doxycycline / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 114 Diseases   151 Trials   151 Trials   5480 News 


«12...7374757677787980818283...167168»
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Journal:  The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma. (Pubmed Central) -  Jan 21, 2022   
    Cotargeting of aberrant p16-CDK4/6-RB signaling and CRTC1-MAML2 fusion-activated AREG/EGFR signaling with the respective CDK4/6 inhibitor Palbociclib and EGFR inhibitor Erlotinib produced enhanced antitumor responses in vitro and in vivo. Collectively, this study provides direct evidence for CRTC1-MAML2 as a key driver for MEC development and maintenance and identifies a potentially novel combination therapy with FDA-approved EGFR and CDK4/6 inhibitors as a potential viable strategy for patients with MEC.
  • ||||||||||  doxycycline / Generic mfg.
    Clinical, Journal:  Overexpression of neuroserpin in larval and adult zebrafish shows different behavioral phenotypes. (Pubmed Central) -  Jan 21, 2022   
    Neuroserpin overexpression was induced by doxycycline in larval and adult zebrafish respectively...Furthermore, RNA-sequencing analysis reveals that neuroserpin overexpression affects neurodegeneration-related gene expression. In summary, we report that neuroserpin overexpression in larval and adult zebrafish shows different behavioral phenotypes.
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Diastereomer recognition of three pairs of tetracyclines by electrospray ionization mass spectrometry. (Pubmed Central) -  Jan 21, 2022   
    The CID spectra of tetracycline and chlortetracycline were different from those of their 4-epimers. The CID spectra of protonated doxycycline and its 4-epimer showed only a subtle difference, but the m/z 154 fragment ion in the CID spectra of the fragment ion at m/z 428 offers the possibility to differentiate both epimers.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. (Pubmed Central) -  Jan 21, 2022   
    To explore the impact of Max dimerization protein 3 (MXD3), a transcription factor that regulates several cellular functions in disorders associated with metabolic diseases, we conditionally expressed Mxd3 proteins using Tet-on mxd3 transgenic zebrafish (MXs) with doxycycline (MXs + Dox) or without doxycycline (MXs - Dox) treatment...Overexpression of Mxd3 also enhanced AR expression accompanied by the increase of AR-signaling pathways resulting in hepatocarcinogenesis in males. Our results demonstrate that global actions of Mxd3 are central to the initiation of obesity in the gMX zebrafish through their effects on adipogenesis and that MXD3 could serve as a therapeutic target for obesity-associated liver diseases.
  • ||||||||||  ceftriaxone / Generic mfg.
    Review, Journal:  Diagnosis and Treatment of Sexually Transmitted Infections: A Review. (Pubmed Central) -  Jan 21, 2022   
    Rates of gonorrhea, chlamydia, and syphilis in the US have increased, while rates of HSV-1 and HSV-2 have declined. Ceftriaxone, doxycycline, penicillin, moxifloxacin, and the nitroimidazoles are effective treatments for gonorrhea, chlamydia, syphilis, Mycoplasma genitalium, and trichomoniasis, respectively, but antimicrobial resistance limits oral therapies for gonorrhea and Mycoplasma genitalium, and no cure is available for genital herpes.
  • ||||||||||  flucloxacillin sodium / Generic mfg., doxycycline / Generic mfg.
    Clinical, Journal:  Septic arthritis caused by Mycoplasma hominis in a patient with systemic lupus erythematosus. (Pubmed Central) -  Jan 21, 2022   
    Fortunately, doxycycline was an effective treatment for this atypical organism. This case outlines the importance of considering atypical organisms such as M. hominis as a cause of septic arthritis in immunosuppressed patients especially those with SLE.
  • ||||||||||  Apretude (cabotegravir extended-release injectable suspension) / ViiV Healthcare
    Enrollment open:  Parrying the Pitfalls of PrEP: Project PEACH (clinicaltrials.gov) -  Jan 20, 2022   
    P4,  N=300, Recruiting, 
    In this cohort, a diagnosis of CE did not negatively impact subsequent reproductive outcomes. Not yet recruiting --> Recruiting
  • ||||||||||  doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
    Clinical, Journal:  Recurrent intracerebral haemorrhage in a 24-year-old female patient (Pubmed Central) -  Jan 19, 2022   
    In retrospect, the intracerebral bleeding events could be identified as septic emboli with secondary haemorrhagic transformation under anticoagulation therapy. The patient showed significant clinical improvement and no further bleeding events occurred after receiving biological mitral and aortic valve replacement and several weeks of doxycycline and gentamicin antibiotic therapy.
  • ||||||||||  doxycycline / Generic mfg.
    Clinical, Journal:  Severe Chest Pain, Odynophagia and Dysphagia in a Young Woman. (Pubmed Central) -  Jan 18, 2022   
    Our data provide the first rationale for clinical trials investigating DOXY therapeutic actions in bipolar disorder mania. No abstract available
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Journal:  A modified Tet-ON system minimizing leaky expression for cell-type specific gene induction in medaka fish. (Pubmed Central) -  Jan 18, 2022   
    The GFP fluorescence intensity was enhanced with longer durations of doxycycline treatment up to 72 h and in a dose-dependent manner (5-45 μg/ml). These findings demonstrate that the Tet-ON system using rtTAm allows for spatiotemporal control of transgene expression, at least in the rod photoreceptors, in medaka fish.
  • ||||||||||  piperacillin sodium/tazobactam sodium / Generic mfg., doxycycline / Generic mfg.
    Clinical, Journal:  Francisella philomiragia bacteremia in an immunocompromised patient: a rare case report. (Pubmed Central) -  Jan 15, 2022   
    Clinical suspicion should be raised if patients with known risk factors are presenting with pneumonia or pulmonary nodules especially as these are the most common manifestations of F. philomiragia infection. Early diagnosis via accurate laboratory identification of the organism through MALDI-TOF mass spectrometry and molecular technique such as 16S rDNA sequencing are vital for prompt treatment that results in better outcomes for the afflicted patients.
  • ||||||||||  Journal:  Antimicrobial Resistance of Campylobacter spp. Isolates from Broiler Chicken Meat Supply Chain in Maputo, Mozambique. (Pubmed Central) -  Jan 14, 2022   
    Overall, isolates from supermarkets showed higher resistance profiles (37.9%) than those from informal markets (31.5%) and slaughterhouses (30.6%); however, the difference was not significant (p > 0.05). The findings of the study showed that there is a high circulation of antimicrobial-resistant Campylobacter in the broiler meat supply chain of Maputo, Mozambique, representing sources for human infections and highlighting the need for measures regulating antibiotics use in livestock production.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Journal:  Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy. (Pubmed Central) -  Jan 14, 2022   
    The problem of cerebrospinal fluid absorbance curve interference might be more common than previously suspected. Due to the potential net bilirubin absorbance-lowering effect of tetracyclines, the author recommends visual examination of cerebrospinal fluid samples in every case.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation. (Pubmed Central) -  Jan 13, 2022   
    Endoderm generated by our method achieves similar transcriptomic profiles, expression of endoderm protein markers, and the ability to be further differentiated to downstream lineages. Furthermore, this method achieves a four-fold increase in endoderm cell number and will accelerate studies of human diseases in vitro and facilitate the expansion of iPSC-derived cells for transplantation studies.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells. (Pubmed Central) -  Jan 13, 2022   
    Although antibiotics, such as doxycycline, effectively treat acute Q fever, a recently identified antibiotic-resistant strain demonstrates the ability of C. burnetii to resist traditional antimicrobials, and chronic disease is extremely difficult to treat with current options...These compounds are poised for future characterization as nontraditional anti-C. burnetii therapies.
  • ||||||||||  cefuroxime / Generic mfg.
    Journal:  Expansion and persistence of antibiotic-specific resistance genes following antibiotic treatment. (Pubmed Central) -  Jan 11, 2022   
    Virome sequencing and plasmid analysis showed an expansion of antibiotic-specific resistance gene homologs even 3 months after antibiotic administration, while paired-end read analysis suggested their dissemination among different species. These results suggest that antibiotic treatment can lead to a persistent expansion of antibiotic resistance genes in the human gut microbiota and provide further data in support of good antibiotic stewardship.Abbreviation: ARG - Antibiotic resistance gene homolog; AsRG - Antibiotic-specific resistance gene homolog; AZY - Azithromycin; CFX - Cefuroxime; CIP - Ciprofloxacin; DOX - Doxycycline; FDR - False discovery rate; GRiD - Growth rate index value; HGT - Horizontal gene transfer; NMDS - Non-metric multidimensional scaling; qPCR - Quantitative polymerase chain reaction; RPM - Reads per million mapped reads; TA - Transcriptional activity; TE - Transposable element; TPM - Transcripts per million mapped reads.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Differentiation of human induced pluripotent stem cells into testosterone-producing Leydig-like cells. (Pubmed Central) -  Jan 11, 2022   
    We herein report a simple and robust protocol for directed differentiation of human induced pluripotent stem cells (hiPSCs) into Leydig-like cells by doxycycline-inducible overexpression of NR5A1 and treatment with a combination of 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) and forskolin...Furthermore, we confirmed the secretion of functional testosterone from the cells into the culture supernatant by a testosterone-sensitive cell proliferation assay. These findings showed that the hiPSCs were able to be differentiated into Leydig-like cells, supporting the expectation that hiPSC-derived Leydig-like cells can be novel tools for treating LOH syndrome.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma. (Pubmed Central) -  Jan 8, 2022   
    In summary, our results revealed that Notch1 activation by doxycycline induces S phase arrest, apoptosis and autophagy by blocking PI3K/Akt/mTOR signalling in human osteosarcoma cells. Notch1 may be a potential clinical antitumour target for osteosarcoma therapy.
  • ||||||||||  JNK-IN-8 - Dana-Farber Cancer Institute, University of North Carolina / Chapel Hill
    Journal:  Regulation and function of AP-1 in insulinoma cells and pancreatic β-cells. (Pubmed Central) -  Jan 7, 2022   
    The analysis of transgenic A-Fos-expressing mice revealed that the animals displayed impaired glucose tolerance. Thus, we show here for the first time that AP-1 controls an important function of pancreatic β-cells in vivo, the regulation of glucose homeostasis.