- |||||||||| doxycycline / Generic mfg.
PK/PD data, Journal: Pharmacokinetic Profile of Doxycycline in Koala Plasma after Weekly Subcutaneous Injections for the Treatment of Chlamydiosis. (Pubmed Central) - Feb 16, 2022
Using probability of target attainment modelling, doxycycline plasma concentrations were likely to inhibit 90% of pathogens with the doxycycline minimum inhibitory concentration (MIC) of 8.0-31.0 ng/mL, and the reported doxycycline MIC to inhibit Chlamydia pecorum isolates at the area under the curve/minimum inhibitory concentration (AUC/MIC) target of ≥24. All koalas were confirmed to be negative for Chlamydia pecorum using loop-mediated isothermal amplification (LAMP), from ocular and penile urethra swabs, three weeks after the last doxycycline injection.
- |||||||||| doxycycline / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Journal: The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline. (Pubmed Central) - Feb 16, 2022
Alterations in the pattern of serum amino acids, antioxidants, purines, and pyrimidines, as well as fecal bile acids, sterols, and fatty acids, were observed in antibiotic-treated groups that were not observed in control cats. However, the alterations caused by either amoxicillin/clavulanic acid or doxycycline of the fecal and serum metabolome were only temporary and were resolved by 10 months after their withdrawal.
- |||||||||| Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi, Halfan (halofantrine) / GSK
Journal, Monotherapy: Resistance to Antimalarial Monotherapy Is Cyclic. (Pubmed Central) - Feb 16, 2022
Furthermore, cyclic resistance is clinically relevant and discourages routine monotherapy, in particular, while resistance is on the rise. Finally, cyclic resistance encourages the combination of antimalarial drugs at distinct phases of resistance.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Antibacterial Effect of Functionalized Polymeric Nanoparticles on Titanium Surfaces Using an In Vitro Subgingival Biofilm Model. (Pubmed Central) - Feb 16, 2022
This investigation aimed to evaluate the antibacterial effect of polymeric nanoparticles (NPs), functionalized with calcium, zinc, or doxycycline, using a subgingival biofilm model of six bacterial species (Streptococcus oralis,Actinomyces naeslundii, Veillonela parvula, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans) on sandblasted, large grit, acid-etched titanium discs (TiDs)...As compared with uncovered TiDs, Dox-NPs induced higher biofilm mortality (47.21% and 85.87%, respectively) and reduced the bacterial load of the tested species, after 72 h. With SEM, scarce biofilm formation was observed in Dox-NPs TiDs. In summary, Dox-NPs on TiD reduced biofilm vitality, bacterial load, and altered biofilm formation dynamics.
- |||||||||| Journal: Novel Therapies for Kidney Disease in People with Diabetes. (Pubmed Central) - Feb 15, 2022
Sodium-glucose cotransporter-2 inhibitors and incretin-related therapies have demonstrated benefit and were associated with improved cardiovascular outcomes. Mineralocorticoid-receptor antagonists are another class of agents with increasing evidence of benefits.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Review, Journal: Pharmacological Treatment of Secondary Lymphedema. (Pubmed Central) - Feb 12, 2022
However, recent discoveries have increased the hopes of therapeutic interventions that may promote lymphatic regeneration and function. The purpose of this review is to summarize current experimental pharmacological strategies in the treatment of lymphedema.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: The expanding spectrum of disease caused by the Lone Star Tick, Amblyomma americanum. (Pubmed Central) - Feb 12, 2022
Healthcare professionals should consider these viruses in patients presenting with an ailment suggestive of a tick-born rickettsial disease that fails to improve with treatment with doxycycline. Additionally, some individuals may develop life-threatening allergic reactions triggered by the bite of the Lone Star tick.
- |||||||||| doxycycline / Generic mfg.
Journal, Tumor-specific neoantigens, PD(L)-1 Biomarker, IO biomarker: Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T cell-dependent manner. (Pubmed Central) - Feb 10, 2022
Using a doxycycline-driven gene expression system, we generated murine MC38, CT26 (colorectal cancer) and B16 (melanoma) cell lines with inducible expression of model immunogenic neoantigens such as chicken ovalbumin and human NY-ESO-1...We propose that a newly emerged neoantigen is sufficient to inhibit tumor growth via preventing immune escape in a T cell-dependent manner. Our results imply that induction of immunogenic tumor neoantigens is a novel strategy to overcome the resistance to immune checkpoint blockade therapy.
- |||||||||| etesevimab (JS016) / Chinese Academy of Sciences, Shanghai Junshi Biosci, Eli Lilly
Clinical, Review, Journal: Interventions in an Ambulatory Setting to Prevent Progression to Severe Disease in Patients With COVID-19: A Systematic Review. (Pubmed Central) - Feb 10, 2022
Based on published data, insufficient evidence of effect was found for bamlanivimab (monotherapy), casirivimab plus imdevimab, ivermectin (monotherapy), nitazoxanide, and peginterferon lambda...Recent trials have shown promising results for a number of pharmacological agents to treat COVID-19 in the ambulatory setting. However, larger, more robust trials are needed to support the routine use of these agents outside of monitored clinical trials.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Doxycycline for Hereditary Hemorrhagic Telangiectasia (clinicaltrials.gov) - Feb 9, 2022
P2, N=30, Active, not recruiting,
Treatment of 1 year with trimethoprim/sulfamethoxazole has good response with complete remission at 1.5 years of follow up. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2022
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Chronic Wound Infection Model of Acinetobacter baumannii in Outbred Mice. (Pubmed Central) - Feb 9, 2022
In conclusion, ICR mice are a viable option as a model of dermal wound infection. They accommodate two simultaneous dorsal wounds, and upon infection, these wounds follow a different pattern of resolution compared to BALB/c mice.
- |||||||||| ampicillin / Generic mfg., amoxicillin / Generic mfg.
Journal: Antibiotic standards stored as a mixture in water: methanol are unstable at various temperatures irrespective of pH and glass container silanization. (Pubmed Central) - Feb 8, 2022
Our results show that several antibiotics in water:methanol are unstable when stored as a mixture and suggest a limited advantage of using base or silanized glass vials for the preparation and storage of antibiotic standards mixed together. Freshly prepared antibiotic standard mixtures are recommended for multi-residue quantitation of antibiotics.Abbreviations AMOX: amoxicillin; AMP: ampicillin; AZ: azithromycin; CAP: chloramphenicol; CE: collision energy; CTC: chlortetracycline; CIP: ciprofloxacin; DOX: doxycycline; ENO: enoxacin; ENRO: enrofloxacin; ERYTH: erythromycin; FF: florfenicol; FFA: florfenicol amine; FLU: flumequine; HDPE: high-density polyethylene; LC-MS/MS: liquid chromatography-tandem mass spectrometry; LIN: lincomycin; MRM: multiple reaction monitoring; NOR: norfloxacin; OFL-D3: ofloxacin-D3; OXO: oxolinic acid; OTC: oxytetracycline; PEN-G: penicillin G; PEN-V: penicillin V; ROX: roxithromycin; SDM: sulfadimethoxine; SDZ: sulfadiazine; SMX: sulfamethoxazole; SMZ-D4: sulfamethazine-D4; SSZ: sulfasalazine; TC: tetracycline; TAP: thiamphenicol; TILM: tilmicosin; TRIM: trimethoprim; TL: tolerance limit; VIRG: virginiamycin; UPLC-MS/MS: ultra-high pressure liquid chromatography-tandem mass spectrometry.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Clinical, Journal: Development of bullous pemphigoid following radiation therapy combined with nivolumab for renal cell carcinoma: A case report of abscopal toxicities. (Pubmed Central) - Feb 8, 2022
Freshly prepared antibiotic standard mixtures are recommended for multi-residue quantitation of antibiotics.Abbreviations AMOX: amoxicillin; AMP: ampicillin; AZ: azithromycin; CAP: chloramphenicol; CE: collision energy; CTC: chlortetracycline; CIP: ciprofloxacin; DOX: doxycycline; ENO: enoxacin; ENRO: enrofloxacin; ERYTH: erythromycin; FF: florfenicol; FFA: florfenicol amine; FLU: flumequine; HDPE: high-density polyethylene; LC-MS/MS: liquid chromatography-tandem mass spectrometry; LIN: lincomycin; MRM: multiple reaction monitoring; NOR: norfloxacin; OFL-D3: ofloxacin-D3; OXO: oxolinic acid; OTC: oxytetracycline; PEN-G: penicillin G; PEN-V: penicillin V; ROX: roxithromycin; SDM: sulfadimethoxine; SDZ: sulfadiazine; SMX: sulfamethoxazole; SMZ-D4: sulfamethazine-D4; SSZ: sulfasalazine; TC: tetracycline; TAP: thiamphenicol; TILM: tilmicosin; TRIM: trimethoprim; TL: tolerance limit; VIRG: virginiamycin; UPLC-MS/MS: ultra-high pressure liquid chromatography-tandem mass spectrometry. Treating physicians should be aware of off-target effects of radiotherapy for oligoprogressive disease, which may include abscopal toxicities and the development of new immune-related adverse effects.
- |||||||||| doxycycline / Generic mfg.
Journal: Case Report: Rocky Mountain Spotted Fever with Adrenalectomy and a Hard-to-Find Tick. (Pubmed Central) - Feb 8, 2022
Other manifestations that a patient's pre-existing conditions can simultaneously cause should not be overlooked and should be examined holistically with other signs, symptoms, laboratory values, and physical examinations. Early treatment with doxycycline is encouraged as evidence strongly suggests that early treatment is correlated with lower mortality.
- |||||||||| doxycycline / Generic mfg.
INTERACTOME OF HIV PROTEINS AND THEIR HOST RNA INTERACTION PARTNERS ([VIRTUAL]) - Feb 7, 2022 - Abstract #CROI2022CROI_807;
For this purpose, an RNA immunoprecipitation (RIP)-seq strategy was established in Jurkat cell lines that express a single FLAG-tagged HIV protein upon doxycycline induction...These Tat interactions were validated by Tat IP in the context of HIV infection, hinting at a regulatory role of Tat in the expression of these SEC subunits. This unique and comprehensive dataset of HIV protein–human RNA interactions broadens our understanding on how HIV manipulates the RNA component of the host’s cellular machinery during the course of infection and can be mined to investigate potential new therapeutic strategies.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: B6-Dct-H2BGFP bitransgenic mice: a standardized mouse model for in vivo characterization of melanocyte development and stem cell differentiation. (Pubmed Central) - Feb 5, 2022
To characterize B6-Dct-H2BGFP mice, we confirmed not only the expression of GFP in all melanocyte lineage cells, but also doxycycline regulation of GFP expression...In contrast, CD34-/secondary hair germ (SHG) McSCs differentiated into pigmented melanocytes, with higher expression of melanogenic markers Tyr (71±1%), Tyrp1 (68±4%), and Mitf (75±7%). These results establish the utility of B6-Dct-H2BGFP bitransgenic mice for future in vivo studies of melanocytes requiring a defined genetic background.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Pharmacological evidence for the concept of spare glutamate transporters. (Pubmed Central) - Feb 5, 2022
Exposing the cells to doxycycline concentration-dependently increased GLT-1 expression and substrate uptake velocity...The curve showing inhibition of uptake by increasing concentrations of WAY-213613 was indeed progressively rightward shifted when tested in cells where the transporter density was robustly induced. As largely documented in the context of cell-surface receptors, the existence of 'spare' glutamate transporters in the nervous tissue and particularly in astrocytes could impact on the consequences of physiological or pathological regulation of these transporters.
- |||||||||| cephalexin / Generic mfg., doxycycline / Generic mfg.
Review, Journal: Elimination of cephalexin and doxycycline under low frequency ultrasound. (Pubmed Central) - Feb 5, 2022
In addition, in terms of mineralization, experimental results showed a reduction of the organic carbon present in the solutions and a significant increase of ions (nitrates and sulfates) concentration, suggesting that part of the organic matter was transformed into CO, HO and inorganic species. Finally, results regarding the samples toxicity indicated that ultrasonic treatment could promote a significant reduction in this parameter, and the potential negative effect associated to CPX and DOX presence in water bodies.
- |||||||||| doxycycline / Generic mfg.
Journal: Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains. (Pubmed Central) - Feb 5, 2022
Here, we applied systems approaches to investigate the effect of UPRmt induced by doxycycline (Dox) on transcriptome, proteome, and lipidome in two genetically divergent worm strains, named N2 and CB4856...We further validated that lipid genes acs-2/20 and fat-7/6 were required for Dox-induced UPRmt and longevity in N2 and CB4856 worms, respectively. Our data have translational value as they indicate that the beneficial effects of Dox-induced UPRmt on lifespan are consistent across different genetic backgrounds through different regulators.
- |||||||||| doxycycline / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer. (Pubmed Central) - Feb 4, 2022
It is first sorted out that doxycycline (Doxy) efficiently inhibits autophagy of the tumor cells, and increases the surface level of major histocompatibility complex class I (MHC-I)...After a proof of concept for overcoming intrinsic and inducible immune evasion, the prodrug nanovesicles are applied to validate the efficacy of cancer immunotherapy in two tumor-bearing mouse models. This research thus provides a novel targeting strategy for reducing tumor immune resistance and potentiating tumor immunotherapy.
- |||||||||| doxycycline / Generic mfg.
Journal: Neoehrlichiosis: A Case Study of the Tick-Borne Pathogen That Can Cause Thromboembolic Events. (Pubmed Central) - Feb 4, 2022
If a patient presents to an emergency department complaining of a recent tick bite and symptoms of a deep vein thrombosis or pulmonary embolism, consider that these symptoms may be related. Treat the tick bite with doxycycline for 3 weeks and manage the thromboembolic event according to standard treatment of care.
- |||||||||| hydroxychloroquine / Generic mfg.
Clinical, Review, Journal: Whipple's disease orbitopathy: case report and review of literature. (Pubmed Central) - Feb 3, 2022
Orbitopathy is a rare form of WD presentation and the diagnosis of this condition may be challenging. As the clinical spectrum may range from an incidentaloma to a severe compressive neuropathy, proper recognition and management of WD orbitopathy is essential.
- |||||||||| Clinical, Journal, Pleural effusion: A severe case of Israeli spotted fever with pleural effusion in Italy. (Pubmed Central) - Feb 3, 2022
A high index of suspicion is required to promptly start life-saving therapy. Pleural effusion and interstitial pneumonia may be part of the clinical picture of severe rickettsial disease and should not lead the physician away from this diagnosis.
- |||||||||| doxycycline / Generic mfg.
Journal: A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence. (Pubmed Central) - Feb 3, 2022
In epithelial Madin-Darby canine kidney cells, upon confluence, doxycycline-induced expression of PRL upregulated apoptosis, reducing cell density...Morpholino-mediated inhibition of PRL expression in zebrafish embryos caused developmental defect with reduced apoptosis and increased epithelial cell density during convergent extension. This study revealed a novel role of PRL in regulating density-dependent apoptosis in vertebrate epithelium.
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