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114 Diseases |  |
151 Trials |
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151 Trials |  |
5480 News |  |
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- || doxycycline / Generic mfg.
Clinical, Journal: Lyme Prosthetic Joint Infection in Total Knee Arthroplasty: A Case Report. (Pubmed Central) - Apr 5, 2022
We recommend considering Lyme disease as a cause of culture-negative PJIs in endemic regions. Early surgical treatment may mitigate adverse outcomes of Lyme.
- | doxycycline / Generic mfg.
Journal: Optimized Doxycycline-Inducible Gene Expression System for Genetic Programming of Tumor-Targeting Bacteria. (Pubmed Central) - Apr 5, 2022
Overall, doxycycline-induced co-expression of two proteins at similar expression levels, we exploited bioluminescence reporter proteins with preclinical but no clinical utility. Future validation with clinically compatible reporter systems, for example, suitable for radionuclide imaging, is necessary to develop this system further towards potential clinical application.
- | doxycycline / Generic mfg.
Journal: Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual. (Pubmed Central) - Apr 5, 2022
We demonstrate that acute cold challenge elicits striking transcriptomic changes specifically within DPP4+ PDGFRβ+ adipocyte precursor cells, including a β-adrenergic receptor CREB-mediated induction in the expression of the prothermogenic cytokine, Il33 Doxycycline-inducible deletion of Il33 in PDGFRβ+ cells at the onset of cold exposure attenuates ILC2 accumulation and beige adipocyte accrual. These studies highlight the multifaceted roles for adipocyte progenitors and the ability of select mesenchymal subpopulations to relay neuronal signals to tissue-resident immune cells in order to regulate tissue plasticity.
- | doxycycline / Generic mfg.
Journal: Countering the rise of syphilis: A role for doxycycline post-exposure prophylaxis? (Pubmed Central) - Apr 5, 2022
Findings suggest that doxycycline PEP will have a modest impact on syphilis incidence when assuming a reasonable level of uptake and adherence. Doxycycline PEP may be most appropriate as a secondary prevention measure to condoms and enhanced syphilis screening for reducing infections among SMM.
- || Seysara (sarecycline) / Paratek, Almirall, AbbVie
Clinical, Journal: Sarecycline Treatment for Acne Vulgaris: Rationale for Weight-Based Dosing and Limited Impact of Food Intake on Clinical Efficacy. (Pubmed Central) - Apr 5, 2022
Co-administration with high-fat food has a limited impact on clinical efficacy. The pharmacokinetic of oral sarecycline provide added convenience and support ease of use and improved compliance for acne vulgaris patients.
- | tamoxifen / Generic mfg.
Preclinical, Journal: Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes. (Pubmed Central) - Apr 5, 2022
As proof of concept, we successfully introduced an oncogenic point mutation to the endogenous KRAS gene locus of this cell line. The cell line will serve as a powerful tool to conduct functional analyses of human genes.
- | bleomycin / Generic mfg., doxycycline / Generic mfg.
Journal: A Novel Regulatory Role of ALCAM in the Pathogenesis of Pulmonary Fibrosis. (Pubmed Central) - Apr 5, 2022
Pulmonary fibrosis was also induced in transforming growth factor-β1 (TGF-β1)-transgenic mice that conditionally overexpress TGF-β1 upon doxycycline administration...Collectively, these results highlight that ALCAM contributes to bleomycin-induced pulmonary fibrosis associated with apoptosis through PI3K and ERK signaling pathways in response to TGF-β. Our findings demonstrate the potential of ALCAM as a therapeutic target for IPF and may aid the development of new strategies for the management and treatment of IPF patients.
- | doxycycline / Generic mfg.
Journal: Granulomatous cheilitis in a patient after SARS-CoV-2 infection treated with antibiotics: a case report. (Pubmed Central) - Apr 5, 2022
Initial treatment with systemic corticosteroids and antihistamines was inadequate. Here we report successful treatment with a combination of doxycycline and metronidazole.
- | tetracycline / Generic mfg.
Journal: Contamination status and the health risk evaluation of dietary exposure of quinolone and tetracycline antibiotics in animal derived foods in Ningbo City from 2018 to 2020 (Pubmed Central) - Apr 5, 2022
Here we report successful treatment with a combination of doxycycline and metronidazole. Quinolone and tetracycline antibiotics such as enrofloxacin and oxytetracycline have no dietary health risk to the population.
- | doxycycline / Generic mfg.
Journal: Fluorescent Imaging-Guided Chemo- and Photodynamic Therapy of Hepatocellular Carcinoma with HCPT@NMOFs-RGD Nanocomposites. (Pubmed Central) - Apr 5, 2022
The tissue distribution and chemo- and photodynamic therapeutic effects of HCPT@NMOFs-RGD were evaluated in a doxycycline-induced zebrafish HCC model and xenograft mouse model...Moreover, the xenografts in mice were eliminated remarkably following HCPT@NMOFs-RGD treatment with laser irradiation, while little morphological change was found in other main organs. The nanocomposites HCPT@NMOFs-RGD accomplish tumor targeting and play synergistic chemo- and photodynamic therapeutic effects on HCC, offering a novel imaging-guided drug delivery and theranostic platform.
- | Abthrax (raxibacumab) / Emergent Biosolutions
Preclinical, Journal: A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis. (Pubmed Central) - Apr 5, 2022
Moreover, ciprofloxacin, when treated in adjunct with a suboptimal concentration of DA-98-WW07 demonstrated augmented activity in protecting mice from B. anthracis infection. Taken together, we report the prophylactic treatment potential of DA-98-WW07 for anthrax and the utility of immunomodulators in combination with an antibiotic to treat infections caused by the B. anthracis bacterium.
- | doxycycline / Generic mfg.
Retrospective data, Journal: Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes. (Pubmed Central) - Apr 5, 2022
These ultrasonographic changes were consistent with the hematology results, which showed a greater elevation of serum liver enzyme levels than renal enzymes. Ultrasonographic changes during CME infection and after treatment with doxycycline can help to monitor and identify persistent pathological changes in the target organs resulting from immune response to CME.
- | tetracycline / Generic mfg.
Journal, IO biomarker: Tetracyclines Enhance Anti-tumor T-Cell Responses Induced by a Bispecific T-Cell Engager. (Pubmed Central) - Apr 5, 2022
In analyses of the peripheral blood mononuclear cells (PBMCs) and lung tumor-infiltrated cells of NSCLC patients, we found that demeclocycline enhanced T-cell cytotoxicity not only in PBMCs, but also in lung tumor tissues. These results support the further application of tetracyclines to combination cancer immunotherapy.
- | cisplatin / Generic mfg., etoposide IV / Generic mfg.
Journal: Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity. (Pubmed Central) - Apr 5, 2022
Etoposide, but not cisplatin or 5-fluorouracil, showed remarkable cytotoxicity in high-density (with GJ formation) cultures than in low-density (without GJ formation) in transformed HeLa cells...In conclusion, we provide the novel finding that MSC increases etoposide-mediated cytotoxicity by enhancing GJ activity, due to elevated Cx expression through a GSH-dependent posttranscriptional mechanism. More generally, the study highlights potential benefit of the combination of GJ modulators and chemotherapeutic agents in anticancer treatment.
- | doxycycline / Generic mfg.
Journal: Transient ETV2 Expression Promotes the Generation of Mature Endothelial Cells from Human Pluripotent Stem Cells. (Pubmed Central) - Apr 5, 2022
The findings of this study on generation of mature iPS-ETV2-ECs provide further insights into the exploration of cell reprogramming from iPSCs. Here, we provide a new protocol for differentiation of iPSCs, thus providing a new source of ECs for in vitro disease modeling and clinical applications.
- | doxycycline / Generic mfg.
Journal: Reconstruction of Large Full-Thickness Abdominal Wall Defects Using a Free Functional Latissimus Dorsi Muscle. (Pubmed Central) - Apr 5, 2022
Donor site seromas occurred in 5 cases and were treated with punction and direct doxycycline injection...Using fLDM as a definitive solution, we are not only able to repair soft tissue defects, but also reconstruct voluntary contractility and dynamic natural functional abdominal wall. Transplanted LDM offers enough contractile capacity and strength to replace the function of the missing abdominal wall muscles.
- hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
Impact of diagnosis and treatment of Tropheryma whipplei infection in patients with pre-existing chronic inflammatory rheumatic diseases: data from the national Tw-IRD registry (Congress Hall A1) - Apr 4, 2022 - Abstract #EULAR2022EULAR_702;
A Tw infection should be considered in IRD patients with peripheral joint involvement and inadequate response to DMARDs, particularly in the presence of extra-articular manifestations, elevated CRP and hypoalbuminemia. In such patients, positive results of screening and diagnostic tests for Tw infection may lead to the initiation of Tw infection treatment which is associated with complete recovery of Tw infection and rapid remission of the IRD, allowing DMARD and corticosteroid therapy withdrawal in most the cases.
- ||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Re: "it's pointed out because people poisoned themselves with veterinary formulations, unlike with azithromycin, doxycycline, etc." https://t.co/Wh9MvVSVf1 https://t.co/EXjQqHC29a (Twitter) - Apr 4, 2022
- |||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Clinical: Who's "leading off with that as a reason to reject IVM as a potential COVID treatment"? Are you attacking a straw man? Again, it's pointed out because people poisoned themselves with veterinary formulations, unlike with azithromycin, doxycycline, etc. (Twitter) - Apr 4, 2022
- | ceftriaxone / Generic mfg.
Preclinical, Journal: Rat bite fever in a total knee arthroplasty: an unusual case of periprosthetic joint infection. (Pubmed Central) - Apr 3, 2022
The 16S rRNA sequencing is helpful in the determination of a causative microorganism in the case of a culture-negative PJI. A DAIR procedure in combination with 12 weeks of antibiotics could successfully treat S. moniliformis prosthetic joint infection.
- || doxycycline / Generic mfg.
Clinical, Journal: Mycoplasma hominis Lumbar Wound Infection After Posterior Decompression and Instrumented Fusion: A Case Report. (Pubmed Central) - Apr 2, 2022
Mycoplasma hominis is a urogenital commensal rarely implicated in musculoskeletal infections. A high index of suspicion is required in spinal surgery patients who develop fever and purulence and have initial negative cultures and poor response to empirical antibiotics.
- || doxycycline / Generic mfg.
Clinical, Journal: Long-Term Inflammatory Rosacea Management with Subantibiotic Dose Oral Doxycycline 40 mg Modified-release Capsules Once Daily. (Pubmed Central) - Apr 2, 2022
A high index of suspicion is required in spinal surgery patients who develop fever and purulence and have initial negative cultures and poor response to empirical antibiotics. After 52 weeks of once-daily treatment, subantibiotic dose doxycycline significantly reduced the relapse rate and inflammatory lesion counts in subjects with moderate-to-severe inflammatory rosacea.
- | doxycycline / Generic mfg.
Journal: A persistent plaque on the back of the hand. (Pubmed Central) - Apr 2, 2022
Diagnosis was confirmed by serology, PCR and histopathological findings. The plaque resolved following a 3-week course of oral doxycycline.
- | tetracycline / Generic mfg.
Journal: A novel fluorescence ratio probe based on dual-emission carbon dots for highly selective and sensitive detection of chlortetracycline and cell imaging. (Pubmed Central) - Apr 2, 2022
More importantly, the DECDs were used for quantitative detection of CTC in living cells, which demonstrated excellent biocompatibility and broad prospects in biomedicine application. Finally, the excellent selectivity of DECDs toward CTC was attributed to the FRET mechanism and the formation of complexes.
- | clarithromycin / Generic mfg.
Retrospective data, Journal: Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study. (Pubmed Central) - Apr 2, 2022
Finally, the excellent selectivity of DECDs toward CTC was attributed to the FRET mechanism and the formation of complexes. This study could contribute to a better understanding of the current epidemiological features of UU, CT, MG, and NG among obstetrics and gynecological outpatients in southwest China, and thus facilitate to development of the more effective intervention, prevention, and treatment of reproductive tract infection.
- || doxycycline / Generic mfg.
Review, Journal: Neurological Facets of Scrub Typhus: A Comprehensive Narrative Review. (Pubmed Central) - Apr 2, 2022
Scientific literature on scrub typhus neurology chiefly emanates from case reports, case series and small studies, and a comprehensive review is warranted to aid clinicians in recognising neurological involvement. This review aims at enriching this gap, and summarises clinical features, laboratory findings, and treatment options for various neurological facets of scrub typhus.
- | doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia (clinicaltrials.gov) - Apr 1, 2022
P=N/A, N=125, Recruiting, Sponsor: Kirby Institute
This review aims at enriching this gap, and summarises clinical features, laboratory findings, and treatment options for various neurological facets of scrub typhus. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
- | doxycycline / Generic mfg., minocycline / Generic mfg.
Journal: Minocycline and doxycycline: More Than Antibiotics. (Pubmed Central) - Apr 1, 2022
Non-antibiotic biological effects for both the antibiotics were identified through searching relevant databases including: PubMed, Scopus, and Web of Science up to 2020, using the keywords 'minocycline and doxycycline'. Anti-inflammatory, anti-oxidant, anti-apoptotic neuroprotective, immunomodulatory and number of other non-antibiotic effects were compiled for minocycline and doxycycline.
- | doxycycline / Generic mfg.
Preclinical, Journal: Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats. (Pubmed Central) - Apr 1, 2022
This suggests that a postnatal high-fat diet is important for the development of cardiac dysfunction in rat offspring after diabetic pregnancy. Our data provide evidence that a diabetic pregnancy is a novel cardiac risk factor that becomes relevant when other challenges, such as a high-fat diet, are present.
- | doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Removal of veterinary antibiotics in swine wastewater using microalgae-based process. (Pubmed Central) - Apr 1, 2022
Microalgae biomass harvested after antibiotics removal presented a carbohydrate-rich content of 52.7 ± 8.1, 50.1 ± 3.3, 51.4 ± 5.4 and 57.4 ± 10.4 (%) when cultured with tetracycline, oxytetracycline, chlortetracycline and doxycycline, respectively, while the control culture without antibiotics presented a carbohydrate content of 40 ± 6.5%. These results indicate that could be a valuable source for bioenergy conversion.
- | doxycycline / Generic mfg.
Journal: Colletofragarone A2 and Colletoins A-C from a Fungus Colletotrichum sp. Decrease Mutant p53 Levels in Cells. (Pubmed Central) - Apr 1, 2022
In this study, we used immunofluorescence staining of Saos-2 cells harboring doxycycline-inducible p53 [Saos-2 (p53) cells] to search for compounds from natural sources that can target mut p53 and found an extract of Colletotrichum sp...The relative and absolute configurations of 1 were determined by the spectroscopic method and DFT calculation. Compounds 1 and 2 inhibited the growth of Saos-2 (p53) cells and decreased mut p53 in the cells.
- | cephalexin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
Journal: Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics. (Pubmed Central) - Apr 1, 2022
In a prospective, randomized study of four clinically relevant antibiotic regimens [doxycycline (20 mg or 100 mg), cephalexin, or trimethoprim/sulfamethoxazole], we investigated microbial alterations on skin after administration of systemic antibiotics to healthy human volunteers. [Figure: see text].
- || levofloxacin / Generic mfg., doxycycline / Generic mfg.
Clinical, Journal: Pneumonia, endocarditis of two valves and pulmonary artery embolism in a 26-year-old male patient (Pubmed Central) - Apr 1, 2022
Under antibiotic treatment with levofloxacin and doxycycline there was an improvement of the symptoms and a normalization of the inflammation parameters. The treatment of the endocarditis was successful.
- | doxycycline / Generic mfg.
Journal: Electrophoretic deposition of novel semi-permeable coatings on 3D-printed Ti-Nb alloy meshes for guided alveolar bone regeneration. (Pubmed Central) - Apr 1, 2022
The treatment of the endocarditis was successful. This study verified that the EPD of CSGDox coatings on the 3D-printed Ti-Nb meshes can maintain space, provide antibiotic release whilst maintaining a barrier against soft-tissue growth, which is essential for the success of GBR treatment.
- | doxycycline / Generic mfg.
Journal: Functionally graded membrane deposited with PDLLA nanofibers encapsulating doxycycline and enamel matrix derivatives-loaded chitosan nanospheres for alveolar ridge regeneration. (Pubmed Central) - Apr 1, 2022
FGM with CE-PD revealed significantly greater new bone formation and defect fill at 4 weeks. In conclusion, FGM with PD reduced early tissue breakdown and with CE-PD nanofibrous composites accelerated wound healing and facilitated osteogenesis, and thus could be an advantageous strategy for ARR.
- | doxycycline / Generic mfg., tetracycline / Generic mfg., sulphadiazine / Generic mfg.
Journal: Impact of fertilization with pig or calf slurry on antibiotic residues and resistance genes in the soil. (Pubmed Central) - Apr 1, 2022
Furthermore a positive association between the presence of antibiotic residues (total antibiotic load) and antibiotic resistance genes in soil was found. One possible explanation for this is a simultaneous introduction of antibiotic residues and resistance genes upon application of animal slurry.
- || Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Review, Journal: Delayed-onset granulomatous reaction presenting as chronic facial edema: a review of the diagnostic and therapeutic challenges. (Pubmed Central) - Apr 1, 2022
Physicians should acknowledge this potential complication of silicone fillers and should inquire about their use with close-ended questions. We also review the diagnostic and therapeutic challenges faced by physicians when encountering this diagnosis.
- | clindamycin phosphate / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
New P2/3 trial: Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension (RATIONALISE) (EUDRACT) - Apr 1, 2022
P2/3, N=300, Not yet recruiting, Sponsor: Monash University
- ||| doxycycline / Generic mfg.
This isn't malaria. Also doxycycline used in malaria. (Twitter) - Mar 31, 2022
- | doxycycline / Generic mfg., pramipexole IR / Generic mfg.
Journal: Dopamine DL receptor density influences the recruitment of β-arrestin2 and G1 induced by antiparkinsonian drugs. (Pubmed Central) - Mar 31, 2022
Taken together, these observations highlight receptor density as a key driver of the signaling transducer recruitment triggered by antiparkinsonian agents. Moreover, given the putative beneficial properties of β-arrestin2 in promoting locomotion, this study provides molecular insights that position the arrestin-biased ligand rotigotine as a putatively more beneficial D receptor agonist for the treatment of early and late Parkinson's disease.
- | tetracycline / Generic mfg.
Journal: Morphological crystal adsorbing tetracyclines and its interaction with magnesium ion in the process of struvite crystallization by using synthetic wastewater. (Pubmed Central) - Mar 31, 2022
The existence of Mg ion would inhibit TCs deprotonation and thereafter improve TCs adsorption onto struvite crystals. Further investigation revealed that continuously elevating initial TCs concentration would promote the formation of 1:2 transferring to 1:1 TCs-Mg chelates, which would result in a fluctuation following a drastic augment of TCs adsorption capacity.
- || doxycycline / Generic mfg.
It's a combo Ivm doxycycline that cures. You're far from stupid. Do you play word games much? (Twitter) - Mar 31, 2022
- || doxycycline / Generic mfg.
Because you're looking at a cure cocktail ivm doxycycline cut in half? 35 studies AS a cocktail including u Broward "astonishing 100% cure" (Twitter) - Mar 31, 2022
- | doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Doxycycline for Elbow Tendinopathy (clinicaltrials.gov) - Mar 31, 2022
P1, N=25, Recruiting, Sponsor: Hospital for Special Surgery, New York
Further investigation revealed that continuously elevating initial TCs concentration would promote the formation of 1:2 transferring to 1:1 TCs-Mg chelates, which would result in a fluctuation following a drastic augment of TCs adsorption capacity. Trial completion date: Jan 2022 --> Jan 2023 | Trial primary completion date: Jan 2022 --> Jan 2023
- ||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Clinical: Ha, 1969-1975 data: Mukerji AC, (1969) A clinical trial of doxycycline in the treatment of UTI. Chemotherapy 14:77–85, Musher DM,(1975) Effectiveness of achievable urinary concentrations of tetracyclines... J Infect Dis 131:S40–S44- referenced in https://t.co/NglcWC9QZh (Twitter) - Mar 31, 2022
- || doxycycline / Generic mfg., tetracycline / Generic mfg., minocycline / Generic mfg.
If using a tetracycline agent which has better urinary penetration: 1. tetracycline, 2. doxycycline, or 3. minocycline? (Twitter) - Mar 31, 2022
- || doxycycline / Generic mfg.
If cystitis, I wonder whether or not someone would consider doxycycline @DrToddLee @OncIDPharmd @ClancyNeil (Twitter) - Mar 31, 2022
- ||| doxycycline / Generic mfg.
Pfft, 7 days into infection and given for 3 days. Early treatment is exactly that..EARLY!.Also additional zinc/doxycycline is usually necessary and for longer than 3 days. Antibiotics on day 7 for 3 days won't help infection, does that mean antibiotics don't work. (Twitter) - Mar 31, 2022
- doxycycline / Generic mfg.
Vomiting and risk of intubation related to preoperative doxycycline use for dilation and evacuation (Hall E) - Mar 31, 2022 - Abstract #ACOG2022ACOG_205;
Our vomiting rates are lower than those previously published. We found no association between doxycycline-associated vomiting and either need for GETA or anesthetic complications.
- || doxycycline / Generic mfg.
You forgot to address * it needs to be taken before you get infected * it only works if given with doxycycline/zinc/etc * it was a poorly done study * big pharma funded this to benefit their antivirals (Twitter) - Mar 30, 2022