- |||||||||| clarithromycin / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
Clinical, Retrospective data, Review, Clinical Trial,Phase IV, Journal: Skin infection by Mycobacterium marinum - diagnostic and therapeutic challenge. (Pubmed Central) - May 25, 2022
The patient was treated with multidrug therapy, including clarithromycin, doxycycline, and rifampicin, due to the lesion extent, with satisfactory results. A brief review of the literature is also provided.
- |||||||||| Cytovene (ganciclovir) / Roche
Preclinical, Journal: Cryogel Scaffold-Mediated Delivery of Adipose-Derived Stem Cells Promotes Healing in Murine Model of Atrophic Non-Union. (Pubmed Central) - May 24, 2022
Using this Col1-tk atrophic non-union model, we hypothesized that the scaffold-mediated lentiviral delivery of doxycycline-inducible BMP-2 transgenes would induce osteogenesis at the fracture site...However, while the addition of BMP-2 promoted the endochondral ossification, it may provide a slower route to healing. This proof-of-concept study demonstrates the potential for cellularized cryogel scaffolds to enhance the healing of non-unions.
- |||||||||| ilaprazole / Generic mfg., doxycycline / Generic mfg.
Trial completion, Enrollment change: Saccharomyces Boulardii as Pretreatment Before Rescue Therapy of Helicobacter Pylori (clinicaltrials.gov) - May 23, 2022
P=N/A, N=106, Completed,
As a result, the current study concludes that doxycycline may be more effective in combination with other drugs for better COVID-19 treatment efficacy. Recruiting --> Completed | N=200 --> 106
- |||||||||| doxycycline / Generic mfg.
Journal: Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis. (Pubmed Central) - May 23, 2022
In the rNLS8 mouse model of ALS-like pathology driven by doxycycline-regulated neuronal expression of human TDP-43 lacking a nuclear localization signal (hTDP-43ΔNLS), slow MNs are more resistant to disease than fast-fatigable (FF) MNs and can mediate recovery following transgene suppression...Collectively, these findings demonstrate that MN identity dictates the susceptibility of neuromuscular junctions to TDP-43 pathology and slow MNs can drive recovery of motor systems due to their remarkable resilience to TDP-43-driven degeneration. This study highlights a potential pathway for regaining motor function with ALS pathology in the advent of therapies that halt the underlying neurodegenerative process.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Preclinical, Journal: Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. (Pubmed Central) - May 22, 2022
Previous pig models with tetracycline regulatory elements were generated through random integration...After eight months of Dox administration, squamous cell carcinoma developed in the nose, mouth, and scrotum, which indicated this pig strain could serve as an ideal large animal model to study tumorigenesis. Overall, the established pig models with controllable and switchable transgene expression system will provide a facilitating platform for transgenic and biomedical research.
- |||||||||| doxycycline / Generic mfg.
Incisional Microenvironments and Reduction in SSIs in Patients Treated with a Local Doxycycline-Eluting Formulation (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1983;
P2
These data demonstrated that the addition of D-PLEX100 to the SSI SOC prophylaxis regimen in elective colorectal surgery provided a 64% reduction in SSIs and importantly this was achieved without affecting the incidence of postoperative colonization by MDROs. As such, D-PLEX100 may be a promising addition to established colorectal SSI bundles for reducing SSIs without the risks associated with systemic antibiotic exposure.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Bacterial Diversity Significantly Reduces Towards the Late Stages Among Filarial Lymphedema Patients in the Ahanta West District of Ghana (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1757;
In addition, the study reports an emerging antimicrobial resistance trend of Staphylococcus haemolyticus and Escherichia coli against commonly used antibiotics such as tetracycline, chloramphenicol, and penicillin in communities' endemic to LF in the Ahanta West District, Ghana. This could pose a huge challenge to the management of the disease particularly as doxycycline is being championed to treat the infection.
- |||||||||| albendazole / Generic mfg., doxycycline / Generic mfg.
Pre-Clinical Development of Corallopyronin A - A Novel Natural Product Active Against Helminths, STIs and Staphylococci (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1591;
We have funding to complete the pre-clinical phase and to prepare and submit a clinical trial application for a first-in-human phase 1 study (planned for 2024) to the German regulatory agency BfArM. Thus, CorA would the first-in-class antibiotic with a novel mode of action to treat neglected tropical diseases and multidrug resistance S. aureus and N. gonorrhoeae in support of the UN Sustainable Development Goals.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
A Novel Mycobacterium Genomospecies Recovered from a Clinical Sample (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1207;
Though the new Mycobacterium genomospecies was most closely related to M. grossiae and saprophytic, mesophilic species such as Mycobacterium madagascariense and Mycobacterium arabiense, it is a distinct mycobacterial species with no clear subgenera classification. Given the phenotypic growth characteristics of the new Mycobacterium genomospecies and its genotypic attributes, it may represent a missing link between the Mycobacterium and Mycolicibacterium subgenera.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS. (Pubmed Central) - May 20, 2022
Here, we investigate the potential for neurite orientation dispersion and density imaging and diffusion tensor imaging (DTI) to detect microstructural changes in an experimental model of ALS with neuronal doxycycline (Dox)-suppressible overexpression of human TDP-43 (hTDP-43)...Together, these results suggest a non-monotonic relationship between DWI metrics and pathophysiological progression with TDP-43 mice exhibiting significantly altered diffusion metrics consistent with early inflammation followed by progressive axonal degeneration. Importantly, significant group-wise changes were observed in the earliest stages of disease when subtle pathology may be more elusive to traditional structural imaging techniques.
- |||||||||| Journal: Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines. (Pubmed Central) - May 20, 2022
A test-of-cure is recommended for all cases of pharyngeal gonorrhea and for rectal chlamydia if treated with azithromycin...Treatment of pelvic inflammatory disease routinely includes metronidazole with doxycycline and an increased dosage of ceftriaxone...Syphilis of more than one year's or unknown duration should be treated with three consecutive weekly doses of intramuscular penicillin G benzathine, 2.4 million units each. A thorough evaluation for otic, ophthalmic, and neurologic symptoms is essential for anyone with syphilis because these complications can occur at any stage and require 10 to 14 days of treatment with intravenous aqueous crystalline penicillin G. Family physicians can reduce STI rates by taking a thorough sexual history, especially in teens and young adults, ordering screening tests and treatment based on the updated Centers for Disease Control and Prevention STI guidelines, and collaborating with public health departments for disease reporting and partner services.
- |||||||||| doxycycline / Generic mfg.
Journal, PARP Biomarker: PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment. (Pubmed Central) - May 20, 2022
As downregulation of PARG has also been implicated in promoting the activation of pro-inflammatory genes, we also followed the gene expression profile of PARG-overexpressing 3 T3 cells using RNA-seq approach and observed that chemokine transcripts are significantly reduced in those cells. Our data suggest that the upregulation of PARG may be potentially useful for the tumor growth inhibition in cancer treatment and as anti-inflammatory intervention.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg.
BARTONELLA HENSELAE ENCEPHALOPATHY IN A PEDIATRIC PATIENT () - May 19, 2022 - Abstract #ESPID2022ESPID_1338;
This report is our attempt to share insight into this unique case to increase awareness and medical knowledge. Our patient's quick resolution of symptoms and short antimicrobial therapy suggests perhaps prolonged antimicrobials are not needed for immunocompetent patients.
- |||||||||| acetazolamide / Generic mfg., doxycycline / Generic mfg.
FEVER, HEADACHE, MIYALGIA, EXANTHEMA : A RICKETSIA CASE DURING PANDEMIC, MISC ? () - May 19, 2022 - Abstract #ESPID2022ESPID_1015;
Acetazolamide treatment was given for increased intracranial pressure...Rickettsia conori IgM ELISA was detected as 1/192 and doxycycline treatment was given for 10 days...Learning Points/ In pandemic era , patients considered mostly for common diseases, but detailed anamnesis should be taken. We present a case which is presented in similar findings with MIS-C and other infectious diseases but anamnesis lead us to specific serology tests.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
ACUTE Q FEVER AND PULMONARY TUBERCULOSIS IN AN ADOLESCENT – A CLINICAL CASE () - May 19, 2022 - Abstract #ESPID2022ESPID_907;
He was admitted with the diagnosis of non-resolving pneumonia, under ceftriaxone...After introduction of doxycycline, the patient became apyretic and his blood parameters normalized...The clinical picture outlined here improved after pursuing the treatment for acute Q fever. Nevertheless, it is essential to emphasize the importance of identification and treatment for both infections.
- |||||||||| SEVERE MEDITERRANEAN SPOTTED FEVER IN A CHILD () - May 19, 2022 - Abstract #ESPID2022ESPID_903;
Doxycycline remains the treatment of choice, principally in immunocompromised patients and with severe disease. IIP proved to be effective even in a context of a severe infection.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Sustainable adsorptive removal of antibiotics from aqueous streams using FeO-functionalized MIL101(Fe) chitosan composite beads. (Pubmed Central) - May 19, 2022
The adsorption of TC, DC and CFX on the surface of FeO-functionalized MIL101(Fe) chitosan composite beads was governed by the π-π interaction, H-bonding and electrostatic interaction between the antibiotics and adsorbent due to protonation, deprotonation and cation exchange in the aqueous solution. These results showed a good prospect for applying the reported beads towards removing antibiotics from pharmaceutical industry wastewater.
- |||||||||| doxycycline / Generic mfg., amphetamine / Generic mfg.
Journal: Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. (Pubmed Central) - May 19, 2022
However, doxycycline-induced reversal of Slc1a1/EAAT3 overexpression in adulthood normalized both the increased dopaminergic firing and AMPH-induced responses. These data indicate that the pathologic effects of Slc1a1/EAAT3 overexpression on dopaminergic neurotransmission and AMPH-induced stereotyped behavior are developmentally mediated, and support normalization of EAAT3 activity as a potential treatment target for basal ganglia-mediated repetitive behaviors.
- |||||||||| doxycycline / Generic mfg.
Journal: Niosome-encapsulated Doxycycline hyclate for Potentiation of Acne Therapy: Formulation and Characterization. (Pubmed Central) - May 18, 2022
These data indicate that the pathologic effects of Slc1a1/EAAT3 overexpression on dopaminergic neurotransmission and AMPH-induced stereotyped behavior are developmentally mediated, and support normalization of EAAT3 activity as a potential treatment target for basal ganglia-mediated repetitive behaviors. This study demonstrated the ability of nano-niosomes containing doxycycline hyclate to treat skin acne compared with the free drug.
- |||||||||| doxycycline / Generic mfg.
Enrollment change, Surgery: D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (clinicaltrials.gov) - May 18, 2022
P3, N=1400, Recruiting,
This case report highlights the importance of suspecting a rare Nocardia species in patients at risk with proper occupational exposure, moreover, TMP-SMX resistance should be suspected with lack of clinical response, this may have important implications on clinical practice when facing similar infections. N=600 --> 1400
- |||||||||| doxycycline / Generic mfg.
Journal: CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis. (Pubmed Central) - May 17, 2022
The advantages of this high-throughput gene editing system are the ability to avoid time-consuming DNA vector subcloning, the flexibility in transfecting cells with unique guide RNA combinations in a 24-well format, and the lower-cost PCR genotyping using crude cell lysates. Studies using this streamlined approach promise to uncover functional redundancies and synergistic/antagonistic interactions between miRNA cluster members, which will aid in characterizing the complex small noncoding RNA networks involved in human disease and better inform future therapeutic design.
- |||||||||| doxycycline / Generic mfg.
Journal: Control of D-lactic acid content in P(LA-3HB) copolymer in the yeast Saccharomyces cerevisiae using a synthetic gene expression system. (Pubmed Central) - May 17, 2022
We used the modified doxycycline-based Tet-On approach to adjust the expression of the stereospecific D-lactate dehydrogenase gene (ldhA) from Leuconostoc mesenteroides to control D-lactic acid formation in yeast Saccharomyces cerevisiae...In addition, we obtained 5.6% PDLA and 19% P(LA-3HB) of the cell dry weight (CDW), which are over two- and five-fold higher accumulation levels, respectively, than reported in the previous studies with yeast. We also compared two engineered PHA synthases and discovered that in S. cerevisiae the PHA synthase PhaC1437 produced P(LA-3HB) copolymers with lower D-lactic acid content, but with higher molecular weight, in comparison to the PHA synthase PhaC1Pre.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Tick-borne Encephalitis and Borrelial Antibodies in Serum (clinicaltrials.gov) - May 17, 2022
P=N/A, N=80, Recruiting,
We also compared two engineered PHA synthases and discovered that in S. cerevisiae the PHA synthase PhaC1437 produced P(LA-3HB) copolymers with lower D-lactic acid content, but with higher molecular weight, in comparison to the PHA synthase PhaC1Pre. Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
- |||||||||| doxycycline / Generic mfg.
Journal: Vibrio metschnikovii, a Potential Pathogen in Freshwater-Cultured Hybrid Sturgeon. (Pubmed Central) - May 15, 2022
This study not only demonstrated that V. metschnikovii was the cause of death of a large number of hybrid sturgeon but also revealed its potential risk in hybrid sturgeon aquaculture. The results provide a basis for the diagnosis and prevention of this disease.
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