modulating C. albicans biofilm formation, we performed a large-scale screen with 2,454 C. albicans doxycycline-dependent overexpression strains and identified 16 genes whose overexpression significantly hampered biofilm formation...Transcript profiling, transcription factor binding, and phenotypic microarray analyses conducted upon overexpression of ZCF15 and ZCF26 demonstrated their role in reprogramming cellular metabolism by regulating central metabolism including glyoxylate and tricarboxylic acid cycle genes. Taken together, this study has identified a new set of biofilm regulators, including ZCF15 and ZCF26, that appear to control biofilm development through their specific role in metabolic remodeling.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Review, Journal: Neglected etiologies of prolonged febrile illnesses in tropical and subtropical regions: A systematic review. (Pubmed Central) - Jul 3, 2024
Clinicians faced with PFI in sub-/tropical LMICs should consider a wide differential diagnosis including enteric fever and zoonotic bacterial diseases (e.g., rickettsiosis, RF-borreliosis and brucellosis), or parasite infections (e.g., leishmaniasis) depending on geography and syndromes. In the absence of adequate diagnostic capacity, a trial of antibiotics targeting relevant intra-cellular bacteria, such as doxycycline or azithromycin, may be considered.
- |||||||||| doxycycline / Generic mfg.
Journal: Nodular Syphilis Seen in an HIV-Positive Man: A Case Study. (Pubmed Central) - Jul 3, 2024
We present a case of a 54-year-old HIV-positive man with nodular secondary syphilis effectively treated with an empiric 2-week course of oral doxycycline...Biopsy demonstrated granulomatous dermatitis, and serology revealed positive Treponema pallidum antibodies with a rapid plasma reagin of 1:256, confirming the diagnosis of secondary syphilis with granulomatous dermatitis. This case indicates that clinicians should consider this unusual cutaneous presentation of secondary syphilis when evaluating patients with nodular skin lesions, especially in high-risk individuals.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
Preclinical, Journal: Efficacy of rifapentine and other rifamycins against Coxiella burnetii in vitro. (Pubmed Central) - Jul 2, 2024
This case indicates that clinicians should consider this unusual cutaneous presentation of secondary syphilis when evaluating patients with nodular skin lesions, especially in high-risk individuals. Since 1999, doxycycline and hydroxychloroquine have been the recommended treatment for chronic Q fever, a life-threatening disease caused by the bacterial pathogen, Coxiella burnetii...Rifabutin and rifaximin were the best performing antibiotics tested with MICs of ?0.01
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: An efficient in vivo-inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies. (Pubmed Central) - Jul 2, 2024
In this study, we present a highly transformable and fully virulent serotype M1T1 GAS strain and introduce a doxycycline-inducible CRISPRi system for efficient repression of bacterial gene expression...Additionally, we present SpyBrowse, an intuitive and accessible genome browser (https://veeninglab.com/SpyBrowse). Overall, this work overcomes significant technical challenges of working with GAS and, together with SpyBrowse, represents a valuable resource for researchers in the GAS field.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Brucellosis and Sacroiliitis Present as Acute Severe Hip Pain. (Pubmed Central) - Jul 1, 2024
Sacroiliitis was documented by positive results from serological tests (ELISA) and magnetic resonance imaging. Treatment consisted of non-steroidal anti-inflammatory drugs (NSAIDs), doxycycline, rifampicin, and IV gentamicin.
- |||||||||| doxycycline / Generic mfg.
Journal: Tick-Borne Relapsing Fever Infection from a Bunker, a Case Report on a "One Health" Approach. (Pubmed Central) - Jul 1, 2024
Prevention among the Israel Defense Force soldiers is based on increased awareness mainly in hyperendemic areas and selective postexposure prophylaxis with doxycycline...Environmental treatment with lambda-cyhalothrin at 9.7% was performed and showed efficacy with no ticks recovered in the infested bunker 124 days after intervention. This study shows that military bunkers may harbor soft ticks infected with B. persica and entrance into bunkers should be considered as a risk for acquiring this infection like entrance into natural caves and archeological ruins.
- |||||||||| ampicillin / Generic mfg., doxycycline / Generic mfg.
Journal, Metabolomic study: Metabolomics analysis of the lactobacillus plantarum ATCC 14917 response to antibiotic stress. (Pubmed Central) - Jun 29, 2024
The metabolic changes of L. plantarum ATCC14917 under antibiotic treatments were determined. Moreover, the metabolome information that was elucidated can be used to help L. plantarum cope with adverse stress, which will help probiotics become less vulnerable to antibiotics during clinical treatment.
- |||||||||| doxycycline / Generic mfg.
Journal: CDC Recommends Doxycycline Prophylaxis to Prevent STIs in US. (Pubmed Central) - Jun 28, 2024
Moreover, the metabolome information that was elucidated can be used to help L. plantarum cope with adverse stress, which will help probiotics become less vulnerable to antibiotics during clinical treatment. No abstract available
- |||||||||| doxycycline / Generic mfg.
Journal, IO biomarker: NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation. (Pubmed Central) - Jun 28, 2024
We demonstrated the pivotal role of NB in cell transformation and survival and identified PIM1as a key downstream target of NB. These findings propose a promising therapeutic strategy for patients with NB fusion-positive leukemia.
- |||||||||| doxycycline / Generic mfg.
Journal: Prurigo pigmentosa: Case report of a (Pubmed Central) - Jun 27, 2024
Here, we describe the typical clinical and dermoscopic criteria so that therapy can be initiated as early as possible. The 17-year-old patient presented here shows that this disease can also be observed in Western Europe and in men, and that doxycycline is a
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: Post COVID-19 Pandemic Increased Detection of Mycoplasma Pneumoniae in Adults Admitted to the Intensive Care. (Pubmed Central) - Jun 27, 2024
Early molecular diagnostics and tailored antibiotic regimens are crucial since beta-lactam antibiotics are ineffective. This study highlights the escalating challenge of severe M. pneumoniae infections in ICUs, necessitating a multifaceted approach involving accurate diagnostics, vigilant monitoring, and adaptable treatment strategies for optimal patient outcomes.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Mouse Congenital Myxomatous Valve Disease. (Pubmed Central) - Jun 26, 2024
Dietary doxycycline was administered for 1 month beginning with MVD initiation (1-month-old) or MVD progression (2-month-old)...Wnt signaling is involved in the initiation of mitral valve abnormalities and inflammation but is not responsible for later-stage valve disease progression once it has been initiated. Thus, Wnt signaling contributes to MVD progression in a time-dependent manner and provides a promising therapeutic target for the early treatment of congenital MVD in Marfan syndrome.
- |||||||||| doxycycline / Generic mfg.
Journal: An Exuberant Case of Ulceronodular-Rupioid (Malignant) Syphilis in an HIV Patient: A Proposal for New Diagnostic Criteria. (Pubmed Central) - Jun 26, 2024
The patient's rash resolved with hyperpigmented scarring after penicillin and doxycycline treatment...Thus, we examined an additional 74 cases from the literature and propose new diagnostic criteria based on rash appearance, histopathologic characteristics, non-treponemal and treponemal test positivity, and response to therapy. We also found that uncontrolled viremia, and not a low CD4 count, is a major risk factor for ulceronodular-rupioid syphilis in HIV patients.
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