- |||||||||| doxycycline / Generic mfg.
Journal: Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone. (Pubmed Central) - Mar 30, 2022
Statistical comparison with over 100,000 manually curated and comparably reanalysed public datasets suggests that the phytogen effects are highly significantly comparable with transcriptomic effects of clinical antibiotics doxycycline and geldanamycin, and that phytogen can reverse transcriptomic effects of a range of viral diseases and malaria. Our data confirmed the hypothesis that similarly to the original essential oil type antimicrobial constituents of phytogenic products, there may be a range of benefits unrelated to their critical antimicrobial action, contributing to improved bird welfare.
- |||||||||| doxycycline / Generic mfg.
Journal: Matrixmetalloproteinase Inhibitors: Promising Therapeutic Targets Against Cancer. (Pubmed Central) - Mar 29, 2022
In this review, we presented different MMP inhibitors, their performance at different stages of models - in vitro, in vivo, small animal models and eventually clinical trials. We provide newer methods of MMPI delivery that may be better targeted to suppress only specific MMPs and avoid toxic side-effects in healthy cells.
- |||||||||| Jakafi oral (ruxolitinib) / Novartis, Incyte
Journal: Congenital deficiency reveals critical role of ISG15 in skin homeostasis. (Pubmed Central) - Mar 29, 2022
Additionally, there were loose architecture and reduced collagen and desmoglein expression, which could be reversed by treatment with ruxolitinib/doxycycline/TGF-β1. These results reveal critical roles of ISG15 in maintaining cell migration and epidermis and connective tissue homeostasis, whereby the latter likely requires its conjugation to yet unidentified targets.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
Journal: Interaction of Carboxyalkylated Cellulose Nanocrystals and Antibiotics. (Pubmed Central) - Mar 29, 2022
XPS analysis revealed that carboxyalkylation significantly enhanced the C-C/C-H bond, while antibiotic adsorption on PCNC enhanced C-N/C-O and C-C/C-H bonds in antibiotic-loaded CNC samples. Overall, carboxyalkylated CNC was observed to have an outstanding affinity for capturing antibiotics, especially DOX, which could pave the way for the use of CNC in such applications that surface/antibiotic interactions were essential.
- |||||||||| doxycycline / Generic mfg.
Journal: Molecular-Gated Drug Delivery Systems Using Light-Triggered Hydrophobic-to-Hydrophilic Switches. (Pubmed Central) - Mar 29, 2022
Light-triggered release of doxycycline (DOX) as a model drug indicated that the spiropyran (SP) molecules provide a hydrophobic layer around the drug carrier and have a good gate-closing efficiency for IPNs with 20-30% hydrogel content...The covalent attachment of SPCOOH to the alcohol groups of the hydrogel and the structural change caused by UV light was indicated with FTIR analysis. XPS results also confirm the presence of SP by indicating the atomic percentage of nitrogen with respect to the hydrogel content.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Role of Prophylactic Antibiotics in Preventing Pelvic Infection After Surgical Evacuation (clinicaltrials.gov) - Mar 28, 2022
P4, N=138, Recruiting,
The bioinorganic composite MAC contains a magnetic iron oxide which was effectively removed from slurry after use through the magnetic process and that was the main reason for high permeate fluxes in MAC/membrane operations. Trial completion date: Nov 2021 --> May 2022 | Trial primary completion date: Oct 2021 --> Apr 2022
- |||||||||| tetracycline / Generic mfg.
Journal: Biodegradation of Tetracycline Antibiotics by the Yeast Strain Cutaneotrichosporon dermatis M503. (Pubmed Central) - Mar 27, 2022
Moreover, the well diffusion method showed that the strain of M503 decreases the antibacterial potency of tetracycline, doxycycline, and chlorotetracycline. These findings proposed a putative mechanism of tetracycline degradation by a fungus strain and contributed to the estimation of the fate of tetracycline in the aquatic environment.
- |||||||||| doxycycline / Generic mfg.
Journal: Rickettsial illnesses, a leading cause of acute febrile illness. (Pubmed Central) - Mar 26, 2022
Almost all rickettsial infections respond to anti-rickettsial antibiotics such as doxycycline within 48-72 hours. Awareness of rickettsial illnesses and their various clinical presentations helps in early diagnosis and institution of appropriate treatment and hence prevent morbidity and mortality.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg., erythromycin / Generic mfg.
Journal: Detection of Antibiotic Residues in Blossom Honeys from Different Regions in Turkey by LC-MS/MS Method. (Pubmed Central) - Mar 26, 2022
The pH, moisture, and electrical conductivity values of the honey samples were determined as between pH 3.78 and 5.41, 17.48 and 18.03%, and 0.25 and 0.47 mS/cm, respectively. In terms of food safety and human health, it is very important to monitor the residues of these pharmacologically active substances with analytical methods.
- |||||||||| doxycycline / Generic mfg.
Journal: Preparation and Characterization of Doxycycline-Loaded Electrospun PLA/HAP Nanofibers as a Drug Delivery System. (Pubmed Central) - Mar 26, 2022
In vitro drug release studies were performed and different drug release kinetics were assessed to confirm the use of these nanofiber materials as efficient drug delivery vehicles. The obtained results indicate that the PLA-HAP-Doxy is a promising system for biomedical applications, the samples with 3 and 7 wt% of Doxy-loaded PLA-HAP nanofibers prepared by physical adsorption are the most acceptable membranes to provide prolonged release in PBS/SBF rather than an immediate release of Doxy.
- |||||||||| tamoxifen / Generic mfg.
Journal: Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability. (Pubmed Central) - Mar 25, 2022
Finally, we showed that HBx, a hepatitis B viral protein capable of suppressing autophagy, also causes mitochondrial permeability-dependent ENDOG mis-localization in nuclei and is linked to hepatitis B virus (HBV)-mediated hepatocellular carcinoma development. Abbreviations: 3-MA: 3-methyladenine; 5-hmC: 5-hydroxymethylcytosine; ACTB: actin beta; ATG5: autophagy related 5; ATM: ATM serine/threonine kinase; DFFB/CAD: DNA fragmentation factor subunit beta; cmtDNA: cytosolic mitochondrial DNA; ConA: concanamycin A; CQ: chloroquine; CsA: cyclosporin A; Dox: doxycycline; DSB: double-strand break; ENDOG: endonuclease G; GFP: green fluorescent protein; Gy: gray; H2AX: H2A.X variant histone; HBV: hepatitis B virus; HBx: hepatitis B virus X protein; HCC: hepatocellular carcinoma; I-PpoI: intron-encoded endonuclease; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MOMP: mitochondrial outer membrane permeability; mPTP: mitochondrial permeability transition pore; mtDNA: mitochondrial DNA; nDNA: nuclear DNA; 4-OHT: 4-hydroxytamoxifen; rDNA: ribosomal DNA; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TET: tet methylcytosine dioxygenase; TFAM: transcription factor A, mitochondrial; TOMM20: translocase of outer mitochondrial membrane 20; VDAC: voltage dependent anion channel.
- |||||||||| doxycycline / Generic mfg.
Journal: Lime Peel Oil-Incorporated Rosin-Based Antimicrobial In Situ Forming Gel. (Pubmed Central) - Mar 25, 2022
This study aims to investigate the role of incorporating lime peel oil (LO) on the physicochemical properties of injectable in situ forming gels based on rosin loaded with 5% w/w doxycycline hyclate (DH) in dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP)...Adding 10% LO to rosin-based in situ forming gel improved the antimicrobial activities, especially for the P. gingivalis and S. aureus. As a result, the study demonstrates the possibility of using an LO amount of less than 10% loading into a rosin-based in situ forming gel for efficient periodontitis treatment.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Risk Analysis of 24 Residual Antibiotics in Poultry Eggs in Shandong, China (2018-2020). (Pubmed Central) - Mar 25, 2022
Therefore, although enrofloxacin, sarafloxacin, danofloxacin, sulfonamides, tilmicosin, doxycycline, florfenicol, which are banned during egg laying, were detected in poultry eggs in Shandong, these residues did not pose a threat to the health of Chinese adult consumers, according to the daily dietary habits of Chinese people. However, it is strongly suggested that Shandong should strengthen the monitoring of antibiotic use during egg laying.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Trial completion date, Trial primary completion date: START: Scrub Typhus Antibiotic Resistance Trial (clinicaltrials.gov) - Mar 23, 2022
P4, N=177, Recruiting,
However, it is strongly suggested that Shandong should strengthen the monitoring of antibiotic use during egg laying. Trial completion date: Oct 2021 --> Oct 2024 | Trial primary completion date: Oct 2021 --> Oct 2024
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Humira (adalimumab) / Eisai, AbbVie
Clinical, Journal: Treatment strategies for hidradenitis suppurativa: real-life data from a tertiary Greek hospital. (Pubmed Central) - Mar 23, 2022
All in all, a wide variety of treatment regimens were implemented, with various combinations of topical and systemic agents. Real-life practice reflects the relative paucity of high-quality evidence regarding HS treatment and the absence of a unanimously preferable therapeutic option, leaving both dermatologists and patients defenceless against disease progress and sequelae.
- |||||||||| tetracycline / Generic mfg.
Retrospective data, Review, Journal: Efficacy and safety of tetracyclines for pemphigoid: a systematic review and meta-analysis. (Pubmed Central) - Mar 23, 2022
Compared to doxycycline and minocycline, tetracycline was significantly associated with better treatment outcomes and fewer adverse effects (p < 0.05). This review revealed tetracyclines' efficacy and safety in pemphigoid treatment and may offer support for clinical use of tetracyclines in pemphigoid.
- |||||||||| ketorolac / Generic mfg., dexamethasone / Generic mfg.
Review, Journal: Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets. (Pubmed Central) - Mar 23, 2022
Atropine, cyclopentolate, scopolamine, and homatropine are among the most frequently used medications for this purpose...A variety of commonly used agents, including prednisolone acetate, loteprednol, difluprednate, dexamethasone, fluorometholone, and methylprednisolone are discussed...Non-steroidal medications, such as ketorolac, bromfenac, nepafenac, and diclofenac, are additionally used for their efficacy in controlling ocular inflammation without incurring side effects seen with steroids...For example, several antibiotics, such as doxycycline and macrolides, have been used for their anti-inflammatory effects on specific cytokines that are upregulated during acute injuries...Neurotrophic corneal disease may occur as a result of severe or chronic injury. In such cases, recombinant human nerve growth factor (cenegermin), topical insulin, and several other novel agents may be an alternate and effective option for clinicians to consider.
- |||||||||| hydroxychloroquine / Generic mfg.
Journal: Plasma Cell-Predominant Lichen Planopilaris. (Pubmed Central) - Mar 23, 2022
Doxycycline and hydroxychloroquine were subsequently added to the patient's treatment regimen, leading to an improvement of symptoms. We present this case to bring awareness to this unusual feature and discuss its differential diagnosis.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: Epidemic retinitis - Factors associated with poor visual outcomes. (Pubmed Central) - Mar 23, 2022
Older age, male gender, diabetic status, delayed presentation, poor presenting CDVA, bilaterality, presence of keratic precipitates, disk pallor, retinal thinning, and subfoveal deposits had a statistically significant association, whereas the absence of skin rash, ellipsoid zone loss, negative WIDAL, Weil-Felix test, and delayed doxycycline therapy or use of steroids without doxycycline had a statistically insignificant association with poor visual outcomes. Apart from presenting CMT and location of retinitis, multiple demographic, clinical, and imaging factors can be implicated for poor visual outcomes.
- |||||||||| ethambutol / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Treatment and Outcome of Culture-Confirmed Mycobacterium marinum Disease. (Pubmed Central) - Mar 23, 2022
Two-drug regimens of ethambutol and a macrolide are effective for moderately severe infections. Tetracycline monotherapy in limited disease should be used vigilantly, preferably with proven in vitro susceptibility.
- |||||||||| doxycycline / Generic mfg.
Journal: D1 Receptor Mediated Dopaminergic Neurotransmission Facilitates Remote Memory of Contextual Fear Conditioning. (Pubmed Central) - Mar 23, 2022
Herein, we investigated the role of dopaminergic neurotransmission via D1Rs in aversive memory formation in contextual and auditory cued fear conditioning tests using D1R knockdown (KD) mice, in which the expression of D1Rs could be conditionally and reversibly controlled with doxycycline (Dox) treatment...Furthermore, expression analysis showed a slight increase in the post-stimulation amount of c-Fos in the hippocampus and striatum, and a significant increase in the amount of phosphorylated SNAP-25 in the hippocampus, striatum, and prefrontal cortex before and after stimulation. These findings indicate that deficiency in D1R-mediated dopaminergic neurotransmission is an important factor in impairing contextual fear memory formation for remote memory.
- |||||||||| doxycycline / Generic mfg.
A COVID-POSITIVE PATIENT WITH ARDS SECONDARY TO ANAPLASMOSIS ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_1111;
There is evidence that some of the mechanism of injury leading to ARDS in patients with HGA is similar to COVID with macrophage activation and excessive cytokine production.8 A thorough social history and avoiding anchoring heuristics can guide diagnosis. Early recognition and treatment with doxycycline can reduce overall morbidity and mortality.
- |||||||||| dexamethasone / Generic mfg.
EHRLICHIOSIS? CHECK FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_961;
Doxycycline was started empirically...Treatment was initiated with dexamethasone, etoposide...Given the high mortality rate with HLH, it is imperative to recognize and treat HLH early in Ehrlichiosis. We suggest checking screening ferritin level in suspected cases of Ehrlichiosis would help in early recognition and initiation of treatment HLH.
- |||||||||| pimecrolimus topical / Generic mfg., tacrolimus topical / Generic mfg., disulfiram / Generic mfg.
Disulfiram-like reactions to topical tacrolimus: a case series () - Mar 21, 2022 - Abstract #AAD2022AAD_2774;
The patients had marked improvement of the periorificial dermatitis with the addition of oral doxycycline and metronidazole 0.75% cream twice daily...Disulfiram-like reactions have also been reported with topical pimecrolimus cream, though this is rare...The mechanism of action is unknown. Patients should be counseled about this potential side effect.
- |||||||||| tetracycline / Generic mfg.
Impact of Telehealth on Duration of Tetracycline Prescription During COVID-19 () - Mar 21, 2022 - Abstract #AAD2022AAD_2761;
In this era of increasing telehealth, the demonstrated decrease in duration of doxycycline prescription in virtual visits is perhaps indicative of increased accessibility afforded by teledermatology. Future studies might explore factors related to provider decision-making in virtual visits compared to in-person visits and holds implications for how televisits may play an increasingly greater role in acne management.
- |||||||||| prednisone / Generic mfg., indomethacin / Generic mfg., doxycycline / Generic mfg.
Keratoderma blenorrhagicum and balanitis circinata: Indicators of reactive arthritis () - Mar 21, 2022 - Abstract #AAD2022AAD_2678;
This case represents the classic presentation of reactive arthritis with keratoderma blenorrhagicum and balanitis circinata with chlamydia trachomatis infection. Keratoderma blenorrhagicum is characteristic of reactive arthritis, although occurring in only 10% of patients.1, 2 In patients with palmoplantar keratoderma or otherwise typically appearing psoriasis and psoriatic arthritis, it is important to consider the diagnosis of reactive arthritis and expand the history and physical to elucidate the diagnosis.
- |||||||||| doxycycline / Generic mfg., ivermectin topical / Generic mfg.
Burning and stinging in rosacea treatments: A review of clinical evidence () - Mar 21, 2022 - Abstract #AAD2022AAD_2629;
Most of these data arise from topical ivermectin monotherapy[3-5], but studies with combination ivermectin and modified-release doxycycline[6], combination metronidazole and modified-release doxycycline[7], and encapsulated benzoyl peroxide[8] also showed reductions in burning and stinging symptoms from baseline.ConclusionsAvailable rosacea therapies have the potential to treat beyond visible features and improve burning/stinging symptoms and therefore patient QoL. Further research is needed to better understand these benefits and optimize rosacea treatment.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Hidradenitis Suppurativa Secondary to Nivolumab () - Mar 21, 2022 - Abstract #AAD2022AAD_2621;
Immune checkpoint inhibitors (ICI) are monoclonal antibodies that target cytotoxic t-lymphocyte-associated protein-4 (CTLA-4: ipilimumab), program cell death protein-1 receptor (PD-1: nivolumab, pembrolizumab), or program cell death ligand-1 (PD-L1: atezolizumab, durvalumab)...He was treated in the office with intralesional triamcinolone (15 mg) and started on chlorhexidine washes, 1% clindamycin lotion, and oral doxycycline...He is scheduled to return to clinic to discuss other treatment options. A potential mechanism for ICI-induced HS could be upregulation of TH17 cells and the IL-17 axis, as they appear to be most incriminated in HS.3 Furthermore, IL-17 has been implicated in ICI-induced colitis.4To our knowledge, this is only the second report of the development of HS following ICI therapy.5
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Women of childbearing age with hidradenitis suppurativa frequently prescribed medications dangerous for pregnancy () - Mar 21, 2022 - Abstract #AAD2022AAD_2613;
Minocycline and doxycycline are pregnancy category D and TMP-SMX and acetaminophen-oxycodone are pregnancy category C. Medications such as isotretinoin, acitretin, alitretinoin, and adalimumab were not referenced in the dataset...Minocycline, doxycycline and TMP-SMX are all well known to cause teratogenicity.It is encouraging that dermatologists are not prescribing drugs that have no indication for use during pregnancy but with relatively higher levels of efficacy evidence such as isotretinoin or alitretinoin. With the Food and Drug Administration approval of adalimumab for HS in 2018 and the increasing evidence supporting the use of biologics in HS, research should be done in order to ensure dermatologists are prescribing these medications, which are safer and more effective alternatives for women of childbearing age.
- |||||||||| amitriptyline / Generic mfg., rifampicin / Generic mfg.
Rare Infectious Diseases Encountered in a Dermatologic Setting () - Mar 21, 2022 - Abstract #AAD2022AAD_2589;
The disease resolved after a two-week course of doxycycline...Treatment with minocycline, moxifloxacin, rifampin, prednisone, methotrexate, and amitriptyline was initiated...PCR of blood and vesicular swabs were both positive for vaccinia virus. The patient was treated with povidone iodine ointment and recovered without issue.
|
